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Zoë Foster Blake - Perimenopause, ADHD & Everything That Helped with Dr Fatima Khan

The Imperfects

1h 30m
Transcript

Original podcast

Summary

Written by a model from the transcript; not yet reviewed.

This episode features author and entrepreneur Zoe Foster Blake joining the hosts alongside perimenopause and menopause specialist Dr. Fatima Khan to discuss the realities of perimenopause, the biological changes behind it, and its intersection with mental health and ADHD. The conversation covers how declining progesterone and erratic estrogen spikes can trigger severe anxiety, rage, sleep disruption, and brain fog in women during their late thirties and forties, often leading to misdiagnosis or unnecessary prescriptions. The guests examine why high-achieving women frequently experience an unmasking of ADHD or a resurgence of past trauma during this transition, emphasizing the need for proper medical understanding, hormone replacement therapy, and self-compassion.

  • Perimenopause typically starts five to seven years before the final menstrual period, often in a woman's late thirties or early forties, and begins in the brain rather than with hot flashes. 0:21
  • The early decline of progesterone removes the body's natural tranquilizer, directly contributing to increased anxiety, sleep disturbances, and feelings of overwhelm. 11:44
  • Many women experience an unmasking of ADHD during perimenopause as fluctuating hormones compromise the brain's buffering systems and worsen executive dysfunction. 30:41
  • When standard medical treatments and hormones fail to resolve persistent hypervigilance and anxiety, addressing unhealed trauma through therapy like EMDR can be essential. 54:47

Chapters

  1. 0:00
    Podcast Intro and Host Setup

    The hosts introduce the episode, explain the special guest host arrangement, and set the stage for a discussion on perimenopause.

  2. 6:48
    Defining Perimenopause vs Menopause

    Dr. Fatima Khan explains the difference between perimenopause and menopause, highlighting early symptoms and the brain‑centric onset.

  3. 8:00
    Practical Tools: Questionnaires and Conversation Scripts

    Dr. Khan introduces the MenOD questionnaire and ready‑made scripts to help patients discuss perimenopause with their doctors.

  4. 11:17
    Hormonal Mechanisms Behind Mood and Sleep

    Dr. Khan details how declining progesterone and fluctuating estrogen lead to sleep disturbances, anxiety, and brain fog.

  5. 12:00
    Post‑natal Transition and Overlap with Perimenopause

    Dr. Khan explains how late‑childbearing and breastfeeding can blur the line between postpartum depression and perimenopause.

  6. 36:41
    Misdiagnosis and the Need for Hormone‑Informed Care

    The conversation covers how GPs often misattribute symptoms to stress, the importance of early HRT, and finding menopause‑informed doctors.

  7. 43:38
    Broader Health Impacts: Musculoskeletal, Metabolic, and Sexual Health

    The hosts explore how perimenopause affects joints, weight, and sexual function, and the emerging concept of a multi‑organ syndrome.

  8. 46:53
    Unmasking ADHD and Mental Health Vulnerability

    The discussion turns to how hormonal changes can reveal ADHD symptoms and the importance of multidisciplinary care.

  9. 48:03
    Closing Reflections and Call to Action

    The episode wraps up with personal reflections, encouragement to seek help, and a reminder to subscribe for more content.

  10. 49:10
    Personal ADHD Diagnosis Journey

    Zoe recounts discovering her ADHD, the challenges of juggling responsibilities, and the relief of finally being diagnosed.

  11. 50:51
    Men’s Role and Support Strategies

    Offers practical advice for partners on how to recognize symptoms, communicate compassionately, and seek professional help together.

  12. 53:45
    Trauma‑Informed Care for Perimenopausal Women

    Discusses the role of EMDR and trauma therapy alongside hormone and stimulant treatments to address hypervigilance and mood swings.

Highlights

  • 7:11

    What Is Perimenopauseinsight

    Perimenopause is not menopause and typically begins in the late thirties or early forties, presenting primarily with anxiety, overwhelm, sleep issues, and brain fog rather than hot flashes.

  • 11:38

    The Role of Progesteroneinsight

    Progesterone acts as the body's natural tranquilizer by stimulating GABA receptors in the brain. Its early decline during perimenopause directly impairs sleep and ramps up anxiety.

  • 13:21

    Volcanic Rage and Hormone Spikesinsight

    Instead of a steady cycle, the brain overproduces estrogen erratically during perimenopause, causing massive spikes and crashes that lead to sudden, uncontrolled bouts of rage.

  • 15:35

    A Window of Vulnerabilitydata

    Women aged forty to forty-five face a distinct window of vulnerability where they are two to four times more likely to experience a first-onset of anxiety and depression without prior history.

  • 20:22

    The Limitations of Antidepressantsinsight

    A Royal College of Psychiatrists position statement notes that midlife mental health shifts do not always respond to antidepressants, because such medications fail to treat the underlying hormonal root cause.

  • 30:41

    Unmasking ADHD in Midlifeinsight

    High-functioning women often find their coping mechanisms fail during perimenopause as estrogen drops, leading to the unmasking of previously undiagnosed ADHD and executive dysfunction.

