233. Anders Corbett: On “Crafting” Your Gut Microbiome, Probiotics, Leaky Gut & Hormone Optimization

The woman who lived to 118 years old had one remarkable characteristic that scientists couldn’t ignore; her gut microbiome resembled that of a 35-year-old. I’m here today with Anders Corbett, CEO of Craft Microbiome, unpacking the science of banking your young bacteria before age-related decline sets in, and how specific bacterial strains are now being correlated to neurodegenerative diseases years before symptoms appear. Your genetic predisposition to Alzheimer’s or Parkinson’s may not be your destiny at all. CLICK HERE TO BECOME GARYS VIP!: https://bit.ly/4ai0Xwg Check out Anders Products here: www.craftmicrobiome.com Connect with Anders Corbett Website: https://bit.ly/495Viuq Instagram: https://bit.ly/4qz2Uvd Facebook: https://bit.ly/44XmbOH LinkedIn: https://bit.ly/44Xmjh9 Thank you to our partners H2TABS: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp WHOOP: JOIN AND GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn CARAWAY: “ULTIMATE” FOR 10% OFF: https://bit.ly/3Q1VmkC HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S RHO NUTRITION: “ULTIMATE15” FOR 15% OFF: https://bit.ly/44fFza0 GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk GENETIC TEST (USA ONLY): ⁠https://bit.ly/3Yg1Uk9 Watch the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps 00:00 Intro of Show 02:03 Anders Corbett’s Background 09:27 How Does Your Gut Bacteria Make Your Muscles Stronger? 16:32 Analysing Gut Bacteria Procedure and Treatment 26:27 Addressing the Symptoms 30:38 Working with NBA and Elite Athletes 36:57 Crafting Your Microbiome (on Your Own Goals) 40:07 Where to Start (When You Have Gut Inflammation)? 48:49 Treating Children’s Skin Diseases 57:09 Successful Patients’ Cases 1:05:36 Mitigating the Risks of Neurodegenerative Diseases 1:08:44 What’s Next for Craft Microbiome? 1:13:30 Restoring Healthy Physiology 1:18:26 Where to Start on Your Health Journey? 1:23:52 What does it mean to you to be an Ultimate Human? Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions. Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature. Learn more about your ad choices. Visit megaphone.fm/adchoices

Speaker names marked ? are inferred from speaking time and the show’s known hosts — they are not voice-verified.

• 0:00Speaker 00

  There's cyanobacteria for oxygen. Those are found in like Olympic swimmers. That's like how you can identify an Olympic swimmer is by the amount of cyanobacteria in their gut.

• 0:08Gary Brecka?

  Really? I think at the professional athlete level, they're all looking for ways to legally, without using a performance enhancement device, but to modify their biology. Anything that they can do to close that last gap.

• 0:20Speaker 00

  Before and after a stressful event, whether it's like a UFC fight, and it's usually saliva, stool, whatever they'll give me. And I measure how those bacteria change. And I'll try to correlate the changes I see in the profile to papers that have talked about this bacteria does X, Y, and Z.

• 0:35Gary Brecka?

  I know that there's enormity of connections between the gut microbiome and everything autoimmune to human performance, to how our mood and emotions work. But never did I understand that we can architect our own microbiome to serve the goals that we have for our health outcomes.

• 0:52Speaker 00

  There's a list of bacteria that I'm confident that I can isolate from a lot of different people. So I present someone with like a menu, like, hey, this bacteria does this, this bacteria does that. Like which ones you think would be valuable for you?

• 1:03Gary Brecka?

  There's a lot of people listening to this podcast. What benefit could they derive from working with Kraft microbiome to actually go in and re-architect the flora in their gut?

• 1:11Speaker 00

  There are changes in the gut that happen years before the symptoms develop. And one of the easiest things you can do is...

• 1:31Gary Brecka?

  Hey guys, welcome back to the Ultimate Human Podcast. I'm your host, human biologist Gary Brecka, where we go down the road of everything, anti-aging, biohacking, longevity, and everything in between. And today's podcast is going to be a fascinating podcast. I mean, first of all, because I am deeply, deeply interested in this subject. I never in my entire lifetime knew that the gut microbiome not only could, I knew that it could serve you, it could degrade your performance. I know that there's enormous, there's enormity of connections between the gut microbiome and everything from autoimmune to human performance, to how our mood and emotions work.

• 2:13Gary Brecka?

  But never did I understand that we can architect our own microbiome to serve the goals that we have for our health outcomes. And that is the most fascinating thing that we're going to delve into today with our guest Anders Corbett. Welcome to the podcast, my friend. Thank you for having me. And you know, there's, there's an interesting theme that runs through a lot of my podcasts. And you know, I find that the most impactful, purpose-driven, passionate people, at some point in their life, they solve the problem. And I know that you were a professional athlete and you were a world-class rower. Yeah, at one point.

• 2:57Gary Brecka?

  Yeah, you were training at the Olympic facility. I think you placed ninth in the, in the, you know, in the world competition. And so here you are, you're, you're, you have this background as a professional athlete. You were folding shirts at one point at Brooks. Brooks Brothers. Brooks Brothers. I'm even repping it today, right? Oh, are you? Let's go, Brooks. Yeah, let's go, Brooks. And, and somehow you made it into a fellowship at Harvard University. Right. And now your work has me so intrigued and I am absolutely fascinated by it. You know, we went to the UFC fights. Well, first of all, we're here in Dubai. Right.

• 3:42Gary Brecka?

  And we went to the UFC fights and I was like, my audience needs to know about this. I normally don't do this with podcasts. I just, I want to read some, some tidbits from, from Anders' background and some of the accomplishments he's, he's had with the gut microbiome, just to set the tone for the rest of this podcast. So listen to this. If you're not fascinated by the end of these, these 10 line items, then this is not the podcast for you, but this, this blew my mind. Simply by altering the microbiome, he proved the concept first with livestock with 20

• 4:20Gary Brecka?

  Before we went into human trials, 25% weight gain using 400 kilograms less feed consumption. He then on himself gained 25 pounds of muscle in one month using a specific probiotic formulation. He was then featured on ESPN's controversial sports exposé on poop doping and the microbiome performance, showing that you could alter the microbiome and significantly significantly improve athletic performance. He worked with George Church, who's one of the world's top genetic scientists, using the gut microbiome to enhance performance. Worked at the National Science Foundation as a research fellow, Harvard Medical School

• 5:03Gary Brecka?

  as a genetics fellow. He actually was able to target testosterone, growth hormone, strength, endurance, and recovery, not just gut health. And, you know, in 2012, he completed the world rowing championships as we talked about. And, you know, many of his competitors have raised millions and millions of dollars, but he went this direct to consumer route with these experimental probiotic formulations and has had astounding success. So, first of all, I want to gain 25 pounds of muscle in one month, so we're going to talk about that for sure. But tell me a little bit about your journey and how you go from folding shirts at Brooks

• 5:46Gary Brecka?

  Brothers to being a research fellow at Harvard University.

• 5:49Speaker 00

  I know, right? I got done rowing and I realized I'd worked my body really hard, but I hadn't worked my brain. And at the world championships, I realized that I was an amateur and all the other people from the other countries were professionals. And I realized like, you know what, I don't want to put another four years in and try for the next Olympics. And so I moved to Boston with not really a plan and I walked into Brooks Brothers. I got a job and then I joined a club at MIT called iGem, which is an international genetically engineered machines team. And I had really like no lab experience.

• 6:27Gary Brecka?

  Really?

• 6:27Speaker 00

  Yeah, I just sat in the back.

• 6:28Gary Brecka?

  Cause you're a very smart guy, man. I've pressed you on some of these topics and I consider myself pretty astute with the gut microbiome, but you've forgotten more than I'll ever know.

• 6:37Speaker 00

  Well, this was a cell to cell signaling. It was like my first interaction with synthetic biology and it was run by this guy named Ron Weiss and the club was great. We competed at the, something called the World Jamboree. I was like a wallflower on it, but it, I got an email from the professor at MIT. He's like, hey, like, you know, you should take, take this graduate course. And so I just started showing up at this graduate course with no lab training.

• 7:05Gary Brecka?

  Right.

• 7:05Speaker 00

  You know, and I got put with these cool guys from the MIT Media Lab and bioengineers and a bunch of crazy people. And then I stumbled into an internship as a biosafety officer intern. And the whole time I'm working at Brooks Brothers and one day George Church walks into the Chestnut Hill Mall and I see him and I just read his book, Regenesis.

• 7:26Gary Brecka?

  Yeah.

• 7:26Speaker 00

  And I went out and I was like, hey, Mr. Churchill, big fan. And he said, put yourself in places you don't belong because that's where you learn the most.

• 7:36Gary Brecka?

  He just gave you the advice right out of the gate?

• 7:39Speaker 00

  Yeah, well, we had a little conversation.

• 7:40Gary Brecka?

  He's like, hey, son, put yourself in places you don't belong because that's where you're learning.

• 7:43Speaker 00

  He's a wild, that guy's wild.

• 7:44Gary Brecka?

  Yeah.

• 7:45Speaker 00

  And totally focused on the science, just.

• 7:48Gary Brecka?

  No, no, he's an.

• 7:49Speaker 00

  Yeah, and like he travels in the same clothes with just a laptop.

• 7:53Gary Brecka?

  Really?

• 7:54Speaker 00

  Yeah.

• 7:55Gary Brecka?

  You know, a lot, a lot of these brainiac scientists are, there's no fluff. It's all just, you know, intentionally focused on their craft.

• 8:05Speaker 00

  And like two weeks later, I still had my ID pass from being a biosafety officer intern and I got through security and I brought some cookies and I, I told the secretary, I'm, oh, I'm one of George's old students. I just want to come say hello. And she gets me a meeting that day within minutes and I say, hey, I'm here. Can I have a job?

• 8:26Gary Brecka?

  At Harvard.

• 8:27Speaker 00

  At Harvard Medical, yeah, in the premier genetics lab in the world.

• 8:30Gary Brecka?

  Yeah.

• 8:31Speaker 00

  And he walks right out of the office, "Get this guy a job."

• 8:34Gary Brecka?

  Really?

• 8:35Speaker 00

  Yeah, and the secretary introduces me to a postdoc at the time, and it was, CRISPR was new at the time. And...

• 8:44Gary Brecka?

  CRISPR is the gene...

• 8:45Speaker 00

  Yeah, gene editing.

• 8:46Gary Brecka?

  And gene editing, yeah.

• 8:47Speaker 00

  She trained me how to do gene editing on George's own stem cells, like, you know, like how to like design primers, how to do transformations, how to do gels, which I was terrible at. She was always pissed at me about it. I couldn't run a gel to save my life. But I had to do sequencing, had to work with all these different companies that the lab's a part of. And then the second postdoc I worked with heard that I had been a former elite athlete. And eventually, we convinced Harvard to send us to the Rio Olympics to do a sports genomic study.

• 9:22Gary Brecka?

  And, and, well, first of all, what is a sports genomic study? But before you answer that, I want you to explain to me and my audience like we're five-year-olds.

• 9:31Speaker 00

  Okay.

• 9:32Gary Brecka?

  How does your gut bacteria make your muscles stronger? I mean, you know, because I, because, you know, my first foray into, into really being fascinated by the gut microbiome was years ago, Dr. Perlmutter wrote a book called The Gut-Brain Connection. He wrote another one called Grain Brain. It was the first book that really drew my attention to how foundational the gut microbiome is and these trillions and trillions of bacteria and how they're actually not just digesting proteins and carbohydrates and nutrients, but they're actually signaling molecules. They create serotonin, dopamine, they drive behavior, they drive mood.

• 10:15Gary Brecka?

  You know, we, we know now that your gut microbiome sort of gets what it wants. It's, it, it has mechanisms to signal the brain to have sugar cravings and other things. And, and it's, it's interesting because... You know, we think that we're in control of all of our choices, but very often we're not. You know, the gut microbiome is in control of a lot of the choices that we make.

• 10:40Speaker 00

  Yeah.

• 10:41Gary Brecka?

  But I've never thought about the gut microbiome, and this is what's so fascinating about your work. I've never thought about the gut microbiome as being something we can use or leverage to improve our processing speed, our memory, our focus, our concentration. And the last thing I thought would be, you know, athletic performance.

