"Andrew Huberman"

What’s up, Doc: it’s the one-and-only Andrew Huberman. Gila monsters, flabby-brain, bed vs. battle, the art of winking, and a multitude of other pearls of wisdom await. Prepare to be glutathione’d to your headphones… on an all-new SmartLess.

Speaker names marked ? are inferred from speaking time and the show’s known hosts — they are not voice-verified.

• 0:00Sean Hayes?

  This episode of Smartless is sponsored by Google Book. So the other day, I wanted to make invitations for my dog Ricky's birthday party. And I've got three things open on my laptop. An adorable photo of Ricky, a picture of a birthday cake, and the RSVP details. Thing is, as much as I look like one, I'm not a canine birthday party invitation designer. That's where Google Book comes in. It's a whole new kind of laptop with a feature called Magic Pointer. I just click the photos and different elements on my screen, and boom, Magic Pointer designs a customized birthday party invitation for Ricky. Click anything on your screen to create whatever you want. Visit googlebook.com. Available to 18-plus users.

• 0:44Sean Hayes?

  Compatibility and availability vary.

• 0:49Jason Bateman?

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• 1:29Sean Hayes?

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• 2:06Sean Hayes?

  Ready for a college degree, but your dog is giving you the side eye while silently judging your life choices? You need to check out Southern New Hampshire University. Their online programs make it possible to earn your degree without sacrificing sleep, sanity, or Scooby snacks. And there's real support from actual humans, if you want that. So you can focus on what matters most: your dog. No, your future. Get the degree your dog approves of. Apply today at SNHU.edu/smartless.

• 2:43Sean Hayes?

  Hey.

• 2:44Will Arnett?

  Hey, Sean, I do wanna, I wanna get into this. I know we gotta do a cold open for the show, but I got, I'm flying to New York today, so I gotta.

• 2:49Sean Hayes?

  Why are you going, why are you coming here?

• 2:50Will Arnett?

  I gotta go take care of some stuff, and I just don't, I mean, I'm not trying to be vague about it, but I know, I just gotta do some stuff. I gotta, I gotta go to New York, I gotta go. I gotta, I gotta come evict you from your apartment!

• 3:03Will Arnett?

  Okay? Are you happy? Welcome to Smartless.

• 3:23Sean Hayes?

  Jason, you're still coughing.

• 3:25Jason Bateman?

  I'm still coughing, I'm still clearing. You guys both got it, right?

• 3:30Sean Hayes?

  Yeah, I'm doing a little better.

• 3:33Jason Bateman?

  But you're still, you've got it in the, in the, in the lungs?

• 3:36Sean Hayes?

  No, I don't.

• 3:37Will Arnett?

  And the body's working for the weekend!

• 3:41Sean Hayes?

  See, I have enough energy to do that.

• 3:43Will Arnett?

  I know, I can get, Sean, I knew I could live. And the body's working for the weekend! Hey, band, right now, JB, who sang that?

• 3:57Will Arnett?

  You wanna piece of my heart?

• 4:00Sean Hayes?

  He had a headband.

• 4:01Jason Bateman?

  Tiger Bomb.

• 4:03Will Arnett?

  Fucking close.

• 4:04Jason Bateman?

  White Tiger.

• 4:05Sean Hayes?

  Tiger Bomb.

• 4:07Jason Bateman?

  Tiger, Tiger's Milk.

• 4:08Will Arnett?

  No, Tiger's Milk?

• 4:12Sean Hayes?

  Wasn't it Loverboy?

• 4:14Will Arnett?

  Yes, Loverboy.

• 4:16Sean Hayes?

  That's weird.

• 4:18Will Arnett?

  By the way, by the way, honestly, and I don't want to get too philosophical because it's the new year and stuff like that, but it is, there is something to it. Everybody is working.

• 4:28Sean Hayes?

  For the weekend.

• 4:28Jason Bateman?

  Job.

• 4:30Will Arnett?

  You know?

• 4:30Jason Bateman?

  I'll tell you what, we just went through the holidays here, listener.

• 4:34Will Arnett?

  Sure did.

• 4:36Jason Bateman?

  And every day seemed like a Saturday and I, I was really excited about that. I loved it, but I feel like my brain got real flabby. Yeah. Like, like I don't, now I'm like afraid to go outside. I feel like I'll have culture shock if I like run into somebody that's like a serious person.

• 4:55Will Arnett?

  Somebody, last night I was talking to JB, you and I were texting a little bit during the, the, the last weekend of football. We're, we're dating this, uh, when we're recording this, but we're talking about football and stuff and I was talking to our old buddy Eli. Is that right?

• 5:08Jason Bateman?

  Oh, I do miss Eli.

• 5:10Will Arnett?

  Sweet Eli. And, um, he was saying, the holidays are over. Like tonight's the last night. Like it was the last football game of the regular season. Like it was the last weekend after the thing.

• 5:20Sean Hayes?

  And the year starts.

• 5:21Will Arnett?

  And honestly, I gotta say, I'm, I'm really happy about that. I had, we were, we were all sick over the holiday, uh, from starting Christmas day.

• 5:30Sean Hayes?

  Yeah.

• 5:31Will Arnett?

  Had the thing JB that you, that you've had, Sean, which you never.

• 5:34Sean Hayes?

  I think Jason gave it to me, yeah.

• 5:36Jason Bateman?

  Yeah, that big Thanksgiving tri, tri kiss that we, we labeled it, right? Just as we were leaning in, we said, let's call this a tri kiss.

• 5:42Will Arnett?

  Mmm.

• 5:43Jason Bateman?

  And then you guys got it.

• 5:45Sean Hayes?

  A turducken. It was a turducken kiss.

• 5:50Will Arnett?

  So I'm just, I'm like, at this point after we spent, which was nice. Again, we felt very fortunate. We got to be at home with the family, with, with all my kids and we had sort of 10 days kind of sequestered on the East Coast, but I'm, I'm looking forward to emerging from this.

• 6:07Jason Bateman?

  Getting after it.

• 6:08Will Arnett?

  Yeah, a little bit from this.

• 6:09Sean Hayes?

  Yeah.

• 6:10Jason Bateman?

  And here we are. We're starting right back. We're, we're at work now. 9:30 Monday morning. I, we're a little out of practice, right?

• 6:16Sean Hayes?

  I know.

• 6:17Jason Bateman?

  I'm really nervous about today's episode, you guys.

• 6:19Will Arnett?

  I know. Nobody's done, and we haven't covered the weather or the traffic yet. I think there's a Sig alert on the 210.

• 6:26Jason Bateman?

  How do you stretch out for a podcast?

• 6:28Sean Hayes?

  I don't know. Jason, you're gonna arrive in about 10 more minutes. I can tell.

• 6:32Will Arnett?

  Jason's got his, Jason's got his, he's, he's wearing a hoodie and he's got the hoodie up and he's got this, his headphones on the outside.

• 6:40Jason Bateman?

  Yeah.

• 6:41Will Arnett?

  Of his hoodie.

• 6:42Jason Bateman?

  Still trying to stay cozy like I'm making fires still.

• 6:45Sean Hayes?

  Wait, yeah, tell me, but what do you mean, Jay, when you said that? Because I think the same thing when I, I was thinking about you about like you, you were like, I love being cozy and watching movies and not going anywhere. I'm kind of the same way. And then I know what you mean, like, oh, shoot, this has to end and like the world starts again.

• 7:01Will Arnett?

  Sean, you're really on the fence between the, well, I got a couple of things. A, there's that. Cause you say you like to cozy and do nothing, but the truth is you also like to just rifle things off the checklist.

• 7:12Sean Hayes?

  Absolutely.

• 7:13Will Arnett?

  You never stop.

• 7:14Sean Hayes?

  That's right.

• 7:14Will Arnett?

  Three in the morning.

• 7:15Sean Hayes?

  I don't want to think about it. Because if I don't, I know, we talked about this a million times. If I don't check it off or respond or something, then it lingers in my head. I'm like, I gotta do that. And I just don't want to think about it.

• 7:25Will Arnett?

  I know. So there's that.

• 7:26Jason Bateman?

  What's your, what's your email inbox look like? Is it clean or is it cluttered?

• 7:29Sean Hayes?

  Always zero. If it's not zero, I panic, yeah.

• 7:32Jason Bateman?

  Me too, empty. Except for the, the only things that are in there means I need.

• 7:36Will Arnett?

  All the emails are in there, but there are just no new messages.

• 7:38Jason Bateman?

  I need, if it's still in my inbox, I need to respond to it.

• 7:42Sean Hayes?

  That's right, that's how I feel.

• 7:43Will Arnett?

  But you don't delete all the emails you got.

• 7:45Jason Bateman?

  No, but I, I, they're, they've, they've been read.

• 7:48Sean Hayes?

  But that's when I'm, I'm amazed when I see people, somebody, I'm amazed when I see somebody's phone and the messages of the emails are like 2,300.

• 7:56Will Arnett?

  That's a sign of, that's a sign of.

• 7:57Jason Bateman?

  I don't know how to sync my accounts yet.

• 7:59Will Arnett?

  No, no, no, no, no, no, no. You need to go and get an assessment if that's happening and you need to.

• 8:03Jason Bateman?

  Or an assistant.

• 8:04Will Arnett?

  A deep, a deep, not a, no, not an assistant. That, that, that, that sort of betrays a deeper, like you need a lot of assistance at this point. And we're going to send somebody over to the house. The other thing is, JB, I want to know.

• 8:16Sean Hayes?

  Yeah.

• 8:16Will Arnett?

  Over the holiday, how much wood did you go through?

• 8:20Sean Hayes?

  Kind of wood chuck chuck?

• 8:22Will Arnett?

  And Sean, that, that question's going to go for you, but it's going to be on a different subject. Go ahead.

• 8:28Will Arnett?

  JB, how much wood did you get through?

• 8:31Jason Bateman?

  Consistent with Sean's answer, I think I went through two loads.

• 8:39Will Arnett?

  Very nice. Wait, don't end that.

• 8:41Sean Hayes?

  See, what did I say? I said you show up in about 10 minutes and it only took like four.

• 8:45Will Arnett?

  He's back, he is back, you guys. 2026, lockout.

• 8:52Sean Hayes?

  All right. Well, speaking of of brain mushiness, this is perfect.

• 8:57Will Arnett?

  Yeah.

• 8:57Sean Hayes?

  My guest today is a fellow podcaster, but that's about where the overlap ends. Uh, he's got a-

• 9:05Will Arnett?

  God, you can't even, you can't even make your own writing sound natural.

• 9:08Sean Hayes?

  Terrible.

• 9:08Will Arnett?

  You wrote it and it makes it sound like it's read. It's insane.

• 9:12Sean Hayes?

  Oh, I'll read the whole thing right in front of you. He's got a PhD in neuroscience. He's a tenured professor at Stanford School of Medicine in neurobiology and ophthalmology, and by courtesy psychiatry and behavioral sciences. His work's been featured in Time, BBC, Scientific American, basically every publication that makes me feel dumb. His podcast is one of the most downloaded in the world. It's the cold plunging, dopamine optimizing, sun staring, science genius Andrew Huberman.

