Pod Insights The Ultimate Human with Gary Brecka 276. Dr. John Kim: On Mold Toxicity, Mycotoxins, Heavy Metals, & Cellular Detox About this episode You might think that once you tear out the moldy drywall and move into a clean house, your body finally gets to heal, but in this episode, Dr. John Kim and I get into why so many people do everything right and still can't shake the brain fog, the fatigue, and the gut chaos. The answer lives somewhere most testing never looks: a stuck "cell danger response," where your cells stay locked in defense mode like a fire alarm that won't stop blaring long after the fire is out. I'll walk you through how Dr. Kim uses his ENCORE method to finally shut that alarm off, because you can't out-biohack a body that's still convinced it's under attack.
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Timestamps
00:00 Intro of Show
04:30 Dr. John Kim's Back Story: Heart Attack
10:42 What to Do When You Discover Mold in Your System?
19:13 Testing for Mold Toxicity
31:26 Cell Danger Response: Definition, Testing, and Resolution
35:59 The ENCORE Method
38:26 E - Environmental Factors Affecting Health
47:45 N - Nervous System Regulation
52:18 C - Cellular Integrity
56:07 Stress Response Increasing Deuterium Production
1:00:24 O - Optimizing Detox
1:05:47 RE - Rebalancing the Microbiome & Enhancing Resilience
1:10:12 What does it mean to you to be an Ultimate Human?
Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.
Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature.
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Transcript 12,958 words · 2 speakers
Speaker names marked ? are inferred from speaking time and the show’s known hosts — they are not voice-verified.
0:00 Speaker 00 Mold is not just about the immune dysfunction or having allergies. It actually causes mitochondrial dysfunction, deep into the cellular level, down to the DNA.
0:08 Gary Brecka? Cells are like human beings. They behave in communities. This is the way that cellular activity influences other cells and how metabolically healthy cells can become metabolically sick because they're in an environment with other metabolically sick cells.
0:19 Speaker 00 So it's vital for the cell membrane to function well. Unfortunately, dealing with mycotoxins and mold in general, it actually damages our cell membrane integrity.
0:27 Gary Brecka? Unfortunately, these are not the types of infections and chronic conditions that drive you to the ER. They're ones that people learn to deal with.
0:35 Speaker 00 This is the reason why when I work with clients, I want to empower you to be the best doctor for your own. And this is one thing that I'd like to teach is enhancing cellular resilience.
0:42 Gary Brecka? I think there's such a positive expertise out there on what to do once you find these infections. How do we actually eliminate mold from the body?
0:50 Speaker 00 One of the things that worked out really well for patients, and you don't need to spend a lot of money on it, and there is a company that supports this.
1:11 Gary Brecka? Hey, guys. Welcome back to the Ultimate Human Podcast. I'm your host, human biologist Gary Brecka, where we go down the road of everything, anti-aging, biohacking, longevity, and everything in between. And I should add mold, mycotoxin, parasite virus, heavy metal, and everything that's affecting your body. You know, today's podcast, this is a guest I've wanted to have on for a long time because I have been deep down the rabbit hole with many of you for the better part of a year now, talking about how these chronic low-grade infections are leading to systemic disease and pathology right before our eyes, not showing up on your labs, and causing all kinds of conditions that we are chalking up to a consequence
1:54 Gary Brecka? of aging, or repeated infection, or we're chalking these up to a consequence of our environment, or stress, or a job, or a career, or kids. And it's none of those things. Very often, it is preventable toxicity. And today, we're going to talk about some of the big offenders and how we can get them out of our body. Welcome to the podcast, Dr. John Kim.
2:14 Speaker 00 Gary, thank you so much.
2:15 Gary Brecka? It is such a pleasure to have you. You know, before you, before the cameras started rolling today, I talked about a lecture that I gave in Salt Lake City, going back about two years. And The first, the morning lecture, which was about genetic methylation, I actually got a standing ovation from this crowd of physicians. And then that afternoon, I did a 45-minute talk on toxicity. And we talked about mold, mycotoxins, heavy metal toxicity and some of the consequences. And I was quite ridiculed, and I don't want to say laughed off the stage, but I could tell they were just being tolerant until my talk ended.
2:59 Gary Brecka? And I actually had some ENTs come to me after the lecture and tell me that they didn't believe in mold or mycotoxins, that these were, everybody, they commented, "Everybody's got mold. It's in and out of our bodies. They're basically tired of the mold cult." And I think over the last two years, through the detox challenges I've had, the experts like yourself that I've had on the podcast, people are accepting that these are real toxic loads with very real consequences. And I've been a part of, I've been really blessed to be a part of the journey of several people who have had young children with repeated sore throats,
3:44 Gary Brecka? where they were just about to remove their adenoids, and they found a functional medicine doctor and said, "Put the brakes on. This child has heavy metal mold and mycotoxins. Let's do a detox and see where we stand." And now they're three, four, five years symptom-free. So if I could, for my audience, I'd like to back up to your story because a lot of the more influential and impactful people, really passionate people that come on this podcast, are passionate and purpose-driven because they solved a problem in their life, a big problem. And at 33 years old, you had a major heart attack.
4:24 Speaker 00 I did.
4:25 Gary Brecka? And I hope it's okay if I say that because I already said it.
4:29 Speaker 00 It's okay. It's okay. I call it the pain to glory story.
4:32 Gary Brecka? Yeah.
4:33 Speaker 00 Everybody has their.
4:34 Gary Brecka? I want to talk about that. I want to talk about that journey because it gives my listeners the why. You know, why are you here? Why are you so passionate? And at that time, I'm sure there were not a lot of resources available for you. You had to become your own citizen scientist. Thankfully, you're a farm D, so you have an intricate knowledge of cellular biology, pharmacokinetics. So at least you had a vantage point to start from and maybe intelligently evaluate what was out there in the world. But I'd love for you to share that story.
5:05 Speaker 00 Yeah, absolutely. So I was 33 years old. I just got back from my friend's wedding down in LA, and this was exactly June 1st. And then three days later, on June 4th, that's when I started having this heartburn. I always had a heartburn issue, and I always had some kind of gut problem to begin with. I completely ignored it. And that particular day, it's a sum is that pain was resonating even higher. And the evening, that pain shut down right to my left arm, completely ignored it, went to sleep, woke up the following day like an idiot. And then having to go back to work and then mid afternoon, that's when I decided to go to the urgent care center instead of ER. And then the urgent care center doctor is like, you're having a heart attack right now. We have to get to the ER right away.
5:48 Speaker 00 Got into the ambulance, got to the ER, and even the ER physician, even the attending cardiologist, didn't believe that this 33 year old guy, who actually got the cholesterol lab report from my doctor six months prior, they were looking at this, there's no sign of possibility actually having a heart attack, but this guy's having chest pain. So they were trying to rule out as being a pericarditis. And then when they did an echocardiogram, they found that my ventricle wasn't pumping well. So it's actually a sign of ischemia. They brought me to the cath lab, 85% blockage in my LAD.
6:22 Gary Brecka? Being your widow maker. Oh, my gosh. Most people are not that lucky.
6:26 Speaker 00 Especially for young people, right? Especially when you're in your 50s and a 60, you have a compensatory mechanism in terms of your. New formed blood vessels, basically, right? To take care of that blockage. But generally for younger patients, they actually die quickly.
6:40 Gary Brecka? You know, I had a cardiologist, I watched the cardiologist give a lecture and he said, what is the first sign of advanced cardiac disease in, I think it was 35 years old, younger?
6:50 Speaker 00 Yeah.
6:50 Gary Brecka? And people gave all these answers and he said, the first sign of advanced cardiac disease is sudden death.
6:54 Speaker 00 Yeah.
6:55 Gary Brecka? That's the first symptom.
6:56 Speaker 00 Absolutely.
6:56 Gary Brecka? So God's got a plan for you, my friend.
7:00 Speaker 00 That was, that was something that, well, I didn't know that, but then I end up having to be in the cardiac ICU unit staring at a wall for three days, wondering how did this happen? And then especially questioned as to what led to this process, right? Having to have a early cardiac disease at age of 33. And then I had this overweight physician coming in and telling me to cut out old meat, cholesterol and everything else. They put me on a tobitostat, 80 milligrams. And I was like, this is nonsense. There's something wrong here. So I got home and I just sat there for seven days, just wondering like, what could I have done differently? So I went to my functional medicine doctor, who I'm good friends with. She actually asked me, I think you're dealing with tick-borne illness. All I wanted to do was a vitamin C drip.
7:45 Gary Brecka? Tick-borne illness, wow.