• 11:02Gary Brecka?

  So talk a little bit about, you know, as if we're five years old. How does the gut microbiome improve athletic performance? How many, how did you put on 25 pounds of muscle in a month without?

• 11:13Speaker 00

  There was this crazy paper from, I think, 2016, February 2016, about how people in Malawi, famine victims, and it took their microbiome, it did a fecal transplant into mice, and it took the microbiome from a Westerner and put it in a different mouse. They fed the mice the same amount of food, the same amount of water, and the Malawian mice became malnourished, like, lost weight, even though they were fed the same amount of calories.

• 11:42Gary Brecka?

  So you took the gut microbiome from someone who was malnourished?

• 11:45Speaker 00

  Yeah, someone else.

• 11:46Gary Brecka?

  Yeah, yeah, and fecal transported into the mouse. And then you have other gut microbiome?

• 11:52Speaker 00

  Yeah, from a Westerner.

• 11:53Gary Brecka?

  From a Westerner.

• 11:54Speaker 00

  Yeah.

• 11:55Gary Brecka?

  Same diet?

• 11:56Speaker 00

  Same diet.

• 11:57Gary Brecka?

  Okay.

• 11:57Speaker 00

  Same water, same everything, and the Western mouse gets obese.

• 12:01Gary Brecka?

  Wow.

• 12:02Speaker 00

  Right, and they repeat this a lot of times. And the Malawian mice wouldn't grow, right? They were stuck on a poor growth pathway, or whatever it was called. And so they found the single bacteria, and they gave it to the Malawian mouse, and then all of a sudden it returned to normal growth patterns.

• 12:19Gary Brecka?

  Wow, with a single bacteria. So by taking the gut microbiome and sequencing the different types of bacteria and looking at different types of levels, it's almost like a dial, right? You dial up certain bacteria, you get one result. You dial it down, you get a different result. So they dialed up the bacteria, you know, in from the Westerners and and all of a sudden, these mice recovered on the same.

• 12:44Speaker 00

  Yeah, they returned to like normal. And that's kind of what happens when you get poor sleep, you have poor diet, you know, you're overweight, like these growth hormone pathways in your body, they don't function, they get blocked, right? There's and so it's not really that well understood. But this lactobacillus reuteri, a specific substrate of it, is able to remove those blocks. So then your body can start producing its own growth hormone.

• 13:07Gary Brecka?

  Yeah, you know, what's fascinating, too, is as I getting further and further down the road of the gut microbiome, you know, we know that antibiotics wipe out your gut microbiome, and that you should take probiotics afterwards. But when you start to look at how we can actually go into the gut microbiome and specifically select different characteristics based on the bacteria. So for example, you know, there are strains of bacteria that are broadly absent in people that have eczema and psoriasis.

• 13:40Speaker 00

  Yeah.

• 13:41Gary Brecka?

  There are certain strains of bacteria that are broadly absent in neurodevelopmental disorders like autism.

• 13:48Speaker 00

  Yeah.

• 13:49Gary Brecka?

  And to me, that's fascinating. And in the the percentage into the degree to which these specific bacteria are correlated to very specific diseases, pathologies, is fascinating to me. Because, you know, I think very often in modern medicine, we get it all wrong. We think that things go wrong for no reason, which is why we diagnose a lot of things as idiopathic, right, of unknown origin. But when you think about the gut microbiome, the different, the different strains of bacteria as potentially being that root cause, this seems like something we could.

• 14:33Gary Brecka?

  You know, we could address mass.

• 14:35Speaker 00

  There are a lot of papers that show like changes in the gut happen years for Parkinson's, changes in the gut happen years before you develop some sort of, any sort of symptoms.

• 14:44Gary Brecka?

  It's like acromansia and, and cancer, you know, they're finding these deficiencies in certain gut bacteria. Dr. Mark Hyman talks about this all the time. Much higher prevalence in patients that have certain forms of cancer.

• 14:59Speaker 00

  Yeah.

• 15:00Gary Brecka?

  And, you know, I think, I'm fully bought in to, to that, you know, but, but.

• 15:06Speaker 00

  We're only at the beginning, right? There's a lot to learn.

• 15:09Gary Brecka?

  Yeah.

• 15:09Speaker 00

  There's a lot to learn.

• 15:10Gary Brecka?

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• 15:51Gary Brecka?

  Visit drinkh2tab.com. That's drinkh2tab.com and upgrade your hydration today. Now, let's get back to the Ultimate Human Podcast. But I want to know, you know, what are you confident in that you can? So first of all, you, you take a stool sample, right? You culture that stool sample and you look at the terrain. You look at the profile of the gut microbiome. Is that fair to say?

• 16:17Speaker 00

  Yeah.

• 16:18Gary Brecka?

  Okay. And then, once you have that person's gut microbiome profile, where do you go from there? Do you, or you, you say, well, what are the outcomes that you would like to have?

• 16:30Speaker 00

  Yeah.

• 16:30Gary Brecka?

  And then you target those bacteria?

• 16:32Speaker 00

  There's a list of bacteria that I'm confident that I can isolate from a lot of different people. So I present someone with like a menu, like, hey, this bacteria does this, this bacteria does that, like which ones you think would be valuable for you?

• 16:44Gary Brecka?

  Yeah.

• 16:44Speaker 00

  I allow like.

• 16:45Gary Brecka?

  And for the record, you're working with LeBron James. I mean, this is not like, this is not voodoo science, you know? He's not doing this in his basement and, you know, in his garage. I mean.

• 16:53Speaker 00

  And it's, yeah.

• 16:55Gary Brecka?

  So go ahead. So you, you, you take the microbiome and you have a, you have a menu. And they say, you know, I have focus and concentration issues. Um, yeah, I have a hard time focusing and concentrating. Let's, let's pick a few things.

• 17:08Speaker 00

  Yeah. But yeah, just to be clear, like it's, we understand like the first tier interactions, like this bacteria, and it's just starting to be this bacteria lives in this part of the digestive tract and it makes B vitamins.

• 17:19Gary Brecka?

  Okay.

• 17:20Speaker 00

  It makes B12 or something, right? And so there's a geography issue and then there's, you don't know if that B vitamin is consumed by another bacteria, right? We don't know like the downstream thing. So the philosophy is I just overload with that bacteria and.

• 17:35Gary Brecka?

  But you are seeing notable results.

• 17:37Speaker 00

  Yeah.

• 17:38Gary Brecka?

  Yeah.

• 17:38Speaker 00

  On blood tests and, you know, a lot of the clients, they do quarterly or monthly blood tests and they'll show like, hey, my B vitamins actually went up this month or my testosterone is up like 300 points or something.

• 17:49Gary Brecka?

  Really?

• 17:49Speaker 00

  Great. Yeah.

• 17:50Gary Brecka?

  Yeah.

• 17:50Speaker 00

  It just sits at like seven or 800 for months and months.

• 17:53Gary Brecka?

  Hmm. After you've made this manipulation in the bacteria.

• 17:56Speaker 00

  Yeah.

• 17:56Gary Brecka?

  Okay. So, so let's unpack that. Um, you know, I would love to, uh, to the extent that you're willing to do so, share an actual story of an athlete that came to you, um, or even somebody that had gut dysbiosis related ailment, maybe it was eczema, psoriasis, um, maybe it was, uh, you know, um, chronic gut issues with digestion, food allergies, food sensitivities. Let's, let's take a real life case that you've had and, and walk me through what you did from, you know, understanding what their deficit was or their goal was to getting their gut bacteria to how you either manipulated or, you know, cultured their bacteria and then what the result was.

• 18:41Speaker 00

  So I guess we can do two examples.

• 18:43Gary Brecka?

  Okay.

• 18:44Speaker 00

  One, I may, originally all the. Bacteria sold direct to consumer were isolated from me. And so there was like strength, endurance and complete.

• 18:53Gary Brecka?

  Okay.

• 18:54Speaker 00

  And so a friend of mine had a pick line in for years and years. He had Lyme disease. He ended up.

• 18:58Gary Brecka?

  Oh, Lyme's awful.

• 18:59Speaker 00

  Yeah, horrible, horrible disease. And he got misdiagnosed and he lost a leg. It was crazy.

• 19:06Gary Brecka?

  Oh, my God.

• 19:06Speaker 00

  Yeah. So in a pick line with antibiotics for years.

• 19:09Gary Brecka?

  Yeah.

• 19:09Speaker 00

  Right. It's got no bacteria left.

• 19:10Gary Brecka?

  None.

• 19:11Speaker 00

  And he does blood tests, you know, every half a year, quarterly or whatever it is. And it was like two, it was a little low. And then he, I.

• 19:21Gary Brecka?

  What was a little low?

• 19:22Speaker 00

  His testosterone.

• 19:23Gary Brecka?

  Oh, his testosterone. Okay.

• 19:24Speaker 00

  And then I give him the craft strength and then it sits at like eight or 900 and it's been there for like four or five years.

• 19:29Gary Brecka?

  When you say I give him the craft strength, so I want to, I want to.

• 19:31Speaker 00

  There's two bacteria in craft strength.

• 19:33Gary Brecka?

  So you get, you get this stool sample, you look at the gut microbiome profile.

• 19:38Speaker 00

  Yeah.

• 19:39Gary Brecka?

  Right?

• 19:39Speaker 00

  I, I don't particularly find the profile that useful. It's okay. It understands, but it tells me what you ate yesterday. Right. What I, what I really like to do is before and after a stressful event. Whether it's like a UFC fight. Or the world's strongest man, or at the Olympics, or an NBA basketball game or something. And it's usually saliva, stool, whatever they'll, they'll give me. And I measure how those bacteria change before and after the stressful event. And I'll try to correlate the changes I see in the profile to papers that have talked about this bacteria does X, Y and Z. And, but in this person's case with the Lyme disease, it was just like a standard, two bacteria, lactobacillus plantarum.

• 20:25Speaker 00

  And then a substrate that came out of South Korea. And then lactobacillus rotari that a substrate that has been shown to lower interleukin-17 alpha. And so your lead egg cells and your testes get larger. And then you produce your own testosterone.

• 20:40Gary Brecka?

  Wow, dude, I mean, there's not a man listening to this podcast right now that's not like, where do I get that bacteria?

• 20:46Speaker 00

  Look at those big balls. Yeah.

• 20:48Gary Brecka?

  Yeah.

• 20:48Speaker 00

  Those huge balls.

• 20:50Gary Brecka?

  You can't say big balls on a podcast. No, you can on The Ultimate Human. We're tough. So, so Lyme disease ravaged from antibiotics.

• 20:59Speaker 00

  Yeah. He's a great example of it.

• 21:03Gary Brecka?

  Get the bacteria and as you repopulate the gut.

• 21:08Speaker 00

  Yeah.

• 21:08Gary Brecka?

  Is testosterone. Now, the, the, the main challenges of wiping out the gut microbiome are way beyond just a decrease in testosterone. I mean, you know, Lyme patients have crushing fatigue. They have muscle soreness. They have brain fog that you can't imagine.

• 21:24Speaker 00

  Yeah.

• 21:25Gary Brecka?

  They have poor focus and concentration, disrupted sleep patterns. And I believe that the vast majority of this does tie back to the gut. Meaning that between the virus and the co-infections, the parasitic co-infection and the bacterial co-infection, you, you have this myriad of consequences that very often, modern medicine doesn't link back to the Lyme disease.

• 21:49Speaker 00

  No.

• 21:50Gary Brecka?

  And, and in your friend's case, it sounds very sad. He had an amputation.

• 21:54Speaker 00

  Yeah. For the misdiagnosis.

• 21:55Gary Brecka?

  For the misdiagnosis, you know, which is why medical error is still the third leading cause of death.

• 22:01Speaker 00

  Isn't that amazing?

• 22:01Gary Brecka?

  And it's not that doctors, you know, I want to not sound so harsh like doctors are intentionally doing things or they're making mistakes. It just shows you, even as far as we are advanced in modern medicine today, the paucity of understanding of true human physiology.

• 22:17Speaker 00

  Yeah.

• 22:18Gary Brecka?

  Right? We're really just scratching the surface.

• 22:20Speaker 00

  That's one of my biggest motivations is I like see this technological advancement, but I don't see the human advancing. And I thought like this would be a good product to like get us off our phones and get us.

• 22:30Gary Brecka?