• 9:38Jason Bateman?

  Great.

• 9:39Sean Hayes?

  Finally.

• 9:41Jason Bateman?

  Good morning and happy new year.

• 9:42Speaker 03

  Good morning. Happy new year.

• 9:44Sean Hayes?

  How are you?

• 9:45Speaker 03

  Doing great.

• 9:46Sean Hayes?

  Yeah.

• 9:47Jason Bateman?

  How's your, how's your brain fog, uh, today? Are you, are you flabby from, from the, from the holiday?

• 9:52Speaker 03

  You know, I spent this holiday, like I've spent so many holidays, uh, working. In the past, it used to be grants and now it was doing book edits. But I'm very familiar with this, uh, what you called flabby brain.

• 10:03Sean Hayes?

  Yeah.

• 10:03Speaker 03

  Thing that happens after about four days away from, I don't know if it's the grind or the work, but it, it's a normal thing and it, you snap right back.

• 10:13Sean Hayes?

  Yeah.

• 10:14Speaker 03

  Yeah. Being sick doesn't help. I, I, I took some notes here as, uh, I was sitting there in the backdrop. Um, this thing that's been going around is rough.

• 10:22Will Arnett?

  It's no joke.

• 10:23Speaker 03

  A couple of, I, I'll just say there are a couple of things that are supported by the peer reviewed literature that can really help accelerate moving through something like what you all know with.

• 10:32Sean Hayes?

  What is it?

• 10:33Speaker 03

  I had it too a couple of months ago. Three things. It turns out that the old practice of hot baths is actually quite good. You don't want to make it scalding, obviously, but you get into a just tolerably hot bath.

• 10:46Sean Hayes?

  I'm writing this down.

• 10:46Speaker 03

  And, um, it turns out it, it mobilizes some features of the immune system in ways that, um, can help you get over your sickness.

• 10:54Sean Hayes?

  Like just because you sweat it out? Is that what it, I mean?

• 10:56Will Arnett?

  Well, no dummy. Just let him finish.

• 10:59Speaker 03

  You're activating some of the, um, mobilization- Some of the cells that go and scavenge for for whatever it is that you're you're dealing with. This is particularly useful at the beginning. Your immune system has two different phases. There's there's a kind of an innate phase where it's like any foreign invader gets kind of the same inflammation response. That's good. That's the kind of like, oh, you know, I'm feeling a little like under. I'm a little extra tired. That's the time, ideally in the hour or two before bed, you take a nice hot bath or hot shower and then just get into bed. And, you know, if you do that for a couple of days in a row, you may be able to fend it off. If not, once you have it, keeping that practice up, provided you don't have a really high fever, is is really useful. That, and you know, I know I'm always talking about the morning sunlight.

• 11:43Will Arnett?

  Please say smoking cigarettes.

• 11:44Speaker 03

  Just at your circadian row. No, but no, but we can talk about nicotine if you want. A lot to say about nicotine, but getting some what we call long wavelength light, so some sunlight. Or I'm not here to to say red light therapy, but getting some sunlight. This is very well supported by the literature because, again, it it's helpful for your mitochondrial function, for your immune system. In in Arctic countries, not so much Arctic, but in Scandinavia and Russia, they actually put babies bundled up out in the cold in the morning.

• 12:14Will Arnett?

  Oh, sure.

• 12:15Speaker 03

  To mobilize these.

• 12:16Will Arnett?

  Yeah, we throw them outside.

• 12:18Speaker 03

  Here we don't do that. Here that'll get you child protection services.

• 12:20Will Arnett?

  No, but up in up in Canada, we'll toss her out. We'll toss her outside for sure.

• 12:26Speaker 03

  And there are a couple of other things we can talk about, but in in a kiss.

• 12:28Will Arnett?

  Wait a second now. Listen, A- Andrew, and I mean, nice to meet you, first of all.

• 12:33Sean Hayes?

  Yeah, it's so great you're here. I wanted you on for so long.

• 12:36Will Arnett?

  Okay, shut up. Can I call you Huberman?

• 12:39Speaker 03

  You can call me whatever you want.

• 12:41Will Arnett?

  Okay, because I refer to you as Huberman as if I know you all the time because I've seen clips of yours online for for years and stuff. And so I like I like a lot of the stuff you talk about. First of all, you lost Jason when you said bath because he just he's thinking about his own juices. He hates marinating in juices.

• 12:56Sean Hayes?

  I don't understand the concept of it.

• 12:57Speaker 03

  A lot of men don't like baths. A lot of men like baths, a lot of men don't.

• 13:01Sean Hayes?

  It's just the math is wrong.

• 13:03Speaker 03

  Sauna would be fine. Sauna would be fine.

• 13:05Will Arnett?

  Okay, so sauna, so interestingly, interestingly enough, and by the way, not that interesting. When I was starting to get this flu. I looked it up, I consulted, uh, I did my own research as they say, meaning I have Google. A lot of people like to talk about research and what they mean is that they use the internet.

• 13:23Speaker 03

  Right.

• 13:24Will Arnett?

  Um, like a bunch of fucking dummies. And it's, it told me because I, I've been a, I've been a proponent of, of sauna and cold.

• 13:32Speaker 03

  And cold plunges always.

• 13:33Will Arnett?

  For, for more than 10 years, I, I, early, early days. And they said to me, uh, the internet, they said, don't expose myself if I have the flu. That they were worried about, cause they said that your body's already working hard enough.

• 13:51Speaker 03

  They were saying, they were saying, don't do the cold plunge or don't do the hot.

• 13:54Will Arnett?

  Don't do either, cause they were saying, cause I'd have to fight hard enough. So, so this was the first time that when, when I was sick, that I did not use the heat and or the cold to try to combat it. And it, it ended up, ended up being harsher. And I, now that I'm hearing you, I'm like, I wish I had, cause historically I've always just gone in and I sauna. Early days when I start to feel that thing in my throat or whatever. And usually I'm able to stave it off. So you're saying.

• 14:20Speaker 03

  Yeah, you know, the, the cold, deliberate cold exposure, right? Cold showers, cold plunges, this kind of thing. It is a stressor. Um, counter to what you hear out there, it does not raise cortisol, but it is a stressor. Your adrenaline spikes when you get in the, the cold, which is part of the reason you do it. And then when you get out, you get that long tail of dopamine and adrenaline that makes you feel much better and more alert, et cetera. That's fine under healthy conditions. I would say if you're battling something or you feel like you're coming down with something, use heat. Um, sauna, hot shower, hot bath, whatever it is that works for you, but.

• 14:53Will Arnett?

  How about that?

• 14:53Speaker 03

  I would drop the cold as you're getting into something that, because it's a very potent stressor.

• 14:59Will Arnett?

  Yeah.

• 15:00Speaker 03

  The thing about heat is if it's too hot, it can also be a stressor. I mean, when you're healthy, using the sauna as a way to get your heart rate up and kind of push it in there a little bit is good. By the way, um, useful tip, um, if you put a towel over your head or, you know, you'll notice that Russian banyas, they wear those.

• 15:15Will Arnett?

  I have a sauna, I have a sauna hat.

• 15:17Speaker 03

  Yeah, it insulates your brain from the heat so you can stay in longer. The impulse to get out is a brain thing, not unless it's very, very hot, a, a burn thing. Um, and then of course, if men. Men want to conceive children in the next 90 days because of the 90 days spermatogenesis cycle. If you're going into the sauna, you need to put a cold packet. You're growing outside your shorts, guys. If you don't want children, also don't use this as a surefire way to avoid having children. It's, you know, many accidents.

• 15:46Will Arnett?

  Yeah, you gotta stick your nuts in ice, eh?

• 15:50Sean Hayes?

  Wait, you're saying that the sauna will cut your sperm count?

• 15:54Speaker 03

  Absolutely. Heat and sperm, not a good combo, which is why, we're getting to anatomy here, which is why the scrotum can extend and contract closer to the body. It's to maintain the optimal temperature for spermatogenesis.

• 16:08Sean Hayes?

  How about that?

• 16:09Speaker 03

  Yeah. And so if you go in a sauna or a hot bath quite a bit in the 90 days prior to trying to conceive, you're going to limit the number of highly mobile sperm. That said, I'm sure many children have been conceived in saunas and hot baths and in hot conditions. But this is on average, right?

• 16:27Will Arnett?

  No comment. No comment.

• 16:30Sean Hayes?

  God, I would have had tons of kids by now.

• 16:33Jason Bateman?

  Now, let's get back to what you were saying, Doctor, about, please expand on nicotine as one of our co-hosts here chews his Nicorette gum.

• 16:41Speaker 03

  Sure.

• 16:42Will Arnett?

  Not Nicorette gum.

• 16:44Jason Bateman?

  It's not, what, are you looking for freebies?

• 16:46Will Arnett?

  I do a Zin gum combo.

• 16:49Speaker 03

  Okay, I have a lot to say about this. Before I do that, just very quickly, there's, there, first of all, I want to put a full disclaimer. I have no financial relationship to what I'm about to describe in any way. There's a beautiful study, published and it's on PubMed. I can send you guys the link if you want. And I learned about this from an ER doc out here in Los Angeles who needed to keep himself healthy during the winter season. N-acetylcysteine, also called NAC, is a glutathione precursor. There's a beautiful study showing that when they, people signed up for a study where they would, where they were deliberately exposed to people who had flu, okay? And they, they either got NAC two or three times a day at about 600 to 900 milligrams per day, or not.

• 17:31Sean Hayes?

  But can, but sorry, just describe what NAC is, because you said that long word. I don't know what that is.

• 17:36Speaker 03

  Yeah. N-acetylcysteine, it's a precursor to some Something called glutathione, which is used in a bunch of different cellular processes. Normally, I think you don't need this, right? You don't need elevate glutathione. I know it's all the rage now to get glutathione drips and that sort of thing.

• 17:48Jason Bateman?

  I don't know.

• 17:49Speaker 03

  I have a, I have a more conventional opinion about all that. But if you feel like you're coming down with something, or you're going to be exposed to things. Or Jason, you mentioned that you're heading off to New York. You've got work to do. You need to recover more quickly. The data on avoiding getting sick by taking 600 to 900 milligrams of N-acetylcysteine two or three times a day, when you're sick, getting sick, or trying to avoid getting sick, is quite robust. In fact, there's a huge difference in the number of people all exposed to the same virus, that flu virus in this case, that did not contract the virus. Some still did. It's in the high twenties, but had they not taken it, the control group was somewhere close to 80%. It's pretty impressive. And, um, and obviously check with your doctor, this kind of thing. But that's the one thing, you know, we hear about zinc, echinacea, all this stuff.

• 18:34Speaker 03

  It's the one thing that the peer reviewed research actually shows can help stave off flu.

• 18:40Jason Bateman?

  Is there any downside to taking it constantly?