7:46 Speaker 00 So she did a blood work and then after a month and a half later, that's when we've tested positive for espadillus antibodies, IgM, IgG, Bartonella infection, Mycoplasma pneumoniae, Epstein-Barr, mercury poisoning, on top of parasitic issues. So why does it occur? Well, there's endothelial damage that occur from a Bartonella infection, which is a cascade for you, which is common, you could get, you get from a tick-borne illness, including a spider bite. So I actually was in Boy Scouts all my life and I probably ended up with contracted that way, right? And then I lived in a very moldy house to begin with, growing up, right? And then also lived in a very stressful environment, growing up as well, you know,
8:28 Speaker 00 living in an immigrant family, parents are constantly working, busy, et cetera. So that led to a lot of the neuroinflammation that I was dealing with. And as you know, all the cascade in terms of inflammatory response goes from the gut. So I always had a gut problem. And that was something that I should have caught, but I was so busy. And, and the unfortunate thing is that a lot of Americans, including entrepreneurs and executives and people that you work with, I'm quite sure have the same issue where
8:57 Gary Brecka? We don't listen to our bodies, you know, it sends us signals.
9:00 Speaker 00 It does.
9:00 Gary Brecka? Yeah.
9:01 Speaker 00 And I wasn't listening.
9:02 Gary Brecka? Yeah.
9:02 Speaker 00 You know, so that, that's when I already had an existing problem to begin with. I had anxiety left and right. I could not sleep that well when I was in my twenties and thirties. And then when I actually had that heart attack, that's when I stopped to listen and figuring out, all right, what's going on? And I got the answer. And it took me about two years to clear it out, but it was a very tough process. And that was the moment that I found out how cellular integrity is so vitally important for your health. And this is when I started diving into lipid membrane medicine, right? And utilizing phospholipid therapy and
9:37 Gary Brecka? Phosphatidylcholine?
9:38 Speaker 00 IVPC.
9:40 Gary Brecka? IVPC, I've done that too.
9:41 Speaker 00 Yep. But specifically at that time, I got connected with Dr. Ed Kane, who's a founder for BodyBio. And he actually read my red blood cell fatty acid analysis. And that particular test is very special, run by Kennedy Krieger, looking, looking at the entire structure of the cell membrane, looking at the lipoproteins and the renegade fats, looking at the fluid index of the actual cell membrane. And he designed a customized lipid therapy that I had to go through. And my goodness, for four months, I was severely sick because all that toxins dealing with was just getting dumped out and my body, especially my nervous system was not ready for it. And I learned a lot from that point on. And that, and that's how I approached the clinical approach
10:23 Speaker 00 in dealing with mold toxicity and CAS and all this different hyper bio-toxin issues that people dealing with. My approach is very different compared to what I had to go through, you know, back in 2015. So this is how everything came into play. So I was able to clear out Bartonella mold toxicity issues, heavy metals and such.
10:42 Gary Brecka? Can we go into some of the details of that? Because I think there's such a positive expertise out there on what to do once you find these infections. How do we actually eliminate mold from the body or in some of these micro How do we cleanse the body of heavy metals? I'd love to start with mold because I really do feel like the medical community is finally starting to grasp these are real infections. They have real consequences. Like we were talking about before the podcast started. Unfortunately, these are not the types of infections and chronic conditions that drive you to the ER like your heart attack or take you to the urgent care. They're ones that people learn to deal with. Right. They just tolerate them.
11:24 Gary Brecka? You tolerated the gut issues probably for years before it manifested in something that drove you to the ER. And, and getting a hold of these at that stage when, you know, for people that are tuned into their body, you know, why do I have constant diarrhea and constipation and cramping, then irritability, then bloating, then gas? And, and it seems to be intermittent and not related to what I'm eating, you know? Am I fatigued all the time? Why do I seem to have brain fog at such a young age? These are, these are sort of signs your body's throwing up there you need to pay attention to. What was the detox protocol? What did that, that look like for you? You did, you said you did the PC.
12:04 Speaker 00 So at that point in time, my doctor put me on BodyBell PC for, from the gut go because we had to deal with the intravascular inflammation that I was dealing with. So that was something that, that's really vital there. But also when you're looking at the disease states of a heart attack or any type of cardiovascular or even types of infection, that's a sign of a mitochondrial dysfunction to begin with. So that's when the lipid membrane medicine is so vitally important to adding in the proper fat to quench the actual inflammation that was going on. So you're working on the upstream issue instead of the downstream problem that the person's dealing with. Right. So that was really, really vital there. And at that point in time, my doctor noticed that I was dealing with biofilm issues as well. So adding a biofilm buster.
12:46 Speaker 00 And there are companies out there utilizing different things. I mean, you could end up using prolytic enzymes like netokinase or serapetidase, N S S sixteen, phospholipid like body bio PC I mentioned before.
12:59 Gary Brecka? Great company, great PC.
13:00 Speaker 00 Right. So it actually act as a biofilm buster as well because it dissolves, it's an emulsifier. It dissolves the biofilms, right? And one of the intricate part of biofilm is that when you have a history of taking antibiotic, for instance, right? And then over exposure to deal with mold, heavy metals, and immune dysfunction on top of this inflammation cascade, increased cholesterol cascade as well, all these are playing into the biofilm structure. And when you have a biofilm, it's very difficult to utilizing antifungal antimicrobials to collect the infection. This reason why people, even though they might be gone through heavy amounts of antifungal protocol, they cannot get to the root of the issue. So that's where oftentimes just using
13:45 Speaker 00 binders or antifungals alone, it's not going to fix the problem. You got to really get to the root of the problem, which is biofilm, mitochondrial dysfunction. But another thing that goes into play is the fact that these patients have trouble getting mycotoxins out to begin with because of their sympathetic nervous systems are overdriven.
14:04 Gary Brecka? Yeah.
14:04 Speaker 00 Things like detox, gut work, lymphatic drain, all these are deal with your parasympathetic nervous system state.
14:11 Gary Brecka? Yeah.
14:11 Speaker 00 And oftentimes when you deal with mycotoxins, they already had an existing nervous system dysfunction to begin with. But when you're dealing with mycotoxins, especially chokolatesins, which is a black mold coming from staccobatrist, it actually causes neural inflammation across the blood and barrier, especially gliotoxins, another one.
14:27 Gary Brecka? And neural inflammation, I wanted to find some of these terms like biofilm and neural inflammation and not assume that my audience knows what those, what those mean. Let's back up to biofilms. I mean, I, I have this image of like Saran Wrap kind of wrapped over your cells, sort of preventing things from getting in and out, and then the cell building up this level of toxicity, but also not being able to get the nutrients. But how would you describe biofilms? You know, what are they?
14:51 Speaker 00 The easiest way to explain is let's just you go to a lake and you have a flat surface of a rock on the, in the lake itself. And you see that there's a phylum, slimy phylum. That's biofilm.
15:02 Gary Brecka? Okay.
15:03 Speaker 00 It's part of our entire ecosystem for the microbial to protect itself from the environment.
15:08 Gary Brecka? I see.
15:09 Speaker 00 But when you're dealing with mold, it colonizes in your system, in your body, and actually has to have that particular defense to protect itself from the immune system. Right? And one of the interesting part about mold is they cause the immune suppression is one thing, but they also deal with the biofilm issues. And then when you have mold, there's always heavy metal getting involved.
15:31 Gary Brecka? Right.
15:32 Speaker 00 So I don't tackle the heavy metal issues. I tackle that mold first. Right? And then, and then when you're utilizing proper lipid membrane medicine, especially using phospholipids, using essential oils. And then butyrate has to be another play to effect because butyrate is a chemical chaperone to help decrease that DNA adduct issue coming from these biotoxins. To be able to get the permanent removal of these things onto the mitochondria in the DNA.
15:58 Gary Brecka? Listen, there's what I share on this podcast and then there's what I share with my inner circle. If you've been following me for a while, you know how I hold nothing back here. But my VIP community, that's where the real magic happens. Picture this, you're struggling with energy crashes, brain fog, or just feeling like you're not operating at your peak and you don't know where to get real answers. But here's what really sets this apart. You're not just getting my insights. When I have incredible guests on the podcast, VIP members get to submit questions for a private podcast segment. So that world renowned expert we just interviewed, you get exclusive access to their knowledge tailored to your specific situation. This section is under the private podcast section in the Ultimate Human Community. And speaking of exclusive, you're getting my personal protocols,
16:42 Gary Brecka? the exact tools I use for water fasting, gut optimization, and morning routines that have taken me decades to perfect. This isn't theory, this is what works in the real world. The community launches challenges throughout the year where you get direct access to me and my network of experts. It's like having a personal health advisory board for less than a hundred dollars a month. Your health is your wealth and this investment pays dividends for life. Join the VIP community at theultimatehuman.com/vip and step into your ultimate potential. Now let's get back to the Ultimate Human Podcast. So when you remove these films,
17:15 Speaker 00 Yeah.
17:16 Gary Brecka? That is essentially a secretion from these toxins to protect itself from the environment. When you remove these films, now that bug is exposed.
