295. Methylation Test & MTHFR Gene - Healf Experience Wellbeing Event 2026 in London

You've been told your whole life that your condition is genetic, that it runs in your family, and you're stuck managing it forever, but I'm telling you that with rare exceptions, we don't inherit disease at all. What we inherit is an inability to refine a raw material, which creates a deficiency, and that deficiency is what shows up as the symptom you've been calling a disease. Find what your body can't make on its own, put it back, and watch what happens. CLICK HERE TO BECOME GARYS VIP!: ⁠https://bit.ly/4ai0Xwg⁠ Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD AIRES: "ULTIMATE20 " FOR 20% OFF: https://bit.ly/4a3Duze BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKpCYMBIOTIKA: "BRECKACYM30" FOR 30% OFF: https://bit.ly/4tjyluP GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk GENETIC TEST (USA ONLY): ⁠https://bit.ly/3Yg1Uk9 GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC H2TABS: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn SNOOZE: LET’S GET TO SLEEP!: https://bit.ly/4pt1T6V WHOOP: JOIN & GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW Watch the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: ⁠https://bit.ly/3RPQYX8⁠ Podcasts: ⁠https://bit.ly/3RQftU0⁠ Connect with Gary Brecka Instagram: ⁠https://bit.ly/3RPpnFs⁠ TikTok: ⁠https://bit.ly/4coJ8fo⁠X: ⁠https://bit.ly/3Opc8tf⁠ Facebook: ⁠https://bit.ly/464VA1H⁠ LinkedIn: ⁠https://bit.ly/4hH7Ri2⁠ Website: ⁠https://bit.ly/4eLDbdU⁠ Merch: ⁠https://bit.ly/4aBpOM1⁠ Newsletter: ⁠https://bit.ly/47ejrws⁠ Ask Gary: ⁠https://bit.ly/3PEAJuG⁠ Timestamps 00:00 - Intro of Show 01:04 - Gary takes the stage 02:39 - Going back to the basics of human physiology 04:22 - The two bold promises and mortality data 05:04 - Why life insurers predict death to the month 06:03 - The myth that disease is genetically inherited 08:11 - Reading deficiencies: tired, sore, brain fog, anxiety 09:53 - Circadian rhythm and bookending your sleep 12:11 - Fasting as a jet lag superpower 13:16 - Live breath work session 16:58 - The second bold promise 17:53 - The methylation chart explained 19:18 - MTHFR and the anxiety-gut link 22:27 - Homocysteine, creatine, and methyl donors 25:31 - Why targeted supplementation beats random stacks 26:22 - Reading a supplement label for cofactors 28:41 - The genetic methylation test 30:06 - Q&A: fibroids, insulin resistance, the Dutch test 33:03 - Q&A: LDL, triglycerides, and Lp(a) 39:58 - Q&A: high cortisol and hormone ratios 43:58 - Q&A: Hashimoto's, the Dutch test, and the COMT gene 47:18 - Q&A: Asperger's and mood numbness 51:18 - Q&A: anaphylaxis and mast cell activation 57:20 - Q&A: vitiligo and red light therapy 59:59 - Q&A: low T3, the liver, and selenium 1:05:28 - Q&A: IBS and the pace of the gut Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions. Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature. Learn more about your ad choices. Visit megaphone.fm/adchoices

• 0:00Speaker 00

  We have believed so much more in pharmaceuticals and chemicals and synthetics than we have in our own human physiology. Because we have been sold so many myths in modern medicine. You wake up sore and achy in the morning like you had a workout the night before when you haven't. The thing you struggle most with is brain fog. You're one of those people that goes to sleep tired. And these are all deficiencies. Fixable by fixing the nutrients that the body needs to do its job. Methylation is the process in the human body where we take a raw material and we convert it into the usable form. If we would stop supplementing for the sake of supplementing and we would start supplementing for deficiency, you would see human beings truly thrive. As soon as you find out that raw material and put it back in the body, that's when magic

• 0:45Speaker 00

  happens. If you don't find the deficiency, nothing else matters. And this is the test that I've been preaching for 10 years that I think every single human being on the surface of the earth should do once in their lifetime.

• 1:15Speaker 00

  Is this on? Did we turn this on? Okay, it's on. You guys can hear me, right? I actually spoke yesterday morning in the desert in Utah. And then went to New York last night and then showed up here today. So I completely lost my voice in the desert. I feel amazing, but I lost my voice. And when we landed this morning, my wife's like, "What the hell are we gonna do?" I was like, "I don't know, give me some ginger." Guys, these are amazing. Munir, Chloe, thank you so much for the Smooth collaboration. I gave one of these to all of you guys. It's got trimethylglycine in it and other methylated nutrients. I hope you enjoy it. Thank you, Smooth. Guys, we're gonna have some fun today.

• 2:00Speaker 00

  You know, usually when I take the stage like this, and last year I spent some time talking about methylation, but today we're gonna take a little bit of a deeper dive. So I hope that some of you are citizen scientists or science nerds like I am. We're not gonna go super, super deep into the science, but I really want you to understand the physiology behind methylation because it is the foundation of so many ailments that we chalk up to a consequence of aging, or our environment, or stress. And it's not a consequence of any of those things. It's a consequence of missing raw material. I have a deep-seated belief in what God gave us, not what man makes us. We have believed so much more in pharmaceuticals and chemicals and synthetics than we have in our own human physiology.

• 2:44Speaker 00

  And as I travel the world and meet with like the leaders in anti-aging and longevity, people there that are really moving the needle, the MDs, the PhDs, the researchers that are really moving the needle for humanity. It's so fascinating to me that we are coming entirely full circle. And we're getting back to the basics. Like, there's just no replacement for sunlight, for grounding, for whole-food diet, for community, for connection, the understanding that faith is medicine, the community is medicine, connection is medicine. And what's even more fascinating is the leading science in the world today advancing the human physiology and extending lifespan and health span is going back into the human

• 3:27Speaker 00

  body and empowering what we already have. Like, the leading theory in aging right now is the theory of immunofatigue. A slow, progressive overwhelming of the immune system. And so, science has gone back into this magical system called the immune system and understanding that we can actually target-direct the immune system now. We can restore its vitality and it can actually eat cancer from our body like a termite. It can reverse the age of our mitochondria. It can make us as strong in our 70s as we were in our 40s. And so, empowering the immune system where centuries of research behind fasting and

• 4:08Speaker 00

  grounding and sunlight and not really tying that back to science led us to believe that this was voodoo science. And now, we have proven this thanks to big data and artificial intelligence. So we're gonna talk about a lot of ways today that you can leave this room and start tomorrow really empowering yourself to heal and to thrive. So, I always, I usually end with "that's just science," but they put it at the front of the presentation, so there you go. I always make two bold promises when I take the stage. One is that if you do what I ask you to do today, I will add seven years, not just to the lifespan, but to the health span of every person in this room.

• 4:52Speaker 00

  And like, what qualifies me to make that statement? Well, for 22 years, I was a mortality researcher for large life insurance companies, which meant that if we got 10 years of medical records on you and 10 years of demographic data, we could tell the insurance company how long you had to live to the month. And I do get a lot of flack for saying that. But the truth is, it's some of the most accurate science in the world. If you look at what happened during the 2008, 2009 financial services crisis, we had in the United States 364 banks fail. Not a single life insurance company failed. Because life insurance companies have data that no other enterprise has, no collegiate university has it, the FDA doesn't have it, the CDC doesn't have it.