• 18:43Speaker 03

  Some people will take a little bit each day. It is a little bit of what's called a mucolytic. So it will make your nose run just a little bit more. It's actually used to treat cystic fibrosis at very high doses, which is a buildup of fluid in the lungs. So it's a well-known mucolytic. So it's going to help you drain out more as well. But no, there's really no downside.

• 19:00Will Arnett?

  He wants to drain out. He, all he heard was drain out and he's so excited.

• 19:04Jason Bateman?

  If I'm losing water weight, I'm happy.

• 19:08Speaker 03

  I have a feeling that's related to our previous discussion.

• 19:11Will Arnett?

  Wait a second, wait a second. I, we're not gonna, an hour is not gonna be enough time with you and Sean. I, we have so many, you have so many boxes.

• 19:19Jason Bateman?

  But I want to know if our friend is, I want to know if our friend, yeah, if our friend is safe, uh, cheering on the zen.

• 19:25Will Arnett?

  Cause there's been so much, and I want to set it up by saying, there's been so much about nicotine is good for you. People are now saying it's great, but all, all this sort of stuff. And so I want to hear once and for all what your take is on nicotine and the various delivery systems.

• 19:40Speaker 03

  Great. Nicotine is a very interesting stimulant. It is a stimulant.

• 19:46Jason Bateman?

  Sure.

• 19:47Speaker 03

  But it's perhaps the only stimulant that also relaxes you at the same time.

• 19:52Will Arnett?

  Thank you, Andrew, for coming on the podcast.

• 19:54Speaker 03

  So that's a very unique property, right? It gives you that alert but focused, kind of puts you in the groove that is so alluring to humans, so much so, and I'm gonna avoid going into a history about nicotine, but let's just say for hundreds of years, but in particular in the last hundred years, humans have figured out ways to get nicotine into their brain. And we know that smoking, vaping, dipping and snuffing all cause cancer, and I did put vaping in there. Vaping is perhaps safer than smoking, but still causes lung damage, the contaminants, etc. Vaping is bad.

• 20:29Will Arnett?

  The science isn't back yet on what the burning of the metal and all that kind of stuff. And I will say, anecdotally, when I tried to use one of the vaping products, I'm not gonna say which one, it increased my blood pressure, it increased my anxiety tenfold, and I went back off it.

• 20:46Speaker 03

  Yeah, I'll take a hard stance, obviously smoking, we now know.

• 20:50Will Arnett?

  Still cool.

• 20:51Speaker 03

  Yeah, no one dips or snuffs really, or people dip, but they don't.

• 20:54Will Arnett?

  My grandfather used to snuff, he used to put a little bit on his...

• 20:56Sean Hayes?

  Yeah, mine too.

• 20:57Speaker 03

  Snuffing is literally putting tobacco up the nostrils, I can't even imagine. Okay, well, okay, so here's the deal. We went from smoking, dipping, vaping and snuffing, then we moved to what they used to call electronic cigarettes, vaping, and then now oral nicotine is the main mode of delivery. Nicotine itself is not carcinogenic. This is very important, doesn't cause cancer, right? It's a stimulant that relaxes you, as I mentioned. It does raise blood pressure, and it increases vasoconstriction. Vasoconstriction is just a clamping off of the little capillaries and vessels, in particular in the periphery, you know, in the fingers, in other extremities, and in the brain.

• 21:38Speaker 03

  And, you know, strokes and other things like that are cutting off a blood supply to small regions of the brain. So if your blood pressure is already high, not a good idea. If your blood pressure is naturally low, and you're doing other things, for instance, sauna, to vasodilate a couple, once a day or several, maybe a few times a week at minimum, or a hot bath if you're traveling or a hot shower, taking some effort, especially before bed, to make sure that your capillaries are dilated, not taking nicotine too late in the day. There is a space where I can say, I can now safely say what I'm about to say, which is, there is evidence... Let me do this backwards. People with Parkinson's and Alzheimer's, if they take nicotine, don't seem to get better.

• 22:22Speaker 03

  However, there is decent evidence in animals and humans that nicotine, not delivered by vaping, dipping, smoking, or snuffing, right? Can be protective against Parkinson's and Alzheimer's because because it offset, seems to protect neurons against degeneration, which is the hallmark feature of Parkinson's and Alzheimer's. That said, I'm gonna, you know, I'm gonna feel very comfortable saying what I just said on the but some people are gonna say, wait a second, I don't want people starting to take nicotine to avoid getting Parkinson's and Alzheimer's. The blood pressure effect, the mild anxiety effect for certain people is significant. And here's the biggie, and then I'll just kind of peel back and hear what you guys have to say about this.

• 23:06Speaker 03

  The biggie is that it is highly, nicotine, delivered in any form, is highly, highly habit-forming.

• 23:13Sean Hayes?

  What?

• 23:13Speaker 03

  Do we call it addicting? Addicting is, you know, continued use despite harm to self or others. I call addiction a progressive narrowing of the things that bring you pleasure. By those two definitions, it's hard to call nicotine addicting. And yet, I know many people that start with one pack of Zin a day, one gum, one four-milligram gum, pretty soon it's two, pretty soon it's four, pretty soon it's a canister every three, four days. So if it's not addicting, it's highly habit-forming. So that's, you know, those are, I'll occasionally take a piece of Nicorette.

• 23:46Sean Hayes?

  Yeah?

• 23:47Speaker 03

  Yeah, sure. But I don't do it very often. I won't do it more than once every couple of weeks because I love the potent effect. The problem is-

• 23:53Sean Hayes?

  Just to get through the day or something, you mean?

• 23:55Speaker 03

  No, for, if I'm doing a particularly long session of writing or a particularly long podcast. But here's the thing, if, if you take a stimulant of any kind, caffeine, nicotine, any stimulant of any kind regularly, pretty soon you need it just to get to baseline. I mean, most of us drink, 90% of the, of the adult population of the world drinks caffeine every single day, just to feel at their normal levels of alertness. And the reason there's so few studies on caffeine that are really solid is because no one wants to go through- You'd have to go into caffeine withdrawal for two weeks.

• 24:27Sean Hayes?

  That's why I don't drink, that's why I don't drink caffeine.

• 24:30Speaker 03

  You seem to have a lot of energy. I don't think you need caffeine. Whereas I need caffeine.

• 24:33Will Arnett?

  That's not why.

• 24:34Speaker 03

  Like you seem very alert, like you're wide, like you have an alertness to you.

• 24:37Sean Hayes?

  Yeah, well.

• 24:38Will Arnett?

  First of all, I just want to say again, it's not like you started, you were like, early on, you're like, I'm not going to drink coffee because I don't want to be my baseline to have to be.

• 24:46Sean Hayes?

  No, no, not, not that. No, that's not why. But I didn't want to drink coffee, you know, in high school and stuff when people were drinking it. Because I, I saw what people went through when they're like, ah, don't bother me, I have it in my coffee. Like, I don't want to be that person that I can't talk to you until I've had caffeine. You know, or I'm, I'm angry until I, I'm not woken up until I have caffeine. So I recognized that and I didn't, I never wanted to be that person. So then I never drank coffee. I've had soda, but I don't really drink soda anymore. And so, um, yeah, that's it.

• 25:16Will Arnett?

  I mean.

• 25:17Speaker 03

  That's the reason I avoided cannabis. I don't have anything, you know, I, I think cannabis has, for some people, it can activate psychosis, I T H C. For some people, they seem to be able to take it and not really have too much trouble with it. The people I knew growing up, growing up, excuse me, who used a lot of cannabis.

• 25:34Sean Hayes?

  Yeah.

• 25:34Speaker 03

  When they didn't have access to their cannabis, they were pretty difficult to be with.

• 25:39Sean Hayes?

  Oh, really?

• 25:40Speaker 03

  To be with, they had this kind of, they were irritable. Yeah. And we will be right back.

• 25:48Sean Hayes?

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• 26:29Sean Hayes?

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• 27:01Sean Hayes?

  Instagram teen accounts have automatic protections on by default. Built-in content settings for the content teens can see, contact limits for who can contact them, and time management tools like daily time limits and sleep mode. Teens are automatically placed into teen accounts, and teens under 16 will need a parent's permission to change any of these settings to be less strict. Instagram will continue adding built-in safety features to help create age-appropriate experiences. Learn more about teen accounts and Instagram's ongoing work to protect teens online at instagram.com/teenaccounts.

• 27:44Sean Hayes?

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• 28:28Sean Hayes?

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• 28:40Sean Hayes?

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• 29:24Sean Hayes?

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• 29:45Sean Hayes?

  And now, back to the show.

• 29:48Will Arnett?

  I've always said that there's nobody grumpier than a stoner who's not stoned. They're always the grumpiest people. And there's a real, you can really draw a pretty firm line there. And there's, we're saying, JB, that people who like to

• 30:04Sean Hayes?

  JB just took a pee break, I think.

• 30:05Will Arnett?

  Cannabis. And when they're not, when they're not using it, can be prone to being grumpy. Thoughts?

• 30:12Jason Bateman?

  Wait, so...

• 30:14Will Arnett?

  Take it easy, man.

• 30:18Sean Hayes?

  He just went to grab some nicotine and some cannabis.

• 30:20Jason Bateman?

  You're saying when people who use cannabis, they get grumpy when they're not using it?

• 30:24Will Arnett?

  Yeah.

• 30:25Speaker 03

  When they don't have access to it.

• 30:27Sean Hayes?

  Like, because I was saying, Jay, I was saying, I don't drink caffeine because I don't want to be like a grumpy person until I reach my base, you know?

• 30:34Jason Bateman?

  I might be a tough person to gauge on that because I think my set, sort of default idol, is, I wouldn't say grumpy, but is...

• 30:50Jason Bateman?

  You know, I'm the guy who sits at the back of the room and doesn't do a lot of talking, but I'll throw a bomb every once in a while.

• 30:57Sean Hayes?

  That's right, and then leaves.

• 30:58Jason Bateman?

  You know, but...

• 30:59Will Arnett?

  Does that make me, I don't know. No.

• 31:01Speaker 03

  You don't hit the bill of what I was thinking of. I was thinking about chronic weed smokers.

• 31:06Will Arnett?

  Yeah, chronic weed smokers.

• 31:07Speaker 03

  You know.

• 31:08Will Arnett?

  Yeah, no, no, no, that's not.

• 31:08Speaker 03

  Cannabis is definitely here to stay. It's kind of amazing how much the reality is changing. Is people sold everywhere. There are some real issues. I think the big one that's very overlooked is that everyone talks about, oh, that, you know, that weed is so much stronger now than it used to be. It's true, THC levels are much higher. But here's the thing. I had a researcher on my show who specializes in cannabis research. And he said, when people take edibles, that's when they tend to go through the like, the, not overdose, like lethal overdose, but they take, it was very hard to gauge the kind of plane of high when people are, take edibles if they don't take them regularly. That's what lands people in the ER with a psychotic episode.