17:25 Speaker 00 Exposed.
17:26 Gary Brecka? Right. And once they're exposed, now you can kill them off and get rid of them.
17:29 Speaker 00 With antimicrobials, but you gotta be careful too. There has to be a step-by-step method there.
17:33 Gary Brecka? Yeah.
17:34 Speaker 00 So I know you had another guest here, he talked about Ichocanazol.
17:38 Gary Brecka? Yeah.
17:39 Speaker 00 Yeah, and deal with that.
17:40 Gary Brecka? Yeah.
17:40 Speaker 00 Yeah. But one of the thing about those type of pharmaceutical drugs is that it's great. It works really well. And for people who are having over colonization, they'll mold. Ichocanazol is a great option.
17:51 Gary Brecka? Okay.
17:52 Speaker 00 Unfortunately, it actually causes hepatotoxicity. At the same time, it actually inhibits cytochrome P453A4 enzyme, which is vital
18:01 Gary Brecka? In the cholesterol transport chain.
18:03 Speaker 00 Oh, no, cytochrome P450, which is a
18:04 Gary Brecka? Cytochrome P450.
18:05 Speaker 00 Yeah, which is a phase one metabolism, right? So major drugs out there, statin drugs, for instance, diltiazem, which is a blood pressure medication. Those drugs are metabolized by cytochrome P453A4 enzyme. So when you have a patient who is actually on those particular drug, which a lot of people do, right? And especially we talk about mold actually increases cholesterol production in the body.
18:30 Gary Brecka? Yeah.
18:31 Speaker 00 These commonly actually are on statin drugs. You cannot put Ichocanazol on those patients right away. So you either have to take off the statins and then add in the Ichocanazol for a short period of time. But because of the hepatotoxicity issues, you gotta do it for a short burst. You cannot be putting on a patient for six months straight. So this is the reason why, instead of actually going after those things, you gotta fix the vital point. What is that? Your gut function, right? There's a condition of mold in your gut. And we could talk about why later, but that's something that first you have to do. And then while you're doing that, you try to lower the actual mold burden in the body. And then once it gets lowered enough, that's when you start to work on these systemic issues with mycotoxins there.
19:14 Gary Brecka? So what would be, what are some of your go-to tests for somebody that's having the types of symptoms that we've been talking about on the podcast? Brain fog, chronic gut issues, weight gain, water retention, poor focus and concentration, hormone imbalance, because a lot of these are estrogen mimetics.
19:35 Gary Brecka? They're gonna go and get a standard panel and they're gonna get told they're fine.
19:39 Speaker 00 You could still a standard panel. There's a lot of story that could be told from a standard panel.
19:44 Gary Brecka? High cholesterol.
19:45 Speaker 00 Not even just that. The issue is that the conventional medicine right now does not know how to read functional blood work correctly. So there are blood panels in terms of the ranges and then there's the functional ranges and there's optimal ways into looking at the blood work correctly.
20:02 Gary Brecka? Right.
20:02 Speaker 00 So you could tell about the story that the person's going through, but another thing is that you have to look at the biggest question is, what are you trying to find? Right? So we talked about your mycotoxin, for instance. So standard lab that I look to look at is a real-time lab, urine mycotoxin testing.
20:20 Gary Brecka? Okay.
20:20 Speaker 00 So this is something that looking at the metabolite of the mycotoxins that's coming out of the urine. There are certain limitations. There's no perfect test out there, but that's a gold standard that I am to recommend.
20:31 Gary Brecka? Okay, I'm gonna put a link to that.
20:32 Speaker 00 Yeah, so that's number one thing. And I'm also looking at, looking at organic acid testing. Why? We want to look at the mitochondrial dysfunction. How's the Krebs cycle functioning? So looking at lactate, pyruvate, right? You're also looking at the glutathione production as well. We were based on the organic acid test and you could also looking at your transmitters. So these patients oftentimes very burnt out, low dopamine levels to begin with. So you gotta work on their, your transmitters. But it's not the point is giving more supplements. You gotta get them outside to get the sunlight, UVA, right into the eye. Actually helps to create that natural dopamine the body really needs. And oftentimes when you deal with mycotoxins, they have photophobia.
21:14 Speaker 00 They have very high levels of sun sensitivity issues. They get burned very quickly. So you gotta build up that sun callus, but it has to be the focal point and just getting the circadian rhythm really balanced there. So that is one of the things that we could talk about later. But organic acid test is really vital and important. The next test we're looking at is a comprehensive stool testing. I like to use a Bible Wellness Gut Zoomer 5.0. We're looking at the full spectrum in terms of their gut inflammation markers. You're looking at the colonization of the actual bacteria, looking at some of the pathogens, especially you're talking about like parasites.
21:52 Speaker 00 All the things like Citrobacter and other types of E. coli, other infection type of it, you want to rule out whether that person's dealing with small intestinal bacterial overgrowth. Because if they actually have SIBO, most likely they have SFO as well. Small intestinal fungal overgrowth in the system. So you have to look at the comprehensive sense of it. By also looking at how well the gut is able to produce short chain fatty acid.
22:16 Gary Brecka? And as soon as somebody gets SIBO, they put on high doses of antibiotics and just buying themselves a problem down the road.
22:21 Speaker 00 Huge. And you cannot use probiotics too much in this scenario. Oftentimes, if you're using the right supplements at the wrong time, you get hurt very bad. Right? And this is a part where use of the right probiotic, but also use of immunoglobulins is very important. So there's a company called Microbiome Labs. They produce immunoglobulin G, so IgG. It actually is a binder that actually binds to selectively for E. coli, strep, Enterococcus, Laper protein saccharide, which is LPS. Which is a biotoxin itself that E. coli produces.
23:03 Speaker 00 And then the other aspect is it actually binds to some of the mold colonization of it. So that's a more gentle way into getting the gut function back. And then really looking at utilizing spore based probiotic there as well. Because that's less reactive on the patient dealing with SIBO. But the spore based probiotic actually acts as an antimicrobial to deal with bacterial overgrowth the person's dealing with. So you have to do a more of a step by step approach into the sequential ways into getting these issues. Instead of actually just throwing the whole thing at the person and trying to see what sticks.
23:35 Gary Brecka? So we've done the test for the secretions from biofilm. We've done a gut stool test.
23:42 Speaker 00 But there's no perfect markers out there to looking at biofilms. There's none. I mean, there are muscle testers out there who are very talented to check if the person's dealing with biofilms. But when you're dealing with over colonization of mold, there's always a play. And then there's all the multiple infections, there's always play of biofilms. And if you actually look at their person's history, if they grew up having... Strep throat issues, including that ear infection. They had years of taking multiple antibiotics for a year, for a long time. There's definitely biofilm issue as well. So you got to understand that that is an integral, integral part of the entire protocol. But there's no perfect test out there to check for that.
24:25 Speaker 00 I wish there was, but so that's how we, so that's the reason why a lot of doctors, including functional medicine practitioners, they don't often miss that part. Right? That, that is vital, but they often miss it. So I was looking at it, so all right, so what is, how's a person's history? How's the function person's happening? But also, how reactive are they? If they actually are reactive in terms of food, chemicals, especially if they go on a Uber, for instance, and then they actually have a car fashion in there and they're getting reactive, they're having brain fog, they're wiped out for two days. That person has major issue dealing with MCAS, which is mass activation syndrome issues, hypersensitivity, but also play the fact that there's a big play of biofilms that's happening there.
25:07 Gary Brecka? Hmm, right. You know, it's, it's also important not to go too far too fast with these patients. You know, I've, early in my journey in functional medicine, when we opened up our clinic, you know, we, we, a lot of people were coming in for weight loss. This is pre GLP ones.
25:24 Speaker 00 Yeah.
25:25 Gary Brecka? One of the things I noticed about very obese patients that go through rapid weight loss is they become so toxic. Migraines, rashes, you know, crushing fatigue, like fatigue where they can't even get out of bed. I'm not talking about somebody who loses 15, 20 pounds. I'm like, somebody's going to lose 100 pounds, 150 pounds. And the release of these toxins without fixing their detox pathways, which is something that I, I learned, was, was kind of fascinating to me because, you know, there, there are a lot of these toxins that are trapped. In these fat cells. And the same thing is true when you start going after some of these infections,
26:08 Gary Brecka? especially sporulating infections, infections that are just creating these biofilms. That in and of itself becomes another toxic load.
26:16 Speaker 00 Huge.
26:16 Gary Brecka? Right?
26:16 Speaker 00 It actually causes more activation of the immune response. So that could be a big problem. So for, in case in point, talking about mold itself, like mycotoxin is lipophilic. It actually lodge into fat cells a lot more readily and the tissues itself. So that's why when you're doing a urine mycotoxin testing, let's just say a person's obese. They've been chronic exposed to mold toxins in a moldy house. Oftentimes, when you're doing urine mycotoxin testing, their levels of mycotoxins are very low. Sometimes you don't even see it. So what's going on? The fat is basically holding on to that. So you need to really do a provoke urine testing to get the urine mycotoxin out. So you've heard of provoke urine testing for heavy metals.
