Episode 442: The Truth About GLP-1s and Peptides for Weight Loss

Listen to the full episode here: https://podcasts.apple.com/us/podcast/habits-and-hustle/id1451897026?i=1000674829479 Are you curious about what peptides like Semaglutide (Ozempic) are really doing in your body? In this Fitness Friday episode on the Habits and Hustle podcast, I talk with Dr. Tyna Moore to discuss today's most talked-about treatments. Dr. Tyna explains how peptides work differently for each person. We also discuss how they're being used to address everything from weight management to recovery, and why some industries might feel threatened by their success. Dr. Tyna is an expert in holistic regenerative medicine and resilient health with nearly three decades of experience in the medical world. As both a Licensed Naturopathic Physician and a Chiropractor, Dr. Tyna brings a unique perspective to building robust health foundations, having graduated from the National College of Natural Medicine and the University of Western States Chiropractic College. She is also a #1 Best Selling author, international speaker, and host of The Dr. Tyna Show Podcast. What we discuss: Differences between GLP-1 peptides How peptides support natural hormone pulsing versus direct hormone replacement When Semaglutide is appropriate for patients Cycling peptides rather than continuous use Using low-dose GLP-1s for cardiovascular benefits and mood improvement How peptides can provide a "leg up" for lifestyle changes Industries potentially threatened by GLP-1 success (Big Food, pharmaceuticals, dialysis clinics) Long-term consequences of metabolic dysfunction (joint replacements, dialysis, dementia) Thank you to our sponsor: Therasage: Head over to therasage.com http://therasage.com/ and use code Be Bold for 15% off TruNiagen: Head over to truniagen.com http://truniagen.com/ and use code HUSTLE20 to get $20 off any purchase over $100. Magic Mind: Head over to www http://www/.magicmind.com http://magicmind.com//jen and use code Jen at checkout. Air Doctor: Go to airdoctorpro.com http://airdoctorpro.com/ and use promo code HUSTLE for up to $300 off and a 3-year warranty on air purifiers. Bio.me: Link to daily prebiotic fiber here https://bio.me/?utm_source=Jennifer, code Jennifer20 for 20% off. Momentous: Shop this link https://www.livemomentous.com/?srsltid=AfmBOorDUIZz3psr1Qsq_n1yE8_6JTq_QUFabOO9lH65HDEXCIoJOPLj and use code Jen for 20% off To learn more about Dr. Tyna Moore: Ozempic Uncovered: https://www.drtyna.com/ozempicuncovered Instagram: https://www.instagram.com/drtyna/ Youtube: https://youtube.com/@drtyna Find more from Jen: Website: https://www.jennifercohen.com/ Instagram: @therealjencohen Books: https://www.jennifercohen.com/books Speaking: https://www.jennifercohen.com/speaking-engagements

Speaker names marked ? are inferred from speaking time and the show’s known hosts — they are not voice-verified.

• 0:01Speaker 00

  Hi guys, this is Tony Robbins. You're listening to Habits and Hustle. Crush it.

• 0:07Jen Cohen?

  Are there hidden benefits to GLP-1s that the FDA just isn't talking about? In this Fitness Friday episode of Habits and Hustle, I sit down with Dr. Tina Moore to break down the truth about GLP-1 medications and the hype surrounding them. Dr. Tina is an expert in holistic regenerative medicine. She shares why these drugs are more than just weight loss tools and how the conversation around them has become very polarizing. This is a short clip from our full interview, where you can find the full episode linked in the show notes below. Please listen and comment with anything you'd like. Enjoy the episode.

• 0:53Jen Cohen?

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• 1:38Jen Cohen?

  routine and it's perfect for when you travel as well, which is why I always take it with me in my bag. If you want to make fiber a part of your daily routine, and I suggest you do, head to bio.me and use code JENNIFER20 for 20% off your first order. That's B-I-O dot M-E and code JENNIFER20 for 20% off. Now let's dive into today's episode.

• 2:17Jen Cohen?

  Are you telling me that GLP-1 and let's say a semoralin peptide, they're both, they're not the same peptide, but they're both in the same class or both peptides?

• 2:26Speaker 02

  They're both peptides, but they're not at all the same. They don't do the same things in the body. No. They, they both may have some anti-inflammatory and some regenerative impacts, but they have different mechanisms.

• 2:37Jen Cohen?

  What does semoralin do?

• 2:38Speaker 02

  That's a growth hormone, I believe, releasing hormone peptide. So that'll help you, your growth hormone declines as you age. And they, back when I was starting practice, you could still prescribe patients growth hormone, but they would get all pink and puffy and we don't want to crank growth hormone. So a lot of people, I think probably in their maybe 50s and 60s, in the, if they've been going to longevity doctors for a long time, probably got some growth hormone at some point. But the FDA put a, you know, snafu on that. And so when I got into practice, I was licensed as an chiropractic doctor in 2008. And my mentor was like, do not prescribe growth hormone. You will get in trouble with the FDA. So I never prescribed it. But I knew people that still were, and I knew doctors that were still taking it or putting their patients on it. And those people would get pink and puffy.

