
Written by a model from the transcript; not yet reviewed.
This episode of This Week in Startups features a discussion with Devin Thomas about his startup Obliteration.ai, which builds unrestricted and obliterated open-source AI models designed to serve underserved industries such as cybersecurity and defense. The conversation explores how frontier labs place heavy guardrails on models, why professionals struggle with refusals even in legal and red-teaming contexts, and how Obliteration separates the underlying model from a custom policy layer. Later in the episode, the host fields live questions from founders covering topics ranging from the evolution of the billable hour in the age of AI to the rise of AI-generated microdramas and the ongoing debate over solo founders versus founding teams.
Jason Caligan opens the episode, introduces himself and the guest Devin Thomas, and sets the stage for the discussion.
The episode features sponsorship ads for Odoo and Northwest Registered Agent, highlighting their services for startups.
Devin explains the founding of Obliteration AI, its focus on underserved sectors, and the problem of frontier labs refusing certain use cases.
The hosts discuss how Obliteration AI removes built-in refusals from open‑source models and lets customers set custom guardrails via a policy layer.
Examples are given of how the platform enables red‑team testing, vulnerability assessment, and other cybersecurity tasks that other labs block.
Jason and Devin conclude the episode, reflecting on the future of AI, potential hires, and the broader industry landscape.
Devin talks about early startup customers, the shift to Fortune 500 clients, and the importance of building a trustworthy brand.
The hosts discuss the difficulties of scaling compute resources, GPU shortages, and the need for partnerships to meet demand.
Jason answers a live caller’s question about AI’s impact on billable hours in law firms and other professional services.
The episode explores the rise of microdramas, AI video pipelines, and the potential future of AI‑generated storytelling.
The hosts discuss the difficulties and grind of launching a comic book startup, highlighting the feast-or-famine nature of the industry.
Exploration of why investors prefer teams of two or three over solo founders, even with AI reducing workload.
Unblocking Underserved Industriesinsight
The guest explains that frontier labs shun critical use cases like cyber defense and biology research, creating an opportunity for obliterated models to unblock these professionals.
Inversion of Controlstrategy
The startup separates the unrestricted model layer from a software policy layer, allowing companies to set stricter or looser custom guardrails than native models provide.
Red Teaming Autonomous Agentsstory
An early success for the startup involves red-teaming company agents by modeling threat actors against them to prevent unauthorized actions like wire transfers.
Closing Gap with Frontier Modelsdata
The guest notes that open-source models like GLM are closing the capability gap with western frontier labs down to about three months.
Handling Self Harm Contentinsight
The guest and host discuss how platforms implement default policies to direct users toward help lines when encountering queries about self harm.
Why Solo Founders Struggledebate
The host argues that solo founders face immense difficulty because the simultaneous tasks of hiring, fundraising, and achieving product-market fit involve too much task switching.
“I always tell my team, like, just like, if you meet a founder, just say yes to meeting, just say yes to having Launch Festival, letting a bunch of founders come together.”
“We separate those two layers, right? We have the unrestricted model is one, one layer, right?”
“So you could have more stringent, uh, guardrails than, than were native, or you could have less in certain areas and stronger in certain areas.”
“I think humans move upstream and do more important work.”
“If you take this software and you do things in the world that aren't illegal, hacking or unethical, you can get sued.”
“Solo founders who are Mark Pincus, Elon Musk, you know, Evan Williams.”
“What would the point be?”
“So you will be able to raise money.”
This Week In Startups is made possible by: Every.io: http://every.io/ Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Odoo: http://Odoo.com/twist Plaud: http://Plaud.ai/twist Today’s show: What can AI do with the guardrails OFF? Devon Thomas of Abliteration.ai thinks defenders should have access to the same kinds of tools, rather than having one hand tied behind their backs. Then, on Ask Jason, learn what AI means for the billable hour from a legal-tech founder. PLUS, are AI microdramas a real ecosystem or a fad, and does AI finally make solo founders fundable? Guests: Devon Thomas on X: https://x.com/founderengineer Abliteration: https://abliteration.ai/ Relevant Links: Abliteration.ai on a16z speedrun — the accelerator Jason congratulated Devon on → https://speedrun.a16z.com/companies/abliteration TechCrunch: "Abliteration.ai is making a business out of removing AI guardrails" — the coverage behind the recent attention → https://techcrunch.com/2026/09/03/abliteration-ai-is-making-a-business-out-of-removing-ai-guardrails/ Abliteration.ai press page → https://abliteration.ai/press Anthropic Frontier Red Team: "GLM-5.3 and the spread of advanced cyber capabilities" — the blog Devon cited on how capable abliterated GLM-5.3 is → https://www.anthropic.com/research/glm-5-3-and-the-spread-of-advanced-cyber-capabilities CNBC: Trump's executive order renaming AI "super intelligence," signed the same day → https://www.cnbc.com/2026/09/29/trump-ai-super-intelligence.html Nextgov/FCW: OpenAI agents accessed Census and SEC data — detail on the dozens of organizations OpenAI notified → https://www.nextgov.com/cybersecurity/2026/09/openai-says-its-advanced-models-may-have-gone-after-government-websites/416250/ Financial Times: "AI wrecking ball fractures billable-hour fee model" Seedance 2.5 — ByteDance's video model Bruno asked about → https://technode.com/2026/07/31/bytedance-launches-seedance-2-5-video-generation-model/ Pixar / Toy Story — the CGI "Toy Story moment" Jason expects for AI video → https://en.wikipedia.org/wiki/Toy_Story Practi — Mathew's platform for helping law firms move from hourly billing to subscriptions → https://practi.ai/hello Timestamps: 0:00 What http://Abliteration.ai does, and who the frontier labs are shutting out 2:44 Plaud: If your work depends on conversations - interviews, meetings, calls - you need a Plaud NotePin S. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 2:56 Why defenders don't get the attackers' tools 4:16 "Inversion of control": letting customers set their own guardrails 6:47 Who's liable? The hammer analogy and the White House self-regulation pact 10:11 Every: For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io. 13:10 Why AI labs publicize their scariest hacks 18:52 Customers: from cyber startups to Fortune 500 CISOs 19:56 Northwest Registered Agent: Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! - Learn more at http://northwestregisteredagent.com/twistdomain 24:41 Chinese image and video models 27:20 Why most businesses still barely use AI 29:02 Ask Jason begins 29:24 Mathew Kerbis (Practi): What does AI do to the billable hour? 30:16 Odoo: The all-in-one business platform. Your first app is free! Get started today at https://Odoo.com/twist 32:45 Will subscriptions replace hourly billing? 37:27 Bruno Vilela: Are AI microdramas an ecosystem or a fad? 39:35 Lon's microdrama pitch to Snapchat and TikTok's PineDrama 48:09 Josh Ezell: Does AI change the bias against solo founders? 49:26 Jason's three-two-one framework and the risks founders must eliminate Subscribe to our newsletters on Substack: TWiST: https://twistartups.substack.com/ TWiAI: https://www.thisweekinai.ai/ TWiVC: https://thisweekinvc.substack.com/ Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com
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