27:00 Gary Brecka? Yes.
27:00 Speaker 00 Same thing in this scenario.
27:01 Gary Brecka? I didn't know you could provoke it for.
27:03 Speaker 00 Yeah. So what you do is you want to utilize minerals and bioflavonoids to metabolize mycotoxins and getting that out to the kidneys. So use of melivudin, for instance, is great to metabolize gliotoxins. You actually have resveratrol and turmeric, so another good bioflavonoid is in there. So there's a company out there, the company name is A-Lite. My mentor, Dr. Jill Krista, she formulated that thing, that entire supplement just for mycotoxin purposes. And I use it a lot. And one of the key supplement that I utilize now is called a Color Guard. Utilized all those things in there to help to metabolize mycotoxins so that you get the patient for about two weeks prior to collecting urine. So that you get a proper reading on it.
27:48 Speaker 00 So that's one way of doing it. There's some doctors who.
27:50 Gary Brecka? And those are oral?
27:51 Speaker 00 Oral.
27:51 Gary Brecka? Okay.
27:52 Speaker 00 There's some doctors who utilize sodium butyrate, for instance, which is why. Sodium butyrate is a chemical chaperone. It actually. Removes the DNA adduct of these microtoxins that binds to the DNA, removes it. Right? So that's another topic that we could talk about too. But this is a really integral part of why mold is not just about the immune dysfunction or having allergies. It actually causes mitochondrial dysfunction deep into the cellular level.
28:18 Gary Brecka? Yeah.
28:18 Speaker 00 Down to the DNA. So when you affect the DNA, it actually affects the epigenetic expression of the actual tissue in itself. And the reason why, especially for women, why is it that they're dealing with a lot of things like lupus? We're talking about Hashimoto's, right? So these are all interplay in terms of why these type of DNA adduct changing the epigenetic expression of the cell and the tissue itself resulted in an actual disease state that we see it right now.
28:45 Gary Brecka? Yeah.
28:45 Speaker 00 Right? So there's always a root cause.
28:46 Gary Brecka? Yeah, and, and you know, I, I, I've seen so many of these. So when, when someone has this suspicion, they do, they, they do these tests. You know, you, you said that you did the IVPC, the phosphatidylcholine, or the PK protocol, similar to the PK protocol. I, I've done that too. I had some clotication in my veins, so I stopped after a little while.
29:09 Speaker 00 Oh my god, my, all my veins are completely collapsed.
29:11 Gary Brecka? Yeah.
29:11 Speaker 00 I had to go through 14 IV sessions using IVPC and it's very, it's, it's great. You know, you get your mitochondrial function back very quickly. It's just, it's very caustic for your veins.
29:21 Gary Brecka? Yeah.
29:22 Speaker 00 So every.
29:22 Gary Brecka? And it takes a long time to come back.
29:24 Speaker 00 Yeah.
29:24 Gary Brecka? It's not, you know, life threatening or anything.
29:26 Speaker 00 It's not.
29:26 Gary Brecka? It is, it is a little unnerving when you look down and they're all, all hard and you can kind of roll them.
29:31 Speaker 00 Yeah.
29:31 Gary Brecka? And you go, I feel like that's a clot and if that leaves, you know, am I going to?
29:36 Speaker 00 It's not gonna happen that way, but yeah.
29:37 Gary Brecka? No, it doesn't happen that way.
29:38 Speaker 00 You get scared initially.
29:39 Gary Brecka? Yeah.
29:40 Speaker 00 Yeah, but it's also, um, you know, IVPC is great. Now, the issue is that when you're looking at the entire phospholipid complex, you're not just talking about phosphocholine. You're talking about phosphinositol, serine and.
29:54 Speaker 00 Ethanolamine as well, so four different lipid, I'm sorry, phospholipid complex that we're seeing. So when you look at a cell membrane structure, for instance, about seventy percent of the cell membrane structure, the outer membrane especially. So when you, audience out there, people don't know what cell membrane is, is a bilateral structure of your entire cell, right? And that bilateral structure dictates into how nutrients go in, waste going out, and then as well as that cell membrane potential to allowing different hormone changes and functions and everything else that goes on. So it's vital for the cell membrane to function well. Unfortunately, dealing with mycotoxins and mold in general, including other biotoxins, just like Lyme, it actually damages the cell membrane integrity.
30:39 Speaker 00 So specifically mold, for instance, it actually causes lipid proxides. So actually, and then also depletes the cardiolypin in a part of the membrane as well. And then when you're looking at the structure in itself, it, the early stage of cell danger response is the mitochondria's role to cause a lockdown of the particular cell by increasing phospholipid production inside the cell to lock the cell in. And this is the issue where the lack of cell-to-cell communication that goes on, but that's the early sign of cell danger response. And why people are stuck in this process? And why it is so vital that you work on that cellular halt by utilizing these types of special lipid
31:24 Speaker 00 to actually help reverse these things as well.
31:26 Gary Brecka? Can you describe what cell danger response is?
31:29 Speaker 00 Yeah, sure. Cell danger response.
31:30 Gary Brecka? Sounds terrible.
31:31 Speaker 00 Yes. So cell danger response was a term coined by Dr. Robert Navio. He's an MD PhD out of UC Davis. And he is still working right now and really doing, he has a different metabolic lab that he does a lot of things. And he's able to prove into what his theory was at that point in time. And he explained why certain disease states, especially like autoinspection disorder that he was working a lot with. Why these patients are stuck in their healing process? Right? Everybody goes through a cell danger response, right? You woke up, that's a cell danger response.
32:05 Gary Brecka? Yeah.
32:06 Speaker 00 Right? You waking up, your cortisol levels shoot riding high and you gotta do all these different things. That's a cell danger response. Everybody goes through it. But why is it that some people going through a certain case scenario? And I call it the Humpty Dumpty effect. The reason being is the Humpty Dumpty is sitting on a wall. It's fine. But if someone comes in or some wind or something comes in and poke them aside, he falls over, his shell completely cracks. And that's how unstable people are right now living. And unfortunately, COVID happening. It blew up the lid in terms of how unstable these people were to begin with. So that's why a lot of people dealing with long COVID sequelae issues right now. So that's all side of cell danger response. So why, what is that?
32:48 Speaker 00 It is, cell danger response is a evolutionary protective mechanism that the cell actually had built into the process to protect itself. From what? From biological issues like mold, bacteria, fungi, talking about parasites, including viruses. And then all the things like physical trauma issues, right? Could be TBI, traumatic brain injury, for instance, or other things like UV radiation. There are other things in terms of psychological traumas, in terms of emotional or PTSD, for instance. And then there are chemical stressors like heavy metals or glyphosate, right? All these different things.
33:29 Speaker 00 But these are causing that much of stress onto the cell in itself. So instead of the mitochondria making ATP, now it's actually shuts that ATP production down, shuts oxidative phosphorylation, goes to complete defense mode. So this is where mitochondria dictates in terms of how the body's gonna shift. But if the stress response is overwhelming, I talked about the toxic bucket effect, right? Everything's later in. If that response is overwhelming, the mitochondria cannot get back to homeostasis. And then it's completely in that on threat mode.
34:06 Gary Brecka? Yeah, that sympathetic state, that fight or flight state.
34:08 Speaker 00 So when you think about like a fire alarm, for instance. It's keep on turned on. Doesn't know when the fire was gone, but still keep on turning on. This is the reason why people who had removed themselves from a moldy environment, for instance, they're still sick because the overall cell danger response has not been resolved correctly. Resulted in a amount of chondro dysfunction and they're consistently sick in dealing with autoimmune disorders, brain fog, fatigue problem, et cetera. You could do all the NAD you want to do. You could do all this analytics, all these different things, but if you have an unresolved issue cellularly in dealing with toxicity, you cannot biohack yourself out of that. You gotta resolve that cell danger response correctly.
34:52 Gary Brecka? What are the top three reasons why I prefer a vertical cold plunge versus a lay down tub? Well, I've used both. When you're in a vertical position, your body naturally regulates your breathing better. So if you're holding on to the sides and you're in a vertical position, you can just focus on your breath work and you can stay calm. A lot of people feel more calm when they're in a vertical position than when they're laying down in the water and think they might slip under the water. So when you're vertical plunging, you're fully immersed faster. You can focus on recovery, inflammation reduction, and you're not struggling to just stay in a lie down position. Your body floats in an awkward way sometimes. So it's just a more efficient, comfortable experience, in my opinion. It takes up way less space, too. It has a smaller footprint. So you can put these on your patio, your garage, your bathroom, your locker room. You can really
35:35 Gary Brecka? put it anywhere. I've got one on my balcony. I've got two in my bathroom. So this is why cold life is my favorite cold plunge on the market. So click the link below and you can order yours today. Make sure you get the ultimate human version. Now let's get back to the ultimate human podcast. And how do you start resolving the cell danger response? Because I would imagine that you're going to solicit some of this cell danger response just by going through the detox process.