• 3:21Speaker 02

  And then came peptides many years later, which would help support your natural pulse of growth hormone at the appropriate times. GLP-1s support natural pulsing of insulin at the appropriate times. They actually work on your pancreas to help heal the pancreas and support natural release of insulin when needed. And also on the cellular level, they help the cells, if you will, in the kindergarten version, hear it better. They help the tissues respond to insulin better. And that's just but one mechanism.

• 3:54Jen Cohen?

  And, and so semoralin, you said, so what, so when would someone take semoralin?

• 3:59Speaker 02

  If they've had an injury, if they're, I'll use it when someone's really burned out. I'll use it when someone's trying to alter body composition and they just can't get up on it. So this is a great time, I think. As we hit middle age, you know, when people are like, okay, I'm lifting weights, I'm doing all the things, but I'm just not having that anabolic response to the work I'm putting in anymore. We can put them on bio-identical hormone replacement and estrogen and testosterone are going to be supportive to muscle protein synthesis. But sometimes we need to get that growth hormone up a little bit. And so there might be a myriad of reasons. Somebody may have gone through a terrible illness and they're just fried on the other side of it, you know?

• 4:39Speaker 02

  Long COVID, I'm not saying it's a specific treatment for that, but I think of these post-viral syndromes and people coming out the other side of a big womp with a virus. That might be a time to give them a leg up, but we cycle them and we pulse them. We aren't just putting people on them forever and saying, hey, good luck. We're using it as part of a comprehensive protocol and we're making sure that we're checking off all the boxes. And we are making sure that we aren't cranking them up on especially one thing alone. I mean, imagine going on just estrogen or just testosterone or just progesterone only. You'd mess up the whole system, right?

• 5:13Jen Cohen?

  But I think this is what people are doing. They're going just on testosterone.

• 5:16Speaker 02

  Yep.

• 5:17Jen Cohen?

  Or and or the semorlin. The reason why I'm asking about semorlin was I've heard a lot of people be, a lot of people are prescribed semorlin in my world. You said another one, Tresemorlin?

• 5:28Speaker 02

  Um, Tessamorlin.

• 5:29Jen Cohen?

  Tess, are they, are they different also?

• 5:31Speaker 02

  They're a little bit different, yeah, but they both work similarly in that we're trying to get a good pulse and activity out of some growth hormone.

• 5:38Jen Cohen?

  Most people, and I feel like it doesn't work for some people, it works for other people. Is that with every peptide? But then GLP-1 seems to work for everybody.

• 5:46Speaker 02

  It doesn't unless, so what's happening is people are cranking the dose into crazy high levels in the standard dosing. In the standard, you know, big pharma pen version, people are going up to these really high, and some people need that though.

• 6:00Jen Cohen?

  Are you talking about GLP-1?

• 6:01Speaker 02

  Yeah.

• 6:01Jen Cohen?

  I'm talking about the semorlin and the other one.

• 6:03Speaker 02

  Right, well, peptides are gonna work or not, I mean, it's all individualized, not everything works for everyone. But also you get much better results when somebody's metabolically optimized. So if you were to come in.

• 6:16Jen Cohen?

  Okay.

• 6:17Speaker 02

  And take a peptide, we would be able to likely keep, or hormone for that matter, any hormone. If you walked into my office, I'd be like, oh, this is gonna be easy. And this is like, you've got good muscle mass, I can tell you're doing all the things, your skin's glowing, you have good vitality.

• 6:30Jen Cohen?

  Wow.

• 6:32Jen Cohen?

  I'm like, should I pay you? And that was for free. I didn't, I didn't pay or just say anything.

• 6:35Speaker 02

  Well, you take care of yourself, you know?

• 6:37Jen Cohen?

  I try.

• 6:37Speaker 02

  So a little bit of hormone, a little bit of peptide is likely going to have a really powerful impact on you. And there's other people who are really not very well metabolically optimized, and peptides don't work as well on them. Do we still use them? Yes, we probably need a higher dose, and it gets a little muckier. It's not as clean and easy on my end.

• 6:56Jen Cohen?

  Can you take too many? Can you take, if someone's taking the testosterone, the semorlin, or do people take semorlin instead of testosterone? Or like, my question is like, if someone wants to like, change their body composition, I'm gonna ask the most basic one that most people want to know about. They want to like, get lean, lose weight, change their body composition. What would be the cocktail that you would prescribe?