• 5:32Speaker 00

  They know the day, the date, the time, the location, and the cause of death for 371 million lives. And they take that data, they triangulate it back into the record, and then we can predict mortality within a month. And I would always say that if that database that I used to have access to could just see the light of day, it would permanently change the face of humanity. I mean, sadly, it never will, other than through what I can remember and regurgitate out to humanity. But if it could see the light of day, it would upend modern medicine in a way that would be catastrophic. Because we have been sold so many myths in modern medicine. You know, one of my favorite to dispel is that the majority of disease is genetically

• 6:16Speaker 00

  inherited. That is patently false. You know, when you look at big categories of disease, hypertension, autoimmune, when you're diagnosed with high blood pressure, 85% of the time, it's diagnosed as idiopathic hypertension, hypertension of an unknown origin. You just woke up one day and for no apparent reason, your blood pressure is skyrocketing. And we did all of these exams on your heart, EKG, EEG, cardiac catheterization, heart sounds, lung sounds. We can't find anything wrong with your heart, so we're gonna look at your family history. "Oh, look at that, your father's brother and your mother both had high blood pressure. You have familial hypertension. You have genetically inherited hypertension."

• 7:00Speaker 00

  And we use this theme in type 2 diabetes, in drug and alcohol addiction, in depression and anxiety. We use it in hypothyroid, we use it in autoimmune, because we are told that these travel in families and they are genetic. Only the sad fact is that for the most of those conditions, that gene does not exist. If you asked your cardiologist when they diagnosed you with hypertension and said you have a family history of hypertension, and you just took it a step further and said, "Okay, well, what gene did I inherit from my ancestor that caused that condition to exist?" That's when their face would go blank, because that gene doesn't exist. We do not, with rare exceptions, and I'm happy to debate those exceptions, but there

• 7:45Speaker 00

  are very rare exceptions, we do not pass disease from generation to generation. What we pass from generation to generation is an inability for the body to refine a raw material, which causes a deficiency, which leads to that disease. And that deficiency can be fixed. If we go back into the soil and we give it the nutrients that it needs, that leaf will heal. Human beings are no different. I promise you. And it's been a very exciting journey for me because I've dedicated the balance of my adult lifetime to the study of genetic methylation. Not genetic mutations, but methylation. How the body processes nutrients and what deficiency in those nutrients leads to.

• 8:30Speaker 00

  What is the expression of that deficiency? If you've ever seen when I look at a genetic report and I don't see a person or a patient, and then the three people sitting in front of me, and I just take three genetic reports and I just read the consequences of what those deficiencies mean. "You wake up sore and achy in the morning like you had a workout the night before when you haven't. The soles of your feet hurt when you get out of bed in the morning to walk to the bathroom and take your first pee. I can see that libido left the building probably 15 years ago. The thing you struggle most with is brain fog. You're one of those people that goes to sleep tired, but as your environment quiets, your mind wakes up and you lay there and you just ruminate. You've had anxiety on and off your entire life, but you can't point to the specific

• 9:14Speaker 00

  trigger that causes it, and then you're told that it runs in your family because you worry like your mother does." And these are all deficiencies. Fixable by fixing the nutrients that the body needs to do its job. So... You know, one of the most common questions I get asked is, you know, when I keep up a travel schedule like I do, I mean, I was in Utah yesterday morning, then New York last night, and London today, I'm in Cannes tomorrow, and back to London the following day. How do I maintain the sleep scores that I maintain? And just how do I keep up the energy level? And so I get asked a lot about my morning routine. There's my exact morning routine. Most of that will cost you zero.

• 9:56Speaker 00

  That's exactly what I suffer with a myth, and exactly my morning routine. You know, another fascinating thing about human physiology and these methylation cycles is we are such circadian creatures. You know, we used to be very tied to the sleep-wake cycle of the sun. And the further disconnected we get from that cycle, the more dysrhythmium we have in the body. The suprachiasmatic nucleus in the brain, which is running all of our biological clocks, when that timing gets off, it throws off a whole series of consequential reactions, not the least of which is hormonal deficiencies, sleep disruption, your cortisol-melatonin cycle. So, learning to allow your body to trust you is very important.

• 10:41Speaker 00

  And how do you get your body to trust you? Routine. You at least give it the same thing every single day, at least a portion of your routine. I call it "bookending" your sleep. When I ask most people, "What do you do to go to sleep?" They go, "What do you mean, Gary? I just get in bed." I go, "Well, when do you get in bed?" "Whenever I'm done my shit, right? Whenever I'm done my stuff." "And what time do you get up?" "Well, I set my alarm for X time." And so what happens is, we throw off this biological clock. But there are simple things that you can do to "bookend" your sleep, like breathwork, exposing your eyes to sunlight, doing the same routine 15 minutes before bed, and the

• 11:22Speaker 00

  same routine 15 minutes out of bed, so that your body begins to key into these as clues that it's time to go to sleep, or it's time to wake up. You remember the old experiment Pavlov's dog? Where they rang the bell, fed the dog, rang the bell, fed the dog, rang the bell, fed the dog, and then they would ring the bell, and the dog would salivate. Right? Not even get food, but the dog would salivate. This is the same type of learned behavior you see in the suprachiasmatic nucleus in the human brain. But it learns to distrust us because we have no rhythm. I'm not saying that you can't sleep and wake at different times. I'm not saying you can't travel to different time zones. But if you keep your digestive cycle, and you "bookend" your sleep, it is an absolute game changer.

• 12:05Speaker 00

  In fact, the thing that I use most when I travel to adjust to rapidly changing time zones is fasting. I use fasting as a human superpower. I never feed myself during my normal sleeping window. Nobody talks about that. They talk about getting sunlight, or grounding, or getting outside, or exercise. The truth is, if your digestion changes its time, there is zero chance you will adjust to a new time zone. So, for example, I go to bed at 10:00 PM in Miami, I wake up at 6:00 AM. So between 10:00 PM and 6:00 AM East Coast time, my body always thinks that it's sleeping. So I never feed myself between the hours of 10:00 PM and 6:00 AM East Coast time. If I come to London and I'm five hours ahead, that means 6:00 AM in the morning is 11:00

• 12:50Speaker 00

  in the morning. So I will not put any solid food in my body before 11:00 AM. Very simple. Just that single shift alone will be a game changer to those of you that are road warriors like myself. So we're going to talk about, we're going to go into the methylation cycle, but before we do, I want to sort of wake the crowd up. How many of you, how many of you actually do breathwork? On a regular basis? Wow. So half of you have nothing to learn from me. The other half of you can pay attention. I do a style of breathwork called Wim Hof breathwork, but there's so many different styles. Pranayama, there's, you know, you can go deep down the rabbit hole of breathwork. I prefer to keep it simple. I do the same routine to go to bed. I do the exact same routine to wake up in the morning.

• 13:35Speaker 00

  Why don't we do a small section of the breathwork that I use every single morning to just wake my diaphragm, increase my circulation, improve my mood and emotional state, and flood my blood with oxygen? You guys want to do it with me real quick? No. All right, let's do it. So sit, sit comfortably. Everybody outside of this room is going to think it's a cult, because it's about to sound really freaky in here. So sit, just sit comfortably, and all we're going to do is take an obnoxiously deep breath in through our nose. We're going to put our hand over our belly button, and we're going to try to push our stomach out. Pretend like you're actually pulling your belly button out. I want to get the air down into the lobes of the lungs, out of the apex of the lungs. You know, hypoxia is the definition of death.