35:58 Speaker 00 Correct.
35:59 Gary Brecka? And so as we detoxify and we go after these biofilms and eventually go after the bugs themselves, there's going to be a period where people may get worse before they get better.
36:09 Speaker 00 Correct.
36:09 Gary Brecka? Right? And you try to manage that by not going too fast, by having this graduated approach. In fact, you call it, which I thought was absolutely genius, the encore method. The environment, the nervous system, cellular integrity, which virtually nobody talks about. You know, Dr. Pampa, and there's few other leaders in this area. Optimized detox and rebalancing the microbiome. I think what happens is most people skip the ENCO and go right to the R and start rebalancing the microbiome.
36:42 Speaker 00 Correct.
36:42 Gary Brecka? Because they think as soon as you have gut dysbiosis, this is a probiotic flora issue, and therefore just probiotics, maybe some digestive enzymes. But the truth is that you're not getting rid of the toxins and the biofilms. And what's truly at the root cause of this, even preventing heavy metal detox, which is going to allow heavy metals to build up, and even interrupting the methylation cycle for the proper use of light metals, right? Which is the way that we, you know, methylate and incorporate light metals like magnesium and zinc and B12. So, you know, once you've disabled or impaired this process, you have to repair that even
37:27 Gary Brecka? before you restore the gut microbiome. And I love that you put that at the very end. You know, because first you clean the terrain. I've been using this analogy so much on my podcast because I think it just said in such a clear picture, when a fish gets sick, the first thing we do is clean the tank, right? And because it's so obvious. When you're looking through murky water, it's full of algae, you know, it's full of dirt, it's cloudy, you understand why the fish is sick. But when you're looking at a human externally, you can't see the cloudy water inside. And so, we don't think about cleaning the tank. And this approach is a very restorative approach. I would love to actually just walk through the Encore method.
38:08 Speaker 00 Sure.
38:09 Gary Brecka? Because I think it's a great foundational framework for identifying, removing the toxins, rebuilding the body's damaged cell membranes and phospholipid bilayers, and then fixing the gut microbiome.
38:23 Speaker 00 Yep.
38:23 Gary Brecka? So, can you walk us through this?
38:25 Speaker 00 Yeah, absolutely. So, the reason that I came up with this particular Encore method was after learning and diving into the whole cell danger response method, when you look at Dr. Robert Navio's work on cell danger response, it's very complex. And it's very difficult for you to take that information and put into clinical use of it. And so, I was just thinking like, what can I do to utilize this correctly for people who are dealing with biotoxin issues? Like, if it was me back in 2015, if I had a particular methodology...
38:56 Speaker 00 What would I do differently? The first thing was basically the environment factor there, right? Environment, if you are stuck in the same environment that made you sick, you're not gonna get better. No chance. I always say that. Right. You cannot out-biohack on that part, right? The environment is the best thing that you could actually into fixing. And this part is often difficult. The reason being is you live in a house where it's very moldy. It could be costly. It could be costing you $5,000 to remediate, up to $150,000 or more, right? So people who have limited budget, that becomes a very triggering issue. So you gotta, you gotta, first off, what you need to do is you need to calm. You need to really settle down in terms of, all right, so what are the issues that we're dealing with right now? Where are the most problematic areas? You need to find the right testing company to come in
39:40 Speaker 00 and assess the overall damage of the actual issue at the house. So I recommend a company called We Inspect. We Inspect. We Inspect, great company too, that's nationally recognized. And they are one of the pinnacle in terms of looking at how proper mold testing should be done at house. It's not just about air sampling. That's the worst you could do, doing air sampling tests in the house. Because depending on whether air is being stagnant or being flowing, that mycotoxin testing is gonna be affected, right? Also, that's the reason why I prefer going with more surface testing. The reason being is mycotoxin especially rise on the dust particles like a carpet on a ride.
40:25 Speaker 00 So that's where mycotoxin settle in. So this is where, when you wanna looking at the overall sediment of the mycotoxin burden that goes in the house, you're looking at that. So Ermi testing is a good one to looking at. And there are other testing companies that you could do as well on your own, if you like to. Doesn't give you the overall comprehensive issues because it doesn't necessarily check for like water damages behind the wall, for instance. So a company called The Dust Test is a great one that I like to utilize. Dust Test. Okay. Yeah. It's like $279. You could do one sampling of the area to figure out, all right, so how much of a mycotoxin issues I'm dealing with. Right. Right? But it's just gonna give you some pictures. But this is where you gotta have to work with a professional company to look at that. Okay. The second thing I would also recommend, if you could hire the same people that does it, great,
41:09 Speaker 00 but building biologist. Why? Non-native EMF.
41:15 Speaker 00 Why is that? And I'm a strong believer in this part now, more and more. The reason being is, why is it that people are getting sicker and sicker even though we have advanced in medicine and such? I mean, you could talk about food, the glyphosate and all these things. But when you look at the bombarding issue, dealing with the cellular stress that we're dealing right now with non-native EMF, it's over than anything we could actually fathom now. Compared to what it was 100 years ago, it's much, much greater. So you're looking at reducing that non-native EMF exposure, especially hardwire everything in the house. Maybe you want to reduce the exposure dealing with wifi signal. Cell phone signal is another problem too, right?
41:56 Speaker 00 So you gotta get in terms of removing that, but that could actually oversensitize a person who's dealing with hypervigilance state. Like for instance, if you're dealing with MCAS, I think you have Dr. Damsian recently.
42:08 Gary Brecka? Amazing.
42:09 Speaker 00 Yeah. So I mean, she's a foremost authority in the topic of MCAS. But when I see clients with MCAS issues, it's not the fact that
42:17 Gary Brecka? That's mast cell activation syndrome.
42:19 Speaker 00 It's not the fact that the mast cell is triggered by mold, but it's just the over-responsive cell danger response that has gone wrong, that the body's in that hypervigilance state. And you gotta talk about non-native EMF. That's the really important factor.
42:36 Gary Brecka? What do you mean by non-native?
42:37 Speaker 00 Non-native EMF, so especially talking about wifi, cellphone signaling, right? There is going to be EMF naturally, right? There's always different cosmic rays that actually occurs up in the sun, everything else in the universe. But when you talk about these non-native EMF that is artificially driven and built because of today's technology that we actually have, is bombarding our cells. And non-native EMF issues, what it does is cellularly, it actually impacts, it liques the cell membrane, number one. Number two, it actually activates the voltage calcium ion channel. So you have an influx calcium going into the cell and then dumping out magnesium. So you have all these people who actually been taking magnesium supplements, they can't get it up, they cannot get it better. Why?
43:21 Speaker 00 Maybe they're getting overexposure to non-native EMF and mold issues that you're not even aware of. So anytime looking at the environment factor in terms of the encore method, non-native EMF is one of the top things I tell people to do. And then second thing is blue light toxicity issues as well. So obviously, I'm every blue light blocking gases.
43:40 Gary Brecka? I usually are wearing mine too.
43:43 Gary Brecka? What happened to my glasses, guys? Are those yours? Now I need to wear them. Give me those fat actors. All right. Thank God.
43:54 Speaker 00 So, blue light, if you... Blue light actually affects methylation.
43:59 Gary Brecka? Not anymore?
44:00 Speaker 00 Yeah, well, but think about it. People who are dealing with already MTHFR issues to begin with, and then they are already getting bombarded with different types of environmental factors. And then you're getting the issue dealing with blue light toxicity. It overwhelms the response. Why? Because blue light affects the methadone pathway. So you can't methylate well. So, all this discussion about methylation, all different things. Listen, you're the first one that's been out there speaking a lot about methylation. I appreciate that.
44:29 Gary Brecka? Thank you.
44:30 Speaker 00 But in a scenario like a person dealing with hypersensitivity issues, you gotta look at the environment as well. Not just about the whole environment.
44:37 Gary Brecka? You know, I've been learning this, you know, the last two years especially. And I'm always trying to evolve. And there were those cases where... Because we had about 200,000 patients that came through our functional clinic. And I would say the majority of them, healthy young adults that were dealing with some challenges there. You fix methylation, and there was some shift in the positive direction. Sometimes dramatic shift. Other ones, there was no change at all. And sometimes they would start over-methylating the... Have negative consequences. Those are the ones that I really started to focus in on. And in the last 24 months, I'm starting to realize
45:20 Gary Brecka? that it's more than just methylation, right? And that it's... You can see the genetic breaks, which makes them susceptible. But it doesn't guarantee their outcomes, like the epigenetic model. But now that I'm further down the rabbit hole on these environmental toxins, that was the missing link in our practice, that we hadn't quite closed the gap. You know, we got the ball like 80 yards down the field. We just couldn't move it that last 20 yards. In a lot of people, and they were very resistant. To treatment. And this has a lot to do with what you're talking about. You know, this has a lot to do with.