  Yeah.

• 22:30Speaker 00

  Yeah.

• 22:30Gary Brecka?

  So, so, so after repopulating his gut bacteria, now, how did you decide what to give him?

• 22:40Speaker 00

  Mainly is I didn't want to hurt the guy. Right, he's been through a lot. I'm like, I would give him the most benign, like lactobacillus strains. Right, it's in yogurt.

• 22:48Gary Brecka?

  Which were wiped out, I'm sure.

• 22:49Speaker 00

  Yeah, yeah. It's in yogurts and kefir, but it's a very specific type of bacteria that has a very specific function. And so I imagine these bacteria is like factories. Right, that just go into your body and turn on as a factory. And you know they turn on by like the, doing something called RNA sequencing. So you know which genes in the bacteria actually turned on in the body versus in the dormant state.

• 23:14Gary Brecka?

  Right, and we know that, that our genes don't necessarily determine our destiny. I mean, our genes are sort of the blueprint.

• 23:21Speaker 00

  Yeah.

• 23:22Gary Brecka?

  Where they say that your genetics load the gun, but you know, your lifestyle pulls the trigger, right? And so in this case, you, you culture these strains of bacteria. He starts to take the probiotic. Testosterone recovers incredibly. How about the other myriad of, of, you know, consequences he was dealing with? Like the myriad of other symptoms?

• 23:48Speaker 00

  Later that year, you know, I'm friends with the guy. We go run a flat mile together, you know?

• 23:53Gary Brecka?

  Yeah.

• 23:54Speaker 00

  He was able to return to athleticism, which is nice.

• 23:59Speaker 00

  And, you know, he's a family man and, you know, he's happily married and all that stuff.

• 24:06Gary Brecka?

  Yeah.

• 24:06Speaker 00

  You know, he's just living a normal life. He was a, I look up to him a lot. He's really highly educated, been a venture capitalist for like 15 years.

• 24:16Gary Brecka?

  Yeah.

• 24:16Speaker 00

  You know, just like had struggled.

• 24:17Gary Brecka?

  So this changed his life?

• 24:18Speaker 00

  Yeah.

• 24:19Gary Brecka?

  Yeah.

• 24:19Speaker 00

  Yeah.

• 24:19Gary Brecka?

  And, and I love, I love the concept of you take my gut bacteria, culture and expand those. And, you know, so if I did a course of antibiotics, let's say, and you had my bacteria banked.

• 24:32Speaker 00

  Yeah.

• 24:33Gary Brecka?

  When I'm done with the course of antibiotics, you could give me back my own bacteria?

• 24:37Speaker 00

  Yeah, that's a really big deal. And I do that for a lot of people as I, and a lot of people, they'll have surgery and I'll do exactly that. They take the unbox and then they get their own bacteria back to them.

• 24:45Gary Brecka?

  I mean, that, that's fascinating to me because, you know, we're trying, there are, I mean, there are lots of good pre-pro and post-biotics that are out there. I mean, there are some that I really trust and I recommend to a lot of my

• 24:56Speaker 00

  Of course, yeah.

• 24:58Gary Brecka?

  Community, but the I always say that, you know, there's, no matter what anyone tells you, there's no better hormone bacteria than one the body produces on its own.

• 25:09Speaker 00

  Yeah.

• 25:09Gary Brecka?

  Right? So if you could take my bacteria, bank them, and then if I did a course of antibiotics, repopulate my own gut with my own bacteria, there's, I mean, there's no better targeted way to restore the gut microbiome.

• 25:24Speaker 00

  And there's, there's even like weird papers that are published about like the bacteria you get at birth and the birth canal through the breast milk seems to have like seniority over the other bacteria.

• 25:34Gary Brecka?

  Really?

• 25:34Speaker 00

  So you can like take that bacteria and it'll organize everyone else, like time to get in line.

• 25:38Gary Brecka?

  Wow.

• 25:39Speaker 00

  And like the first performance bacteria actually was from a World War I veteran.

• 25:44Gary Brecka?

  Hmm.

• 25:45Speaker 00

  And he was in the trenches and everyone in the trench like died or got super sick from dysentery, except this one guy, he was healthy, he was fine, no problem.

• 25:52Gary Brecka?

  Hmm.

• 25:53Speaker 00

  And so after the war, they've, they've tried to figure out what happened. And so they isolated an E. coli strain.

• 25:59Gary Brecka?

  Fascinating that even had the impetus to do that back then.

• 26:02Speaker 00

  It was a scientist of almost 100 years ago, more than 100 years ago now.

• 26:06Gary Brecka?

  That's what I mean, yeah.

• 26:07Speaker 00

  And it's still sold today, you can still buy it.

• 26:09Gary Brecka?

  Wow.

• 26:09Speaker 00

  It's called Mutiflora.

• 26:10Gary Brecka?

  Wow.

• 26:11Speaker 00

  And you can buy it and it's still the same isolate of that same bacteria from that World War I veteran.

• 26:16Gary Brecka?

  Wow.

• 26:16Speaker 00

  And to this day, it's a constant, it helps constipation, helps diarrhea, it helps all sorts of digestive issues for travelers.

• 26:24Gary Brecka?

  Hmm.

• 26:25Speaker 00

  It's a great product.

• 26:26Gary Brecka?

  So, so where do you see this technology that you've developed going? I mean, eventually, do you see it as like literally like a menu? You could come in and say, here are the challenges that I have. I have poor focus and concentration, I don't sleep well, I've got intermittent diarrhea and constipation, I mean, my gut's constantly bothering me.

• 26:50Speaker 00

  Yeah.

• 26:51Gary Brecka?

  I get cramping, I get bloating. And you could dial up or dial down certain bacterial strains and repopulate the flora in a way that would address those symptoms?

• 27:03Speaker 00

  Yeah, I'm trying to, well, it's

• 27:08Speaker 00

  I have a foundational model, you know, for someone that's not doing that well. And then I go up different levels depending on how customized you want to be.

• 27:15Gary Brecka?

  Okay.

• 27:16Speaker 00

  Right?

• 27:16Gary Brecka?

  So, yeah, tell me what exists today. So today, if I send a stool sample in, what are the possibilities that I could get back for that? And I'd love to see this.

• 27:29Speaker 00

  Yeah, it's on the web.

• 27:30Gary Brecka?

  Because I want to go through the menu myself.

• 27:32Speaker 00

  Yeah.

• 27:33Gary Brecka?

  Because I've got some things I'd like to get.

• 27:36Speaker 00

  Well, it's, um, it's on the website and under the about us page, there's like the studies we can, what bacteria and what study are cited on there. And for the most part, I can isolate those from people.

• 27:48Gary Brecka?

  Okay.

• 27:48Speaker 00

  And there's anywhere from bone density to serotonin, dopamine.

• 27:57Speaker 00

  There's androgen bacteria and cyanobacteria for oxygen. Those are found in like Olympic swimmers. You know, uniquely, that's like how you can identify an Olympic swimmer is by the amount of cyanobacteria.

• 28:12Gary Brecka?

  Really?

• 28:12Speaker 00

  Yeah, you can like identify a lot of different sports by like.

• 28:15Gary Brecka?

  So if you actually just saw nothing other than somebody's got microbiome profile, you could say this person's a professional athlete, elite level.

• 28:23Speaker 00

  At the Olympic, you know, level.

• 28:25Gary Brecka?

  Yeah.

• 28:25Speaker 00

  With other sports like, you know, professional basketball is a little bit more challenging. But like, I did saliva sampling with UFC fighters and that the world's strongest man. And at the world's strongest man, I did four tests before, during and after the competition.

• 28:42Gary Brecka?

  Okay.

• 28:43Speaker 00

  And I could tell which athletes had competed two weeks earlier based on the amount of bacteria that eats lactate inside of them. Because there was still food for that bacteria. And that means that it hadn't cleared their body. Like the lactate was still being consumed by the, it's a bacteria called villanilla.

• 29:02Gary Brecka?

  And the lactate is obviously what's produced when you're.

• 29:04Speaker 00

  Yeah, yeah, there's some controversy on lactate and exercise and things like that. I'm not. You know, I'm not an expert on that.

• 29:10Gary Brecka?

  Right.

• 29:10Speaker 00

  But at least every athlete I competed in Europe's Strongest Man two weeks earlier had elevated levels of that bacteria.

• 29:17Gary Brecka?

  Wow.

• 29:17Speaker 00

  And you could be like, that person is tired.

• 29:20Gary Brecka?

  Right.

• 29:20Speaker 00

  Yeah, or, and then with the UFC fighters, we did saliva sampling again four times, but the most interesting difference was four hours before the fight and then within five minutes after the fight.

• 29:34Gary Brecka?

  So as soon as they're done, press, get to the locker room.

• 29:37Speaker 00

  Yeah, a bunch of blood.

• 29:38Gary Brecka?

  Take a saliva sample.

• 29:39Speaker 00

  A bunch of blood and saliva all mixed up.

• 29:41Gary Brecka?

  Are they actually willing to sit down and do a blood draw right after a fight?

• 29:44Speaker 00

  With the, you know, with this guy named Forrest Griffin tells them to do it.

• 29:48Gary Brecka?

  Yeah, yeah.

• 29:48Speaker 00

  They do it.

• 29:49Gary Brecka?

  I love Forrest. Yeah. Shout out to Forrest Griffin.

• 29:51Speaker 00

  You're doing this right now.

• 29:54Gary Brecka?

  It's like the last thing on my mind. I've just gotten kicked and punched in the face and like, maybe I won, maybe I lost, but you know, you're like, hey, can I get some blood in?

• 30:02Speaker 00

  That was a wild week, yeah.

• 30:03Gary Brecka?

  So you, so you sample these, but I want to get back to the practical applications for like my audience that's listening. So, because all of us have something that we're.

• 30:15Speaker 00

  Yeah. Well, I'm just talking about this stuff because that's how I get data to isolate new bacteria. Like I go, I love the stressful event, measuring that.

• 30:24Gary Brecka?

  Yeah.

• 30:24Speaker 00

  And then that informs me what is happening to a body that goes through that, what bacteria, what food is available, what populations go up or down.

• 30:32Gary Brecka?

  So I want to go back to this concept of targeting the gut microbiome again.

• 30:38Speaker 00

  Okay.

• 30:38Gary Brecka?

  Cause I'm, I really am fascinated by this.

• 30:40Speaker 00

  Yeah. And we got a menu.

• 30:41Gary Brecka?

  And we got a menu, which I'm gonna, I'm gonna read because I'm also fascinated by this. But, so talk to me like about what you did for LeBron. Like how did, what would have been his interest in altering his gut microbiome? Cause things seem to be going pretty well for him.

• 30:57Speaker 00

  Yeah.

• 30:57Gary Brecka?

  You know, right now.

• 30:58Speaker 00

  Yeah. I'm, I'm happy to talk about it, but it's been, he sent me a.

• 31:08Speaker 00

  You know, I got connected through mutual friends. Sent me a sample in the mail. And I worked with this trainer mostly of understanding how he is recovering mostly. And so, and through work with other NBA players, it's quite a challenging season for travel and sleep is like a big issue for these guys. And there are big differences in offseason versus in-season microbiome content. And so for him, it's specifically for recovery.

• 31:37Gary Brecka?

  Yeah, to say, he wanted the best gut microbiome. And, you know, again, what's fascinating to me is you can go onto someone who is a professional athlete. Because I think at the professional athlete level, they're all looking for ways to legally, you know, without enhancing, you know, using a performance enhancement device, but to modify their biology.

• 32:02Speaker 00

  Right.

• 32:02Gary Brecka?

  Whether it's through red light or hyperbarics.

• 32:05Speaker 00

  Absolutely, yeah.

• 32:06Gary Brecka?

  You know, sleep or, or, you know, eating very clean foods. Anything that they can do to close that last gap.

• 32:12Speaker 00

  This is just a tool, right?

• 32:13Gary Brecka?

  Yeah, to close that last gap.

• 32:15Speaker 00

  Right.

• 32:15Gary Brecka?

  So, so when you, and, and, and most of us are not looking for that elite level of performance. So I want to bring this back down to, you know, what this means to working folks.

• 32:25Speaker 00

  There's two types of these bacteria. The bacteria that can impact day of performance and then also, you know, day-to-day maintenance.