• 14:20Speaker 00

  Every human being leaves this world the same way. The definition of death is not enough oxygen to maintain brain function, which we call hypoxia. A lot of us are slowly suffocating to death, and it's very easy to shift that. So all we're going to do is we're going to take an obnoxious, and I mean obnoxious, like you shouldn't be able to hear your neighbor breathe because you're breathing so obnoxious. Right? We're going to take an obnoxiously deep breath in through our nose like this. And then we're going to go out through a straw. We're going to take a second one, ready? And out through a straw.

• 15:05Speaker 00

  Last one, in. And out through a straw. Now I want you to just hold your breath right here for 10 seconds. Fight the urge to breathe in. Fight the urge to breathe in. Big breath in through your nose. And let it out. If you got lightheaded, that is a very good sign, but that shows you the oxygen tension in your brain. It shows you how low the oxygen tension is in your brain.

• 15:46Speaker 00

  So simple things like this, when you wake up in the morning and tell your body it's time to wake up, like Pavlov's dog, your body will begin to wake up. There is clinical research that shows that it has an impact on our cortisol and our melatonin cycle, our waking hormones and our sleeping hormones. And this is portable, and it's free, and you can do it anywhere, anytime, your hotel room, you can do it wherever you want. My wife will tell you, "I haven't missed a session of breathwork in probably four and a half years." I'll miss a commercial flight not to miss breathwork. So, so that's the morning routine. Let's go into the methylation. Let's talk about supplementation. Let's talk about methylation. And then I, my favorite part is at the end when we open it to questions.

• 16:28Speaker 00

  And my second bold promise, which is that I will take any ailment that you or a loved one suffers from, either in this crowd or a loved one suffers from in your sphere, and I will tell you right from this stage what raw material is missing from their body that is causing that condition to exist. And it can be autoimmune, ADD, ADHD, OCD, manic depression, bipolar, hypertension, hypothyroid, Hashimoto's, Crohn's disease. We're going to go deep into the science of human physiology and say, "Why would this condition exist? And what is the raw material that was deficient that allowed that process to occur?" It's a, it's a real message of hope. Okay. Gary, how about a simple nighttime routine?

• 17:12Speaker 00

  Well, we just went through the morning routine. This is my favorite chart. If you've seen me talk, you've seen this chart before. We're going to go a lot deeper into it today. But this is, I should do a quiz on this later. So can you guys commit this to memory? How many of you have committed that chart to memory? Right there. There's my fellow nerds. Let's just unite right there. So, there are those of us that have committed this chart to memory, and he will tell you that if you were, this is, this is essentially a chart of what's called our genetic methylation. Methylation is the process in the human body where we take a raw material and we convert it into the usable form. You see, the human body is like an oil refinery.

• 17:57Speaker 00

  We pull crude oil out of the ground, but we know we can't put crude oil into our gas tank. And we can't put it in our gas tank because the car doesn't understand that fuel source. But if you take crude oil and you convert it to gasoline, now the car can run. Human beings are no different. There is not a single nutrient known to mankind that we put into the human body that is used in the format that we put it in. Every protein, carbohydrate, mineral, nutrient, vitamin, amino acid, everything that enters our body gets converted into the usable form, and then the body can operate. So what if you have an impairment, an inability to make a certain conversion?

• 18:41Speaker 00

  Like the MTHFR gene mutation. How many of you have that gene mutation? How many motherfuckers in here? Yes. Doesn't stand for the motherfucking gene. It's methylene tetrahydrofolate reductase, you dirty birds. So, one of the most common gene mutations in the world. Nine times more likelihood of infertility. Seven times increase in miscarriages. Four times increase in ADD and ADHD. 11-fold increase in obsessive-compulsive disorder. Six-fold increase in gut dysbiosis. And it is a nutrient deficiency.

• 19:21Speaker 00

  It is the inability to convert folic acid and folate into something called methylfolate, the gasoline that your body needs to run. This is why I have never, in 10 years of doing these talks and of owning a functional medicine clinic, I have never once met a single person that suffers from anxiety that didn't also have gut issues. And if you're somebody that has rampant anxiety and you don't have gut issues, I want to bring you up on stage because you're a unicorn. All right? These two are inextricably linked by the same nutrient deficiency. When you're deficient in methylfolate, the peristaltic activity in your gut is impaired, the methylation cycle for serotonin and dopamine is impaired, and you have a mood disorder.

• 20:06Speaker 00

  You have a mental illness. You have high catecholamines, so you worry all the time. And guess what? You worry, just like your mother did. All right? The deficiency travels in families. You have a temper, just like your father. You drink like your uncle drank. The characteristics are what is expressed from these deficiencies. It is not a disease, it is not a pathology. These deficiencies lead to certain characteristics. Warriors, warriors. Type A personality, type B personality, being reclusive, being gregarious. These are all found in our genes. People with ADD or ADHD, these people don't lack the ability to pay attention, they lack the ability to pay attention to so many things.

• 20:50Speaker 00

  It's not an attention deficit, it's an attention overload disorder. And it comes right from this chart. So what's fascinating is you can go into this chart, and you can find the deficiencies that lead to mood disorders and mental illnesses. You can find deficiencies that lead to poor gut motility, which leads to gut dysbiosis. Not food allergies, not food sensitivities, not disruption of the gut microbiome. The wrong pace of the gut. The gut is moving like a conveyor belt at the wrong pace. And you can go in here, and in addition to all of those disorders, you can find athletic performance and recovery. How well do we repair myofibril tissue? How well do we regenerate mitochondria? How well do we produce and process the nutrients

• 21:33Speaker 00

  that are required to make ATP? And all of this is fixable. So, you know, a lot of talk about creatine lately. And creatine because, not because creatine is, you know, a bodybuilding supplement, which is kind of the category it's been in for decades. What's really fascinating, that we knew 15 or 18 years ago in the mortality space, it's really fascinating is, the way the human body works is we take certain nutrients, like vitamin B12. We take that vitamin, and it gives its life to the conversion of one nutrient into another.

• 22:16Speaker 00

  And so, for example, if you have a gene mutation that does not allow your body to break down an amino acid called homocysteine. Homocysteine starts to rise, but homocysteine is supposed to be converted into another amino acid called L-methionine. And then that goes up and quiets the mind. And then L-methionine becomes S-adenosylmethionine, SAME. And SAME is what elevates mood and emotional states. And then that turns back into something called SAH, and it turns back into something called homocysteine. The body is such a fascinating machine, because it's almost like that saying, "One man's trash is another man's treasure." You put a protein into the body. Protein is useless when you put it into the body, until it is converted to amino acids.

• 23:01Speaker 00

  Amino acids are not proteins, they're the building blocks of proteins. We have protein equivalents. One kilogram of protein, I mean, one gram of protein for every kilogram of body weight. Not because we need a protein equivalent, because we need an essential amino acid equivalent. So we're getting to the raw material. The body is going to break that protein, whether it is collagen, or fish, or egg, or plant protein. It is eventually going to turn that into amino acids. And then amino acids are going to go build structures in the human body. And sadly, we cannot target direct protein in the human body. Right? We don't eat our nails to grow our nails, and we don't eat our hair to grow our hair. And we don't eat collagen to grow collagen. Collagen, like any other protein, is going to turn into amino acids.

• 23:46Speaker 00

  And yes, if your body needs collagen, elastin, fibrin, it can build those structures. But from the same amino acid as an egg protein. So, what's fascinating is, you know, when we talk about creatine specifically, it is a part of this methylation cycle, and it is absolutely critical to something called SAME. SAME is the main, the number one methyl donor in the human body. When you become deficient in creatine, which your body does produce, but when you're deficient in this nutrient, it converts SAME. It actually eats it from SAME. It's like when we fast.