45:58 Speaker 00 Yes.
45:59 Gary Brecka? Toxic load.
45:59 Speaker 00 And then there's another issue where over methylation you just mentioned before.
46:03 Gary Brecka? Yeah.
46:03 Speaker 00 So, so in my practice, what I do is instead of actually going after methylation first, I'm looking at the methyl, a methyltransferase choline pathway. So if you look at that pathway itself, it's part of the whole homocysteine cycling. If you look at that, what the, what is body producing? Fossil choline and creatine.
46:20 Gary Brecka? Yes.
46:21 Speaker 00 So if you supplement those two, right? It puts less stress on the homocysteine pathway. Person is not overreactive.
46:29 Gary Brecka? Leaving more methyl groups for homocysteine to methionine. And, you know, the, the other big one that we uncovered was the SAW. You know, not this, this hyper homocysteineemic symptoms, not coming from hyper homocysteineemia, but coming from elevated N-succinyl homocysteine. And that's a very difficult one to test for, at least it has been historically. Because of the stability of how you have to keep the, the sample and everything else. And that was, that was another big key that we unlocked. But what you're saying is supplement for the methyl groups that are being overutilized in the homocysteine pathway, so that you can leave more of that methylation cycle
47:14 Gary Brecka? for the recycling of homocysteine, which has its own set of, of consequences. Most of these hyper homocysteineemic patients, in fact, above a certain level. We saw hypertensive, you know, results because of the vascular constriction. We saw all kinds of, you know, you know, consequences. And it's actually rarely tested even on cardiac panels.
47:34 Speaker 00 Yeah.
47:35 Gary Brecka? You know, we're all looking at C-reactive protein and CK and, and, you know, the classic markers, but not looking at what could be irritating.
47:44 Speaker 00 Absolutely.
47:44 Gary Brecka? Those pathways.
47:45 Speaker 00 Yeah. So, so these are things that we are looking at there. And then looking at the environment, more factors in terms of the person's trauma, how the relationship they are living inside the house. Are they living in an abusive household? How's their work environment? All those things are really important there. Generational trauma is a big one, too. Right. So this is part of the E. The N of the encore method, dealing with nervous system regulation. Oftentimes because of the microtoxin causing neuroinflammation. These patients are in a hyperdriven, hypervigilant, parasympathetic nervous system. So how do we create that parasympathetic? One of the things that worked out really well for patients, and you don't need to spend a lot of money on it, and there is a company that supports this. I do heart math breathing, called a heart coherency breathing technique.
48:30 Gary Brecka? Wow.
48:30 Speaker 00 So you probably heard of box breathing technique.
48:33 Gary Brecka? Oh, yeah, yeah. And heart coherence too.
48:35 Speaker 00 Yeah, so heart coherency. Why there's such a different thing is that when you're doing that heart coherency breathing technique, it creates the coherency state from your heart to your brain. And that actually helps to calm a lot of the issue dealing with mast cell, immune dysfunction, and then much more in terms of the hypersensitivity the person dealing with. So how do you do that?
48:55 Gary Brecka? Yeah, I was gonna say, can you just grab this first?
48:57 Speaker 00 Very easy. All you need to do is close your eyes and then focus on the sense of your heart. And then afterwards, you want to focus on what is making you happy, joyful, and grateful about. So when you think about those three positive things, what it does is shift your overall brain state into coherency based on the positive affirmation and thoughts. And while you're doing that, you're gonna breathe into the nose five seconds.
49:25 Speaker 00 And you're gonna exhale out five to seven seconds.
49:31 Speaker 00 Inhale to the nose again.
49:35 Speaker 00 Exhaling out.
49:39 Speaker 00 One more time, inhale.
49:43 Speaker 00 Exhaling out.
49:48 Speaker 00 And that is it.
49:49 Gary Brecka? Better.
49:50 Speaker 00 Yeah, that's all I do. And so what I also recommend patients to do is I give them actually, it's called a heart math device. It actually checks for your coherency state between your heart and your brain. It's a five feedback device. You just put in your ear, and the company called HeartMath actually sell this.
50:05 Gary Brecka? HeartMath?
50:06 Speaker 00 Yeah, HeartMath. So that's an institute that trains physicians and clinicians out there to doing this particular breath work and managing of nervous system regulation by creating coherency state and not only affecting positive waves into the body. But also working in terms of deep rooted issue to the trauma issue as well. Why? Your heart actually is another nervous sensory. Has 40,000 different nerves stemming from the heart. And then is able to take in all that information and bring it to your brain. Not the brain to the heart itself. So you think about person dealing with trauma issues, hypervigilance state, all these different things. Once you create the coherency state in the heart, a lot of symptoms end up having to disappear. I'll give you a perfect example.
50:49 Speaker 00 I had a client who actually lost her son 18 years ago. Had a boating accident. The son fell off a boat. Watched the son die. She constantly dealing with hypervigilance state, anxiety, et cetera. Was affecting her life. And she was not ready to do, to work with me. And I do work with clients one on one.
51:08 Gary Brecka? Yeah.
51:09 Speaker 00 And all I did was taught her how to do this particular breathing technique. Her resting heart rate used to be 90. After six weeks, her resting heart was at 60.
51:17 Gary Brecka? Wow.
51:18 Speaker 00 Yeah. Crazy. I couldn't even believe it. That, that particular change. And one thing that you start noticing is that the person's face completely changed as well. Why? Cause they're not living in the stress response state anymore. They're in a coherency state.
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52:16 Gary Brecka? Now let's get back to the Ultimate Human Podcast.
52:19 Speaker 00 So this is the reason why when you're working with people dealing with body toxins, it's so vital that not only you work on the environment, work on the nervous system.
52:26 Gary Brecka? I love that.
52:26 Speaker 00 Because environment, nervous system now affects your cellular health. Right? Your mitochondria is not just about making ATP. Immune system as well. So it's not just about making ATP. Mitochondria is a sensory organelle is able to dictate everything that goes in the body, including the mitochondria dictating just how you methylate, also how you detox, but also how you heal.
52:49 Gary Brecka? So fascinating, the interconnectivity. You know, I've always said that some of the worst experiments that we do are when we take structures out of the body, cells out of the body, what have you, and we look at how they behave in a laboratory. And then we assume that when we put them back in the body, they're going to behave the same way, way, and they don't. I mean, because cells are like human beings, they behave in communities, you know? And you know, there's something psychiatry called the herd mentality, right? And when you're in a crowd, if the crowd starts surging and everybody just starts running one direction, you'll just start running. You don't even know why. It's like everybody else is running. And this is the way that cellular activity influences other cells and how metabolically healthy cells can become metabolically sick because they're in an environment with other
53:33 Gary Brecka? metabolically sick cells. And it's kind of analogous to this herd mentality. And maybe nothing that we can do would touch the entire system simultaneously as things like heart coherence and getting our autonomic nervous system out of this sympathetic state into a parasympathetic state, you know, as a singular intervention. I can't think of anything that has more of a systemic effect and more of an immediate effect.
54:04 Speaker 00 Exactly. And one thing that I learned more and more about, you know, cell membrane medicine is that cortisol especially.
54:13 Speaker 00 Push the body to producing phospholipase A2 enzyme, which ligates a cell membrane. So the higher stress response you're dealing with affects the cell membrane. Right? So like the works of Dr. Bruce Lipton, for instance, and he talks a lot about the mindset and the feeling and how that affects the cellular health. It's all connected there. And it's really vital there. So one of the things that I do, obviously, we talked about the lipid membrane medicine. The first thing I help people to do is getting your circadian rhythm balanced. That's the first thing. Right? So that light day cycled aspect of it has to be really dialed in. So I actually utilize an app called MyCircadian. It was actually formed by my friend Sarah Kleiner. And that particular app tells you when the daylight,
54:55 Speaker 00 a daybreak is going to be occurring to get that person out the door, getting that initial start of that blue light emitting from the sun and the infrared. The infrared affects positive changes within the overall mitochondria function.
55:09 Gary Brecka? And this is the first, what, 45 minutes?
55:11 Speaker 00 I would do about 40. Obviously, you know, people have busy lives and, you know.
55:16 Gary Brecka? I'm not saying 45 minutes outside. I'm saying within the first 45 minutes of the sun cresting their eyes, what they call first light.
55:21 Speaker 00 I would recommend the first thing. So for instance, like we're in Miami, obviously. And the daybreak for this morning was at 6:45 a.m. So I usually like to go out between, you know, within the 10 minute window of that time.
