Skip to content

Bubble Gum and Cyanide

Conan O'Brien Needs A Friend

Hosted by Conan O'Brien

26m
Transcript

Original podcast

Summary

Written by a model from the transcript; not yet reviewed.

This episode features a conversation with Jeremy, a flavor scientist based in San Francisco who worked on the flavor system for Impossible Nuggets. The guest explains how he transitioned from a PhD in physical chemistry at UC Berkeley studying tailpipe emissions to identifying flavor molecules using analytical instrumentation like gas chromatography olfactometry. The discussion covers sensory testing methods, taster fatigue, and unusual flavor compounds, along with playful banter about food science, dating apps, and unusual snack concepts.

  • When conducting sensory evaluations, panelists limit tasting sessions to one or two hours to avoid taster fatigue. 17:20
  • To cleanse your palate during flavor testing, you should use lukewarm water, an apple slice, or a saltine cracker instead of cold water. 6:14
  • For smelling tests, you can cleanse your nose by sniffing the back of your hand, your shoulder, your wrist, or coffee beans. 6:31

Chapters

  1. 0:03
    Podcast Intro and Product Pitch

    The episode opens with a quirky ad for pistachio chocolate snacks, setting a playful tone before transitioning to the main content.

  2. 1:35
    Conan Announces Guest and Host Intro

    Conan welcomes Jeremy and Taylor Tomlinson, establishing the episode’s format and introducing the flavor scientist guest.

  3. 3:09
    Jeremy’s Background and Flavor Science Overview

    Jeremy explains his journey from chemistry to flavor science, detailing the tools and techniques he uses to identify flavor molecules.

  4. 4:52
    Gas Chromatography Olfactometry Explained

    Jeremy demonstrates how GCO works, sniffing molecules and translating them into sensory descriptors for flavor development.

  5. 6:14
    Tasting Protocols and Sensory Training

    Jeremy shares best practices for palate cleansing, taster fatigue, and how repeated exposure trains the sense of smell for flavor work.

  6. 13:15
    Scatol and Flavor Chemistry Deep Dive

    The conversation turns to the compound scatol, its presence in foods, and how it contributes to flavor profiles despite its odor.

  7. 15:49
    Advertising Interludes and Product Promotions

    The episode includes multiple ad breaks for insurance, AI scams, LifeLock, T-Mobile, BetterHelp, and other sponsors, interspersed with comedic commentary.

  8. 23:06
    Cyanide and Dark Humor Segment

    Conan jokes about making cyanide taste like bubblegum, prompting Jeremy to explain how flavor masking could theoretically work.

  9. 24:11
    Personal Stories and Cultural Flavors

    Conan and Jeremy discuss personal food memories, cultural influences, and the role of flavor in everyday life, touching on Armenian cuisine and childhood experiences.

  10. 30:44
    Closing Remarks and Future Flavor Ideas

    The episode wraps up with a playful promise to create new flavors, a nod to Impossible Nuggets, and a final comedic sign-off.

Highlights

  • 2:03

    Transitioning to Flavor Sciencestory

    The guest explains how his background using analytical instruments for car tailpipe emissions at Berkeley led him into the fragrance and flavor industry.

  • 4:52

    Gas Chromatography Olfactometrystrategy

    The guest describes the analytical technique where individual flavor molecules pass through an instrument and exit a sniffing port for identification.

  • 10:40

    Managing Taster Fatigueinsight

    The guest explains why sensory panelists limit their tasting to one or two hours per day to prevent flavor overload.

  • 12:05

    The Smell of Feces in Flavorinsight

    The guest identifies scatol as a compound with a fecal odor found in trace amounts in certain animal-based meat products.

  • 15:32

    Developing Impossible Nuggetsstory

    The guest discusses working on the flavor system and sensory optimization for Impossible Nuggets to increase consumer acceptance.

  • 27:23

    Ingredients in Impossible Nuggetsdata

    The guest shares that the main protein in the nuggets is soy, combined with yeast extracts and glutamates for a savory, umami flavor.

Quotes

  • “I did know that the same technology that I was using is also used in perfumes and fragrances and flavors to identify those molecules are responsible for individual flavors and sensations.”
    Conan O'Brien · 2:40
  • “In 2025, AI fraud spiked 1,210% and cost Americans $893 million. That's incredible.”
    Conan O'Brien · 16:12
  • Wonderful Pistachios 0:03–0:12
  • Granger 0:52–0:58

About this episode

Conan and special guest Taylor Tomlinson speak to flavor scientist Jeremy in San Francisco about how to properly cleanse a palate, performing over 100 sensory tastings in six months, and the one flavor that is universally despised. Wanna get a chance to talk to Conan? Submit here: teamcoco.com/apply

Transcript

0:00
26:13

5,742 words · 8 speakers

Speaker names marked are inferred from speaking time and the show’s known hosts — they are not voice-verified.

Topics

  • Impossible Nuggets
  • scatol
  • San Francisco
  • GCO
  • Apple cider
  • Berkeley
  • Oreos
  • Boston
  • Red Sox mug
  • Nurtac ODT

Page updated · transcript and summary are machine-generated