• 24:29Speaker 00

  We don't go without having energy, we just start to eat ourselves. We take senescent cells, we break them apart into energy, into amino acids, and we continue to build structures. So when the body is deficient in certain nutrients, why you're seeing creatine now topping the charts for cognitive function, why you've probably heard me say that every woman over 40 years old has to be on a creatine supplement, why you're seeing it now creep into neurodevelopmental disorders, mood and mental illnesses? Because this compound is a substrate that is made in the human body. And if you are deficient, it will take the primary methyl donor, which creates mood and emotion, and it will steal that methyl donor in order to produce creatine.

• 25:13Speaker 00

  And so, what's fascinating is, when we go into the human body, and we look at all of these compounds, if I keep zooming in on this chart, most of you are going to recognize these. And also, when we supplement the human body, it's important that we don't supplement just a B12, or just a single B vitamin. Targeted supplementation is where most people go wrong. We pile all of these supplements into the body, but we don't ask ourselves, "What are we deficient in?" If you don't find the deficiency, nothing else matters. Which is why your sister took NAD, and she felt like a rock star, and you took NAD and felt nothing. This is why resveratrol cleared up the skin of a friend of yours, and you take resveratrol, and nothing happens.

• 25:55Speaker 00

  So, every human being has this exact methylation cycle, but we all have different deficiencies. If we would stop supplementing for the sake of supplementing, and we would start supplementing for deficiency, you would see human beings truly thrive. That's when your supplements would make an impact. When you find a deficiency, and stop supplementing for the sake of supplementing, that's when your supplements start to have an impact. So I'm a huge believer in supplements, but usually what I'll do is I'll take a supplement label, and I'll turn it around. And first, I'm looking for the quality of the ingredient. But then I'm actually looking for whether or not they understand the methylation cycle. Are they putting the cofactors in there to get this to the target tissue?

• 26:39Speaker 00

  There was a rage with NAD. I'm a huge fan of NAD. Delivering it through the gut requires a liposome. Right? Or else it's destroyed in something called first-pass metabolism. Or you can inject it, or you can do it in a patch, or you may be able to do it sublingually. But if you're going to put NAD into the body, and get it through the stomach, you need this liposome. By the way, I don't sell liposomal NAD. But now that you've got that molecule through the stomach, and it lands in the gut, it is still very, very, very, very far from the mitochondria. It has to go through the gut wall and enter the bloodstream. Then it has to be carried to a cell wall. Then it has to go through a gating channel of a cell wall. It has to cross the cytoplasm of the cell. Then it meets the mitochondria. Now it has to go into the mitochondria, and then it exerts its effect in the electron transport chain and the growth cycle.

• 27:25Speaker 00

  But the amount of cofactors that are needed to target direct that NAD, things like phosphatidylcholine, trimethylglycine. If you don't have those cofactors, you've gotten NAD through the gut, and you've dropped it into the gut. It's crossed into the serum of the blood, and it stays right there. Until it meets a hydrogen ion, and then it's reduced. So, again, we should obey the laws of physiology, and look for nutrient deficiencies before we assign pathology and disease.

• 28:03Speaker 00

  Those are...

• 28:06Speaker 00

  This is the ultimate human wellness formulation of supplements. It took me two and a half years to formulate these. I'm extraordinarily proud of these. Because if you spin any of these labels around, what I have done is I have assumed that you can't convert anything. I assume that you have the same series of gene breaks as people suffering from more significant ailments. And we already methylate these nutrients, so that if your body can't produce them or absorb them, it is absorbed already for you. It enters directly into the methylation cycle.

• 28:41Speaker 00

  And this is the test that I've been preaching for 10 years, that I think every single human being on the surface of the earth should do once in their lifetime. A genetic methylation test, so that you can stop supplementing for the sake of supplementing, and you can start supplementing for deficiency. That test, which you do once, because the genes you're born with are the genes that you die with, you will never repeat this test. That test will tell you exactly what you are deficient in. And at no point in your lifetime will you be able to create those nutrients. Because if that genetic mutation exists, like it existed in your ancestor, your mother, or your uncle, or your mother's sister, which is where we get all of this genetic transgression of disease. It will continue to travel in your family.

• 29:26Speaker 00

  The characteristics will continue to travel in your family. The autoimmune, the deficiencies will continue to travel in your family. Yet, none of you have a genetic disease. You have a deficiency. As soon as you find out that raw material, and put it back in the body, that's when magic happens. So, I tried to get to the end of my presentation as fast as I could, because my favorite part of being in front of audiences like this is to open the floor to questions. And I have, do we have microphones out there?

• 29:59Speaker 00

  Okay. So, these lights are so bright, I'm having a... Yes, ma'am.

• 30:06Speaker 01

  Hi, it's a pleasure to be here.

• 30:08Speaker 00

  It's a pleasure to meet you too.

• 30:09Speaker 01

  You said that if we brought up some sort of ailment that we have, that you would be able to answer the question, and I hope this is the right time to bring that up. But I wondered specifically about fibroids, and how that fits into what you've been saying.

• 30:23Speaker 00

  Yeah, so fibroids, endometriosis, uterine fibroids, which usually has other connective tissue correlations related to it. These conditions, believe it or not, in the human body, it's very rare, if ever, that multiple systems fail at the same time. Usually what happens is one domino falls and causes an entire consequence of events. Like, you will never convince me that somebody has more than one autoimmune disease. You will never convince me that people have multiple mental illnesses or multiple mood disorders. Usually, one domino falls that causes everything. So in fibroids, what is the domino that falls? Believe it or not, uterine fibroids specifically.

• 31:08Speaker 00

  And when you image the uterus, and they usually do fibroidectomies for these, and you see these fibroids that are penetrating from the interior of the uterine wall, sometimes all the way through multiple layers in the uterine wall. The first domino to fall is insulin resistance. You generally see a decade of elevated blood sugar prior to. We see this in neurodevelopmental disorders now. You know, there's an entire class of science that is calling Alzheimer's type 3 diabetes, insulin resistance in the brain. And the big fallacy is that people are losing their memory. But they're not losing their memory. They're losing access to their memory. So when you look at, especially in female hormone therapy,

• 31:51Speaker 00

  the consequences of insulin resistance and hormonal cycling, which causes not estrogen dominance because you are overproducing estrogen, but estrogen dominance because you are under eliminating estrogen, the one that nobody tests for on female hormone therapy labs. Which is why I recommend, if you're a woman and you're gonna do a hormone test, that you do something called a Dutch test. So if you have uterine fibroids, I would highly recommend that you get a Dutch test done. Because a Dutch test will actually look at the entire complement of hormones, and it will look at all of the precursors. If you're deficient in pregnenolone, you have all these downstream consequences with cortisol, with aldosterone. You have your sleep-wake cycle is off. You sleep eight hours. You wake up exhausted.

• 32:36Speaker 00

  You have spells in the middle of the afternoon that they call crushing fatigue. And it doesn't show up on a blood test, because a blood test is gonna look at the level of your hormones, but not also how you are eliminating those hormones. I would absolutely do a Dutch test, the 24-hour urine test if I was in that shape. Yes, sir, right on. Yeah, yeah, yeah. You looking for somebody else? Yep, you're still looking for somebody else, right up here. He's like, "Me? Are you kidding me? You actually called on me?" I did.

• 33:09Speaker 02

  You've spoken a lot in the past about LDL cholesterol, which has been really fascinating. I have very, very high LDL, but I've also have very high lipoprotein A.

• 33:22Speaker 00

  Ah, okay.

