
Hosted by Jason Calacanis
Written by a model from the transcript; not yet reviewed.
A panel of venture capitalists discusses the political and economic landscape following an unexpected election result that established a split government. The conversation explores the challenges facing data centers, autonomous vehicles, and artificial intelligence, focusing on the tension between technological progress and the economic anxieties of everyday workers. They also examine structural shifts within the venture capital industry, including Sequoia Capital's recent operational changes, the rise of capital-efficient alicorns, and the increasing convergence of private markets with public trading behaviors and decentralized financial instruments.
Jason Calacanis opens the episode, introduces guests and sponsors, and sets the stage for the discussion.
Ilana Gold explains Two Roads Capital’s syndicate model and investment focus across AI and hardware sectors.
Tomasz Wallach discusses Theory Ventures’ second fund, seed and Series A investments, and target industries.
The hosts debate how a divided U.S. Congress affects data centers, AI policy, and startup funding.
Discussion on how AI can improve everyday life, build trust, and shift public perception of technology.
Jason discusses SpaceX’s new Colossus 2 launch and how engineers are moving to Elon Web Services for higher payouts.
Jason explains Sequoia’s closure of its London office, ARC accelerator, and merging of early and growth funds into a single entity.
Panelists debate how Sequoia’s streamlining reflects broader shifts toward mega‑funds and the diminishing role of scout programs.
Jason and guests discuss the rise of alicorns—profitable, AI‑native startups that skip traditional funding rounds.
Panelists explore how accreditation rules limit average investors’ access to venture capital and propose more inclusive models.
The conversation turns to secondary buying, uncapped investment terms, and the emerging boiler‑room trading culture.
Jason introduces Hyperliquid and tokenized markets, highlighting how they could democratize access to private company valuations.
Election Results and Split Governmentinsight
The hosts and guests analyze the unexpected blue wave that created a split government. They debate whether a do-nothing Congress will calm the markets by eliminating policy chaos.
Data Center Power Constraintsinsight
The panel discusses the political backlash against data centers while emphasizing that underlying power shortages will persist. Startups must therefore adapt by creating more energy-efficient hardware.
Intergenerational Wealth and Anxietyinsight
A speaker highlights a growing intergenerational divide where older generations benefit from equities while younger workers face economic displacement and rising costs.
The Rise of Local AI Inferencedata
The discussion turns to local AI execution, noting that studies show the vast majority of non-coder tasks can run locally on personal hardware.
The Rise of Alicornsinsight
The panel explores how modern AI-native companies can reach profitability with tiny teams, allowing them to bypass traditional venture capital fundraising.
Private Markets and Derivativesinsight
The group discusses the emergence of synthetic and prediction-based trading instruments that allow market participants to gain exposure to private companies and non-traditional assets.
“We want this vacillation between the parties. We don't want a monarchy.”
“And that's good, you know, that's good for business.”
“I think one of the biggest narratives are happening right now is people are saying, okay, like, no more build-out of data centers.”
“True, found 56% of voters called AI and data centers a crucial or major factor in their vote.”
“If you invest in SpaceX at the Series B price, your fund would have done great.”
“I think it's complexity. It's obviously sad for me, because I was literally the first one.”
“I think what they need to do is get rid of the concept of accredited investors.”
“The average person should be able to hold private equity in their 401K account, should be able to hold private credit in their 401K account.”