• 31:48Jason Bateman?

  Yeah, me too.

• 31:48Speaker 03

  And people who are prone to psychosis definitely need to avoid high THC. A lot of the madness you see out there.

• 31:54Will Arnett?

  When you're eating, it's hard to know how much is too much.

• 31:57Jason Bateman?

  Yeah, dude, cause like I might be hungry and the cookies look good.

• 32:00Will Arnett?

  That's the problem, dude.

• 32:02Jason Bateman?

  I dig brownies.

• 32:03Sean Hayes?

  Yeah, I've, I've OD'd on THC a couple, not OD'd, but I've taken too much THC a couple of times and it was just like, I was lying on the bed one time, I took so much and I was like rocking and I'm like, Scotty, Scotty. And he's like, it's okay, it's gonna be okay. And I go, God, it's been like three or four hours. He goes, it's literally been two minutes. And I was like freaking out. I slept with my eyes open the whole night. It was awful.

• 32:26Will Arnett?

  It was not sleep, by the way.

• 32:28Sean Hayes?

  No, it was not sleep.

• 32:29Speaker 03

  Yeah, well, people who, who take cannabis to sleep of, of any kind, at any amount, they're getting no REM sleep, no rapid eye movements, very little. Everyone that comes off cannabis gets in, they talk about how incredible their dreams are, how vivid their dreams are. You get a REM rebound. REM is when you consolidate memories, REM is when you learn the most information, you consolidate what you learned. REM is essential. Just a little tip outside of cannabis, for anyone that wants to increase the amount of REM sleep they get, there's a wonderful trick, which is you'll have to adjust the thermostat if you don't have a way to adjust the temperature of your bed. But either way, increase the temperature in your sleeping environment in the last hours of sleep. So every, you, you want the room cold to fall asleep and stay deeply asleep, but toward

• 33:10Speaker 03

  morning, even if you have to heat up the room as you get toward morning and your REM sleep will increase fairly significantly.

• 33:18Sean Hayes?

  I won't do it.

• 33:19Will Arnett?

  You won't do it? You won't do it? And would you say that your REM sleep is really good?

• 33:22Sean Hayes?

  I mean, it's okay.

• 33:23Will Arnett?

  So maybe you should do it.

• 33:24Sean Hayes?

  No, but I mean, like, what wakes me up is when it's too hot.

• 33:27Jason Bateman?

  Are you saying, Doctor, that if a good, if I'm dreaming a lot and I'm kind of remembering a bit of my dreams, does that mean I'm getting REM?

• 33:36Speaker 03

  Yes, especially if the dreams are vivid dreams. We tend to get more REM toward the end of the night and more deep sleep at the beginning of the night. The way to get, the brief description of this is that at the beginning of the night, you go into a deep, slow wave sleep that's more about bodily repair. The dreams are kind of unusual, they don't really have a lot of emotional content. The way to maximize the amount of deep sleep, in addition to not drinking caffeine too close to bed, et cetera, all that, is to try and get to bed at more or less the regular time, plus or minus 45 minutes. We're all human, right?

• 34:07Jason Bateman?

  Right.

• 34:08Speaker 03

  Because you're going to capture that deep sleep, and then the wave passes. The way to maximize your REM sleep is to, basically, make sure you sleep long enough, okay? So, some people need six, some people need eight hours, whatever it is for you to feel refreshed.

• 34:21Jason Bateman?

  Yeah.

• 34:21Speaker 03

  But that last part of the night, if you can increase the temperature. Now, Sean, it sounds like you have a high core body temperature. That's great, that reflects a high metabolism.

• 34:30Jason Bateman?

  Oh, he's hot.

• 34:31Speaker 03

  Wonderful thing.

• 34:31Jason Bateman?

  He's super hot.

• 34:32Speaker 03

  So you might just need to keep the room a little bit cooler than most. This is all relative.

• 34:36Sean Hayes?

  Yeah, yeah.

• 34:37Will Arnett?

  Listen, can I just say, you're just making me think. So last night, this dream, this is not a joke, I was just thinking about it, it just came to me. I had a sick dream last night. I was in the back of a truck, this is totally true, with a bunch of dudes, and we were all wearing, this is not, I'm not making this up. We're all wearing ghillie suits, right? Like those, um...

• 34:56Jason Bateman?

  Like a onesies?

• 34:57Will Arnett?

  You know, like snipers wear when they go, when they're like, you know, trying to camouflage themselves. And the rest of our crew went off, and then this one guy goes, "You and me," and we jumped off, and we went in, and then we, we, we, um, we put up a bunch of branches so nobody knew which way we went. We went off from our regular crew.

• 35:15Jason Bateman?

  Sure.

• 35:15Will Arnett?

  And then, and we went off on this path, and we saw this, I'm not kidding, I'm just, and we saw this hill, and we saw this shadow of, and he's like, "Those are the Russians." And they were up on this hill, and we were going to go and try to outflank these, these, this like, this sort of like Spetsnaz group over on the other, on this other... It was sick. I'm just, I'm just, it was so vivid.

• 35:36Jason Bateman?

  End of story?

• 35:37Will Arnett?

  Shit, hang on, let, let him speak.

• 35:39Speaker 03

  Well, there's actually, what we say in science, a mechanistic weave here that, that's, so get this. One of the things that happens during REM sleep is your acetylcholine levels are high. Nicotine, believe it or not, is called nicotine because it binds to the nicotinic acetylcholine receptors. People who take nicotine, and I'm not suggesting people to go out and start taking nicotine. And I have no financial relationship to any company that makes nicotine whatsoever. That when you boost your acetylcholine levels by taking nicotine, activation of that system with nicotine, it actually will.

• 36:11Will Arnett?

  You turn into a sniper?

• 36:12Speaker 03

  No, you'll, well, in your case, yes, but you, you will increase the amount of REM that you get a little bit that night when you sleep. But Will, there's one thing I really have to give you. Because, because, and I'd say actually for all, all the men out there and on this podcast, but it, it will offset some of the vasoconstriction and blood pressure increase of your nicotine. But I had a guy on my podcast who's a colleague of mine at Stanford, Mike Eisenberg. He's our, he's our head of male sexual health and hormone clinic at Stanford. He's an M.D., Ph.D., he is the, the top notch doctor in urology and this area, okay? He's a serious scientist and clinician. Every male, his words, every male forty years or older should be taking

• 36:55Speaker 03

  low dose, meaning two point five to five milligrams of Tadalafil each evening to lower their blood pressure, dilate their capillaries. At higher doses, this is known as Cialis, right? Used for erectile dysfunction. However, this drug, Tadalafil, was initially developed to treat blood pressure and for for, excuse me, to dilate the small capillaries of the brain and body in order to encourage prostate health and into encourage brain health. And there's a, a lot of evidence as to why this is a good thing. It's very inexpensive. It costs pennies now because it's generic for people out there. You do need a prescription, but. My colleague, Mike Eisenberg, you know, he didn't tell me to say this, but when we're talking about vasoconstrictors, high blood pressure, stress, stroke, you know, some of

• 37:39Speaker 03

  the leading causes of death, you know, every male in particular, because of the prostate, women should talk to their doctors, whether or not this is applicable to women, but it will help offset some of that blood pressure and vasoconstriction increase.

• 37:50Sean Hayes?

  That's amazing. You know, now, listen, I, I, every single day, I know you talk about supplements too. I wanted to bring this up to you because this is what I take and it has the word nicotine in it. I take, I take Metformin and then I take Nicotinamide, is that what I'm saying? And Resveratrol.

• 38:04Speaker 03

  Okay, so you're taking Nicotinamide?

• 38:05Sean Hayes?

  I take it every day for like three years.

• 38:07Speaker 03

  Yeah, which is in the NAD pathway. Okay, so let's break these into, Metformin is to lower blood sugar.

• 38:13Will Arnett?

  How much, how long does he have to live? Just say it.

• 38:15Speaker 03

  I mean, you guys, I, I can do like an age guess thing, but everyone here looks like they're in their late 30s, early 40s.

• 38:22Sean Hayes?

  Likewise.

• 38:25Speaker 03

  Yeah, thanks. Yeah, I just turned 50. I feel, I feel really good.

• 38:28Will Arnett?

  We're all mid 50s. We're all over 55.

• 38:30Speaker 03

  Wow.

• 38:31Sean Hayes?

  But can play, I don't know what kind of scripts you've got. We can play probably mid 30s, late 30s.

• 38:37Will Arnett?

  I don't know. Can even go boyish, like, you know what I mean? Like he's, he's a boy.

• 38:42Speaker 03

  By the way, I loved your Macaulay Culkin episode. I, I listened to that. I was like, this guy is so grounded. I can't even imagine being famous from that young of an age, you know? And I mean, and he's like, and he, he's like, you know, he's hyper famous. He just seems so, so grounded. I'm sure he's gone through the wickets to get there, but I was very impressed at the person he is. He's talking about it and how grounded he is about everything from Legos to parenting to acting and just, it was awesome. It was great. Yeah. Great. Um, that came up because you were talking about child actors or something. I think I still frame him in Home Alone.

• 39:14Will Arnett?

  Yeah.

• 39:15Speaker 03

  So supplements, to be very clear, I know I often get kind of put into that supplement cold plunge category. Look, get great sleep, sunlight. I'm all about sleep, sunlight. If you drink alcohol, limit it, offset it with good behaviors, cardio resistance training. I mean, I've been doing that stuff since I was in my teens and I've been, I'm really committed to the behaviors come first. There is a place for some people for supplements. Metformin is lowers blood glucose, blood sugar.

• 39:42Sean Hayes?

  Right. So I can have more cheesecake. Yeah.

• 39:45Speaker 03

  I mean, it seems to work for some people, especially who tend to run high, high blood, uh, blood sugar levels.

• 39:51Sean Hayes?

  Very high.

• 39:52Speaker 03

  Some people will know the kind of a poor man's version of this is a actually a tree bark extract called berberine, which is which accomplishes the same thing.

• 40:00Will Arnett?

  Sean writing it down.

• 40:01Speaker 03

  I mentioned that because but then you would want to stop taking metformin. You'd obviously want to talk to your doctor. The other thing you're taking nicotinamide, nicotinamide, RABICIDE, is in the NAD pathway. Okay, NAD got a lot of attention a few years back as a potential longevity.

• 40:18Sean Hayes?

  Yeah, right.

• 40:19Speaker 03

  We all make NAD and levels of it drop off with age.

• 40:22Sean Hayes?

  Right.

• 40:22Speaker 03

  There is no direct evidence yet in humans that increasing NAD either by taking what's called NR, which is what you're taking, or NMN can extend lifespan. However, it does seem to increase energy and NR in particular, what you're taking seems to, there's some good human studies that it can reduce inflammation in the body.

• 40:42Sean Hayes?

  Oh, nice.

• 40:42Speaker 03

  And I'll say also again, no financial relationship to any NAD, NR, etc.

• 40:47Sean Hayes?

  Likewise.

