
Written by a model from the transcript; not yet reviewed.
This episode covers two distinct frontier startups reshaping their respective industries through novel engineering approaches. In the first segment, Zach Hudson, CEO of Onton, demonstrates how a neurosymbolic AI search engine outperforms traditional LLMs by reasoning through aesthetic taste, multi-category e-commerce queries, and real-time learning without expensive retraining. Later in the episode, Ashi Disanayaka, co-founder and CEO of Spacium, explains how her team built zero-boil-off cryogenic fuel tanks and ultra-precise robotic actuators in-house to solve the critical bottleneck of in-space satellite refueling. Both founders discuss the mechanics of building lean, obsessed teams that iterate rapidly on complex physical and computational hardware.
Hosts open the show and present the episode’s sponsors before introducing the guest.
The host welcomes Zach Hudson and briefly explains Onton’s neurosymbolic AI search engine.
Zach demonstrates Onton’s real‑time, explainable search using mood boards and product images.
Comparison of strengths, trust, and cost between neurosymbolic models and LLMs.
Discussion of affiliate commissions, API launch, and scaling beyond e‑commerce.
Plans to add apparel, electronics, and broader search categories using Onton’s learning engine.
Hosts wrap up, highlight upcoming announcements, and encourage listeners to engage with sponsors and the guest’s platform.
A new segment introduces Spacium’s mission to provide in‑orbit fuel stations.
Details on cryogenic and storable fuels, zero boil‑off tanks, and launch vehicle dependencies.
Explanation of the actuator’s sub‑millimeter accuracy and its importance for safe docking.
Discussion on the need for a universal USB‑C style standard for in‑space refueling to simplify connections and reduce equipment.
Predicting a shift in spacecraft design within 3‑5 years as companies build around future refueling infrastructure.
Real-Time Learning Outperforms Giantsdata
The guest explains that their neurosymbolic search engine runs at 2.5 times the performance of major search companies while updating in real time at a fraction of the cost of frontier model training runs.
One-Shot Multi-Category Searchinsight
The guest demonstrates how the neurosymbolic model handles multi-category, multi-object e-commerce searches by understanding visual aesthetics and materials like organic burlwood and brass without human labeling.
Union of Logic and Intuitioninsight
The guest breaks down the architecture as a union of intuitive large language models acting like System One thinking and graph databases acting as a logical System Two.
Solving Cryogenic Boil-Offstory
The space startup founder details how her team cracked zero-boil-off technology during Y Combinator to safely store and transfer extremely cold cryogenic fuels like liquid oxygen in space.
Building a Record-Setting Actuatordata
The space founder shares that she and her co-founder built their first payload in just five months, producing the most precise robotic actuator ever tested in orbit.
Upcoming Orbital Xenon Transfersdata
The guest reveals exclusive details about upcoming missions within the next year to transfer Xenon fuel in orbit and test free-flying docking maneuvers.
Multi-Billion Dollar Pipelinedata
The space startup founder reports that her company has secured close to 100 million dollars in commercial contracts and over two billion dollars in letters of intent.
“When you need to remove hallucination and you need trust, you need to be able to see inside the model.”
“And a little bit of, a little bit of background about Onton.”
“The thing that I want to call out here is that it's learning in real time.”
“And the performance of it is already 2.5x greater than some of the largest search companies in the world.”
“Space industry will benefit life on earth. So once people understand that, people will pay more attention.”
“I think a lot of people started giving more attention to the space industry after SpaceX IPO. They're like, oh, space industry.”
This Week In Startups is made possible by: Vanta https://www.vanta.com/twist Agree https://agree.com YSecurity https://YSecurity.io/TWIST Today's show: Frontier AI models can ace PhD-level exams, but it's still bad at tracking down the product you want in the style that suits you. Onton's Zach Hudson tell us that the problem is that models are a black box. His solution? A neurosymbolic model, Ontology 1, that learns about your taste and preferred aesthetic over time, then produces product searches tailored specifically to you, rather than just using keywords and relevant tags. How do neurosymbolic models work, and how does Onton understand your prompts and favorite design trends? And why aren't the frontier labs working on neurosymbolic models of their own? Zach joins Jason and Lon to discuss. PLUS, following a record-smashing SpaceX IPO, Ashi Dissanayake of Spacium makes the case that the real bottleneck in space isn't launching rockets off the ground any more. It's refueling in orbit. Guests Zach Hudson on X: ****https://x.com/nosduhz Onton: https://onton.com/ Spacium: https://spaceium.com/ Spacium on X: https://x.com/SpaceiumInc Relevant Links Poolside's journey to AGI: https://poolside.ai/vision/purpose Startup Archive: Sam Altman on the Paul Graham advice that saved OpenAI: https://www.startuparchive.org/p/sam-altman-on-the-paul-graham-advice-that-saved-open-ai-always-make-an-api Kelly Wearstler: https://www.kellywearstler.com/ Ennis House: https://franklloydwright.org/site/ennis-house/ Los Feliz Living: Ennis House profile: https://www.losfelizliving.com/los-feliz-historic-homes/ennis-house-los-feliz-hcm-149 Indiewire: Ennis-inspired "The Studio" offices: https://www.indiewire.com/features/craft/the-studio-production-design-interview-seth-rogen-1235114365/ Monocle Magazine: https://monocle.com/ Spaceium on Y Combinator: https://www.ycombinator.com/companies/spaceium-inc Orbit Fab's RAFTI: https://www.orbitfab.com/rafti/ James Webb Space Telescope: https://science.nasa.gov/mission/webb/ Houzz: https://www.houzz.com/ Timestamps: 0:00 Zach Hudson joins: What is "neurosymbolic search" 4:03 Ontology 1 isn't a black box 6:31 Who is using Onton? 9:36 Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist 11:35 Could neurosymbolic models reach AGI? 13:19 Jason loves Wright's Ennis House 17:03 The shape of AI companies is changing 19:28 Agree.com - Stop chasing invoices and automate your entire contract-to-cash stack. Go to https://agree.com and tell them Jason sent you to get 50% off for life! 22:32 UGC as a data moat 26:03 The Dead Internet Theory 28:13 Ashi Dissanayake of Spacium joins 29:52 YSecurity - The on-demand security team for startups. Need enterprise-grade security without hiring a $400k CISO? YSecurity gives you 40+ expert engineers, matched to exactly what you need, by the hour, with your first six hours completely free. Go to https://YSecurity.io/TWIST 31:50 Storables vs. cryogenics: the zero-boil-off breakthrough 34:11 All kinds of propulsion requires refueling 36:09 Getting more value from LEO to GEO 38:28 Moving at rocket speed 44:54 Why demand is so acute 49:37 The investing climate for space, post-SpaceX Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason's suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com
10,550 words · 6 speakers
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