Hosted by Molly O'Shea
Written by a model from the transcript; not yet reviewed.
This episode features venture capital investor Annie Lamont discussing her four-decade career managing $14 billion across healthcare, fintech, and technology, along with her firm Oak HCFT's evolution. The conversation examines the transformative impact of artificial intelligence on life sciences, drug discovery, and healthcare administrative efficiency, noting how companies like Devoted Health and Chai Discovery are redefining their respective industries. Lamont also shares insights on evaluating elite entrepreneurs, navigating geopolitical threats in biotech, and the evolving landscape of mergers and acquisitions in the AI era.
The host welcomes listeners and introduces the episode’s focus on Annie Lamont’s investment career.
Discussion on when legacy healthcare institutions will feel the pressure from AI-driven changes.
Lamont explains how Oaks HCFT has grown, its investment focus, and check size strategy.
Lamont discusses China’s growing influence in drug development and the strategic implications for the U.S.
The conversation shifts to how mergers and acquisitions are evolving in the healthcare sector amid AI adoption.
Lamont outlines the fund’s capital allocation, early vs. late stage focus, and founder-friendly approach.
Lamont highlights newer portfolio companies, their AI-driven models, and their potential impact.
Lamont explains how Oak sometimes builds or acquires companies, the process, and the importance of retaining talent.
The host welcomes listeners and introduces the episode’s focus on Annie Lamont’s investment career.
Annie reflects on how AI accelerates learning and how this fuels her engagement with startups.
Annie shares key mentors and partners who have motivated her throughout her investing journey.
Annie highlights the collaborative dynamic with her partner Andrew Adams and its impact on her work.
AI Transformative Impact on Healthcareinsight
The guest explains how Devoted Health has tripled in size and halved its operating ratio by integrating AI alongside primary care and health insurance ownership.
China's Threat in Life Sciencesdebate
The discussion highlights how China's research output and patent generation pose an existential threat to the American pharmaceutical and biotech industries.
Administrative Burden in Healthcaredata
Administrative costs consume twenty-five to thirty percent of all healthcare spending, a massive inefficiency that AI tools are beginning to alleviate for clinicians.
Repeat Founders and Palliative Carestory
The guest shares the story of backing repeat founder Brad Smith across three successful companies, including the creation of Carebridge to lower healthcare costs.
Lifecycle Investing and Check Sizesstrategy
Oak HCFT scales its fund sizes to match market opportunities, writing checks from one million up to committing one hundred million dollars from day one.
Supply Chain Orchestration with Augurstory
The guest describes investing in Augur, founded by former Amazon executives, which deploys AI agents to execute operational decisions across enterprise supply chains.
“In my over 30 years of investing, there has nothing been as interesting as this or seminal in terms of just realigning the entire economy.”
“We have invested in supply chain in the past. You know, we've invested in, you know, risk and cyber and fraud.”
“I think no fundamental tension because we have invested over time in horizontal platforms that apply to healthcare and fintech.”
“The thing that always excites me and that I always look forward to in this job is just meeting the next great entrepreneur.”
“And then, you know, what, what's amazing about meeting with entrepreneurs, and this is why they're entrepreneurs and we're the investors, is they're dreaming up this next new company.”
“And had been a manager himself and he said, he said to me, and it's always great when people are direct and honest, you are not, the bar for your entrepreneurs is not high enough.”
Annie Lamont is Co-Founder and Managing Partner of Oak HC/FT, the healthcare and fintech investment firm she built with Andrew Adams. Across 40+ years she has managed $14B, backed 70+ successful exits and 15 IPOs, and been named the top healthcare investor on the Forbes Midas List multiple times. Her portfolio includes athenahealth, Devoted Health, One Medical, CareBridge, VillageMD, Main Street Health, Komodo Health, and Chai Discovery. Recorded at the New York Stock Exchange, the conversation covers China taking 50% of pharma's outside research dollars, clinical trial reform at the FDA, and Chai Discovery's roadmap from antibodies to peptides to small molecules. Lamont also explains how AI can cut the 25% to 30% of healthcare costs that are administrative. On the investing side, she walks through backing repeat founders Todd Park and Brad Smith, CareBridge's acquisition by Elevance, Oak's $1M to $100M check sizes across a $2B fund, and newer portfolio companies Halluminate and Auger. The episode closes with the Brex Performance segment on mentors. "I just think you've got 10% of the world that's worth it & 90% that's not." We cover: › Why AI drug discovery changed in the last 2 years › China's rise in life sciences › Devoted Health tripling in size and halving its operating ratio › Why only 10% of AI companies justify their valuations › Auger and Dave Clark's $100M AI supply chain build Annie Lamont: https://x.com/annielamont Molly O’Shea: https://x.com/MollySOShea Sourcery: https://x.com/sourceryy 𝐄𝐏𝐈𝐒𝐎𝐃𝐄 𝐋𝐈𝐍𝐊 YouTube: https://youtu.be/sjd_G6-k930 https://youtu.be/sjd_G6-k930 𝐒𝐏𝐎𝐍𝐒𝐎𝐑𝐒 • Brex https://brex.com/sourcery—The modern finance platform, combining the world’s smartest corporate card with integrated expense management, banking, bill pay, & travel. https://brex.com/sourcery • Zone https://zonefrontier.com/—develops next-generation data center campuses, partnering with AI companies, site developers and technology leaders to bring compute online faster and at scale. Visit: https://zonefrontier.com https://zonefrontier.com/ • Turing https://turing.com/sourcery—Turing delivers top-tier talent, data, and tools to help AI labs improve model performance—and enables enterprises to turn those models into powerful, production-ready systems. https://turing.com/sourcery • VCX https://fundrise.com/vcx—VCX is the public ticker for private tech, allowing investors of all sizes to invest in venture capital. View The Portfolio at http://GetVCX.com http://getvcx.com • Deel https://www.deel.com/sourcery—Deel is the global people platform that helps startups hire, manage, pay, and equip anyone, anywhere. Trusted by more than 35,000 fast-growing companies, Deel is the people platform that just works, so teams can scale without the chaos. Visit: https://www.deel.com/sourcery • Public http://public.com/sourcery–Investing platform Public just launched Generated Assets https://public.com/generated-asset, which lets you turn any idea into an investable index with AI. With Generated Assets, you can build, backtest, refine, and invest in any thesis with AI. Gone are the days of one-size-fits-all ETFs. https://public.com/sourcery Follow Sourcery for the latest updates! https://www.sourcery.vc https://www.sourcery.vc/ Disclosure Paid Endorsement. Brokerage services by Open to the Public Investing Inc, member FINRA & SIPC. Advisory services by Public Advisors LLC, SEC-registered adviser. Crypto trading provided by Zero Hash LLC, licensed by the NYSDFS. Generated Assets is an interactive analysis tool by Public Advisors. Output is for informational purposes only and is not an investment recommendation or advice. See disclosures at public.com/disclosures/ga. Matched funds must remain in your account for at least 5 years. Match rate and other terms are subject to change at any time. 𝐓𝐈𝐌𝐄𝐒𝐓𝐀𝐌𝐏𝐒 (00:00) Annie Lamont, Co-Founder & MP at Oak HC/FT (00:56) How AI reshaped the line between Healthcare and Fintech (08:35) The China threat to American drug development (17:03) Are Hospitals actually at risk from AI? (23:26) How AI will transform your healthcare experience (32:58) How M&A is changing in Healthcare (58:49) What's kept Annie Lamont going for four decades
9,855 words · 2 speakers
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