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312. Perimenopause Symptoms Can Start in Your Late 30s - Dr. Remina Panjwani

The Ultimate Human with Gary Brecka

1h 5m
Transcript

Original podcast

Summary

Written by a model from the transcript; not yet reviewed.

Gary Brekka hosts internal medicine physician Dr. Ramina Panjwani to discuss the foundational role of the autonomic nervous system, why perimenopause can strike in a woman's late thirties, and how chronic stress and generational trauma sabotage biological health. The conversation exposes major blind spots in modern medicine, arguing that standard blood panels fail to capture true hormone balance and that high performers often push past yellow-light warning signs of burnout until a medical crisis hits. They also examine advanced diagnostic tools like the DUTCH test, the importance of gut-brain healing through fermented foods and breathwork, and why patients must regulate their nervous system before attempting any biohacking interventions.

  • Schedule dedicated time to pause every morning because you cannot outperform a dysregulated nervous system that is stuck in fight or flight. 0:50
  • Listen to early bodily signals in your thirties such as sleep disruption, brain fog, and unexpected body composition changes as potential signs of early perimenopause. 13:40
  • Utilize comprehensive hormone assessments like the DUTCH test rather than standard blood panels to accurately track hormone metabolites, methylation, and vitamin deficiencies. 19:17
  • Regulate daily stress and tap into the vagus nerve by practicing simple, portable breathwork techniques like box breathing or the physiological sigh. 44:43

Chapters

  1. 0:55
    Understanding Burnout and Nervous System Dysregulation

    Discussion of how constant stress leads to burnout and the importance of regulating the nervous system.

  2. 6:41
    Early Warning Signs of Burnout and Perimenopause

    Identifying subtle symptoms that precede burnout and early menopause indicators in women’s late 30s.

  3. 35:30
    The Dutch Hormone Test vs. Standard Panels

    Exploring why the Dutch test provides a comprehensive hormonal profile compared to typical blood panels.

  4. 48:00
    Generational Trauma and Its Health Impact

    Examining how ancestral stress and trauma can influence current health and behavior.

  5. 50:44
    Podcast Introduction and Host Greeting

    Gary Brecka introduces the episode and welcomes listeners to the show.

  6. 51:46
    Sleep, Brain Fog, and Hormonal Disruption

    Cortisol’s impact on sleep quality, cognitive fog, menstrual irregularities, and early menopause symptoms is explored.

  7. 1:00:00
    Practical Tools for Nervous System Regulation

    Breathing techniques, meditation, and lifestyle habits to maintain autonomic balance.

Highlights

  • 0:33

    Generational Trauma in Biologyinsight

    Chronic psychological or physical stress causes cellular changes that alter DNA and get passed down through generations, locking the nervous system into constant protection mode.

  • 4:23

    Regulate Before You Stimulateinsight

    The guest explains the impetus behind her TED Talk, arguing that modern biohackers constantly overstimulate their bodies with advanced tactics while ignoring foundational biological regulation.

  • 6:57

    Subtle Signs of Burnoutinsight

    High performers often miss the yellow lights of burnout, which manifest as subtle fatigue, sleep disruption, brain fog, hormonal shifts, and gut issues long before hitting a wall.

  • 8:52

    Perimenopause in the Thirtiesstory

    The host shares his wife's journey with early perimenopause symptoms starting in her mid-forties, and the guest confirms that modern environmental and lifestyle stressors mean symptoms can begin as early as the late thirties.

  • 18:56

    Limitations of Standard Blood Panelsdebate

    Standard medical blood work offers only a basic snapshot in time, missing full hormone complements, metabolite pathways, and vitamin levels that specialized tests uncover.

  • 26:30

    Chronic Disease and Healthcare Spendingdata

    The United States spends five trillion dollars annually on healthcare while forty-two percent of prepubescent children suffer from at least one chronic disease.

  • 56:18

    The Gut-Brain Connectionstrategy

    The guest explains how chronic stress impairs the gut lining, leading to inflammation and food sensitivities, and why stool tests like GI effects provide superior clinical data.