55:35 Gary Brecka? Okay.
55:36 Speaker 00 So start to getting that blue light emission there.
55:38 Gary Brecka? Okay.
55:38 Speaker 00 So once you start having that blue light and this first light, it actually helps to lower cortisol response. Right? Also helps with proper fatty acid metabolism and metabolic process. But another thing that the sunlight does is, obviously, you know this, our mitochondria makes its own water. So that structural water that occurs in the cell.
56:00 Gary Brecka? Gallons of it every day.
56:01 Speaker 00 Right. And that structured cell, structured water is a vital point in doing cellular detox.
56:07 Gary Brecka? I wonder if if the stress response increases the production of deuterium.
56:12 Speaker 00 It does.
56:12 Gary Brecka? It does.
56:13 Speaker 00 It does.
56:13 Gary Brecka? We know that destroys the the the crop cycle.
56:17 Speaker 00 Yeah, so so you know, sometimes that is very hard to discuss with with clients, but I started using a company called Light Water. So so you have five percent million is one good thing to start with. You don't want to do too high of a deuterium depleted water too fast. I mean, that causes another level of issues because now you're dumping everything out.
56:34 Gary Brecka? Right.
56:35 Speaker 00 So you got to be very careful with that. Another water that I started using is Gerald Steiner.
56:42 Speaker 00 Sparkling water at the supermarket. So the higher the altitude of the water sourced, the lower the deuterium stake.
56:49 Gary Brecka? Ah, I did not know that.
56:50 Speaker 00 Yeah, so that's really vital.
56:51 Gary Brecka? Deuterium water is hard to get a hold of. There's like a place in, I want to say Bucharest.
56:55 Speaker 00 Bucharest is one, but then also one part of Mexico, Tijuana.
57:00 Gary Brecka? Okay.
57:00 Speaker 00 There was a there's a crater. I might be wrong on the location, but there was one parts of Mexico where the meteorite hit that area. So that there that area is depleting deuterium depleted water source there. So a lot of these mitochondriacs apparently go down there.
57:20 Gary Brecka? Did you just make up a word?
57:21 Speaker 00 No, no, no, this is this is a term that that's a term by actually Dr. Jack Cruz.
57:25 Gary Brecka? I've heard of hypochondriacs, but never mitochondriacs.
57:28 Speaker 00 Mitochondriacs, yeah. Dr. Jack Cruz, I mean, he's foremost in terms of looking at this whole. You know, cellular health and looking at circadian rhythm, but no, it's it's really the powerful part. Even like deuterium is very important to when you the studies out also. I think it was six weeks into drinking deuterium depleted water was able to reverse type two diabetes.
57:48 Gary Brecka? Yeah, no, I I've I've read these studies and and deuterium, you know, our bodies make this intracellular water and. And estimates are as high as 100 gallons a day. When you start telling people that you make 100 gallons of intracellular water every day, they go, that's impossible. I only drank a half a gallon of water. We make it the same way we make it in space. You take two hydrogens, one oxygen, you slap it together, you have a water molecule. So we're not capable of drinking enough water to feed our mitochondria. So we manufacture this from a gaseous state. And when you add this extra proton, it becomes heavy water, or deuterium. And deuterium, when it enters the Krebs cycle, is like the Tasmanian devil. It breaks it. And yeah, I've been talking
58:32 Gary Brecka? about this and been a fan of it for a long time. Because and stress and other things, we produce a lot more deuterium water. There's a lot of evidence even that keto dieting and being in a ketotic state increases the production of deuterium depleted water.
58:50 Speaker 00 Yes.
58:50 Gary Brecka? It makes, it does.
58:51 Speaker 00 It does, yeah. And then certain things like seafood, for instance, like oysters, wild-caught fish. So the cold water fish and seafood are great for deuterium depleted food source. Eating things more seasonally based on where you are is really important. So anytime we're with these type of biotoxin clients, you probably could ask about, you know, what kind of diet is good for you?
59:11 Gary Brecka? Yeah.
59:12 Speaker 00 Paleo-based seasonal diet.
59:13 Gary Brecka? Paleo-based seasonal diet, love that.
59:15 Speaker 00 The seasonal, why? Because depending on where you are, that sun codes a different message into the food. And that actually helps to empower your mitochondria to function well. It's not about picking up avocado somewhere up in the North Pole. That's not what you want to do.
59:31 Gary Brecka? Right, right.
59:31 Speaker 00 You don't want to eat banana in the middle of a winter either. That actually impacts more on the cellular function there. So you could do all the biohacking you want to do.
59:38 Gary Brecka? Fascinating how we were just designed to be in sync with nature.
59:43 Speaker 00 Yes.
59:44 Gary Brecka? You know, and Western medicine has been using, or Eastern medicine has been using forest bathing and things for centuries, very effectively. And I always say, if something has been around for centuries, like acupuncture, what have you. It's probably because it works, right? Things don't last 5,000 years that don't work. And I think our reluctance is to put our faith back in the basics. You know, very often because, you know, we believe a lot more in what man makes us than what God gave us. I mean, you even are a leading expert on drug induced mitochondrial dysfunction, which I find a whole, should do a whole podcast on just that. I want to finish the encore method. So we went through the environment, we went through the nervous system.
1:00:22 Speaker 00 Cellular health right now.
1:00:24 Gary Brecka? Cellular health.
1:00:24 Speaker 00 So a big question about the circadian rhythm and why it's an important part. Grounding is another thing that you could definitely do, really impact there.
1:00:30 Gary Brecka? Love it. I'm being so vindicated right now.
1:00:31 Speaker 00 Yeah, so really impacting those of doing that.
1:00:34 Gary Brecka? You watching this?
1:00:34 Speaker 00 Why? Because that, that overall grounding actually increased redox potential to cell membrane. Right? So all those things there. So the next, and then while we're doing that, we could incorporate doing like lipid membrane medicine. So phospholipid, so Body Biopc specifically, I recommend all the time.
1:00:51 Gary Brecka? I just take it prophylactically every morning.
1:00:53 Speaker 00 Yeah.
1:00:53 Gary Brecka? You know.
1:00:54 Speaker 00 With that too, but I, when I work with clients who deal with biotoxin issues, generally what I would recommend is around, you know, 10 to 15 mL of PC liquid from Body Bio.
1:01:03 Gary Brecka? Okay.
1:01:04 Speaker 00 So that's one of the vital thing. But when I work on cell membrane, I'm looking at in terms of how these biotoxins cause DNA damage. So DNA adduct we talked about.
1:01:12 Gary Brecka? Right.
1:01:12 Speaker 00 And we talked about how butyrate actually act as a chemical chaperone.
1:01:16 Gary Brecka? And most of us are so butyrate deficient, we're not getting enough fiber, we're not getting enough soluble fiber, insoluble fiber.
1:01:22 Speaker 00 And you could do a stool analysis to see that the short chain fatty acid production is down, keystone bacteria down. So all these things are affecting your butyrate production. And butyrate is vital to protect your DNA. Not only about digestion, not about feeding your colonocytes, but really impacting the DNA function.
1:01:40 Gary Brecka? Correlated links to cancer are mind numbing.
1:01:42 Speaker 00 Absolutely. And butyrate also actually affecting positive change in your metabolic process, especially glucose, right? So GLP-1s especially, right? All those are things. But one other thing about the DNA adduct I mentioned before is that these things like aflatoxin, even mercury, heavy metals, these things end up binding to the DNA structure, change the epigenetic of how the particular cell is supposed to function. And these are the reason why you're chronic disease states. What butyrate does is acts as a chemical chaperone, cleaves that off. And then you have phospholipid, like PC for instance, comes in sweeping that while helping to mend the actual cell membrane structure by adding in that. And this is where the other things like bioactive oil, like Bounce Oil from Body Bio.
1:02:25 Speaker 00 Adding in linolase, which is omega six, and alpha linoleic, which is omega three, help to restructure our cell membrane. Adding in gamma linoleic, like evening primrose oil, help to further decreasing the inflammation pathway, right? Adding in things like special pro-resolvent mediators, right? So SPM-based fish oil is really vital there. So body biology has a protocol, resolvin. And why am I adding SPM? Is that in the early stage of cell danger response, I mentioned about the ATP production is not there anymore.
1:02:53 Gary Brecka? Right.
1:02:54 Speaker 00 What the mitochondrial chondrodoze is, it dumps out that ATP out of the cell to act as a extracellular ATP. Is something called a DAMP. It's a danger-associated mediator property.
1:03:07 Gary Brecka? DAMPs and PAMPs.
1:03:08 Speaker 00 So that signals to all the cells that there's a danger going on. Well, thing is, everything in terms of the body is a frequency.
1:03:14 Gary Brecka? We talk about herd mentality. Here's the actual mechanism that it's creating. It's poisoning its environment.