• 33:23Speaker 02

  And that's become quite... There's a lot of talk about that now, and there's, I think, new medication coming out for it. But constantly told it's genetic, can't be changed. You're born with it. Your mother had it. Your mother's... all that.

• 33:37Speaker 00

  Believe it or not, the lipoprotein A is a genetically inherited component.

• 33:40Speaker 02

  Yeah.

• 33:41Speaker 00

  Yeah.

• 33:44Speaker 00

  Yeah, you're screwed. Next question.

• 33:49Speaker 00

  Yeah, that is terrible for you. No, I'll answer your question. So, yes, lipoprotein A, lipoprotein B, those are concerning cholesterol markers. What I have consistently preached about, and what the big data says, and so do meta-analyses, and we knew this 18 years ago, because this is what the big data said, regardless of what randomized, peer-reviewed, published clinical trials showed, was that there was zero, and I will say this again clearly, zero correlation between elevated LDL cholesterol on its own and cardiovascular disease. We found that you had to have a corresponding increase in triglyceride. In fact, if you didn't, if you had low triglyceride,

• 34:34Speaker 00

  75 mg/dL or less, and you had high LDL cholesterol, we would extend your life expectancy. Why? Because cholesterol, which is not a fuel source, it's a construction material. We make every cell wall, every cell membrane, every hormone in the human body. A large percentage of your brain is cholesterol. Cholesterol is how we make vitamin D3, sunlight and cholesterol, the only vitamin that a human being can make on our own. Cholesterol is a necessary construction material. It does not just randomly and inadvertently jump out of the bloodstream and stick to the arterial wall. There needs to be damage to the endothelium in order for cholesterol to be called to that site. It is not the amount of cholesterol, LDL cholesterol, that matters. It is the size of the cholesterol molecule.

• 35:17Speaker 00

  So if you remember from high school geometry, as the size of a sphere gets smaller, its surface area to volume ratio goes up. What does that mean? That means that if cholesterol was a tennis ball, the fuzzy yellow surface would be a triglyceride. It is transporting those around the blood. So if I actually had two basketballs sitting on a table, okay, and those represented two basketballs of cholesterol, and they were covered in fat, both of them, and I raised the amount of triglyceride, well, I keep cholesterol consistent. Those two basketballs become four softballs. I raise triglyceride more, they become eight baseballs. I keep raising triglyceride, they become 16 golf balls.

• 36:02Speaker 00

  I continue to raise triglyceride, they become 32 little BBs. Exact same amount of cholesterol in two basketballs or 32 BBs. Those 32 BBs are very dangerous, very high markers for cardiovascular disease. The two basketballs? Markers for longevity, not for cardiovascular disease. In fact, one of the interesting things that artificial intelligence is about to do, that I believe is going to upend modern medicine in the next five years in a way that is going to be catastrophic for some pharmaceutical companies, is you're gonna see the big data surpass peer-reviewed clinical studies. Because now that we have early detection, big data, and artificial intelligence, we can take 700 trillion independent variables

• 36:47Speaker 00

  and create an actionable result. We are significantly better at doing artificial intelligence-guided clinical studies because of these 700 trillion independent variables that it can monitor than we are doing myopic, narrow clinical studies. In fact, there's... To be patently honest, there is zero evidence, for example, that parachutes work. None. No one can make the claim that parachutes are effective, that they are safe, or that they should be used when you're jumping out of an airplane. There has never been a randomized placebo-controlled clinical trial. Right? Who wants to be in the placebo group? Johnny, you're over here. Yeah.

• 37:32Speaker 00

  Give me your phone. You're not gonna need that anymore. And, you know, Sarah, you're over here. You're gonna jump out with this fancy backpack on, and you're gonna jump out with a hope. And, oh, look at that. So we have no proof that they work. Why would nobody jump out of an airplane without one? Because we have data. And we have ignored data for half a century. When the data was screaming in the opposite direction, when we started hammering LDL cholesterol, and you saw skyrocketing rates of neurodevelopmental disorders, early-onset Alzheimer's, early-onset dementia, and cognitive decline in people who were holding cholesterol artificially low. You know, so what makes it dangerous? Oxidation. What causes oxidation? Lots of things cause oxidation and free radical damage,

• 38:17Speaker 00

  but the main one is insulin resistance. I think the Bible should say blood sugar is the root of all evil, not the love of money. People are not dying because they love money. They are dying from blood sugar. That's a joke, all you Christians out there. I'm a Christian too. Believe in Jesus. Calm down. But, so lipoprotein A, which there is no pharmacological solution for today, there will be by the end of this year. There's some very promising drugs coming out towards the end of the year, which I am actually a fan of for lipoprotein A. But what I have found works very good to lower lipoprotein A are three things. The peptide phimosin alpha and a combination of bergamot O, which is a citrus peel extract,

• 39:01Speaker 00

  and slow-release niacin. Make sure that you take the slow-release form of niacin. And it is one of the most effective ways, 15% to 30% reduction in lipoprotein A, which there's no pharmacological solution for. So if I had elevated lipoprotein A, which I do, I would be taking slow-release niacin, bergamot O, and consider the peptide phimosin alpha. I hope that answered your question? Yes, ma'am. Yeah, no, right behind you, and then I'll get to you. Yeah.

• 39:32Speaker 00

  By the way, are you guys getting something out of this? Is this good or awesome? I love you guys. I love London. I really do. I love your sense of humor. You guys had the wackiest sense of humor. Like, you can't just give somebody a compliment and let it go. You're like, "Hey, you know, you look pretty good for a fat guy." It's like, do you always have to do that? Like, you guys have the sickest sense of humor. I love you guys.

• 39:57Speaker 03

  Hi, Gary. Thank you so much for that. I would like an advice from you to the person who has high cortisol but a leaves-not-stressful life.

• 40:09Speaker 00

  The person that has high cortisol and not a stressful life. So, here's a theory in hormones that I want you to understand. We make hormones, cortisol's one of them, and these levels can be elevated because we are overproducing them, right? Estrogen dominance is very common in women that have high estrogen levels. Estrogen dominance is also common in women that have normal estrogen levels. Why? Because of the ratio of that hormone to another hormone. So, in the human body, we are always, the body's, it's called homeostasis. The body is always trying to stay in this state of homeostasis. So, it's trying to maintain certain ratios.

• 40:54Speaker 00

  So, for example, and I'm going to answer your question, if a man has estrogen at 70, which is very high, but his testosterone is 900, no problem. If he has estrogen at 70 and his testosterone is 200, huge problem. Huge problem. In hormones and in cortisol, the level is less important than the ratio. So, the question is, what ratio is off driving cortisol high? So, if any of you men that are on hormone therapy or testosterone therapy, you know that if you do an injection of testosterone and you do nothing else, your testosterone's going to skyrocket. What else is going to skyrocket? Estrogen.

• 41:39Speaker 00

  Your estrogen level is going to climb, which is very often why they pair hormone therapy, testosterone with aromatase inhibitors like anastrazol or eczotomestane or dianolomethane, DIM, to try to control that aromatization of testosterone. Again, I would go back to the gold standard test called the Dutch test. And in this test, you're going to see the entire cascade of hormones. And you are going, "Yes, you've done it? Thank you. You want to come up on stage and share it with us?" No. No, I just went through menopause with my wife. We were in menopause together. Trust me. Trust me. It's a, it was... I think it was harder on me than it was on her, but it's just my opinion.

