
Written by a model from the transcript; not yet reviewed.
This episode explores the absolute lower limit of human sensation by examining what the smallest measurable thing is that a person can feel, hear, taste, smell, or see. The host and the guest walk through each of the major senses, discarding internet infographics with unsourced claims about candle flames thirty miles away and instead digging into actual scientific thresholds, from the trillions of molecules needed to trigger sound to the millions of molecules required to register scent. They investigate remarkable extremes like lugdaname, a sweetener detectable in millions of gallons of water, and examine how cosmic rays and single photons interact with our cells.
Throughout the discussion, the host and the guest debate what counts as true sensory detection versus bypassing our sense organs entirely, touching on phenomena like mirror-molecule enantiomers and the resting state of retinal rod cells. What makes the episode worth listening to is the rigorous breakdown of physical scales, comparing thresholds across senses to ultimately arrive at the astonishing conclusion that a single photon of light is enough for the human eye and brain to register that something happened, even at a non-conscious level.
Michael and Hannah introduce the episode’s central question: what is the smallest thing you can feel, and set the stage for a deep dive into human sensation.
A brief digression about ancient foot bone cancer research illustrates how deep-rooted biology is, segueing back into the sensory exploration.
The hosts debate the value of extreme minimalism versus maximalism in sensory experiences.
The hosts reflect on how much energy and resources go into producing a podcast, joking about excess.
One host proposes a new podcast concept while acknowledging the current show's extravagance.
An advertisement for Milo's Rewards credit card and special offers at Lowe's.
Unreliable Sensation Infographics Onlineinsight
The host points out that popular internet infographics claiming absolute sensory thresholds—such as hearing a watch tick from twenty feet away—frequently lack any valid scientific sourcing.
Lugdaname Sweetness Extremedata
The host describes lugdaname, an artificial sweetener engineered to cover all available sweet receptors on a cell, making it so potent that a fraction of a teaspoon can be detected across hundreds of thousands of gallons of water.
Sieve-Like Skull Anatomy for Smellinsight
The guest and host examine anatomical models to explain how olfactory nerves pass directly from the brain through tiny holes in the ethmoid bone of the skull to sample odors.
Mirror-Image Molecules and Scentinsight
The guest explains enantiomers, where two molecules with identical bonds arranged as mirror images smell completely different, such as spearmint versus caraway seeds.
How Rod Cells Process Lightinsight
The host reveals the counter-intuitive mechanism of retinal rod cells, which are constantly firing in the dark and actually go quiet and become depolarized when light hits them.
Sub-Conscious Detection of Single Photonsdata
The hosts discuss experiments where subjects cannot consciously see a single photon shot at their eye, yet perform better than chance when asked if something happened.
“The quietest thing we can hear, they say, is the ticking of a watch 20 feet away in an otherwise silent environment.”
“A wing of a fly falling on your cheek from a height of 7.6 centimeters.”
“We can smell this at a level of 0.3 parts per trillion.”
“I accept. I accept your answer and now have a new life's mission to have that experience, the most minimal experience possible.”
“Movies? I don't watch movies. No, that's maximalism. For me, just a single photon shot at my eye, more than half the time I'll know it happened. That's enough for me.”
“Yeah, exactly. So, I don't think there's any way we're going to beat an individual photon.”
“We move trillions upon quadrillions upon bazillions of molecules around for your enjoyment and pleasure.”
“Just, I mean, 1 is enough. 5 to 9 is more than enough.”
What is the smallest thing you can possibly feel? Michael Stevens and Professor Hannah Fry journey through varying levels of perception, from the faintest touch on skin to the faintest trace of flavour and odour, and on to the remarkable question of whether the eye can register a single particle of light. This is an exploration of human senses at their most sensitive, blending physics and neuroscience with everyday experience to reveal where our biology draws the line between nothing and something, and what about emotion... how do we feel those? What is the smallest thing you can possibly feel? Michael Stevens and Professor Hannah Fry journey through varying levels of perception, from the faintest touch on skin to the faintest trace of flavour and odour, and on to the remarkable question of whether the eye can register a single particle of light. This is an exploration of human senses at their most sensitive, blending physics and neuroscience with everyday experience to reveal where our biology draws the line between nothing and something, and what about emotion... how do we feel those? Darwin's The Expression Of The Emotions In Man And Animals. Lisa Feldman Barrett - How Emotions Are Made: The Secret Life of the Brain. ------------------- For more information about Cancer Research UK, their research, breakthroughs and how you can support them, visit https://cancerresearchuk.org/restisscience Cancer Research UK is a registered charity in England and Wales (1089464), Scotland (SC041666), the Isle of Man (1103) and Jersey (247). A company limited by guarantee. Registered company in England and Wales (4325234) and the Isle of Man (5713F). Registered address: 2 Redman Place, London, E20 1JQ. ------------------- Find The Rest Is Science all over the internet by clicking here. ------------------- Video Producer: Adam Thornton + Oli Oakley + Jack MeekAnimator: Sam BensonVideo & Social: Bex TyrrellAssistant Producer: Lucy LipscombeProducer: Simona RataSenior Producer: Lauren Armstrong-CarterChief Digital Officer: Samuel OakleyExec Producer: Neil Fearn Learn more about your ad choices. Visit podcastchoices.com/adchoices
9,500 words · 9 speakers
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