• 40:47Speaker 03

  I take, I take sublingual NMN in the morning to increase energy and I do take NMN.

• 40:54Sean Hayes?

  Oh, got it.

• 40:55Speaker 03

  It's different. You could either take NR or NMN. Here's the interesting thing about increasing NAD. I noticed, this is just anecdotally, but so do other family members, etc. When I take NMN or NR, my hair grows very, very fast and my nails grow very thick.

• 41:10Sean Hayes?

  Yeah, me too.

• 41:11Speaker 03

  It definitely is doing something for growth of those cells.

• 41:15Sean Hayes?

  Yeah.

• 41:16Speaker 03

  For me, for me.

• 41:16Sean Hayes?

  For me, too, yeah.

• 41:17Speaker 03

  There's been no clinical trials on this. I would just continue with what you're doing if you feel good and you have a good doctor that you're working with.

• 41:24Sean Hayes?

  Yeah.

• 41:24Speaker 03

  And how do you feel? Do you wake up feeling pretty good?

• 41:27Sean Hayes?

  Finally, thank you for asking. I feel great. I feel terrific. No, I feel, I'm, I could, we need to do like a side comp, you know, zoom or whatever.

• 41:37Will Arnett?

  Well, well, Sean, can we get into, it will cost you. Can we get into a little bit because we touched on it and you do feel good and you, and you're, there's very good observation, Sean does have, tend to have a lot of energy in a release room, but, and I give you a lot of shit about it because I do love you and it's funny, but it's also, I do worry about your sleep.

• 41:58Sean Hayes?

  My sleep and also sugar.

• 42:00Will Arnett?

  Well, sugar and there might might be a correlation and I'm sure there is. But Sean, and and correct me if I'm wrong, you'll go to sleep at a relatively decent hour.

• 42:08Sean Hayes?

  Yeah.

• 42:08Will Arnett?

  And you'll often wake up, and this has been for years.

• 42:11Sean Hayes?

  Yes.

• 42:11Will Arnett?

  In the middle of the night.

• 42:12Sean Hayes?

  That's right.

• 42:12Will Arnett?

  And then you're up and you send emails and you text and you do stuff, you make phone calls and you're up. And then that might be three, four in the morning.

• 42:19Sean Hayes?

  Correct.

• 42:20Will Arnett?

  You'll be up till like seven.

• 42:21Sean Hayes?

  Correct.

• 42:22Will Arnett?

  And then you'll go back to sleep for like two hours.

• 42:24Sean Hayes?

  Or hour, two hours, yeah.

• 42:25Will Arnett?

  Hour, two hours.

• 42:26Sean Hayes?

  And I'll sleep really hard.

• 42:27Will Arnett?

  And you'll sleep what you think is really hard because you're exhausted. But but there's, and this isn't just sort of once a week, this is. That is the the rule more than the exception.

• 42:37Sean Hayes?

  That is correct.

• 42:38Will Arnett?

  That that is how you get your rest.

• 42:41Sean Hayes?

  Yeah. Is that bad? Because I read one, like, you know, I read a long time ago, a doctor said, you know, we should all sleep like babies, like if you're tired, lay down, if you're not, get up.

• 42:51Speaker 03

  I many nights do exactly the same thing, Sean. And I would.

• 42:57Sean Hayes?

  Call you back.

• 42:58Speaker 03

  Okay, great. Yeah, we'll work side by side.

• 43:03Speaker 03

  You know, a couple of things, I mean, some people, there's a theory that some people have this sleep architecture just naturally. That theory has been kicked around back and forth. Here's the thing.

• 43:15Sean Hayes?

  Because I sleep, I sleep worse if I fight it.

• 43:17Speaker 03

  Don't fight it. One of the worst things you can do, this is very important for everybody listening. One of the worst things you can do is stay in bed trying to sleep for more than half an hour.

• 43:26Sean Hayes?

  Yeah.

• 43:27Speaker 03

  Your brain is a prediction and sort of parrot association machine, which is nerd speak for you will start to associate your bed with a battle with.

• 43:36Sean Hayes?

  That's right.

• 43:36Speaker 03

  You do not want that. Get up and get out of bed if you're, if it takes you more than 30 minutes to try and get back to sleep. Get up and get out of bed, go do something. It is a good idea, however, to have a more or less normal to bedtime that's right for you.

• 43:50Sean Hayes?

  Like sleep hygiene, yeah.

• 43:52Speaker 03

  Well, and we know that some people do great going to bed late and some people go to bed earlier. Oftentimes, people who wake up at three or four in the morning, or two or three or four in the morning, can't get back to sleep but are still tired and then need to go back to sleep. I'm raising my hand here as one of these people. Sometimes getting to bed a little bit earlier than you happen to be getting to sleep can help. Meaning getting into bed around nine, nine thirty, falling asleep at ten. And then it just may be that you're not getting enough of that early, deep sleep that you, your body craves. Because it's very easy to push through tiredness. It's hard, we can't make ourselves sleep. But I have some great tools to help you fall back asleep if you want them.

• 44:31Sean Hayes?

  Yeah.

• 44:31Speaker 03

  But my first question is, what time do you go to sleep?

• 44:33Sean Hayes?

  About eleven o'clock, between eleven and twelve. I'm always almost like sleeping by twelve fifteen.

• 44:39Speaker 03

  Okay, so you're falling asleep quickly. So we could go through a lot of diagnostic aspects.

• 44:44Will Arnett?

  And you're watching, and you're watching television generally after that point, right?

• 44:48Sean Hayes?

  No, right up to, yeah.

• 44:49Will Arnett?

  Or looking at your phone.

• 44:51Sean Hayes?

  Like last night, we started watching The Godfather Part Two. I had to put that subtitle on because I couldn't hear, anyway.

• 44:55Speaker 03

  Yeah.

• 45:00Speaker 03

  Okay, I'm gonna give a general theme for everybody because some people are early risers and late night owls.

• 45:05Will Arnett?

  Wait, but before you, before you get it, because this might be a part of it. And maybe you can answer this too. Because I actually said it to my seventeen year old last night. Again, I had heard, read, whatever, because we're all experts these days.

• 45:18Will Arnett?

  That going to bed earlier, getting those early, those first hours before midnight and the importance of those hours versus post midnight, et cetera. Can you factor that into it too?

• 45:30Speaker 03

  Yeah, and it changes across the lifespan. So teens often need more sleep. For social reasons, they're gonna push later sometimes and we just have to live with that. And like, no, no healthy kid wants to go to bed at nine o'clock.

• 45:42Sean Hayes?

  Right, right.

• 45:42Speaker 03

  You know, it's just, you know, so I think it's important to eventually, by the time you hit your thirties, to figure out kind of what, when would you go to sleep if the rest of the world didn't exist? When would you wake up? And what's your natural rhythm? And it may be that this is just your natural rhythm, Sean.

• 45:58Sean Hayes?

  Yeah, that's right, yeah.

• 46:00Speaker 03

  It is true that you can create lighting environments that are best for sleep and wakefulness. And it's very simple. I'll just make this very, very simple. You want very bright mornings and you want dim, dark nights. In fact, there's a beautiful study out of the UK. That showed with more than eighty thousand human subjects that just making your days brighter, working near a window, obviously, I'm big on getting sunlight in your eyes first thing in the morning. But if you can't do that, bright, bright lights inside. Getting outside as much as you can during the morning, especially before ten AM, whatever you can get, even if you're taking the kids to school, etc. And then dimming the lights in the evening. I'm not saying everyone has to go to a red light environment and look like a biohacker. Dimming the lights, bringing the lights down, dimming your screens.

• 46:45Sean Hayes?

  Totally.

• 46:45Speaker 03

  That in combination, that in combination greatly offsets depression, anxiety, symptoms of OCD.

• 46:53Sean Hayes?

  Yeah.

• 46:54Speaker 03

  Mania, so much so that even if people are in dark environments during the day, if they make their nighttime environment truly dark, they benefit. And there's a whole story about cortisol behind this, but for, for time's sake, I won't get into it. But this is a very real thing and a modern life has completely inverted this. Our days are too dim and our nights are too bright. So just try and adjust things a little bit in each direction.

• 47:17Sean Hayes?

  I don't understand what, how people can sleep with like blacked out curtains. Like if I wake up and it's, you know, and it's bright outside.

• 47:25Will Arnett?

  You're trapped underground.

• 47:27Sean Hayes?

  Yeah, exactly. Or like in a drug, you know, you know, free day drug excursion. But like, so I have to sleep with, right? That's good to sleep with the curtains open so light comes in in the morning, right?

• 47:37Speaker 03

  It's great. I, I think everyone should invest, because it's very inexpensive, in a very, in a comfortable eye mask. You know, or these soft eye masks that, that Velcro in the backs, you can adjust it. You know, not one that's just like.

• 47:48Will Arnett?

  And that lets your eyes, and that lets your eyes.

• 47:51Speaker 03

  Yeah, lets them breathe a bit. And then, you know, you may, try this for me one night, Sean. Get, get a hold of some earplugs that are those, they're like wax. There's like a firm wax that you put on the outside of yours. You don't jam.

• 48:03Sean Hayes?

  Oh, yeah.

• 48:05Speaker 03

  You may be waking up because there's noises in your environment that you're not aware of. And just see if.

• 48:09Will Arnett?

  No.

• 48:10Speaker 03

  No, he's, you're convinced.

• 48:11Will Arnett?

  The noises are coming from inside out.

• 48:12Speaker 03

  I'm thinking this is you. I'm thinking.

• 48:17Speaker 03

  I'm thinking.

• 48:22Speaker 03

  Scotty.

• 48:24Speaker 03

  Fuck.

• 48:25Sean Hayes?

  No, I sleep with a fan on, because it's sort of block out all noise.

• 48:28Speaker 03

  And I, I think you're doing great.

• 48:29Sean Hayes?

  Yeah, my biggest fan.

• 48:30Speaker 03

  And if you can afford to get back to sleep a little bit, that, that sleep, that you said you sleep really hard late in the morning.

• 48:36Sean Hayes?

  Yeah.

• 48:36Speaker 03

  That, that's REM. You're dropping back.

• 48:38Will Arnett?

  Sean, have you thought about propofol?

• 48:41Sean Hayes?

  By the way, I get it.

• 48:42Jason Bateman?

  Steady drip.

• 48:43Sean Hayes?

  I get it.

• 48:44Jason Bateman?

  Hey, hey, Doc, what got you into medicine? Why, why, you have a parent that, that was in it? Or did you have a fascination with health when you were a kid, or both?

• 48:55Speaker 03

  Okay, well, I'm a researcher, not a clinician, so I, I profess a lot of things. I'm not gonna, I want to be clear about that. But my dad's a theoretical physicist.

• 49:06Speaker 03

  So I was exposed to a lot of science.

• 49:09Will Arnett?

  So none of it's been proven?

• 49:12Speaker 03

  Good.

• 49:12Will Arnett?

  Yes, for what it's worth.

• 49:14Speaker 03

  I like that.