• 32:34Gary Brecka?

  Okay.

• 32:34Speaker 00

  Levels of your body.

• 32:35Gary Brecka?

  And what is it specifically doing? Is it reduce, is it reducing the lactate threshold? Is it improving, you know, oxidative phosphorylation? I mean, is it enhancing mitochondrial function? What, what, what is it that's having the impact on?

• 32:53Speaker 00

  The, based on a number of papers, the Villanelle bacteria sits between the blood and gut barrier. And it pulls the lactate out of the blood and consumes it in the gut and then excretes another metabolite.

• 33:05Gary Brecka?

  Wow.

• 33:06Speaker 00

  Yeah, which is pretty cool, right?

• 33:07Gary Brecka?

  Yeah.

• 33:08Speaker 00

  Yeah. And so. You know, overloading that over time, I think, would help recovery.

• 33:14Gary Brecka?

  Yes.

• 33:14Speaker 00

  Yeah.

• 33:14Gary Brecka?

  No, it would help recover if you're actually, because, you know, the performance degrades as you get into that lactate threshold, you know, the, the longer you can maintain aerobic respiration.

• 33:27Speaker 00

  Yeah.

• 33:27Gary Brecka?

  Right? We know that there's aerobic and anaerobic respiration. So, you know, as you get anaerobic, you know, your muscles start to burn, you know, hydrogen ions build up. There's all, all kinds of things that are going on that are, that are actually causing a degradation in performance. So, highly conditioned athletes, higher VO2 max, better circulation, shuttling oxygen and carbon dioxide back and forth from the lung to the tissue is what really makes the difference between someone who can perform well athletically and someone who can't.

• 33:59Speaker 00

  Yeah.

• 34:00Gary Brecka?

  So, but, but what's interesting and fascinating to me is I've never inserted the gut microbiome into that.

• 34:06Speaker 00

  Yeah.

• 34:07Gary Brecka?

  To think, how could the gut microbiome push you further, either extend how long you can stay in aerobic respiration, or help you recover from anaerobic respiration faster by consuming these byproducts of those processes?

• 34:22Speaker 00

  Yeah.

• 34:22Gary Brecka?

  You know, lactate, pyruvate, these, these metabolic byproducts that are degrading performance.

• 34:29Speaker 00

  Right.

• 34:29Gary Brecka?

  So, in my biological mind, you know, if you have these byproducts that are degrading performance, and there are bacteria that consume those byproducts.

• 34:39Speaker 00

  Right, yeah.

• 34:40Gary Brecka?

  You have an increase in performance.

• 34:41Speaker 00

  Right.

• 34:42Gary Brecka?

  I mean, that makes.

• 34:42Speaker 00

  You just described my whole business.

• 34:44Gary Brecka?

  Did I really?

• 34:45Speaker 00

  Yeah.

• 34:45Gary Brecka?

  That's awesome.

• 34:46Speaker 00

  That's my whole business.

• 34:47Gary Brecka?

  This menu is pretty fascinating. So, these are, these are strains that are clinically proven to enhance certain areas of performance. I won't go through a lot of these names, but bacteria one, let's just call it, found in the gut of elite athletes and acts as an energy source for the body.

• 35:04Speaker 00

  Yeah.

• 35:05Gary Brecka?

  Increasing your ability to gain muscle mass, improve exercise performance, and exert anti-fatigue effects. There is another strain that increases your ability to gain muscle mass more effectively and improve digestion. A separate. One that increases your ability to gain muscle mass, improve exercise performance. I just read that one. Enhance your gut barrier and improve digestive system and gut function. The gut barrier is another massive, we know that leaky gut, this sort of single cell layer that lines the inside of our, our gut and keeps our outside environment separate from our inside environment.

• 35:42Speaker 00

  Yeah.

• 35:43Gary Brecka?

  I mean, a lot of people don't realize that's only a single cell layer.

• 35:45Speaker 00

  Yeah.

• 35:46Gary Brecka?

  And the gut microbiome influencing that cell layer to prevent leaky gut, which has its whole set of downstream consequences, inflammation, calling the immune system, all kinds of things. Boosting oral health, relieving irritable bowel syndrome.

• 36:01Speaker 00

  Yeah.

• 36:02Gary Brecka?

  And improving cholesterol when combined with other probiotics.

• 36:07Speaker 00

  Yeah.

• 36:08Gary Brecka?

  And then this one is an all around strain that promotes gut and immune health, reduces cholesterol, relieves irritable bowel syndrome, reduces allergy symptoms, prevents and treats vaginal infections. I mean, that's, I don't have vagina, but all the other ones I want to do. Relieve symptoms of digestive disorder and promote overall gut health.

• 36:29Speaker 00

  Yeah.

• 36:29Gary Brecka?

  Boost oral health, relieve irritable bowel syndrome, improve cholesterol,

• 36:35Gary Brecka?

  treat constipation, reduce inflammation, improve the immune system. Improving.

• 36:43Speaker 00

  Yeah, and there's more and more papers published every day.

• 36:46Gary Brecka?

  Yeah, so.

• 36:46Speaker 00

  More and more published every day.

• 36:48Gary Brecka?

  This is, this is incredible. So, jumping out of the elite athlete, and I love how you're called craft microbiome,

• 36:58Gary Brecka?

  because you're sort of crafting the microbiome.

• 37:00Speaker 00

  Yeah.

• 37:00Gary Brecka?

  So it's a great, great marketing tool there. But the average person listening to this podcast, if they were to close their eyes and say, here's my wish list, you know, and it started with things like, you know, duct dysbiosis, because the vast majority of people do have something that they would love to fix about their gut. Maybe it's gas, maybe it's bloating, diarrhea, constipation, irritability, cramping,

• 37:30Gary Brecka?

  you know, bloating, inflammation.

• 37:32Speaker 00

  Yeah.

• 37:33Gary Brecka?

  Where, where did they start? What would a stool sample arriving to your lab look like before it turned into a probiotic for them?

• 37:43Speaker 00

  So I take about as much stool or saliva that covers a penny. Each of those bacteria has a different growth condition. So, meaning some bacteria like to grow with oxygen, some like without oxygen. Some like, because these things are alive, they need to eat. So I need to put different ingredients to, you know, kind of farm these bacteria. And so, once I dilute the bacteria and make these growth plates, colonies will grow on the growth plates. A little tiny, single cells or, you know, not, you know, but enough that's a single, isolated bacteria. I take that bacteria, I do genomic sequencing of it to identify the strain, the substrain,

• 38:27Speaker 00

  and then any interesting genomic sequences within it. Once I have that ID verified, I put it in a media jar or a bioreactor with the same growth conditions that it, how I found it originally. And then it grows large quantities. I freeze dry the bacteria, it's like a goo at that point, so it turns into freeze dried bacteria.

• 38:49Gary Brecka?

  And this is their bacteria?

• 38:51Speaker 00

  It came from them.

• 38:51Gary Brecka?

  Yeah, it came from them, that's great.

• 38:54Speaker 00

  And then I save some of it, and then I put the rest in these capsules and then ship it to you.

• 38:58Gary Brecka?

  Okay, and then, but you have it banked?

• 39:00Speaker 00

  Yeah, I do.

• 39:00Gary Brecka?

  So you can continue to grow that bacteria? Because, you know, I have a number of professional athletes and folks that I work with. Several of them, just to give you one example. I have a very well-known athlete that had to have some dental work done. And because of the extensive dental work, they put him on a very powerful course of antibiotics. He actually did develop a jaw infection, which required another course of antibiotics. And there was noticeable degradation in performance.

• 39:35Speaker 00

  Yeah.

• 39:36Gary Brecka?

  After this massive.

• 39:38Speaker 00

  Pretty amazing, right? Yeah.

• 39:39Gary Brecka?

  Yeah, and. We struggled for a while. We fixed it now, but we struggled for a while to repopulate his gut. I mean, I tried all kinds of things, 38 Terra, BioComplete 3, my standard mechanisms for re-inoculating, you know, the gut. It took much longer than we originally anticipated. But if you had an, it doesn't even need to be an athlete. I want to, I want to actually just stop talking about elite athletes because most people are not looking to close that last two tenths of a mile in performance. But, you know, just average mom and dad, you know, goes and gets some, you know, dental work done, or for whatever reason, goes on a massive course of antibiotics, wipes out their gut bacteria. Where would you start with someone like that?

• 40:24Speaker 00

  I would try to find something called a Bifidobacterium infantis, which by most indications is the first bacteria that inhabits your gut. And it's one I was talking about earlier for, that seems to have seniority over the other bacteria to tell them what to do to organize. And that seems to like settle down a lot of people's guts.

• 40:44Gary Brecka?

  Wow.

• 40:45Speaker 00

  You know, just kind of settle things, you know, get them, you know, like just stable. And then from there, after a few months, try to like build it up from there.

• 40:52Gary Brecka?

  If you want protein to build lean muscle, but without the caloric impact or need to cut, you need Perfect Amino. It's pure essential amino acids, the building blocks of proteins in a precise form and ratio that allows for near 100% utilization in building lean muscle and no caloric impact. So we build protein six times as much as way, but without the excess body fat we normally get during bulking. This is the new era of protein supplementation, and it's real. If you want to build lean muscle without having to cut, you need Perfect Amino. Now, let's get back to the Ultimate Human Podcast. So when you, when you, when you look at people that have severe gut dysbiosis,

• 41:33Gary Brecka?

  there's a lot of people listening to this podcast that have been diagnosed with Irritable Bowel Syndrome, Ulcerative Colitis, diverticulitis, Crohn's Disease.

• 41:42Speaker 00

  Right. A lot of inflammation.

• 41:44Gary Brecka?

  Yeah, they're all inflammation. Itis is inflammation. And in those

• 41:51Gary Brecka?

  If they're listening to this podcast right now, what benefit could they derive from working with Kraft Microbiome to actually go in and re-architect the flora in their gut?

• 42:03Speaker 00

  The goal for me always is just to start small, right? And just start with like, does this help you or not? Because you should be able to feel better within a few days, right? And from there-

• 42:16Gary Brecka?

  Really, just within a few days?

• 42:18Speaker 00

  Usually, that's usually the feedback I get. Like, hey, like, you know, things are quiet, I'm sleeping better, I'm feeling better. You know, I'm... And so, you know, I like to, I'm very cautious. And so I like people to say they're feeling better and then we can start isolating new and different types of bacteria for their own goals, right? I like the consumer to kind of drive the-

• 42:40Gary Brecka?

  Oh, the consumer does too. I mean, there's nothing, you know-

• 42:43Speaker 00

  Right, I don't want to tell people like, you need this, you need that. I'm like, no, like, hey, what's important to you?

• 42:48Gary Brecka?

  Yeah. And what you're doing in the lab is taking their goal-

• 42:54Speaker 00

  Yeah.

• 42:54Gary Brecka?

  And sort of selecting the bacteria. That's the thing that's so fascinating to me is that we're now, because we know that, for example, we, you know, we, our gut bacteria will methylate tryptophan, an amino acid, into the neurotransmitter serotonin, or phenylalanine and tyrosine into the neurotransmitter dopamine. Dopamine is the main driver of behavior. Serotonin is one of the main drivers of mood. So you could see that if you're, if these conversions are off-

• 43:22Speaker 00

  Yeah.

• 43:23Gary Brecka?

  You have issues with mood and behavior.

• 43:24Speaker 00

  Yeah.

• 43:25Gary Brecka?

  Now, I've always looked at genetic methylation, you know, the deficiencies that impair-

• 43:30Speaker 00

  And that's the bleeding edge of the microbiome right now. Right, if finding out which bacteria help turn on or turn off specific genes in your human DNA.

• 43:39Gary Brecka?

  So if I could add targeted supplementation-

• 43:43Gary Brecka?

  For the deficiencies that these people have to targeted probiotics.

• 43:47Speaker 00

  Right.

• 43:47Gary Brecka?

  That to me would be the holy grail.

• 43:49Speaker 00

  Yeah, it's it's coming.

• 43:51Gary Brecka?

  Yeah.

• 43:51Speaker 00

  There's research published now about that exact thing.

• 43:54Gary Brecka?

  But you're already doing it. That's the fascinating thing. You've had success in these areas.

• 43:58Speaker 00

  Yeah, yeah.

• 43:59Gary Brecka?