• 42:21Speaker 00

  Because I would wake up in the morning, I would look at my wife, and I would go, "Babe, I am so sorry." She's like, "For what? For anything, whatever." She would literally turn around at the stove, and I would walk into the kitchen, and she'd go, "I think you should leave the room." I'd go, "Why?" She goes, "I am furious with you. You've done nothing wrong, but I'm just telling you, if you don't leave the room, I'm going to snap my radish." And I go, "Thank you for the warning." Right out, we go. So, when you do this test, one of the things you're going to see is the other complement of hormones, like pregnenolone. There are multiple estrogens, E1, E2, E3, and certain ones of those. Estrogen is a category, not an actual hormone. You have estradiol, estrogen.

• 43:06Speaker 00

  So, when you see that these get out of ratio, it causes other consequences. The thing I love about this Dutch test, and by the way, I sell them the Dutch test hard, I have no affiliation with the Dutch test. When you see these ratios, what I love about this test is it sets these dials. And so, you see that your cortisol is extremely elevated, and you can see, is it overproduction or under elimination? And then, you can target precisely that. But especially in women's hormone therapy, you want to be very cautious about treating your hormones off of a snapshot in time. A single blood test is a very dangerous way to prescribe hormones to women, especially

• 43:48Speaker 00

  if they are pre-peri or menopausal. So, I hope that helps. Yes, yes, ma'am. Yeah, now you. Who's got the microphone?

• 43:57Speaker 04

  Hi. So, I had a, I had done a Dutch test, and actually, it showed that I metabolized the hormones very slowly or low. So, all my hormones are low, and then my cortisol, it kind of like wakes up in the morning, but straight away, it goes down. And it showed that I can't metabolize it. Basically, it stays in my system. And so, a quick one, and I also have Hashimoto's. So, I know you mentioned it at the start, and it's big for women.

• 44:28Speaker 00

  Love this talk about Hashimoto's.

• 44:29Speaker 04

  So, yeah, I think sugar is evil, because I think I got it from the sugar, and it led to me having endometriosis as well.

• 44:37Speaker 00

  So, interestingly, if you look on the Dutch test, this is one of the most overlooked things on the entire Dutch test. Remember that methylation chart that I put up here? There is a gene mutation on the Dutch test called COMT. It stands for catecholomethyltransferase. So, I already know that you suffer, can I speak openly to you? Because I don't want to throw your dirt on the street. I already know that you have suffered with mild anxiety on and off your entire lifetime. And I know that it's hard for you to point to the specific trigger that causes it. Tell me if I'm wrong.

• 45:11Speaker 04

  Yes. Not so early on, but later on in life, yeah, massive anxiety. Just came recently, like two years ago.

• 45:19Speaker 00

  Yeah. And because of that mutation, you're also a ruminator, and you have a tendency to carry things to the worst-case scenario, especially if you think about them at night. So, if you are considering a scenario, it will always end horribly if you're laying in bed and considering that scenario at night. It's high levels of fight-or-flight neurotransmitters. That same mutation is what eliminates estrogen. It sends it down what's called the E2 pathway. So, now, we're talking about not a hormone issue. We're actually back in this methylation chart. And we're back in this chart in the gene mutation COMT, C-O-M-T, catecholomethyltransferase. In your case, the anxiety, the ruminating thoughts, the poor sleep patterns, and if

• 46:04Speaker 00

  I looked at your sleep, your sleep duration would be normal, but your deep and REM sleep would be compromised, especially deep sleep would be very narrow. See? Again, tell me if I'm wrong, because you're shaking your head. You can say...

• 46:15Speaker 04

  Yes, I think recently, the sleep has been an issue.

• 46:18Speaker 00

  Yeah. So, here is exactly the point that I'm making. I'm going to overgeneralize this. A mood issues, anxiety, you know, mental issue. You also have sleep and circadian dysrhythmia. If you, I'm going to actually give you that methylated multivitamin. So, just go to the booth after this. I want you, I'm not kidding, I want you to take two of those in the morning and one at night, trimethoglycine, and that sleep formula. And 30 days, you let me know how you feel. If it hasn't changed, well, you didn't pay for it, so I can't give you your money back.

• 46:55Speaker 04

  Thanks.

• 46:56Speaker 00

  30 days, if it doesn't change your life, the heck with you. Yeah, I know. So, I'm going to give that to you. It's going to be life-changing for you. Yes, right there in the back, in the middle, yes. Pointing to yourself, yeah, with the sunglasses on. I love how you guys are like so like, like me? Yeah?

• 47:18Speaker 05

  Hi, App.

• 47:19Speaker 00

  Hi.

• 47:20Speaker 05

  You've mentioned neurodevelopmental disorders quite a few times. I was wondering what you would recommend or have to say about to someone like myself who has high functioning autism or Asperger's syndrome?

• 47:35Speaker 00

  Has what?

• 47:36Speaker 05

  Asperger's syndrome.

• 47:37Speaker 00

  Oh, Asperger's, yeah.

• 47:39Speaker 05

  Because the only thing I've ever been helped with in any capacity for it was being put on psychiatric medication as a teenager that took five years to come off.

• 47:49Speaker 00

  Yeah. So, I'm really glad you asked about Asperger's syndrome. So, Asperger's syndrome is a flattening of mood. So, what happens in Asperger's is the peaks and the valleys of mood disappear. So, generally, Asperger's patients will have passion, elation, joy, arousal, libido. Those leave the room. But so do the lower-tier emotions, like vengeance, despair, jealousy, anger, like the really intense, low-tier emotions. And you're left with this mid-tier, which we call mood numbness. This is not depression, it is mood numbness. It is an inability to transcend the normal categories of mood.

• 48:33Speaker 00

  Eventually, it leads to something called flat affect, okay? But for decades, it stays, and you stay in this mood numb state. The reason why we don't aggressively treat this is because you can live with it. It's not the thing that drives you to the emergency room or takes you to the urgent care. And so, you become mood numb. So, the question is, how do we make mood in the human body? Right? What is the main driver of mood? Serotonin? What's the main driver of behavior? Dopamine? And where do we make those neurotransmitters? We make them right here in the gut. And 90%, for example, of the serotonin in your body is right here. So, if you don't have it here, you can't have it here. This is why depression can begin in your external environment, but it always continues in your internal environment.

• 49:15Speaker 00

  In fact, the serotonin hypothesis of depression used to define depression as an inadequate level of serotonin, yet we never had a single drug to raise serotonin. So the question is, how do you get the raw material to break out of that center section of mood? This has to do with going into the gut. And it has to do with fixing the gut so that we can turn the serotonin factory back on. In fact, if I go into this, here it is, right here. We take an amino acid called tryptophan, and we methylate it into the neurotransmitter serotonin. And then that neurotransmitter goes up the vagus nerve and it populates the brain and you have mood and mental issues or normopathic mood.

• 49:58Speaker 00

  Same thing happens with tyrosine and phenylalanine. This is how we make dopamine. So deficiencies in amino acids or breaks in the methylation cycle cause low serotonin, low dopamine, which creates aberrant relationships between the other neurotransmitters and flattens your mood for an entire lifetime. These are not speech or neuromotor issues. These are not neuropathological disorders. The imaging in the brain is perfectly normal. If you've ever had your brain imaged, it is normal. It is the mood, mental, and behavioral characteristics. Mood, emotion, mental, and behavioral characteristics start with neurotransmitter production in the gut.

• 50:43Speaker 00

  And we never, ever go to the factory that makes the resources that create the mood that we diagnose as this illness. So I think that genetic methylation test could change your life. If you haven't done it, I will give it to you. So come by the booth, I'm gonna give you that test, because I think it could be really life-changing for you. Yes, sir. You're right there in the white shirt. Oh, you're clapping, right? Woo! I love it. I'm just, my team's like, he's just giving shit away up there. Get him off the stage.