This Week In Startups is made possible by: Every: https://every.io/ Vanta: https://www.vanta.com/twist G2i: http://G2i.co/twist Plaud: https://Plaud.ai/twist Fintrx: https://www.fintrx.com/ Today’s show: Democrats took the House and Senate, and overnight trading suggested a huge market drop. But in the morning, the markets went another way, and D. A. Wallach thinks he knows why. A Congress that can’t get anything done can’t do anything BAD, like start a war or a tariff fight. The only thing markets hate than gridlock is uncertainty. On the first post-midterm This Week in VC roundtable, Jason is joined by Wallach (Time BioVentures), Elana Gold (Two Roads Capital), and Tomasz Tunguz (Theory Ventures). Together, they work out what a split government could mean for tech and venture. Data centers are now a political target for both parties. 2027 might be the last major window for big M&A. Plus, D. A. worries that an intergenerational war could be brewing, between the people who own AI’s upside, and the young workers who fear getting replaced. Plus thoughts on Cava’s 22% layoffs, Sequoia shutting down its Scouts and Arc program, the SPV “boiler room,” and more. Guests D. A. Wallach on X: https://x.com/dawallach Time BioVentures: https://www.timebioventures.com/ Elana Gold on X: https://x.com/ItsElanaGold Two Roads Capital: https://tworoads.vc/ Tomasz Tunguz on X: https://x.com/ttunguz Theory Ventures: https://theoryvc.com/ Relevant Links: NBC exit poll: 56% say AI and data centers were a crucial or major factor (DCD): https://www.datacenterdynamics.com/en/news/nbc-exit-poll-56-say-ai-data-centers-were-a-crucial-or-major-factor-in-congressional-vote-decision/ How AI backlash shaped the 2026 midterms (TIME): https://time.com/article/2026/11/04/midterm-elections-results-ai-industry-data-centers/ Musk on chips outrunning electricity in 2026, with Elon's reply: https://x.com/elonmusk/status/2117649850644705591 Panthalassa raises $140M for wave-powered AI compute at sea (Tom's Hardware): https://tomshardware.com/tech-industry/artificial-intelligence/palantir-co-founder-peter-thiel-backs-usd140m-wave-powered-ai-data-center-startup-panthalassa-aims-to-run-offshore-compute-nodes-using-ocean-energy Marvell to buy Lumentum in a $115B deal (The Next Web): https://thenextweb.com/news/marvell-lumentum-acquisition-115bn-all-stock San Francisco mourns bodega cat killed by a Waymo (CBS SF): https://www.cbsnews.com/sanfrancisco/news/sf-mission-district-mourns-store-cat-killed-by-waymo Meta launches $115M program to train workers for data center jobs (Axios): https://www.axios.com/2026/06/08/meta-data-center-workforce-academy-job-guarantee Keep track of the value you're getting from AI (TWiST): https://twistartups.substack.com/p/keep-track-of-the-value-youre-getting-da4 Meta's Muse hits 10.9M downloads (Yahoo Finance): https://finance.yahoo.com/markets/article/metas-muse-ai-agent-hits-109-million-downloads-as-chatgpt-slides-25-153532560.html Curbie (Revere Robotics): https://www.revererobotics.com/ Canva lays off over 1,200 people amid slowing growth (TechCrunch): https://techcrunch.com/2026/11/04/canva-lays-off-over-1200-people-amid-slowing-growth/ Ollama raises $65M as it nears 9M developers (Startup Fortune): https://startupfortune.com/ollama-raises-65-million-as-it-grows-to-nearly-9-million-developers/ Sequoia hits rewind, undoing 20 years of expansion (TechCrunch): https://techcrunch.com/2026/11/04/sequoia-hits-rewind-undoing-20-years-of-expansion/ "The Sequoia of Tomorrow" (Sequoia): https://x.com/sequoia/status/2117961312143855764 Travis Kalanick's Atoms raises $1.7B (TechCrunch): https://techcrunch.com/2026/07/22/travis-kalanicks-robotics-company-raises-1-7b-led-by-a16z/ Vast: https://www.vastspace.com SEC accredited investor exam could expand private-market access (CNBC): https://www.cnbc.com/2026/10/01/sec-accredited-investor-exam-private-markets.html General Compute raises a $100M Series A (DCD): https://datacenterdynamics.com/en/news/neocloud-general-compute-raises-100m-in-series-a-funding-round Hyperliquid CEO Jeff Yan on democratizing pre-IPO access (Motley Fool): https://www.fool.com/investing/2026/10/19/hyperliquid-ceo-jeff-yan-says-perpetual-futures-ma/ Kalshi Perps: https://kalshi.com/perps Aalo Atomics: https://www.aalo.com Exowatt: https://www.exowatt.com Timestamps: 0:00 The Blue Wave: Dems take Congress 0:10 Plaud: If your work depends on conversations - interviews, meetings, calls - you need a Plaud NotePin S. You can check it out at https://plaud.ai/twist and use code TWIST for 10% off! 6:42 What a split gov’t means for defense tech 9:21 Is 2027 the last big window for tech M&A? 11:04 Every.io: For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io. 13:44 Are anti-robotaxi laws coming? 18:51 The need for positive AI stories 24:12 Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist 25:59 How AI can make voters smarter 31:22 Self-driving and the future of car insurance 40:17 G2i has been recruiting software engineers for over a decade. Go to https://g2i.co/twist to find out how G2i vets engineers, and can help you hire them in days, not weeks. 45:00 Jason’s $12K Mac Studio 50:12 Sequoia retires its Scouts and Arc programs 58:21 Jason’s barbell: Zipline, Atoms, and Vast 1:01:19 When VC firms go public 1:08:42 Scrap the accredited investor rule 1:14:26 Hyperliquid and permissionless synthetic markets 1:17:17 Kalshi perps and Anthropic price discovery Subscribe to our newsletters on Substack: TWiST: https://twistartups.substack.com/ TWiAI: https://www.thisweekinai.ai/ TWiVC: https://thisweekinvc.substack.com/ Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com
15,940 words · 5 speakers
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