  And so I, I, you know, take, take this test. I tell you what my goals are. You get my bacteria and now you're trying to select these certain strains. Like to improve my cognitive function or what have you. But let's, let's actually talk about some of those conditions. Diureticulitis, ulcerative colitis, Crohn's disease, irritable bowel syndrome. All of these conditions mainly all have the common theme of inflammation in the gut. Where do you start with someone that has one of those conditions? You, you sequence the microbiome and then you're targeting the bacteria that will help them reduce inflammation.

• 44:40Speaker 00

  Yeah, just the most benign and most, you know, quieting bacteria I can. And that's usually a Bifidobacterium, like, you know, one of the animalis or infantis or whatever it is. Like just the most benign bacteria I can from them. And the sole focus would just be reducing inflammation.

• 45:01Gary Brecka?

  Okay.

• 45:02Speaker 00

  That's the sole, that would all be my total focus. I wouldn't try to, you know, get like turn you into a D1 athlete right off the bat.

• 45:11Gary Brecka?

  Right, right.

• 45:11Speaker 00

  Right, yeah.

• 45:11Gary Brecka?

  No, that's not their goal. I mean, they want to be out of pain. They want, they don't want their day to be centered around their gut.

• 45:17Speaker 00

  Yeah.

• 45:17Gary Brecka?

  And, and it's one of those quiet things that just, you know, it's, it's in the back of their mind all, all the time. You know?

• 45:24Speaker 00

  Yeah.

• 45:24Gary Brecka?

  You know, when your, your gut is sort of determining your choices, you're not determining your own choices. And, and I, I have hundreds of clients like this, you know? Their, their day is centered around the condition that they're dealing with.

• 45:36Speaker 00

  Right, yeah.

• 45:37Gary Brecka?

  You know, like they're literally, when they get to a

• 45:39Speaker 00

  Yeah.

• 45:40Gary Brecka?

  Public event, they're thinking, okay, where's the restroom? I need to be able to access this.

• 45:44Speaker 00

  You know, I, I call and talk to all the, my clients right now. I'm sure that will change, but the

• 45:52Speaker 00

  You know, I ask certain questions like people that tell me they have allergies. I know I can't give them lactobacillus.

• 45:58Gary Brecka?

  Right.

• 45:58Speaker 00

  Right? I know that causes problems for whatever reason. You know, I also ask, can you eat garlic and onions? And like, no, I can't eat garlic and onions. So that will like change a whole bunch of different bacteria that I get them. And I'm not sure why this is the case.

• 46:10Gary Brecka?

  Yeah.

• 46:11Speaker 00

  But I know if I-

• 46:12Gary Brecka?

  But we know that correlation.

• 46:13Speaker 00

  Yeah, it's like, you know, you know, okay, now I go. And usually the bifidobacteriums are the best choice just because of all the numerous symptoms.

• 46:21Gary Brecka?

  Yeah.

• 46:22Speaker 00

  That they've talked about.

• 46:23Gary Brecka?

  I'm super excited about this. In fact, if you want to be, send a message to my team at [email protected].

• 46:29Speaker 00

  Let's go.

• 46:30Gary Brecka?

  Because I really like to do these real world trials, if you will, and see if we can address their primary challenge and achieve their primary goal. Because I know that the clients I have, for example, that have eczema, psoriasis, a lot of what we do is focused on the gut microbiome. But we're not as selective. And you know, it's a little bit of guesswork there because you're throwing the strains in there, not knowing what they have an overgrowth of, what they have an undergrowth of, and which populations they really need to target. Whereas you can actually target those specific populations. That's what I find fascinating.

• 47:14Gary Brecka?

  And eventually we get there. But we're getting there, you know, it's like spaghetti against a wall, you know, to see what sticks. You're getting there by putting enough in that eventually the gut returns to its homeostatic.

• 47:27Speaker 00

  There's a few customers that were like, I don't care what it is, just give it to me.

• 47:33Gary Brecka?

  I'm one of those.

• 47:34Speaker 00

  Are you sure?

• 47:35Gary Brecka?

  Most of my VIP committees like that too.

• 47:37Speaker 00

  Does this work or not? Yeah, so I don't know.

• 47:39Gary Brecka?

  There's very, you know, this is the low risk proposition.

• 47:43Speaker 00

  Right, it's your own bacteria came from you.

• 47:45Gary Brecka?

  Exactly. That's what I love. You know, I have a saying I say all the time, more of what God gave us, less of what man makes us. So if we can actually go into our God given, you know, strains of our own bacteria to solve the challenges. And by the way, this isn't voodoo science. I mean, they have mapped very specific bacteria, eczema and psoriasis, for example. There is a very strong correlation between deficiencies in certain strains. You're aware of that, right?

• 48:13Speaker 00

  Yeah.

• 48:13Gary Brecka?

  And which strains are those?

• 48:15Speaker 00

  I can't tell you off the top of my head, but I know the papers exist.

• 48:17Gary Brecka?

  Yeah. And so could we, and you know, this is particularly troublesome when I get really, really young children that are suffering from this because there's nothing worse than being a mother or father and your child is suffering from this skin condition and the only option you have are steroids, you know, the corticosteroids and anti-inflammatories. And you're stuck in this really, you know, it's like the rock in the hard place decision because you want to help your child. The only thing that gives them some relief is something that you know is borrowing from their future.

• 48:54Speaker 00

  Yeah.

• 48:55Gary Brecka?

  And you know, there are going to be further consequences. You just want to help them right now. You know, it's why we stick an iPad in front of our kid to calm them down because we're in a public place, but you know, and I really want to offer some hope to them that, you know, this may be, the answer may lie in sequencing the gut microbiome and targeted probiotics to give them a lifetime of relief, permanent.

• 49:20Speaker 00

  Yeah, the two important technologies here are the storage of the complete biome. So as the technology improves, we can always go back to the original sample and isolate more and more and more from that original sample.

• 49:32Gary Brecka?

  Yeah.

• 49:33Speaker 00

  So as our skill increases, that original sample becomes more and more valuable.

• 49:36Gary Brecka?

  Now, tell me that you're using AI.

• 49:38Speaker 00

  I've done it for some evaluations of, you know, large groups of people that I'm testing, right, to see patterns that I can't see.

• 49:47Gary Brecka?

  Yes, exactly. Over the last 20 years in human biology, one compound I've trusted again and again is NAD plus. It's critical for energy, focus, and cellular repair, but your levels drop around age 30. I used to administer NAD via IVs in my clinics, but now I take Ro Nutrition's liposomal NAD, the first oral formula that actually works. Their advanced delivery tech gets NAD straight into your bloodstream. I take one teaspoon daily and the results are real. Clean energy, sharper focus, and better recovery. You can try it risk-free with the ULTIMATE15 code at checkout for 15% off. Just put in ULTIMATE15 at checkout, you'll receive 15% off and your cells will thank you.

• 50:32Gary Brecka?

  Now let's get back to the Ultimate Human Podcast.

• 50:35Gary Brecka?

  So let's touch on that one for a moment. So eczema, psoriasis. We know that there are deficient bacterial strains. If you were to get a stool sample from one of these children,

• 50:47Gary Brecka?

  what would be the next step?

• 50:49Speaker 00

  So my process would be to do deep into the research to try to find some sort of metabolite or groups of metabolites that may be overproduced in the gut, underproduced. And it'd be my intention to either find bacteria that... It's a lot harder to get rid of the bad bacteria, but what we can do is outcompete the bad bacteria.

• 51:12Gary Brecka?

  Right.

• 51:13Speaker 00

  And so that would be my goal, is to find the metabolites that may be causing the eczema or the psoriasis and either have them consumed or overproduce the beneficial metabolites.

• 51:26Gary Brecka?

  Yeah, because we know that it's not a complete guessing game. I mean, there's quality data on the missing strains. And I think what you just touched on, I want to make sure it doesn't get missed, is that you say outcompete, because we know in a healthy gut microbiome, there are always pathogenic flora. We have healthy parasites.

• 51:45Speaker 00

  Every single person has chigella and salmonella.

• 51:49Gary Brecka?

  Exactly.

• 51:50Speaker 00

  All sorts of crazy stuff.

• 51:51Gary Brecka?

  We all have SIBO going on, just not at a level that's symptomatic, right? So we all have...

• 51:56Speaker 00

  There's bacteria on your skin everywhere inside of you.

• 51:58Gary Brecka?

  Exactly. But homeostasis is where you have a proliferation of the healthy bacteria. And it's not just that they're there to do their role. It's they're there to also suppress the negative effects from some of these other bacteria. And we know that things like highly processed foods, refined sugars, grains, genetically modified foods, you know, foods that have pesticides, herbicides, insecticides, things like that, actually do wipe out and sometimes benefit bad bacteria.

• 52:32Speaker 00

  Yeah.

• 52:32Gary Brecka?

  And so the idea that we could actually repopulate the gut with the beneficial bacteria and let that do the policing, right?

• 52:39Speaker 00

  Yeah.

• 52:40Gary Brecka?

  Let the body's normal homeostatic, biophysiological process keep these strains in check.

• 52:48Speaker 00

  Variety is good. And there's like a collapse in these western... in our western stomachs about the variety of bacteria that we have. It's just continually going down and down and down every year. The more... How they process foods we eat, the more we live in a sterile environment.

• 53:04Gary Brecka?

  Yes.

• 53:04Speaker 00

  The more like all these things are just killing our bacteria.

• 53:07Gary Brecka?

  Yes, I totally agree. And so, so your next step would be, again, back to the excrement, psoriasis. We would try to find the bacteria, deficient bacteria, repopulate those, and specifically isolate the strains that we know are pro-inflammatory and use beneficial bacteria to restore those.

• 53:31Speaker 00

  Yeah, to try to outcompete those pro-inflammatory bacteria. Geography is starting to be an important issue, too, like where in the digestive tract they're, they live. And, and also try to produce as many anti-inflammatory metabolites as possible.

• 53:49Gary Brecka?

  Can you give me some stories without, without names or identifying people? Non-athletic stories where you actually had someone with a condition related to the gut? It could be irritable bowel syndrome, diverticulitis, ulcerative colitis, Crohn's disease. One of these conditions in, in the gut, and you saw miraculous.

• 54:09Speaker 00

  Yeah, there's this actress that's had two or three fecal transplants in her life. Advisable or not, I don't want to say, I can't, I can't say.

• 54:21Gary Brecka?

  Yeah.

• 54:22Speaker 00

  But to this day, or maybe not to this day, but she'd been dealing with these issues. And I took the sample, I evaluated it, I produced a report. And then it turned out, I just need to continually reduce the inflammation in her body. And so I just made extra powerful inflammation-reducing bacteria.

• 54:43Gary Brecka?

  So you, you took her bacteria, cultured and grew it, and you expanded the flora that actually helps to reduce inflammation? And what was the consequence, the outcome for her?

• 54:55Speaker 00

  She had been like losing her hair, she'd been losing weight. You know, and I know these actresses want to be skinny, but it was getting a little crazy. And because of the reduced inflammation, you know, her hair started to grow back. She, you know, got some movie roles, you know, things like, things like that.

• 55:10Gary Brecka?

  Wow.

• 55:11Speaker 00

  Right, she just felt better.

• 55:12Gary Brecka?

  Ah, okay.

• 55:13Speaker 00

  Which was the number one issue.

• 55:15Gary Brecka?

  Okay.

• 55:17Speaker 00

  For.

• 55:20Gary Brecka?

  How about anything in the realm of, you know, one of these gut dysbiosis conditions like an ulcerative colitis or diverticulitis, Crohn's? Have you had experience in manipulating the gut bacteria with positive outcomes there?

• 55:34Speaker 00

  Um, it's, uh, in a, a side life. I did, um, I, I did all the.

• 55:42Gary Brecka?

  Side life.

• 55:43Speaker 00

  In a side life, I did all the.

• 55:45Gary Brecka?

  Sounds so shady.

• 55:46Speaker 00

  I did all the, uh, training to become a Pilates instructor.

• 55:49Gary Brecka?

  Did you really?

• 55:50Speaker 00

  I did pass.

• 55:51Gary Brecka?

  Dude, I've done two days of Pilates and I could move when I got up this morning. And all I did was the core stretch thing.

• 55:58Speaker 00

  It was great. It was great. So.