• 51:17Speaker 06

  Hi, Gary. Can you hear me? Oh, yeah, sir.

• 51:20Speaker 00

  I can hear you just fine.

• 51:21Speaker 06

  Fantastic. Always a pleasure to hear you speak. Thank you so much. My question is, anaphylaxis seems to be affecting an increasing number of people. Specifically, in my case, it's my seven-year-old son, since he was a few months old. Severe allergies to dairy, eggs, nuts, fish, lentils, chickpeas. And it just seems really crazy to me that something, the human body's so resilient, but like a drop of milk can basically kill someone. He has to have the epipen if he's accidentally ingested as much as a drop. And he also has asthma as well, so I don't know if that's linked. Secondly, yeah, like, just kind of in the anaphylaxis topic as well. Random family members who've had no history of anything, apparently from like a pear or fruit, have had to have been given epipen. So I don't know if that's linked, but yeah, just around anaphylaxis, please.

• 52:05Speaker 00

  Yeah, so anaphylaxis caused by rapid, severe cytokine storms and histamine elevation. If you have a pen, you might want to write this down. I would look up and investigate something called MCAS, Mast Cell Activation Syndrome. Anaphylaxis is hyperactivity in the mast cell. So mast cells are cells are all over your body. They're in your skin, they're in your blood vessels, they're throughout your arterial system. A mast cell is what secretes inflammatory cytokines and histamines.

• 52:44Speaker 00

  When these cells become hypersensitive and over-secrete inflammatory compounds, this is called mast cell activation syndrome. So now that we know it is a mast cell that is the villain, the question is, what is irritating the villain? And I will tell you, does someone have like a top to a water bottle? I'll use this example here, I'll just use this. This is the most overlooked thing, in my opinion, in all of modern medicine. If this was a heavy metal, mercury, lead, arsenic, palladium, or it was a mycotoxin,

• 53:21Speaker 00

  fungi, or mold, or virus, or parasite, this does not hide outside of a cell like this. Let's say that this is a healthy cell. It hides like this. So the immune system and mast cells are hyper vigilant, meaning they want to get to this perpetrator. In autoimmune, very often what happens is, the immune system arrives at the wall of this cell to get to the perpetrator, and it doesn't have permission to come inside. So what is, how does the body gain permission to go inside the cell? It manufactures an antibody, not to kill you or your friendly tissue to get to the villain.

• 54:02Speaker 00

  And we never think about subtracting from the body, subtractive medicine. The first thing we do when a fish gets sick is we clean the tank. Why? Because you can look at the tank and you see it's all cloudy and mercury, and you know that's why that fish is sick. When human beings get sick, we never assume that it could be a pathological invader that is causing the activation. So what I would implore you to do is, heavy metal, mold, mycotoxin, and viral testing. Those four. I will say from this stage, there's an 85% chance that this is the root of the issue. This is not an anaphylactic issue. This is an issue with your son walking around, instead of his inflammatory cascade at a

• 54:46Speaker 00

  one or a two, he's walking around at a six or an eight. So a very small insert pushes him over the edge. Right? Just like, if I had two people on this stage, and I said, okay, I'm gonna push in on your back, and you tell me how much pain you feel. And I push in on the first person's back with a pressure of two, and they're like, barely felt it. And I push in on the second person's back, and their pain level is 10, because they had a pinched nerve, and started at an eight. Same pressure, massively different results. So same insult, and your son, meaning whatever it is, dairy, wheat, gluten, soy, the same insult, but a massively different result. It is where the mast cell, it is how inflamed and hyperactive the mast cell is.

• 55:29Speaker 00

  This is why very often that food sensitivity and food allergy testing is very inaccurate, because it doesn't delete your existing state of inflammation. Right? So when we do most food allergies and food sensitivity tests, we take a membrane, and we wash your blood down one side of the membrane, and on the other side of the membrane, we wash down all of these allergens, wheat, gluten, soy, dairy, blueberries, whatever. And what we're doing is, we're measuring the amount of inflammation across this membrane. Right? So if it's a zero to a four, it's mild. If it's a four to a seven, it's moderate. If it's a seven to 10, it's severe. But what if you were starting at a six?

• 56:14Speaker 00

  Something shows up at a two, it shows up on the test as an eight. So you go get this allergy test done, and you are allergic to everything under the sun. And then you eliminate all of it, and nothing works. I mean, how many of you have had an experience like that? Right? You start going down this food allergy, food sensitivity test, and you're like, you go on a, you know, you go on a diet, or a food maps diet, and nothing seems to work. It's because the baseline sense of inflammation is high. And it is usually one of these five perpetrators. Mold, mycotoxin, parasite, virus, heavy metal, with heavy metal being the most likely. So I hope that helps. Yeah. Yes, ma'am, and the red glasses. Dude, I love it.

• 56:56Speaker 00

  You guys are like, I can do this all day. How much time do I have left? Oh, I'm two minutes over my time, so I'm at least gonna do one more question. All right. Whoever just screamed in agony, you're next. She's gonna ask her question, and then the very loud British woman in the back. Because now I'm actually scared of you. So I'm gonna answer your question.

• 57:19Speaker 07

  I'll try to be quick. First of all, thank you so much for everything you do. I'm part of your VIP, and I benefit so much.

• 57:26Speaker 00

  Oh, thank you.

• 57:27Speaker 07

  So thank you. I wanted to ask you about VITI Laigo. I've been having it for nine years, and it's been growing. But the last three months, I've been on a protocol that I made up myself, which combines several peptides, and topical vitamin D, of course, a lot of supplements, including vitamin D, high doses, and red light therapy.

• 57:54Speaker 00

  Yes.

• 57:55Speaker 07

  It has improved so much.

• 57:56Speaker 00

  Yes.

• 57:57Speaker 07

  But I want to know, from your point of view, which one of all of these that I've done has been the cause of this improvement?

• 58:04Speaker 00

  The greatest one for that improvement is red light therapy. And the reason for that is photobiomodulation, red light therapy. One of the hallmarks of red light therapy benefits is that when red light passes through the skin, and then passes through the cell wall, it actually goes into the mitochondria, certain wavelengths of light, 640, 820 to 840, and 940. They go into, they pass through the cell membrane of the mitochondria, and it kicks out a gas called mitochondrial nitric oxide. When you kick this gas out, from cytochrome c oxidase, oxygen docks. When oxygen enters this cycle, called the Krebs cycle, in the mitochondria, you have

• 58:48Speaker 00

  a 16-fold step-up in cellular energy. So that's why they call like red light like a battery charger. Because, you know, as we create ATP in the human body, and this cycle is turning around inside your cells, called the Krebs cycle, every time it makes one revolution, it has two choices. It can make two ATP, or it can make 36 ATP. Those are its two choices, 16 times more energy or 16 times less energy. What determines whether it's more or less powerful? The presence of oxygen. What, where we go lost on modern medicine is we disobey the laws of physiology. So, everything that enters the body doesn't make it to the mitochondria. Red light doesn't ask permission. It goes right through the cell wall, right through the mitochondrial wall, kicks this gas

• 59:32Speaker 00

  out, forces oxygen to dock, and kickstarts the, and kickstarts the mitochondria, which means it now has 16 times more energy. And what does that mean? Now, for the first time, maybe in your adult lifetime, the immune system can function in the dermal layer of the skin. And this is where you're getting the benefit from.

• 59:53Speaker 08

  Thank you.