Quotes

  • “We live in a world that's constantly stimulating us.”
    Unnamed speaker · 0:00
  • “The Dutch test gives you everything personalized to your body, like the breakdown of the pathway.”
    Unnamed speaker · 19:17
  • “If you're constantly stressed, even if it was a physical or psychological, it turns into physiological, and that gets into your biology.”
    Unnamed speaker · 0:33
  • “If you schedule those simple moments, that's going to regulate you throughout the day.”
    Unnamed speaker · 11:00
  • “If you listen to the signs that something is off, then you can do something about it.”
    Unnamed speaker · 14:01
  • “You cannot outperform a dysregulated nervous system that's always in fight or flight.”
    Unnamed speaker · 0:50
  • “So if the main one I want to focus on is cortisol.”
    Unnamed speaker · 50:54
  • “Think about the metabolic aspect of it, right?”
    Unnamed speaker · 51:04
  • “So one of those, how that shows up is everything you eat, you just can't digest it.”
    Unnamed speaker · 54:39
  • “So getting into the mindset of really giving yourself permission to pause, because in that pause, you're doing so much, you're giving back to yourself and getting the tools to get to that next level and prevent burnout.”
    Unnamed speaker · 59:09
  • Ultimate Brew 17:03–17:24
  • Baja Gold Sea Salt 32:08–32:50
  • H2 Tab 48:34–49:18

About this episode

You might think perimenopause is a 50s problem, but Dr. Remina Panjwani says it can start in your late 30s. She and Gary Brecka go through the early signs, from 3 a.m. wakeups and brain fog to a belly that changes no matter what you eat. They also cover why she prefers the DUTCH test over standard blood work, and how chronic stress and cortisol affect your hormones. Listen to Dr. Remina Panjwani on all your favorite platforms! YouTube: https://bit.ly/4hxX3ov Spotify: https://bit.ly/4j3Lruy Apple Podcasts: https://bit.ly/4hzIKjl Connect with Dr. Remina Panjwani Website: https://bit.ly/4zkxixJ YouTube: https://bit.ly/4zdExrk Instagram: https://bit.ly/475fR8E Facebook: https://bit.ly/4yBCaif TikTok: https://bit.ly/4znvZhR LinkedIn: https://bit.ly/4yBkJyp Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD AIRES: “ULTIMATE20” FOR 20% OFF: https://bit.ly/4a3Duze BAJA GOLD: “ULTIMATE10” FOR 10% OFF: https://bit.ly/3WSBqUa BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsVBREW: THE ULTIMATE COFFEE: https://bit.ly/4elHM82 COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp CYMBIOTIKA: “BRECKACYM30” FOR 30% OFF: https://bit.ly/4tjyluP GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk GENETIC TEST (USA ONLY): https://bit.ly/3Yg1Uk9 GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC H2TABS: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn SNOOZE: LET’S GET TO SLEEP!: https://bit.ly/4pt1T6V WHOOP: JOIN & GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW Watch the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps 00:00 - Introduction: nervous system, burnout and menopause 04:22 - Regulate Before You Stimulate TED talk 06:09 - Early warning signs of burnout 07:31 - Morning breathing before your phone 11:14 - Menopause journey and frozen shoulder 13:40 - Perimenopause in your late 30s 17:30 - Joint pain and hormone therapy 18:18 - DUTCH test vs standard blood work 20:34 - Internal medicine to functional medicine 28:01 - Odd Girl Out and The Doctor Within 32:53 - How generational trauma gets passed down 38:37 - Spotting generational trauma in seven-year stages 40:21 - Hypnosis and vibroacoustic therapy 42:56 - Breathwork, HRV and heart-brain coherence 47:47 - Stress, cortisol and weight loss resistance 52:40 - Fasting insulin vs A1C and gut inflammation 55:26 - Gut testing, probiotics and fermented foods 58:57 - Why you can't outperform your nervous system 1:02:10 - Peptides for the right person 1:03:27 - What it means to be an Ultimate Human Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions. Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

0:00
1:05:27

11,698 words · 3 speakers

Topics

  • cortisol
  • Ultimate Human Podcast
  • Dutch test
  • biohacking
  • TED
  • glucose
  • Regulate Before You Stimulate
  • The Gut‑Brain Connection
  • sauerkraut
  • fiber

Page updated · transcript and summary are machine-generated