• 56:00Gary Brecka?

  So bad.

• 56:00Speaker 00

  So when I was done rowing, my body was a little broken.

• 56:03Gary Brecka?

  Yeah.

• 56:03Speaker 00

  And so Pilates helped me put back together. So I did all the training. I didn't, um, do all the teaching, so I don't, I'm not certified. But the teachers warned you like, hey, if a customer, if a client comes in and it, it becomes your job to fix them, uh, you're never going to make that customer happy.

• 56:19Gary Brecka?

  Good.

• 56:20Speaker 00

  Right? And so I've taken that approach too with the, the company like I, you know, I can try to help, but I'm not sure I can, I can fix everything.

• 56:28Gary Brecka?

  Mm hmm.

• 56:28Speaker 00

  Right? So I try to like, you know, like, is this something, how long have you been working on this? You know, um, what's your doctor saying? You know? How can I be supplemental to what you're doing?

• 56:40Gary Brecka?

  But have you had a supplemental role in helping people reduce their symptoms or put these things into remission? Do you have cases where you can say, hey, this person had XYZ condition post, you know, targeted.

• 56:56Speaker 00

  Yeah.

• 56:56Gary Brecka?

  Microbiome. Okay.

• 56:57Speaker 00

  Yeah.

• 56:57Gary Brecka?

  That's, that's, that's very exciting.

• 56:59Speaker 00

  Yeah.

• 57:00Gary Brecka?

  Like, I don't want to, I don't want to pay you, like not giving yourself enough credit here. I'm trying to give you some credit because, you know, I, I really believe that this is, um, a massive frontier for, for modern medicine. Cause there's so little focus. Um, there's a lot of focus on the microbiome, but there's so little focus on the individuality of people's microbiome and actually taking their microbiome to culture and expand it to address the conditions that they have.

• 57:29Speaker 00

  Yeah.

• 57:29Gary Brecka?

  I mean, obviously on that, on that list of, uh, you know, that wish list, if you, whatever you want to call it, um, you know, a lot of those things on there, I mean, check the box and probably 70% of my audience.

• 57:44Gary Brecka?

  Has one of those that they would love to have addressed.

• 57:47Speaker 00

  Yeah.

• 57:48Gary Brecka?

  The idea that you're addressing it by using their own bacterial strains.

• 57:53Speaker 00

  Yeah.

• 57:54Gary Brecka?

  To me is really fascinating.

• 57:55Speaker 00

  Yeah, it's, it's a wild world.

• 57:57Gary Brecka?

  Yeah.

• 57:58Speaker 00

  It's wild.

• 57:58Gary Brecka?

  So you, you have had success.

• 58:01Speaker 00

  But I'm also very cautious not to go against the FDA. Like I'm not intended to treat, cure, prevent a disease.

• 58:09Gary Brecka?

  And I, and I don't want you to make a medical claim, but

• 58:11Speaker 00

  Yeah.

• 58:11Gary Brecka?

  And the fact that you have been, and I'm, I try to be cautious about that too. But people need information and it's, it's sad how frightened we are sometimes to speak about successes that we've had. Maybe we don't want to use the term cure or treat.

• 58:25Speaker 00

  Yeah.

• 58:25Gary Brecka?

  Or prevent.

• 58:26Speaker 00

  Well, like for example, um, someone has high glucose. They wake up, their glucose is at 200 or something outrageous. And to solve that problem, it was, um, uh, first doing oral sequencing to finding out and then, uh, which bacteria are actually living in there? And then finding papers showing that you're 70% likely to be pre-diabetic or diabetic from peer reviewed paper, if you're missing these bacteria.

• 58:53Gary Brecka?

  Yes, is exactly what I'm talking about.

• 58:54Speaker 00

  Right. And then so the process was like, okay, how do I actually develop a product for this problem?

• 58:58Gary Brecka?

  Mm hmm.

• 58:59Speaker 00

  And so it's like isolate the bacteria they're missing first from me to try it if it helps them.

• 59:05Gary Brecka?

  Mm hmm.

• 59:05Speaker 00

  And then eventually maybe if I can keep trying to, because sometimes bacteria don't want to grow, no matter if it's, it shows up in the sequencing, sometimes it doesn't want to grow.

• 59:13Gary Brecka?

  Right.

• 59:13Speaker 00

  Uh, but then making like a mouthwash, like, hey, like, let's try, uh, signaling, um, to the brain about 10 minutes before you eat your meal. Swish this bacteria around your mouth and spit it out.

• 59:26Gary Brecka?

  Mm hmm.

• 59:26Speaker 00

  That didn't work.

• 59:27Gary Brecka?

  Right.

• 59:28Speaker 00

  But then finding a bacteria that actually consumes glucose

• 59:31Gary Brecka?

  Mm hmm.

• 59:32Speaker 00

  And loading the person up, like, take this 90 minutes before a meal. It eats glucose and let's, uh, I was wearing these glucose monitors for a while and, uh, I would go to Wendy's every day and eat the same meal.

• 59:43Gary Brecka?

  Oh dude, you're killing me.

• 59:45Speaker 00

  It was horrible. It was horrible. But I'd go to Wendy's every day, eat the same meal. I'd take the bacteria and I'd trial it.

• 59:51Gary Brecka?

  Yeah.

• 59:51Speaker 00

  Right. Until my glucose wasn't spiking crazy.

• 59:54Gary Brecka?

  Mm hmm.

• 59:54Speaker 00

  Yeah. Oh, I, I tracked it, I guess for a few weeks where the glucose. Pre-supplement would spike to like 120, 140, something like that. And then post-taking the bacteria gets up to like 115, 120. My God, now I've handed off to the client and now his glucose doesn't spike.

• 1:00:11Gary Brecka?

  Yeah, see, this is, this is just fascinating. See, now we're getting somewhere, okay? This is what I was after. All right, and I understand we got to dance around the FDA, but we're going to get some specific answers here. Because, because I think if you're able to eventually get enough data to crack this code.

• 1:00:27Speaker 00

  Yeah.

• 1:00:29Gary Brecka?

  The gut microbiome is so foundational. It's 70% in my opinion. I mean, there's a reason why 70% of your immune system is right outside of your gut. Because that's where all the action is. There is also, in my opinion, an enormous body of data that says that the first domino to fall in the sequence of, of multiple chronic diseases is gut dysbiosis.

• 1:00:56Speaker 00

  Yeah.

• 1:00:57Gary Brecka?

  So what happens is we have severe gut disruption, whether it was antibiotics, or whether it was infection, or whether it was just poor food over a prolonged period of time, wiping out our gut microbiome. And that was the first domino to fall. And now 50 dominos later, they've got their first autoimmune disease. 50 dominos after that, they've got their second autoimmune disease. We know that, you know, early onset Alzheimer's, dementia, early onset cognitive decline, that's everybody's greatest fear.

• 1:01:29Speaker 00

  Yeah.

• 1:01:29Gary Brecka?

  We know now that that doesn't start when you're 75 years old.

• 1:01:33Speaker 00

  No.

• 1:01:33Gary Brecka?

  It starts when you're 35 or 40 or 45 years old.

• 1:01:36Speaker 00

  Right.

• 1:01:36Gary Brecka?

  And so the possibility to intervene from a preventive standpoint, the possibility to address, I won't say treat or cure, but to address ailments that you're suffering from now, that we know have strong evidence are linked back to the gut microbiome. This is the whole reason why I brought you on this podcast, because I'm, I'm, I'm I don't have the wherewithal, the knowledge myself, to know specifically how we do it, but I do have a keen appreciation that if we figure that out.

• 1:02:10Speaker 00

  Yeah.

• 1:02:11Gary Brecka?

  That is potentially the panacea. In fact, you know this woman that just passed away at 118 years old?

• 1:02:17Speaker 00

  Oh, you saw the paper?

• 1:02:18Gary Brecka?

  Yeah, I saw the paper. Can you talk about that for a second?

• 1:02:21Speaker 00

  Yeah.

• 1:02:21Gary Brecka?

  Yeah, because that's validating about everything that you've talked about on this podcast.

• 1:02:25Speaker 00

  Right.

• 1:02:26Gary Brecka?

  What was unique about her?

• 1:02:28Speaker 00

  I believe she had a high percentage of Bifidobacterium.

• 1:02:32Gary Brecka?

  Exactly.

• 1:02:33Speaker 00

  Which is a genus inside of her, a genus of bacteria. And she had it relative to someone, you know, at a midlife age or something like that.

• 1:02:42Gary Brecka?

  Yeah, they said a 35-year-old.

• 1:02:44Speaker 00

  Yeah, isn't that wild, right?

• 1:02:45Gary Brecka?

  At 118.

• 1:02:46Speaker 00

  Yeah.

• 1:02:47Gary Brecka?

  So you can't just overlook that, right?

• 1:02:50Speaker 00

  No, right.

• 1:02:50Gary Brecka?

  So, and I believe too, that, you know, when, when we look at Blue Zone studies, a lot of the data was regional, meaning if you took a centenarian from Sardinia that was eating that, you know, genre of foods and what have you. But if you had 50 years earlier, put that person in a different area of the world, they would have had a different outcome.

• 1:03:20Speaker 00

  Yeah.

• 1:03:20Gary Brecka?

  Because their gut microbiome had adapted to, to that geographic location and those types of foods, and it was very adept at breaking them down, you know, creating energy from those. And, you know, we're such a nomad world. I mean, I did 14 cities in 18 days, right? So, and I'm very intentional about what I eat, but I couldn't control it to that extent.

• 1:03:45Speaker 00

  No, no.

• 1:03:46Gary Brecka?

  And, and so.

• 1:03:47Speaker 00

  Your circadian rhythms and all that stuff.

• 1:03:49Gary Brecka?

  Yeah.

• 1:03:49Speaker 00

  Might got microbiome driven, yeah.

• 1:03:51Gary Brecka?

  But if we could keep the consistency in the gut microbiome, our ability to adapt to, you know, a different environment and, and actually metabolizing, you know, different types of food, you know, I think. That, to me, is one of the secrets to longevity. But you're right, she had very specific strains that were in excess, especially for her age.

• 1:04:15Speaker 00

  Yeah. And these were taken, the studies were done about a year before she died? Or something like that, so near the end of life.

• 1:04:22Gary Brecka?

  Yeah.

• 1:04:23Speaker 00

  Right?

• 1:04:23Gary Brecka?

  Yeah, so near the end of life and still.

• 1:04:25Speaker 00

  Still crushing it.

• 1:04:26Gary Brecka?

  Yeah, still crushing it largely because of her gut microbiome. Let's go to, you know, a big fear that grips a lot of people, which is Parkinson's, Alzheimer's, dementia, these neuroinflammatory conditions that cause different forms of cognitive decline. Right? They interrupt the communication of our, you know, in our brain so that we appear to be losing our memory, or we get disoriented, or we get confused. I mean, that's everybody's biggest fear. And most of us have either had a friend or a family member and we've seen this occur.

• 1:05:05Gary Brecka?

  And what could somebody do now to mitigate the risk of? Because you did talk earlier about Parkinson's.

• 1:05:15Speaker 00

  Yeah, for a lot of these like neurodegenerative issues, there are changes in the gut that happen years before the symptoms develop. And one of the easiest things you can do is get your microbiome sequenced over time, because it's a dynamic system like you talked about. Right? And you can monitor those changes and how they can determine if you're potentially going to develop Parkinson's or not, are ratios of separate type of two different or three or four different types of bacteria. Right? How is this ratio of this bacteria to that bacteria? You know, and how is that ratio changing over time? How does that increase your risk factor?

• 1:05:52Gary Brecka?

  Yeah.

• 1:05:53Speaker 00

  For these type of.

• 1:05:54Gary Brecka?

  So at a minimum, if I knew that I either had a genetic predisposition, which there are to some of these conditions, they're not, they're not a genetic inheritance of the disease, but they're a genetic predisposition to the disease. So if I knew I was in that risk category, or I had cognitive decline, Parkinson's, Alzheimer's, that ran in my family.

• 1:06:15Speaker 00

  Yeah.

• 1:06:17Gary Brecka?

  What would you be doing right now? If you're listening to this podcast and that's one of your concerns. What would you be doing right now? You send the bacteria into your lab and start culturing the bacteria that combat those neuroinflammatory conditions. And we know what they are. And so at a minimum, this would be a good risk mitigation tool.