• 49:16Speaker 03

  The internet would say, we don't know anything. I mean, it's kind of scary what's happening now with kind of like calling off all fact into a question. So here's the deal, my, my dad is an academic. He, he came here from Argentina, first generation immigrant, and to study physics. And I grew up in the South Bay area at a time before the personal computer, et cetera. But I was surrounded by science and technology as a kid.

• 49:39Sean Hayes?

  Your whole life?

• 49:40Speaker 03

  And always loved biology, always loved fish. I've got my fish tanks. I've always been fascinated by animal behavior, human behavior. So, and then in high school, I went to a quite good public high school.

• 49:53Speaker 03

  I, you know, I, for reasons related to, you know, teenage rebellion and, and home environment, I rebelled against all of that. I got really into the skateboarding punk rock scene in the Bay area and have a lot of friends who went on to start skateboard companies. And I got, we could talk stories about that at some time. But I was actually, Tony Hawk's dad took me to his house when I was a kid, so I got to sleep in Tony's room. No, Tony wasn't there. People always ask me when he was there. And I, I got exposed to a lot of action sports and music culture and really loved that. But it wasn't until college that I circled back to science and biology. I realized I need to get good at something. I wasn't very good at skateboarding. I wasn't going to be a an athlete or a musician or anything like that.

• 50:36Will Arnett?

  You look like you you look like you could be an athlete, though.

• 50:38Speaker 03

  Well, I've always worked out. I've always done skateboarding, soccer, swimming, running, lifting. I enjoy sports, but I wasn't very good. I wasn't bad, but I wasn't very good. And so I had the the the good sense, fortunately, and some input to go, you know, what do I really love and what could I get good at? And I love learning and I love teaching. I love learning. I love you. That's just kind of like who I am. I can't help myself. And so I got really into psychology and biology. At that time, they called it biopsychology. There was no field of neuroscience. And I started working in a laboratory and I got super serious about school. So did my undergraduate, my masters, my PhD, did a postdoc at Stanford and eventually was hired back to Stanford as a as a tenured faculty member.

• 51:20Speaker 03

  Running a lab and doing experiments with my hands is pure joy for me. I don't do it these days because of the podcast, but I still teach at Stanford. I still have my position there. And nothing makes me happier than learning information that I think people can make use of. Yeah. And telling them and not telling them what to do, but just go, hey, you might want to check this out. Or, you know, you're not sleeping well, or hey, maybe your sleep is just fine. And I feel I feel like there's been very little opportunity out there in in formal education to teach scientists and and physicians, clinicians.

• 51:51Will Arnett?

  Yeah.

• 51:52Speaker 03

  How to communicate with the general world. And it's usually like they have to like market their book or they're talking about their thing. I love actually talking about other people's science. I never I hardly ever talk about the science from my lab, but we've published lots of papers and have fun doing that. We could talk about that, but I just love learning and teaching. And so I'm, like I said, I'm 50 and I'm just like in bliss. The podcast lets me teach very broadly. Stanford's been super supportive. I still teach to students there. And I guess it was faded through my dad. My mom's a writer. My dad's obviously a scientist. But I just I I feel like the only downside of getting old for me is or is that I'm excited about what science and medicine are going to discover. And I just want to learn about it. It's not even so much that I can use it. I'm not thinking about eternal life or anything.

• 52:38Speaker 03

  It's like, think about how much we've learned in the. Last 10 years about gene editing, immunotherapies for cancer. I'll make a hard stance here and I'm not about doing this for any political reasons. I mean, whether or not you were like pro or anti or skeptical about vaccines during the pandemic. These mRNA technologies are incredible for cancer. Let's just leave, let's just, you can edit this out if you need to, but let's leave COVID aside.

• 53:02Will Arnett?

  Let's get into chemtrails after this, but.

• 53:04Speaker 03

  No, but these, these, you know, I went on Bill Maher and talked about this and I take a lot of heat for this because I'm sort of at the interface between the standard academic medical community and the kind of wellness. I hate the word, but biohacker community and they're really like at loggerheads. But the truth is there, there are pearls of wisdom all over the place. But science and medicine are the bedrock of everything I described. It's, you know, the only reason we even know what glutathione is or that light and temperature impact sleep cycles. And I mean, it's so important and, and I'm, I'm like, I'm on a mission to teach what I think is the best of science and medicine as I can see it so that people can make it useful to themselves and understand that one of the reasons

• 53:48Speaker 03

  that we are where we are these days is because of science and I just love it.

• 53:54Sean Hayes?

  Right.

• 53:56Speaker 03

  We'll be right back.

• 54:00Sean Hayes?

  Instagram teen accounts have automatic protections on by default. Built in content settings for the content teens can see, contact limits for who can contact them and time management tools like daily time limits and sleep mode. Teens are automatically placed into teen accounts and teens under 16 will need a parent's permission to change any of these settings to be less strict. Instagram will continue adding built in safety features to help create age appropriate experiences. Learn more about teen accounts and Instagram's ongoing work to protect teens online at instagram.com/teenaccounts.

• 54:43Jason Bateman?

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• 56:12Sean Hayes?

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• 57:01Speaker 03

  And back to the show.

• 57:04Will Arnett?

  There's so much noise out there and there's so many people out there now professing like a lot of people learned about that they should sleep with their room at 68 degrees because they heard Tom Brady say that in an interview, right? So like we're all, everybody's getting their like these little bits and pieces and they're going, I heard that you should, I just did it myself.

• 57:20Speaker 03

  Everything's a trend.

• 57:21Will Arnett?

  I heard you should get the sleep before midnight. I heard that you should get this. The vaccines, I heard this. And there are so many people out there who are speaking about in this space, whether it's wellness or medicine or whatever they're calling themselves. And, and, and you even, I forget the term you used, the sort of the, what'd you say? The sort of the cold plunge.

• 57:38Speaker 03

  Of the biohacking.

• 57:40Will Arnett?

  The biohacking cold plunge crew. Everybody's a fucking expert. There's all these fucking people and it, and there's a little bit of fatigue because I, part of me is like, God, it feels like I want to put everybody in the same bath. They're all anti-vax, fucking chemtrail, fucking nobody, don't trust the government, don't trust anything. And there's just so much of that out there that it's like, what the fuck do, what is, what is real anymore, dude?

• 58:04Speaker 03

  What does a person do? Yeah, exactly. So what I like to do is take a step back and think, okay, you know, why do people end up in these bins, right? Like why, not how did we get here, but kind of like where, where are people showing up to the table? And I think that, um, I said a lot in favor of science and medicine. I'm now going to say as an insider, what I also know, which is that the field of science and medicine has done a mediocre job of explaining why. The why behind things. They tell people what to do, but people like to understand the why. They, people are deeply rational at some level until they're not, right? And so I think that something I really believe in is that how people come to learn information

• 58:46Speaker 03

  strongly impacts whether and how they use that information. One of the reasons I do longer form podcasts where I explain mechanism, okay, is because I do think that if you understand that bright light, cold water, exercise and caffeine will spike your cortisol in the morning. And guess what? You want your cortisol high early in the day and dim light, lack of caffeine, cooler temperatures. Will lower your cortisol in the evening and help you sleep. Once you understand that you want that seesaw tilted high in the morning, high cortisol, you want this. I don't care if you're male, female, pregnant, young, old, whatever. And low cortisol in the evening, lower your heart rate, do some long exhale breathing, et cetera. Once you understand there's a mechanism behind it, then when somebody says,

• 59:29Speaker 03

  cold plunge is great, and you say, yeah, but early day makes more sense than later day. Or how about, you know, bright light early in the day? Makes sense. You need your cortisol high. Cortisol sets a wave front of energy for the day. You want it low later in the day. Once people start to understand a little bit of mechanism about dopamine, about cortisol, about sleep, then all this stuff coming at them, they can filter it through a rational filter. Wait, does this make sense based on the bulk of what we know? Now, when it comes to things like vaccines and prescription medication, let's take a slightly less barbed wire version of this, but that's very timely, which is all this stuff about the GLP-1s, right? People are saying, oh, you know, so many people are on GLP-1s.

• 1:00:09Sean Hayes?

  What is that?

• 1:00:10Speaker 03

  It's very interesting.

• 1:00:11Will Arnett?

  The weight loss.

• 1:00:12Speaker 03

  The weight loss thing.

• 1:00:13Sean Hayes?

  Oh, like Ozempic or whatever, yeah.

• 1:00:14Speaker 03

  Very, very interesting peptide that we knew about from Gila monsters. You know it was discovered in Gila monsters, these reptiles that only need to eat once every year or so. A smart biologist said, how come they don't get hungry all year long? Turns out they have very high levels of GLP-1 circulating. Isolated the peptide. We now GLP-1s is perhaps the first

• 1:00:33Will Arnett?

  Whoa.

• 1:00:34Speaker 03

  Really effective treatment for obesity and diabetes. Amazing. And it's also turning out to be very effective. We need more data, but for people who have what they now call alcohol use disorder, it can really reduce cravings for alcohol and sugar. So what happened was the medical community came out and I know that's what they call alcoholism now.

• 1:00:53Will Arnett?

  Wow.

• 1:00:54Speaker 03

  Yeah, everything's a pseudonym.

• 1:00:56Will Arnett?

  Hi, my name is Will and I'm an alcohol use disorderer.

• 1:01:01Speaker 03

  It's interesting, the only people, the people who have no trouble with the word alcoholic, I have a lot of friends, I go to meetings, like they are like alcoholics, right? Former alcohol, they go, they're like, part of, right? But everyone, you know, anyway. Here's what's really, I think so vital for us to understand is that, you know, if you look at the GLP-1s, they're very effective at lowering body weight. They are high cost because there's still not generic versions of them out there. The wellness biohacking community was very disparaging of this, like, oh, this is just a shortcut, this is bad for you. There were some side effects and indeed you have to be careful with these things. I'm not taking them, but I know people that do and they can be taken safely.

• 1:01:41Speaker 03

  But the moment that the GLP-1s hit the compounding pharmacy market and it was inexpensive, it was suddenly like the wellness biohacking community was like, oh, okay, this is great. This is just like a supplement, no problem. So people are just too entrenched in the camp they're in. I like to think, Will, I don't know, you tell me. I like to think that there is a league of reasonable people out there that represents the majority of people that are not so polarized. They're not talking about chemtrails, and now I'm going to get hate from the chemtrail people. I don't believe in chemtrails.

• 1:02:13Jason Bateman?

  What is a chemtrail? I have no idea what that is.

• 1:02:16Speaker 03

  There are people that think that the government is using chemicals from airplanes across the sky to reflect sunlight and...

• 1:02:24Will Arnett?

  Block the sun to reduce the effects of global warming, et cetera, or depend on the day. Oh, yeah, yeah.

• 1:02:29Speaker 03

  There were plans to put a mirror in space not that long ago to reflect sunlight in the other direction.

• 1:02:34Will Arnett?