1:03:19 Speaker 00 Yeah, exactly. So DAMP situation is unresolved issue that goes on. So what the body does is taking that extracellular ATP and then turns into SPM. Our body produces own special pro-resolvent mediators, SPM, to shut that inflammation down. And oftentimes, with an ongoing inflammation, that SPM reserve goes down, right? So this is where getting proper fresh cold water fish is very important and just adding into a particular diet. But I like to using SPM as an actual supplementation to resolving it. And then the other part that I mentioned before, the cell membrane and how the DNA adduct, well, these type of mycotoxins also causes protein misfolding, right? When you have protein misfolding, that in itself affects how the tissues
1:04:04 Speaker 00 and proteins are being synthesized. So how do you resolve that? Adding in totka, which is secondary bile salt, relieves pressure on the endoplasmic reticulum as a de-stressor.
1:04:17 Speaker 00 But also helps to unfold the protein misfolding properly. So this is how you able to get the cellular impact damage from the microtoxins there.
1:04:26 Gary Brecka? Makes so much sense.
1:04:27 Speaker 00 This is a really important point. Then you start working on the optimize the detox pathway. Specifically gut function has to be number one.
1:04:32 Gary Brecka? Yeah.
1:04:33 Speaker 00 You gotta be establish bioflow as well.
1:04:35 Gary Brecka? Yeah.
1:04:35 Speaker 00 And mold and microtoxins, it actually affects bioflow. Specifically mold, for instance, like aflatoxin, ocartoxin and trichothecins, for instance. Those end up having to impact something called cytochrome 7A1. So I talked about the cytochrome P450, 3A4. Well, there's a particular enzyme called 7A1, which is needed as a rate limiting step for bio production. Unfortunately, mold affects that.
1:05:03 Gary Brecka? So it reduces the secretion of bio?
1:05:06 Speaker 00 Production of bio, right?
1:05:07 Gary Brecka? Production of bio.
1:05:08 Speaker 00 Production of bio. And then the other part is there's a transport chain called B-SAP, which is a bio salt export pump. And that particular pump gets shut down by microtoxin as well. So you cannot produce it and you cannot even get the prop bioflow going on. So this is where people cannot get to do the natural detox they're looking to do.
1:05:28 Gary Brecka? Yeah.
1:05:28 Speaker 00 So this is why adding in-
1:05:29 Gary Brecka? Impairing fat metabolism and all kinds of-
1:05:31 Speaker 00 Correct. Even estrogen metabolism there. So like when you're doing a comprehensive stool analysis, I see that the person's beta glucuronate is elevated. That's a number one sign that there's mold and there's a bioflow that's affected. So they're recirculating, basically.
1:05:44 Gary Brecka? Yeah.
1:05:44 Speaker 00 Retoxifying the entire body because of lack of bioflow happening.
1:05:47 Gary Brecka? That makes so much sense. And then rebalancing the microbiome.
1:05:49 Speaker 00 My biome. So this is where the proper use of antifungals is really important there. I mentioned about the spore based probiotic, but antifungals, I would recommend decreasing the fungal overload in the body. Then working on the microtoxins. And there are different herbals like golden thread, milia, all the different types of things, including olive leaf. And then the last part is the use of pharmaceuticals. And I don't say not to, I use it at the last. I'll recommend using it to conosol for about two weeks just to get the internal conization deal with mold permanently. And this is where oftentimes when I work with clients, about five to six months, they're able to reverse their microtoxin issues there.
1:06:29 Gary Brecka? Wow.
1:06:29 Speaker 00 Unless they're dealing with hypersensitivity issues, but some of the minor, non-complicated issues, they tend to get to recover from mold and microtoxin issues within five to six months.
1:06:39 Gary Brecka? That's fantastic.
1:06:40 Speaker 00 Yeah.
1:06:41 Gary Brecka? Wow. I hope that you'll come back on the podcast again because I would love to do an entire deep dive on drug-induced mitochondrial dysfunction. I would love to. Because I think the, the leading scientists in, in longevity and aging now are inside the mitochondria. We've actually found like the deepest tip of the root and we understand that most of these bugs, mold, mycotoxins, parasites, viruses, heavy metals, at the end of the day, they are all disrupting this critical organelle and the consequences of that are so vast. There's such a myriad of consequences and even in the functional medicine space, we, we still do chase these consequences instead of getting deeper, deeper,
1:07:26 Gary Brecka? deeper down into the mitochondrial function. So I'd love to bring you back to even just do a whole deep dive on that.
1:07:30 Speaker 00 May I add two things there?
1:07:31 Gary Brecka? Yeah, of course.
1:07:32 Speaker 00 So one thing, you talked about the drug-induced mitochondrial dysfunction. It's something that I'm always passionate about. I'm also passionate about pharmacogenomics. This is why I looked at the whole cytokine P450 enzyme structure.
1:07:43 Gary Brecka? That's what your PhD is into.
1:07:45 Speaker 00 One of the things that was interesting when I was looking at the mycotoxin is that we have some drugs out there that are derived from mycotoxins, right? So there's a drug called mycophenolate. The, the brand name is called Cellcept. They utilize a particular drug for kidney transplant patients so that you don't have a organ rejection. Well, that mycophenolate, that's a drug name derived from mycophenolic acid, which is a mycotoxin itself.
1:08:09 Gary Brecka? Wow.
1:08:10 Speaker 00 So utilizing mycotoxins to derive the particular acid, that's how powerful these mycotoxins are of causing immunosuppression. Reason why a lot of times when you're seeing, I'm questioning there's parents out there listening, kids who are dealing with constant strep issues, right? And colonization dealing with these things, they are derived from mold, especially aflatoxin, ochratoxin causing that problem.
1:08:33 Gary Brecka? Yep.
1:08:34 Speaker 00 When you're having chronic UTI issues also. Why? Because mold and mycotoxins unfortunately affect the mucosal lining of the bladder. Right? And then you have a higher issue dealing with UTI.
1:08:47 Gary Brecka? Yep.
1:08:48 Speaker 00 Right? So why is that the woman dealing with chronic UTI issues and they're trying to get to the root of it? They use multiple antibiotics and I can't do it. Mycotoxins.
1:08:55 Gary Brecka? Yeah.
1:08:56 Speaker 00 Specifically, citronin and ochratoxin.
1:08:58 Gary Brecka? Yes.
1:08:58 Speaker 00 Those are the big ones that I see.
1:08:59 Gary Brecka? Those are showing up on everybody's urine test. You know, we do a lot of vibrant total toxicity testing and that one is always pegged on there.
1:09:07 Speaker 00 And the second thing I want to add is that this is where the enhancing the resiliency part is coming. As you start to increase that redox potential in your cell membrane, a lot of issues deal with mold, parasites, and all these different type of toxins is none of an issue anymore. Reason why is you built that cellular resiliency and that negative ion charge and then the electric potential in the cell membrane, your body's mechanisms to repel those out. Unfortunately, we are losing that ability. And I think, and I strongly believe it's because of the environment is one thing, but I think it's none of the VMF issues and blue light issues. That's bombarding our entire system that the body doesn't have that.
1:09:48 Speaker 00 So this is the reason why when I work with clients and I jokingly say this is this is that at some point, I don't want to ever see you again.
1:09:55 Gary Brecka? Yeah.
1:09:55 Speaker 00 Right? It's not because I don't like them. It's just that I want you to be self-reliant on yourself to be the right doctor. I want to empower you to be the best doctor for your own. And this is one thing that I'd like to teach and this is why, this is the reason why part of the encore method is enhancing resiliency. Cellular resiliency, that is.
1:10:12 Gary Brecka? Love that.
1:10:13 Speaker 00 Right?
1:10:13 Gary Brecka? Love that. So I wind down all of my, we're going to go into my VIP group because these are the guys that I let know ahead of time who's coming on to the podcast. They, they know that you're coming on. They've got a whole list of questions for you.
1:10:25 Speaker 00 Yeah, so the questions.
1:10:26 Gary Brecka? Um, I want to get to my VIPs, but, but I always wind down my podcast by asking every guest the same question, which is, what does it mean to you to be an ultimate human? There's no right or wrong answer to this.
1:10:36 Speaker 00 Of course not. The ultimate human is, is to have cellular resiliency.
1:10:44 Speaker 00 To live your full life to your potential that God has given you.
1:10:48 Gary Brecka? Wow, I love that to have the cellular resiliency. Hear that, guys? The cellular resiliency. I love it. Thank you so much. Dr. Kim, for coming on the Ultimate Human Podcast. I have a feeling that you're going to be a regular guest. Such a paucity of expertise in this area and, and even though you provided the scientific background, I think you made it understandable for my audience.
1:11:09 Speaker 00 Thank you.
1:11:09 Gary Brecka? And we deeply appreciate that. And guys, until next time, that's just science.
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