• 1:06:38Speaker 00

  Yeah, at least have an understanding of what's going on over time.

• 1:06:41Gary Brecka?

  Yeah.

• 1:06:41Speaker 00

  Right, a single test is gonna be okay, but it's the overtime testing that will determine a lot of risk factors. And then saving your original young bacteria, right, is really important.

• 1:06:53Gary Brecka?

  Yeah.

• 1:06:54Speaker 00

  Right, so as these ratios of your bacteria change and you get older, you can always go back to that young bacteria that we have in storage.

• 1:07:01Gary Brecka?

  So if you have 30, 40, if you're in your 30s, 40s, or 50s, you have, either have the genetic predisposition to one of these conditions, or it runs in your family, which is one of the things I don't like to, I don't like a lot of these familial characteristics in disease because it makes people feel like, there's nothing I can do.

• 1:07:24Speaker 00

  Right.

• 1:07:24Gary Brecka?

  Right, when Parkinson's runs in my family, I'm just gonna get Parkinson's. It's not true. You know, Alzheimer's runs in my family, I'm just predestined to get Alzheimer's.

• 1:07:32Speaker 00

  That's why I like my product as a catalyst for change.

• 1:07:34Gary Brecka?

  Yeah.

• 1:07:35Speaker 00

  Like a user-driven, like, people are aware of these things.

• 1:07:37Gary Brecka?

  Yeah.

• 1:07:38Speaker 00

  Right, and it's like, oh no, like, with this product, I can start the change that can happen.

• 1:07:43Gary Brecka?

  So right now, I can send my stool and saliva sample in. And I can, you know, look at my profile and I can at least begin to re-inoculate bacteria that are known to be the antithesis of those conditions.

• 1:08:01Speaker 00

  Correct, that can happen today.

• 1:08:03Gary Brecka?

  That's amazing. So, in a perfect world, where do you see Kraft Microbiome going? Where's Kraft Microbiome gonna be in five years, based on what you're doing now?

• 1:08:22Speaker 00

  Well, I, next year.

• 1:08:26Speaker 00

  The dream.

• 1:08:27Gary Brecka?

  Say it, just say it.

• 1:08:28Speaker 00

  The dream, the app, the dream is the application, like an app on your phone that you plug in that says like, I have a meeting today, I want to run a mile and you know, I have dinner tonight. And then you have a box next to it and the app spits out, oh, take probiotic number one, three and six. And you have, and you have the box of like all your different bacteria, like take this one at this time, take that at that time, you know, to like show the, you know.

• 1:08:53Gary Brecka?

  I love that.

• 1:08:53Speaker 00

  Yeah. So that's, that's next year.

• 1:08:55Gary Brecka?

  Yeah. We do that now with, you know, certain, you know, just certain supplementation. We take focus pills and, and neurotropics and, you know, nicotine and caffeine and, you know, so we, we do try to manipulate, you know, our cells for certain activities. But the fact that we could do it with, you know.

• 1:09:14Speaker 00

  Bacteria that produce neurotransmitters, like at one point, a customer wanted to get super, like, he's like, I need something for golf, right? And so I, I'm like, I, I don't know.

• 1:09:26Gary Brecka?

  There's somebody with no problems in their life, right? By the time that their biggest concern is their golf game.

• 1:09:31Speaker 00

  A lot of people love golf, a lot of people.

• 1:09:32Gary Brecka?

  I know, but I mean, I want to be that dude. Like, I mean, a lot of things would go on my list before I got to my golf swing.

• 1:09:38Speaker 00

  But so I'm like, I, I grew up, I played a little golf. I don't play that much now.

• 1:09:44Speaker 00

  I'm like, oh, hey, so you need to be calm, you need to be relaxed, you need to do X, Y and Z. So I made these bacteria for dopamine, for serotonin that produce this stuff. I give it to the guy, his golf game gets a little better, but what really changes it is it helps him sleep at night. Right? And so sometimes you, you make this concoction, like you take this and, but it doesn't do what you want, but then it has a benefit for something else.

• 1:10:08Gary Brecka?

  Yeah. Well, I mean, you know, that's why the gut microbiome is so fascinating. We don't realize that, you know, just saying that, oh, that produces neurotransmitters. Yeah, but neurotransmitters are the foundation of mood.

• 1:10:20Speaker 00

  Yeah.

• 1:10:20Gary Brecka?

  They're the foundation of behavior. They're, they're, they're the foundation of our emotional state.

• 1:10:25Speaker 00

  Yeah.

• 1:10:26Gary Brecka?

  You know, and aberrations in those things get us diagnosed with mood disorders and mental illnesses.

• 1:10:33Speaker 00

  Yeah.

• 1:10:34Gary Brecka?

  When the truth is, these are deficiencies that are expressing themselves as these conditions. And the next thing you know, you know, you're on an SSRI or, you know.

• 1:10:47Speaker 00

  Which causes all sorts of microbiome problems.

• 1:10:49Gary Brecka?

  Right. Which again, it's just, so the.

• 1:10:53Gary Brecka?

  The fact that we could get out of the chemical synthetic pharmaceutical realm and get into the bacterial realm.

• 1:11:00Speaker 00

  Yeah.

• 1:11:00Gary Brecka?

  Which is, you know, instead of saying, I, you know, have a mood disorder, and I hate these words, but a mood disorder because I have a deficiency in the neurotransmitter serotonin. So I'm just going to take a selective serotonin reuptake inhibitor. Instead of doing that, to say, I'm going to take the bacterial strain that give me the proper level of serotonin. So I can just have normal mood without intervention.

• 1:11:27Speaker 00

  Right.

• 1:11:28Gary Brecka?

  Like, that to me is what's so fascinating about this. I mean, like, I'm going to follow your work. I would love to select, you know, eight or 10 of my, you know, VIP clients or for my VIP community and see what challenges they are currently facing that we know map to the gut microbiome. What are the risks that they want to mitigate in the future? Maybe they have Alzheimer's dementia or cognitive decline in their family. Maybe they have an autistic loved one, which we know.

• 1:12:00Speaker 00

  Which is also being correlated.

• 1:12:02Gary Brecka?

  Yeah, they're two specific bacteria.

• 1:12:04Speaker 00

  Yeah.

• 1:12:04Gary Brecka?

  And they're two, correlated to inflammation in the gut. Interestingly, the FDA just approved folic acid.

• 1:12:10Speaker 00

  Really? I didn't know that.

• 1:12:12Gary Brecka?

  Yeah, they just approved folic acid, prescription strength folic acid, which is the, essentially the methylated form of folic acid or folate as one of the frontline prescriptions that a physician could write for.

• 1:12:28Speaker 00

  Awesome.

• 1:12:28Gary Brecka?

  Neurodevelopmental disorders.

• 1:12:30Speaker 00

  I know you're huge into that.

• 1:12:31Gary Brecka?

  I'm huge into that. And I was so excited to see that happen. It was like a eureka moment for me because finally, something that is not chemically or synthetically altering our natural biology.

• 1:12:46Speaker 00

  Yeah.

• 1:12:46Gary Brecka?

  To fix.

• 1:12:48Speaker 00

  You have anything to do with that?

• 1:12:49Gary Brecka?

  You know, a symptom.

• 1:12:50Speaker 00

  You have anything to do with that?

• 1:12:52Gary Brecka?

  So.

• 1:12:56Gary Brecka?

  And, you know, finally, something that is not altering our physiology to get the result that we want, it's going back to our physiology.

• 1:13:04Speaker 00

  Yeah.

• 1:13:04Gary Brecka?

  And saying, could this deficiency?

• 1:13:07Speaker 00

  Yeah.

• 1:13:07Gary Brecka?

  Cause this symptom? And instead of going after the symptom, let's go after the deficiency. And that's why I think that, you know, whatever you want to call it, my work, my passion, which is restoring healthy physiology to get the outcomes that we want.

• 1:13:24Speaker 00

  Mm hmm.

• 1:13:25Gary Brecka?

  You know, autism, I don't need to tell you about autism rates in the United States and statistics are scary. You know, one in 5,000 to one in 32 children. And that is expected to double, double again in the next, in the next five years. I mean, the rate, the parabolic rate at which it's increasing. And, and yet we don't, we can't say this causes this. Vaccines cause autism. The acetaminophen during pregnancy causes autism. We haven't, we haven't reached that. We know that there is correlations.

• 1:13:59Speaker 00

  Yeah.

• 1:14:00Gary Brecka?

  The reason why I believe that these are correlated is because of their impact on the microbiome. I don't have the specific peer reviewed randomized clinical trial to prove it, but maybe you do. That would vindicate me.

• 1:14:13Speaker 00

  Well, it, um, it reminds me of a paper about super centarians and how the microbiome ages over time. And they tracked people, I forget how long, but they had age groups. It was like something like 30,000 people they took samples from, all different ages from 20 to 80. And they identified specific bacteria that decrease as you age.

• 1:14:34Gary Brecka?

  Mm hmm.

• 1:14:34Speaker 00

  Right? And so that's part of the storage. That's one of the bacteria isolate is these young bacteria.

• 1:14:40Gary Brecka?

  Mm hmm.

• 1:14:41Speaker 00

  But what also was found in the paper was the amount of oxygen tolerance in the gut goes down as you age. And what that means is the, um, the bacteria that, you know, they're not oxygen tolerant, but are, they're fed by the.

• 1:15:01Speaker 00

  They increase relative to the number of pharmaceuticals you're on.

• 1:15:05Gary Brecka?

  Hmm.

• 1:15:05Speaker 00

  Right, and it.

• 1:15:07Gary Brecka?

  Meaning you are degrading the capacity for normopathic bacterial function the more you. We absolutely knew that in the mortality space.

• 1:15:15Speaker 00

  Yeah.

• 1:15:16Gary Brecka?

  The more pharmaceuticals you were on, the easier it was to predict your life expectancy.

• 1:15:20Speaker 00

  Yeah, and it's it's now.

• 1:15:22Gary Brecka?

  And not a good way.

• 1:15:23Speaker 00

  Now correlated or related, directly related to your microbiome and how much inflammation, how much oxygen tolerant you are.

• 1:15:31Gary Brecka?

  Yeah.

• 1:15:31Speaker 00

  Inside the gut.

• 1:15:32Gary Brecka?

  Yeah, I think I think that's just, it's just so fascinating to me. And and now that we are beginning to map causal relationships between certain bacterial deficiencies and well-known disease processes, not the least of which, you know, acromansia and cancer.

• 1:15:53Speaker 00

  Yeah.

• 1:15:53Gary Brecka?

  For example, should wake everybody up to the absolute importance and the necessity for healthy microbiome.

• 1:16:01Speaker 00

  Yeah.

• 1:16:01Gary Brecka?

  And that and that our modern day lifestyle is the polar opposite of what we need to have a healthy gut microbiome.

• 1:16:10Speaker 00

  Yeah, yeah.

• 1:16:11Gary Brecka?

  And, you know, I always talk about this theory, I talked about it earlier in the podcast, of the one domino that falls that causes all the other dominos to fall.

• 1:16:18Speaker 00

  Yeah.

• 1:16:18Gary Brecka?

  And very often, the first domino to fall is this dysbiosis.

• 1:16:23Speaker 00

  Yeah.

• 1:16:24Gary Brecka?

  In fact, there are a lot of, you know, when when pathogens invade us, bacteria, parasites, viruses, even even heavy metals and mold and mycotoxin.

• 1:16:37Speaker 00

  Yeah.

• 1:16:38Gary Brecka?

  The vast majority of what they are impacting is the microbiome.

• 1:16:42Speaker 00

  Mm hmm.

• 1:16:43Gary Brecka?

  And then the microbiome deficiency is giving us the symptoms.

• 1:16:46Speaker 00

  Totally, yeah.

• 1:16:47Gary Brecka?

  Okay.

• 1:16:48Speaker 00

  Right, like oftentimes for myself, like. You know, before you get sick or have a cold or something, you'll have some diarrhea or something beforehand, like a few days beforehand.

• 1:16:56Gary Brecka?

  Mm hmm.

• 1:16:56Speaker 00

  And that was found during COVID too. They could track Google searches on diarrhea before the COVID would show up in the sewage samples that they were testing.