  And they tried to conflate it, they tried to conflate it with cloud seeding, which is a totally different, which has been done since the 50s.

• 1:02:39Speaker 03

  That's crazy.

• 1:02:40Jason Bateman?

  Mirrors in space is something I've been a proponent of for a long time.

• 1:02:44Will Arnett?

  That's true, by the way, it is true.

• 1:02:45Jason Bateman?

  Okay, that's the way you look and look back into time, effectively.

• 1:02:48Will Arnett?

  He, we had Neil deGrasse Tyson and Jason had a very robust conversation with Neil about...

• 1:02:53Jason Bateman?

  About time travel.

• 1:02:54Will Arnett?

  About time travel using mirrors.

• 1:02:55Jason Bateman?

  It has to do with the speed of light and stuff like that, Doc, you wouldn't understand.

• 1:02:59Speaker 03

  No, but my father would. Yeah.

• 1:03:02Will Arnett?

  In theory.

• 1:03:03Speaker 03

  So, in theory, no. So, the important thing, I, here's what I'm hoping. We're 2026. Here's what I'm hoping. That the, there are.

• 1:03:13Sean Hayes?

  What are you most excited about 2026?

• 1:03:15Speaker 03

  There are most, because there are so many useful tools that don't involve taking anything, supplement or drug, that are very useful. There are also very useful prescription drugs out there that have helped save lives. And I, you know, and I think, I think people are coming to that clarity now. And there are also some over the counter supplement things that can help that are not as extreme as either. But I think that we are finally seeing a blending between the silos of these extremes of conspiracy theory versus, unless there's a double-blind placebo-controlled study, there's no way I'm gonna do it type people.

• 1:03:47Sean Hayes?

  Yeah.

• 1:03:48Speaker 03

  And, and I think Los Angeles, to be fair, I might have lived at west of Interstate 5 my entire life, northern, southern California, middle of the state. Los Angeles is the place where this stuff got blended together.

• 1:03:59Will Arnett?

  Yeah.

• 1:03:59Speaker 03

  Okay?

• 1:04:00Sean Hayes?

  Right.

• 1:04:00Speaker 03

  And as a, because people here are experimental, okay?

• 1:04:04Sean Hayes?

  Right.

• 1:04:04Speaker 03

  They're experimental. They like to try things and see what works and things get marketed and get put out there.

• 1:04:08Will Arnett?

  There are no bad, there are no bad suggestions, you know, especially after midnight.

• 1:04:11Sean Hayes?

  Right, right, right. Um, back to Jason's original question. So, your dad was, uh, I'm kidding.

• 1:04:17Will Arnett?

  I know.

• 1:04:17Sean Hayes?

  So, uh.

• 1:04:18Will Arnett?

  I do want to do, I was thinking.

• 1:04:19Speaker 03

  We can talk about my dad. He's still active as an 82-year-old scientist and he's physically well.

• 1:04:25Sean Hayes?

  I love that.

• 1:04:26Speaker 03

  Yeah.

• 1:04:26Sean Hayes?

  I love that.

• 1:04:26Speaker 03

  He's still super strong.

• 1:04:27Will Arnett?

  He doesn't look like, he doesn't look like that dude who's trying to biohack his age, right?

• 1:04:31Speaker 03

  Oh, not at all.

• 1:04:32Will Arnett?

  No.

• 1:04:33Speaker 03

  No, no. He's quite virile and robust.

• 1:04:35Will Arnett?

  Okay.

• 1:04:35Sean Hayes?

  Would you agree that our generation, like us, us four ding-dongs, have a good shot of living to be 100? That this generation?

• 1:04:42Speaker 03

  Easy.

• 1:04:42Sean Hayes?

  Yeah?

• 1:04:42Speaker 03

  Easy.

• 1:04:43Sean Hayes?

  Oh, really?

• 1:04:43Speaker 03

  100, yes. So, I think 120 is probably the genetic limit, natural genetic limit on age. I think.

• 1:04:50Will Arnett?

  At this point.

• 1:04:51Speaker 03

  At this point. I, look, I, I posted something, um, yesterday that I just found online of a confirmed ninety year old guy, not on any hormone augmentation.

• 1:05:01Will Arnett?

  Oh, I just saw that.

• 1:05:02Speaker 03

  Twenty, twenty.

• 1:05:03Will Arnett?

  Twenty pushups.

• 1:05:04Speaker 03

  And real pushups. And the best part is, is in front of his kids and grandkids. He's got his family there, takes his glasses off, gets down on the floor, and he does ten full, like, chest to the floor, full rep, full range pushups, stops midway, teases his son about doing partial reps, and then goes back and does the remaining ten, and then stands up, and basically, guy's ninety years old. It's so clear that, because, to answer your question, Jason, by drinking a little bit less, focusing on sleep a little bit more, working on limiting our stress a bit or a lot more, doing things that really bring us meaning, this is huge, we know this from all the Blue Zone stuff, but from everything else, social connection, like, really trying to put the phone away and drop in with people, and really, it's

• 1:05:50Speaker 03

  such a critical.

• 1:05:51Will Arnett?

  Sean.

• 1:05:51Speaker 03

  It, it's wonderful, it's also biological, right? It's biopsychological, how it benefits us. Plus, you know, nutrition's gotten better. I think that it's harder, the problem is, it's expensive to access good food, right?

• 1:06:04Will Arnett?

  Yes.

• 1:06:04Speaker 03

  But nutrition's gotten better than it was in the nineties. We're no longer messing around with trans fats, not everyone's smoking, um, if you're using nicotine, hopefully you're using it.

• 1:06:13Will Arnett?

  The nerds aren't smoking.

• 1:06:14Speaker 03

  You know, I know a lot of nerds, I'll tell you. I know a Nobel Prize winning neuroscientist, everyone in my community knows who he is. And the first time I met him about fifteen years ago, he chewed no fewer than five pieces of Nicorette during our meeting. And I said, "Why do you do it?" And he said, "It's protective against Parkinson's and Alzheimer's." And he said, "But you don't want to smoke, because it'll give you cancer." That, so, that, that's an anecdote, but, you know, so.

• 1:06:36Will Arnett?

  I, I want to take a photo, you and me, we're gonna go out, we're gonna go to, we're gonna get a cheese, we're gonna go get a Big Mac and smoke a cig, and we're gonna post it online, just to fuck with people's brains.

• 1:06:45Speaker 03

  All right.

• 1:06:45Will Arnett?

  Just to cause it, let's just do it.

• 1:06:47Speaker 03

  Fair enough.

• 1:06:48Will Arnett?

  Just fucking, you know what I mean? Just fuck it, just, just mess with everybody so they all can relax.

• 1:06:52Speaker 03

  Wait, to be clear, I'll eat a cheeseburger.

• 1:06:53Will Arnett?

  Yeah, good.

• 1:06:54Speaker 03

  I eat meat, cheese, fish, eggs, I mean, I eat fruits and vegetables, you know, I eat like a human. I eat like an adult. The thing to do is. Eat like an adult.

• 1:07:02Sean Hayes?

  Right, right, right.

• 1:07:02Speaker 03

  Don't slurp your food, don't drink your food.

• 1:07:04Will Arnett?

  Sean, what'd you have for breakfast today? Be honest, go.

• 1:07:06Sean Hayes?

  I haven't had anything except.

• 1:07:07Will Arnett?

  What's coming up? What's coming up?

• 1:07:08Sean Hayes?

  I'll probably have.

• 1:07:10Will Arnett?

  Be honest.

• 1:07:11Jason Bateman?

  Cinnamon roll?

• 1:07:11Sean Hayes?

  Uh, there's a cinnamon roll in there. There's also a chocolate chip cookie and also there's.

• 1:07:16Speaker 03

  Oh, my.

• 1:07:16Sean Hayes?

  Um, yeah, but I'll probably have yogurt.

• 1:07:19Speaker 03

  That's why you take them at Foreman's.

• 1:07:19Will Arnett?

  What'd you have yesterday? What'd you have yesterday morning when I called you and you were on the way? You were in the car with Sean.

• 1:07:24Sean Hayes?

  I did really good. I had carrots and cucumbers dipped in ranch.

• 1:07:27Will Arnett?

  No, yesterday when you drove.

• 1:07:29Sean Hayes?

  Oh, I went to Portillo's. Yeah.

• 1:07:31Will Arnett?

  Yeah.

• 1:07:32Sean Hayes?

  I drove to Portillo's in Buena Park. There's one in Buena Park.

• 1:07:35Jason Bateman?

  Oh, I was gonna say, you're in Chicago.

• 1:07:36Speaker 03

  So sugar's your thing, huh, Sean?

• 1:07:38Sean Hayes?

  Yeah, it's too bad. Anyway, listen, Andrew, we only have a couple of minutes left because we're taking you way too long. Um, and I just want to know, just as fast as you can, because I don't want to keep you, is my, my mom died of Alzheimer's and I, I, I, I like talking about it just to learn more about like what causes it and how to prevent it. And I took the, is it APO1, APO4 gene or whatever you? I don't have the gene. It doesn't mean I can't get it, but I, I'm less likely to get it because I'm not right predetermined through, um, genes, but what, you know, I, I, I mean, anytime, um, a report comes out that we're three to five years away from a cure or we're three to five years away from

• 1:08:18Sean Hayes?

  something positive about conquering this horrible, horrible disease. I don't know if you've been around it, but it's just awful to see somebody go through it.

• 1:08:28Sean Hayes?

  Is that the pharmaceutical companies like making sure we don't come up with the cure? Like, what are the realistic, you know, feelings about?

• 1:08:36Speaker 03

  Yeah.

• 1:08:36Sean Hayes?

  The future of, of, of cure for it?

• 1:08:39Speaker 03

  Yeah. Well, first of all, I'm, I'm really sorry. It's, it's devastating. I don't think people can understand until they see someone who's alive, but deteriorating.

• 1:08:46Sean Hayes?

  Yeah, yeah.

• 1:08:47Speaker 03

  It's awful. Um, the pharmaceutical companies are absolutely working very, very hard to try and solve this problem. As are many labs. I'll just put in a plug funded by US taxpayers. I might, you know, I have to say my lab was funded by NIH for many years. This is the, this is the, this is the thrust of discovery, not just in the United States, but all over the world. Like this, I'm working hard behind the scenes. To try and make sure that funding is maintained.

• 1:09:12Will Arnett?

  Yeah.

• 1:09:13Speaker 03

  Those discoveries get turned over to companies which pharma companies which test drugs on animals and then humans. So it is happening. Yes, they're not trying to keep us sick. Those theories need to go. Also, think about the finance. If it was just purely purely financial incentive, the person that comes up with that treatment for Alzheimer's.

• 1:09:29Will Arnett?

  Yeah.

• 1:09:30Speaker 03

  Like, I was like, okay.

• 1:09:32Will Arnett?

  Right.