• 59:54Speaker 00

  No question. Yeah. And the women, the woman that screamed.

• 59:59Speaker 08

  I'm not scary, honestly.

• 1:00:01Speaker 00

  I'm just scared of you.

• 1:00:02Speaker 08

  And you would turn to that side, you didn't come to this side at all. And I was like, yeah. But thank you so much. First heard you on the Skinny Confidential many years ago. I also have a human biology background and work in research in the life sciences. Have figured out a lot of stuff for myself, reversed a lot of stuff for myself, but something that is not moving is my T3 conversion from T4 with Hashimoto's. My antibodies are lowering, but my T3 is just consistently low. My reverse T3 has been tested multiple times and it's normal. And I can't figure out why my T3 is low. It definitely impacts body temperature and fat loss.

• 1:00:43Speaker 00

  Yeah.

• 1:00:44Speaker 08

  So, I don't know how to get it up.

• 1:00:47Speaker 00

  So, so just quick, you're probably already aware of this, but just to bring everybody up to speed, we're talking about low T3 from, from the thyroid. So, the thyroid is right here in your neck. It produces two hormones, right? It produces T4 and it produces T3. These are the two hormones that are secreted by the thyroid. Only the little known fact about the thyroid is that it only produces 20% of the T3 in your blood, 20%. So, when your T3 is low, we call this hypothyroid. But when your T3 is low, there's an 80% chance it's not the thyroid. Yet, in 100% of the cases, we put you on thyroid medication, levothyroxine, synthroid,

• 1:01:32Speaker 00

  armor thyroid. So, the question is, where does the other 80% come from? And now, I'm getting to your question. The other 80% of this thyroid hormone, T3, is converted from T4 into T3. The vast majority of this happens in the liver through a process called deionization. We take an iodine from the outer ring and, and, of the outer ring and, and, and remove that, and this deionization, deionization causes T4 to become T3. The majority of this happens in the liver. For you science nerds, some of it also happens in the periphery in the gut, but very little. So, now, we go into the liver and we say, what raw material is required for the, for

• 1:02:16Speaker 00

  the liver to deionize thyroid hormone T4 and turn it into thyroid hormone T3? And it is three, these three nutrients, and they are the most commonly overlooked nutrients, and they are genetically inherited. Their deficiencies are genetically inherited. One is selenium. The second is selenocysteine. And the third is selenomethionine. And I could take you right into this chart and show you exactly how those are methylated. So, if you are deficient in the complex of B vitamins, you're deficient in methylfolate, you're deficient in trimethylglycine, TMG, then your body cannot take selenium, which

• 1:02:57Speaker 00

  comes into the body, you can take a selenium supplement, convert it to selenomethionine, convert that to selenocysteine, which is the catalyst for that transaction. In the absence of those nutrients, the body, the liver cannot deionize T4 into T3. Your T3 stays low, you get autoimmune antibodies, and you have a lifetime of hypothyroid. I would bet my entire career that is one of those three nutrients. And again, that gene test could potentially change your life, at least change your thyroid.

• 1:03:31Speaker 08

  I supplement selenium, but I need to get the specific, make sure that it has all three forms?

• 1:03:36Speaker 00

  Yes, that's where we go wrong, right? Because selenium is where it starts. Selenium gets converted to selenomethionine. Selenomethionine becomes selenocysteine, and selenocysteine is what catalyzes that transaction. So, if you put this raw material in, remember I said, nothing enters the body and is used in the form that you put it in? Selenium enters the human body, it's not used as selenium. It's converted to selenomethionine and then to selenocysteine. It's the selenocysteine that deionizes T4 into T3. In the absence of that, you can't make that conversion, and you have hypothyroid. The second thing I would say, and this goes with anyone that has autoimmune thyroid, the 85% of the time, when you're diagnosed with autoimmune thyroid, Hashimoto's, you are

• 1:04:21Speaker 00

  told it's random, or even worse, that it runs in your family. We've already dispelled that myth. So, the immune system doesn't randomly attack the thyroid. The thyroid has an affinity for heavy metals. It is literally like a magnet for heavy metals. So, mercury, lead, palladium, cadmium, they get embedded in the thyroid, and the immune system goes after the metal, not the tissue, right? So, I would really encourage you to get heavy metal toxicity testing. Probably the best one is a, a urine test called a Vibrant Wellness, or you can get a provoked heavy metal test, which is where you do chelation and then collect urine for the next six hours. And you'll see, I would be absolutely shocked if you had autoimmune thyroid and didn't

• 1:05:06Speaker 00

  have heavy metals. Look, full stop.

• 1:05:09Speaker 08

  Thank you.

• 1:05:09Speaker 00

  You're welcome. Okay, can we do one more question? Awesome. Dude, I love it, I love this. I'm, I'm, okay. Yes, yes, ma'am, in the orange. Warsaw.

• 1:05:25Speaker 00

  How you doing?

• 1:05:28Speaker 09

  Hello, Gary. Thank you very much for, for the opportunity to ask this question is regarding IBS. I wanted to ask if you think that IBS is correlated with nutrition deficiency? Or do you think it's a nervous system kind of influence? And also, how do you approach in general to improve this?

• 1:05:51Speaker 00

  Yeah. So, IBS, Irritable Bowel Syndrome, which, please don't take this the wrong way. I, I think that is such a nonsensical diagnosis, right? IBS is a name for a category of symptoms. If you have gas, bloating, diarrhea, constipation, irritability and cramping, you have Irritable Bowel Syndrome. So, all I did, thank you very much, was just take all of those symptoms and give it a name, right? So, now, you have a name to call all of your symptoms, so you just don't have to describe them one at a time. So, the question is, what is causing the, this condition? By, by the time most people make it to me, they have already done food allergy and food sensitivity testing. Most have done a GI map, so they have checked their gut microbiome.

• 1:06:33Speaker 00

  If you haven't, a good GI map stool test would be an excellent place to start. What they have overlooked, in my opinion, is the most overlooked thing in all of bariatric medicine. That is the pace of the gut, right? Because the speed of the conveyor belt is more important than the contents. Your gut is 30 feet long, it's a 30-foot-long conveyor belt. We drop contents on it at one end, as they leave the stomach, they exit the rectum 30 feet later. The pace, the timing of that is critically important. And the reason is because it takes a certain amount of time to pass contents from one pH environment to another. So, think of it like a factory as an assembly line. You run it too fast, diarrhea. Run it too slow, constipation.

• 1:07:14Speaker 00

  If it pauses, bloating, cramping, diverticuitis, ulcerative colitis, right? And if they pause for too long and erode the single cell layer of the luminal wall of the intestine, now, you have something called leaky gut. That calls the immune system. And the immune system spends too much time there, it manufactures an antibody to the colon, now you have Crohn's disease. So, but at the root, the first domino to fall was poor pacing in the gut, was the absolute poor pace of the gut. If you have Irritable Bowel Syndrome, the one thing I know you also have is dysregularity in bowel movements, right? They're never consistent. Off for two days, three times in one day.

• 1:07:55Speaker 00

  Then every 24 hours, then skips two days, then normal, then skips three days, right? There is an exact indication that it is the pace of the gut. And I mean, I hate to keep bringing it back to that gene test, but that gene test could materially change your life. Because if you have the gene mutation, MTHFR, MTR, MTRR, you are going to find that your intestinal motility is off. You can supplement to fix the motility. You fix the motility, then you fix the, the problem. Okay, guys, awesome. I'll be around. Thank you so much. Thank you so much.

• 1:08:36Speaker 00

  Amazing, amazing, nice. I love you guys.