• 1:17:08Gary Brecka?

  Wow.

• 1:17:08Speaker 00

  Yeah, so like a few days before, like searches for diarrhea or gut dysbiosis or whatever would spike a few days before actually the, uh, the virus would show up in the, in this, in the sewage.

• 1:17:18Gary Brecka?

  Yeah.

• 1:17:19Speaker 00

  Or before cases.

• 1:17:19Gary Brecka?

  Yeah, you know, interestingly, Whoop noticed certain trends.

• 1:17:22Speaker 00

  Yeah, right.

• 1:17:23Gary Brecka?

  In their Whoop data, um, which I found really fascinating, you know, like respiratory rates starting to increase.

• 1:17:29Speaker 00

  Yeah.

• 1:17:30Gary Brecka?

  Substantially, um, in the days before they became symptomatic. So they were infected, um, but while the viral load was rising before the patient even knew that they had it, um, they noticed this massive correlation between respiratory rates and the onset of COVID to the point where it actually became predictive.

• 1:17:47Speaker 00

  Yeah.

• 1:17:48Gary Brecka?

  Um, so, you know, but, but, but again, if, if you're listening to this podcast, um, you know, what should, if, if someone wants to take the next step?

• 1:17:58Speaker 00

  Yeah.

• 1:18:01Gary Brecka?

  I feel like everyone could benefit.

• 1:18:03Speaker 00

  Yeah.

• 1:18:04Gary Brecka?

  From sending a stool or saliva sample into your lab. First of all, could you handle that kind of influx?

• 1:18:09Speaker 00

  I can handle that volume now.

• 1:18:10Gary Brecka?

  You can now, okay.

• 1:18:11Speaker 00

  Recently, yes, I can handle the volume.

• 1:18:13Gary Brecka?

  Okay, so, so sending in a stool and a saliva sample, having their, um, microbiome sequenced and at least getting on a basic probiotic coming from their own flora.

• 1:18:26Speaker 00

  Yeah, starting with one or two.

• 1:18:27Gary Brecka?

  Starting with one or two.

• 1:18:29Speaker 00

  Yeah.

• 1:18:29Gary Brecka?

  Um, addressing the deficiencies in bacteria that we know have major impacts on mood, major impacts on emotion, major impacts on inflammation.

• 1:18:37Speaker 00

  Yeah.

• 1:18:38Gary Brecka?

  Um, so that you don't buy yourself a con- consequence down the road. And I, I like that idea better than, I mean, I know some phenomenal probiotic manufacturing companies and.

• 1:18:49Speaker 00

  Yeah.

• 1:18:49Gary Brecka?

  But again, this is the one size fits all, but it's all we have right now.

• 1:18:54Speaker 00

  Yeah.

• 1:18:54Gary Brecka?

  Um, and I utilize them a lot and there are some phenomenal products out there.

• 1:18:58Speaker 00

  Like, like we were talking about before, like the World War I soldier and.

• 1:19:01Gary Brecka?

  Yeah, yeah.

• 1:19:02Speaker 00

  You know, there's tons of great companies.

• 1:19:03Gary Brecka?

  I really, well, I want some of his, if you've got it lying around the lab.

• 1:19:07Speaker 00

  I can send you some.

• 1:19:07Gary Brecka?

  I want some of his back there. Okay, good. Yeah, I got it in, guys, so. And, and then I'll, and then I'll start reselling it and maybe I'll, it's like.

• 1:19:16Speaker 00

  You should, yeah. We can sell Gary Breck's own. Yeah.

• 1:19:20Gary Brecka?

  But no, I, I, I think for the vast.

• 1:19:23Speaker 00

  From Gary for the world.

• 1:19:26Gary Brecka?

  I like it.

• 1:19:26Speaker 00

  Yeah.

• 1:19:27Gary Brecka?

  Let's, uh, let's trademark that today. So I, I think that, you know, you send in a stool and saliva sample. You get this profile, you culture those bacteria and you begin to re-innoculate. What is the worst thing that can happen? Your inflammation goes down, your mood improves. You see that your cognitive function begins to improve, that brain fog starts to lift.

• 1:19:50Speaker 00

  Yeah.

• 1:19:51Gary Brecka?

  And potentially you are mitigating the downstream risk of neurocognitive decline.

• 1:19:57Speaker 00

  Right.

• 1:19:58Gary Brecka?

  Which is, you know, what none of us want. I mean, this woman that passed away at 118 years old, I, I saw some of the, the interviews with her. And fascinating to me how cognizant she was at 116 and 117 years old. I mean, very, very, very good grasp of where she was, what was going on in the world, her environment. You know, she wasn't living in the past, she wasn't aloof, she wasn't despondent. And, you know, if, if the very things that create thought, neurotransmitters are made in the gut. And that those are made in a factory that is run by bacteria.

• 1:20:37Speaker 00

  Yeah.

• 1:20:39Gary Brecka?

  There's a linear correlation between these.

• 1:20:42Speaker 00

  Yeah.

• 1:20:43Gary Brecka?

  So would you recommend that everyone at least start their stool and saliva sample?

• 1:20:48Speaker 00

  Store it and get the test done.

• 1:20:50Gary Brecka?

  And begin to take your own probiotics?

• 1:20:52Speaker 00

  Yeah.

• 1:20:53Gary Brecka?

  Yeah. That's fascinating.

• 1:20:54Speaker 00

  Take your own.

• 1:20:55Gary Brecka?

  What is, what is one question I haven't asked you that, that you think everyone needs to know about the gut microbiome? And/or could be solved by what you're doing in your lab today?

• 1:21:08Speaker 00

  One question you haven't asked. I guess where I think it's all going?

• 1:21:13Gary Brecka?

  Yeah. Where's it all going?

• 1:21:16Speaker 00

  Where's it all going?

• 1:21:20Speaker 00

  You and I talked a little bit about this the other day, but like the virome, did we talked about this?

• 1:21:25Gary Brecka?

  Yeah.

• 1:21:27Speaker 00

  And how there's a really crazy paper and bacteria have viruses just like humans have viruses, but these viruses only attack the bacteria.

• 1:21:41Gary Brecka?

  Hold on, bacteria have viruses?

• 1:21:43Speaker 00

  What do you mean? Like?

• 1:21:45Gary Brecka?

  Bacteria carry viruses?

• 1:21:46Speaker 00

  No, no, like there's a virus that will only go after lactobacillus.

• 1:21:51Gary Brecka?

  Oh, right, right.

• 1:21:53Speaker 00

  And that's called like a phage. And so this crazy study, bacteria infected by a phage makes mice and makes flies smarter. Increases memory, increases, right? No one knows why this is the case, but in the flies, they have a longer memory and in the mice, they can solve the maze quicker.

• 1:22:14Gary Brecka?

  Okay.

• 1:22:14Speaker 00

  Right, early, early stuff. But that's it, that's really interesting to me. Like, why is, why is that happening?

• 1:22:20Gary Brecka?

  Yeah.

• 1:22:21Speaker 00

  You know, I know it sounds a little scary, but you know, those viruses have no effect on us. This, they're only dangerous to the lactobacillus.

• 1:22:31Gary Brecka?

  Mm hmm.

• 1:22:32Speaker 00

  But.

• 1:22:33Gary Brecka?

  But then the lactobacillus has an effect on us.

• 1:22:35Speaker 00

  Yeah.

• 1:22:35Gary Brecka?

  You know, and so again, we're getting back to that first domino that fell.

• 1:22:38Speaker 00

  Yeah, and soon it will be possible to model, I'm getting too technical.

• 1:22:47Gary Brecka?

  No, go ahead, get technical for a second.

• 1:22:50Speaker 00

  Soon it'll be possible to model all.

• 1:22:52Gary Brecka?

  Through AI?

• 1:22:53Speaker 00

  Yeah.

• 1:22:53Gary Brecka?

  Yeah.

• 1:22:54Speaker 00

  Through all the metabolites produced by one bacteria eaten by another downstream effects, like be able to create a digital twin of all the bacteria and be able to model the food you eat and all the metabolites, you don't have a. This many grams of B vitamins or whatever are produced, you know, as which I think will be really cool.

• 1:23:16Gary Brecka?

  I think that'll be really cool, too.

• 1:23:17Speaker 00

  Yeah.

• 1:23:17Gary Brecka?

  Well, Anders, this is amazing. I have a group of folks, the community that I'm building called the VIP community. So when the podcast is over, we're going to go into this VIP community because they're the community that I let know ahead of time who's coming on the podcast.

• 1:23:32Speaker 00

  Okay.

• 1:23:32Gary Brecka?

  And so they've looked into your background. They have a series of questions for you. If you're interested in becoming a VIP, just go over to the ultimate human, theultimatehuman.com/vip. Sign up to be one of my VIPs. You can cancel at any time. I have a 10-month course on becoming the ultimate human in there. I do lots of live Q and A's. I do private podcasts. I've written guides on mold detoxification, heavy metal detoxification, whole food diet, travel tips, sleep, morning routines, even exercise. And there's just an amazing community of like-minded human beings in there. So head over to theultimatehuman.com/vip and just sign up to be one of my VIPs

• 1:24:13Gary Brecka?

  and I'll see you in there. But I end all my podcasts by asking all my guests the same question. And there's no right or wrong answer to this question.

• 1:24:21Speaker 00

  Okay.

• 1:24:21Gary Brecka?

  And that is, what does it mean to you to be an ultimate human?

• 1:24:28Speaker 00

  I'm still very athlete driven.

• 1:24:32Speaker 00

  I, I still want to compete at an elite level and as many different sports as I can.

• 1:24:38Gary Brecka?

  Hmm. How old are you now?

• 1:24:40Speaker 00

  Thirty-eight.

• 1:24:40Gary Brecka?

  Oh, you're not old.

• 1:24:41Speaker 00

  I'm an old man.

• 1:24:42Gary Brecka?

  Hey dude, I mean, Tom Brady, you know, Cristiano Ronaldo. I mean, there's a lot of.

• 1:24:48Speaker 00

  A week ago, I raced at the Heather Charles, the world's largest rowing regatta.

• 1:24:51Gary Brecka?

  Oh, you did?

• 1:24:52Speaker 00

  Yeah.

• 1:24:53Gary Brecka?

  Oh, right on.

• 1:24:54Speaker 00

  Did pretty well. We got eighth in our category.

• 1:24:57Gary Brecka?

  Okay. And is it aged?

• 1:24:59Speaker 00

  I was in the alumni event.

• 1:25:00Gary Brecka?

  Okay.

• 1:25:01Speaker 00

  So former college and national team athletes. Yeah. And, but that's awesome. You know, I want to be able to do that every year and I want to win that thing.

• 1:25:08Gary Brecka?

  Yeah.

• 1:25:09Speaker 00

  Every year. Yeah.

• 1:25:10Gary Brecka?

  You know, like, one of my favorite things is, it sounds crazy, but just being able to like work out with my family and my, my sons. And my oldest son was over here in Dubai with me and my, my, the rest of my family.

• 1:25:28Speaker 00

  He was very nice.

• 1:25:28Gary Brecka?

  Yeah, he's, Cole's great. And, but not just being in same industry together and building businesses together, but be, but. To have a shared part of your lifestyle because he, you know, he's very athletic. So is my, my other son. So are both of my daughters and, but to be able to just, you know, he's 23 years old and to be able to just go and just rock a gym session with him, do a HIIT cardio workout. Like it's, I sat down last night and I was telling my friend, Umar Kamani, I was like, this is the best that life gets. You know, like we had, we had a great day with business meetings and then, you know, my son and I and a bunch of our buddies,

• 1:26:09Gary Brecka?

  we just went to the gym. We had a trainer run us through this crazy CrossFit style, you know, wad workout. And then at the end, we did these 30 second interval sprints and just to be able to do that with him. I'm like, this is as good as life gets. And I want that for everybody because when you have your health and you're pain free and you're mobile.

• 1:26:28Speaker 00

  For as long as possible.

• 1:26:29Gary Brecka?

  For as long as your relationships deepen.

• 1:26:32Speaker 00

  Yeah.

• 1:26:32Gary Brecka?

  Really is so true. Well, Andrew, thank you so much for coming on the Ultimate Human Podcast. I'm excited to talk to you in the, in the VIP group. And for the rest of you guys, until next time, that's just science.