• 1:09:32Speaker 03

  What can we do? Obviously, blood sugar management seems to be one important piece. It used to be people are starting to talk about quote unquote type three diabetes, not a real thing. Some people do seem to benefit from a ketogenic diet for offsetting some age related dementia, but not everybody. But it has to be truly ketogenic and it's hard to stay on a ketogenic diet. Okay. Some people rare, not everybody, but managing your blood sugar. It does seem that the effects of exercise and quality sleep and avoiding environmental toxins, and I can talk about that in a moment. Are significant toward offsetting age related dementia. People with these gene repeats are at higher risk.

• 1:10:16Speaker 03

  I'm great to hear that you don't have these repeats, but everyone should be trying to up. I hate the word optimize, trying to optimize on a daily basis, I should say, in real life context. Get the best sleep they can. It's so clear that resistance training, doing some form for women and men. This is like a whole new world now, right? He used to tell women that he needs resistance training. They'd be like, I don't want to be too big, this kind of thing. Resistance training for strength in particular. So if you can get strong without getting bigger by training with very, you know, safe.

• 1:10:44Will Arnett?

  Yeah.

• 1:10:45Speaker 03

  These are the things.

• 1:10:46Will Arnett?

  Low weights, tons of reps.

• 1:10:47Speaker 03

  Yeah. Or, okay, I would go the other direction, but, but in any case, the to maintain strength. It's not sufficient to just walk and garden and do yoga. I'm sorry. I know there's some yogis.

• 1:11:00Will Arnett?

  I agree.

• 1:11:01Speaker 03

  It's not sufficient.

• 1:11:02Will Arnett?

  Yeah, you need weight. You need.

• 1:11:03Speaker 03

  And so maintaining maintaining healthy blood sugar.

• 1:11:05Will Arnett?

  Wait, which goes back to do you lift, bro? I mean, honestly, that's just.

• 1:11:09Speaker 03

  Well, now it's you lift girl because I'll tell you, I have, I have a female training partner and she's a beast, but she's not big. She's just super strong. They're women and, you know, I have a mom in her eighties. I'm trying to tell her like, listen, you need to lift heavy for you objects. You need to do this. People, when they stop moving, I know it sounds like the usual advice, but when they stop moving.

• 1:11:31Will Arnett?

  Sedentary.

• 1:11:32Speaker 03

  Feedback to the, well, there's feedback to the, to the brain that that may. Help kickstart some of that neurodegeneration.

• 1:11:41Speaker 03

  That said, there are some genetic predispositions. Nowadays, we're all much better off because we all know the don't do's. The environmental toxin thing is interesting. There was the data that living next to a golf course put people more at risk for Parkinson's. These are correlative things. We are now discovering, okay, this goes in the opposite direction, Will, where people were, you know, all this like roundup stuff and, you know, cancer causing agent. It turns out that was a real thing.

• 1:12:06Will Arnett?

  Oh, yeah.

• 1:12:06Speaker 03

  You know, so.

• 1:12:07Will Arnett?

  We have a friend who's.

• 1:12:08Speaker 03

  Limiting exposure to environmental toxins to the extent that you can is going to be good, but you don't need to be hyper paranoid about these things. So I believe there will be a solution.

• 1:12:19Sean Hayes?

  I just think like your time is your time, like you're, you know, eat right, exercise, yeah, eat right, exercise, do good things.

• 1:12:26Jason Bateman?

  We could have saved an hour.

• 1:12:28Speaker 03

  And stay and stay and stay socially engaged. You know, my big push for 2026, I know we're out of time, but and I forgive me, I like to fire hoses.

• 1:12:37Sean Hayes?

  No, I love it.

• 1:12:39Speaker 03

  Useful things. I know they come here to hear you guys, not the guests.

• 1:12:42Sean Hayes?

  No, are you kidding? This is fascinating.

• 1:12:44Speaker 03

  Well, is we are like any technology humans build, it takes about 10, 15 years before we go, oh, my goodness, we really screwed up. And we're now realizing that with, here's the thing, people will listen to things for a long time, but they like to view things now in rapid succession. And when you put your phone away, it's going to feel a little boring for a bit. Good. Your brain, it's like a palate cleanser between life events. Putting your phone away, it'll feel like you'll feel restless, you'll feel bored. Engaging with people socially or even with your thoughts, getting back to that a bit. I have a lockbox for my phone that that it's a, it's a, it's locked in there for portions of the day and it's rough, right?

• 1:13:28Speaker 03

  You're like online, all these movies, all this stimulation is very exciting. Listening to podcasts is great, audio, long form stuff is great.

• 1:13:35Will Arnett?

  I agree.

• 1:13:36Speaker 03

  This is my push, people, put your phone away for a short while and drop in with people. And yes, it's going to feel boring for a bit, but then that's where from the health promoting and kind of life enriching stuff.

• 1:13:46Sean Hayes?

  Yeah.

• 1:13:47Speaker 03

  That's where the good stuff is.

• 1:13:49Will Arnett?

  I completely agree. And again, I see it, you know, because we, you know, Jason and I both have teenagers. We see with the kids on the phones, et cetera. And I see with my own kids, it's my, I've mentioned this many times, my big regret was giving my kids phones too early. But then I see it in myself and if you guys, if you can, and this again, this is just an observation, I started noticing in public places where I just sort of try to clock people on their phone, not just randomly, but especially people going in, like let's say going into an elevator or going to a restaurant, they order a coffee, I was in New York last week, and I watched people when they had, they make an order and then they have a minute where they gotta wait, and everybody just out of habit pulled out of their phone, and sometimes they do it out of insecurity because they don't want to look like they got nothing to do.

• 1:14:33Sean Hayes?

  Right.

• 1:14:34Will Arnett?

  So they want to look like they're doing something, otherwise they feel exposed and they feel too vulnerable in that moment to just stand there and be present.

• 1:14:44Sean Hayes?

  I know.

• 1:14:44Will Arnett?

  Check it out, it's really fascinating. If you start watching people in stores, in restaurants.

• 1:14:50Sean Hayes?

  I'll do it on an elevator, Will. Like if I'm in an elevator and I'm with somebody and I'm just, I'll pull out my phone because I'm, what am I gonna say?

• 1:14:56Will Arnett?

  By the way, and the other guy does it too.

• 1:14:57Sean Hayes?

  It's super entertaining.

• 1:14:58Will Arnett?

  People don't know how to engage.

• 1:15:00Sean Hayes?

  You know, it's fun to not pull it out on an elevator and just stare at someone.

• 1:15:03Will Arnett?

  And just, yeah.

• 1:15:04Sean Hayes?

  The whole time.

• 1:15:05Will Arnett?

  When everybody's looking out towards the door, you just stand inward, looking inwards.

• 1:15:09Sean Hayes?

  And then wait till they look at you and then just raise your eyebrows like, what? I'm not on my phone. It's weird, isn't it?

• 1:15:16Will Arnett?

  And also bring back the art of winking, you know, stop winking at people.

• 1:15:20Sean Hayes?

  A slow wink will really offset someone.

• 1:15:22Will Arnett?

  It's real nice.

• 1:15:24Sean Hayes?

  Andrew, we're winking at you. Thank you for coming today.

• 1:15:28Will Arnett?

  Honestly, I know.

• 1:15:29Sean Hayes?

  This is so great.

• 1:15:30Speaker 03

  Thanks so much for having me.

• 1:15:31Sean Hayes?

  I could listen to you for hours and a half. And so I just, I'm a huge fan and I love.

• 1:15:37Jason Bateman?

  Thank you for starting our year off just right, sir.

• 1:15:40Speaker 03

  Well, thanks, guys. I want to say, and I know I'd speak for many, many people, I'm a huge fan of what you guys, no, I know everyone's always jockeying you guys, but here's the deal, from a very young age in many of your cases, and, but still now, you really enrich the world with really entertaining and really like stimulating, thought provoking stuff. And I think, you know, long form podcasts, movies, TV, that stuff I actually think can enrich us in a real way. And so that's not what I'm referring to when I talk about the phone stuff, and I think we all know. So I just want to say thank you. It's an honor and pleasure to be here and I'm a big admirer of the work you do.

• 1:16:16Sean Hayes?

  Thank you likewise.

• 1:16:17Will Arnett?

  Thanks, dude. Thank you, man.

• 1:16:19Sean Hayes?

  Thank you, buddy.

• 1:16:20Will Arnett?

  Keep fighting the good fight. Thank you so much.

• 1:16:22Sean Hayes?

  I'd love, yeah, you have to come back and I have so many more questions.

• 1:16:24Speaker 03

  Anytime.

• 1:16:25Sean Hayes?

  Thanks, Andrew.

• 1:16:26Speaker 03

  All right.

• 1:16:27Sean Hayes?

  Thanks, Andrew.

• 1:16:28Will Arnett?

  See you.

• 1:16:30Sean Hayes?

  He's one of those guys that, he kinda said it, that he breaks down all that information so you can digest it in a way, you know, that we can understand it. And like, how does a person know all that?

• 1:16:42Jason Bateman?

  Yeah, it is great. That's something that didn't, yeah, that didn't exist a while. Well, I mean, what, like WebMD and stuff like that started to like, you could, you could just go there and start asking a bunch of questions. You didn't need to like make a doctor's appointment and stuff. And now it's like ChatGPT will kinda break it down a little bit more for you. But these podcasts, or even like TikTok or Instagram, you get these little bite-sized pieces of information. But as he said, you do have to kinda like thin out what is just the entertainment crap and what is the real science-based stuff.

• 1:17:10Will Arnett?

  Yeah, and like what's conspiracy shit? And that's what I was saying, like, there's so many people out there. At least he's a guy who's, you know, a professor at Stanford. So you have to try to like, I'm gonna try to lean towards the people who have a little bit more sort of academic credentials.

• 1:17:25Jason Bateman?

  Yeah, I mean, science is still science and the other stuff is sort of, I guess it's always been there, but it never had, as we've talked before, it never had the platform, the amplification, the microphone that it does today. And so it does seem like, whoa, what do you know? Like now, like, you know, you never know what's real. No, it's just that the noise just got noisier. The science is still there and still valid. You just have to self-edit this new level of volume for nonsense and put it back down to its right size.

• 1:18:01Sean Hayes?

  Yeah, I mean, like, and all the stuff that he does at Stanford and like, he's into ophthalmology, psychiatry.

• 1:18:09Will Arnett?

  You couldn't even, Sean, you know what I was gonna, okay, you know what I was gonna say, Sean? Just because you have, no, hang on. I think that, Sean, this is what I wanted to get to, cuz you've had a few. And I can feel you building up, cuz you couldn't even get through your own setup.

• 1:18:25Jason Bateman?

  No, that's okay.

• 1:18:25Will Arnett?

  But I wanna say, as I heard you, as I heard him talking to you and you were talking about your sleep, and I was thinking like the different things, the light, the sound, the thing, the bedtime, and maybe, maybe all you really need for a good night's sleep is just a good, old-fashioned lullaby.

• 1:18:45Sean Hayes?

  Bi-yi. Bi-yi, I was gonna do, I was gonna do neuro-bio-science.

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