  • 54:47

    Reactivating Past Traumainsight

    When fluctuating hormones remove the calming effects of progesterone, the brain's panic response can reactivate unresolved past trauma, causing persistent hypervigilance that requires trauma-informed therapy.

Quotes

  • “Perimenopause is not menopause because it typically starts five to seven years before your last menstrual period and it starts in the brain, typically late 30s to early 40s.”
    Unnamed speaker · 0:21
  • “If you try and connect the dot, it makes sense that if you're losing that progesterone, you're not gonna have good sleep.”
    Unnamed speaker · 12:02
  • “Women are two to four times more likely to develop first onset of anxiety and depression without previous history.”
    Unnamed speaker · 15:39
  • “We need to use more validated questionnaires like MenOD, which is a specific questionnaire for screening for mental health in women transitioning to perimenopause and menopause, developed from a Monash group here in Melbourne.”
    Unnamed speaker · 20:40
  • “Suddenly they're just finding they can't find the words, they're losing train of thought.”
    Unnamed speaker · 48:07
  • “And so we add in a little bit of estrogen to stabilize it.”
    Unnamed speaker · 48:21
  • “They're losing hundred and fifty thousand dollars of earnings a year.”
    Unnamed speaker · 58:10
  • My Imperfect email 1:28:11–1:30:00

About this episode

This is not your mother’s perimenopause. 💌 To join our journaling club, subscribe to my imperfect email - https://www.theimperfects.com.au/sign-up-to-our-newsletter/ Joined by guest host Zoë Foster Blake, and Dr Fatima Khan, we’re diving head first into perimenopause: the what, the why, and the how-the-f**k to deal with it. Typically beginning in your late 30’s, and in your brain of all places, perimenopause symptoms include heightened anxiety, irritability, sleep disturbances, brain fog … all things that make you feel further and further away from your best self. Beginning 5 -7 years BEFORE your last menstrual period, perimenopause can coincide with postpartum, the most important presentation of your career to date, and the uncovering of neurodivergence, which may have been painstakingly masked until this shift in hormones. With the expertise of Dr Fatima, and the lived experience of Zoë, we hope this episode makes you feel seen, less alone, and ready to have THAT conversation with your GP. Chapters 00:00:00 The Truth of Perimenopause [TRAILER] 00:01:09 The Meet Cute of Zoe Foster Blake and Dr Fatima Khan 00:06:55 Is this Perimenopause? Early Signs + Symptoms 00:07:41 Zoe’s Perimenopause Journey: No Sleep, Anxiety, Rage, Repeat. 00:09:56 Volcanic Rage, Explained 00:14:59 What Doctor’s Miss: Misdiagnosis + Antidepressants 00:15:57 Why Your Husband Is Breathing Too Loud 00:20:18 Perimenopause Mental Health Screening 00:21:25 Debunking the “You’re Too Young” Myth 00:23:43 Is it Anxiety? Depression? Perimenopause? 00:25:26 The Pill, The Mirena + The Modern Woman in Peri 00:30:44 Loosing Yourself in Peri: Brain Fog + Dementia Fears 00:32:10 The Importance of Testosterone 00:36:00 HRT Myths: Re-educating a generation 00:39:04 A Script for a Script: What to say to your GP 00:41:12 Perimenopause Is a Multi-Organ Syndrome 00:46:09 High Achieving Women + Peri = Shame 00:46:47 When Perimenopause Unmasks Your ADHD 00:54:26 Trauma Reactivation in Perimenopause 00:57:17 Pills + Skills: Why HRT Alone Isn’t Enough 00:58:41 The Longevity of It All 01:00:30 Nutrition 📚Things to read Group Chat, by Zoë Foster Blake - https://bit.ly/4efqR70 Hormone Health is Mental Health, by Dr Fatima Khan - https://bit.ly/4j6G2Ts 💻Things to check out Australasian Menopause Society - menopause.org.au Meno-D questionnaire - https://bit.ly/3Toj3sN Zela Wellbeing - https://bit.ly/4ARGFXu 🎧Imperfects episodes for MORE on hormones Zoë Foster Blake - Zero Lucks Given - https://bit.ly/4y8xwHx Dr Louise Newson - Maybe it’s Menopause - https://bit.ly/4i7xM3F Dr Louise Newson - It’s Hormones. Period. - https://bit.ly/47ya9w2 🩷To host your own Vulnerabilitea House, purchase here - theimperfects.com.au/shop 🩵To purchase our journal (or your novel) My Imperfect Life, click here - theimperfects.com.au/shop 🩵To join our subscriber community, A Little More Imperfects, follow this link - patreon.com/theimperfects 🩷 AND you can subscribe to A Little More Imperfects through Apple Podcasts http://apple.co/theimperfects The Imperfects is not a licensed mental health service and is not a substitute for professional mental health advice, treatment or assessment. The advice given in this episode is general in nature, but if you’re struggling, please see a healthcare professional, or call lifeline on 13 11 14.

Transcript

0:00
1:30:09

16,938 words · 6 speakers

Topics

  • perimenopause
  • menopause
  • HRT
  • ADHD
  • estrogen
  • progesterone
  • Australia
  • EMDR
  • heart disease
  • Lifeline 131114

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