• 7:19Speaker 02

  Uh, that gets tricky, because I don't want to get in trouble with my board or anyone else. But I'll tell you what I do. I'll tell you what I do. First, I'm gonna run labs, obviously, and see where we're at with everything. Second, I'm gonna do a very in-depth analysis of what their lifestyle's like, because if they're fucking around with a bunch of alcohol, and they're eating, you know, not the right foods that are conducive to longevity, and we're dealing, or honestly, in my world, I can't tell you the amount of people who came in who were just balls of stress, like high-level CEOs that were just burning the candle at all ends. There's, you know, then we're just like, trying to supplement to keep up. We're not even getting any headway.

• 7:57Jen Cohen?

  Not getting any headway, yeah.

• 7:58Speaker 02

  So it really depends on a lot of factors, and then lifestyle factors, how well muscled they are matters a lot. And then I'm not gonna ever put anybody on anything forever. I think that that's the problem, is all of these potentially are pro-gro. And my, I'm conservative, in my opinion, taking something like PPC 157 even, all the time, every day, I think that's a bit of a danger. I think we want to cycle those, right? We want to go on them and come off of them. We want to use them as we need and come off of them. But I'm conservative with use. And I'm also concerned about all of these, including GLP-1s, about receptor sensitivity. Are we gonna, basically, any cell that gets bombarded with a peptide or hormone, or anything for that matter, is gonna start cleaving off

• 8:43Speaker 02

  receptors. And so you're gonna start, the cells are no longer gonna hear what we're doing for it. Where they're not going to hear the hormone in the system anymore. And so we have to start using higher and higher doses. I don't like that cycle. I think that gets really messy. And so I'm looking for folks who are really well optimized. Those are much better candidates, I think, for peptides. Do the other folks out there need it? I mean, the argument I get all the time when I say this for people is, well, you know, 70% of Americans are obese or overweight and, you know, 94%, at 2018 data showed close to 94% were cardiometabolically busted. So what about them? And I'm like, here's what I say. We use peptides whilst they're getting their lifestyle in order because it does give you a leg up. And some people need a leg up.

• 9:28Speaker 02

  So that's where I come back to this obesity conversation and, oh, is it the easy way out? Well, why wouldn't we give somebody a leg up? Why wouldn't we give somebody the opportunity to have a window open where it's actually inducing some neuroplasticity and they can make the appropriate lifestyle changes with good counseling, right? With actually good guidance from their physicians or their health coach or whatnot. And they can start to rewire different pathways with good lifestyle habits. I'm all for giving people a leg up. So I use peptides differently for different categories of patients.

• 9:59Jen Cohen?

  Okay, so let's just say, let's just get back to the Ozempic because there's so many questions I have for it. The microdosing or the doses? Can everybody microdose it and get a benefit from it?

• 10:11Speaker 02

  I suppose it would matter on what their personal history is, what their family history is. So I've got a patient who's got a pretty severe family history of cardiovascular disease, history themselves of high blood pressure. They're just using it at a very low dose to keep their blood pressure mitigated. And it does seem to have some impact, but only if they're doing all the other things, right? If they start messing around, and we're doing other things in there as well. I'm using different herbs, different nutrients, different supplements, different lifestyle interventions. But it is one of many in a toolkit. I've got people on it who have found it to be really spectacular for boosting their mood and their neurocognition and allowed them to go off antidepressants and allowed them to discontinue some of the things they were doing.

• 10:53Speaker 02

  It's, it's really, I think this is the problem, and I think this is maybe what got me in trouble, is the need for a lot of other pharmaceuticals may go by the wayside in certain people, depending on how impactful this GLP-1 is in their body. Because it not only potentially is abating some of the pathology. I mean, we have hard data showing Its impacts on the cardiovascular system as well as what it's doing to the cardiovascular cells, the cells of the heart, actually, the damage that's done when there's pathology is being abated and potentially reversed and mitochondrial function is returning. And we're seeing this in different organ systems of the body. So this is where I'm like, who has something to lose? Which industries have something to lose? Who turned off my Instagram?

• 11:37Speaker 02

  Was it big food? Was it big food? Because big food has a lot to lose and they've come out recently and like different CEOs have come out, flat out and said, go look it up on Forbes. They're concerned, like their snack food sales are down. McDonald's fast food sales are down. Big Pharma might have something to lose because those big pharma companies who don't have a patent on a GLP-1, who are doling out lifestyle drugs, like high blood pressure medications and statin drugs, that's their bread and butter. Type 2 diabetes and obesity is very profitable to a lot of industries. So maybe people aren't needing those medications anymore that are on GLP-1s. The, the big, the companies that make the joint replacements are concerned because hip

• 12:19Speaker 02

  and knee replacements are a massive, massive industry right now because all the boomers are just, the obesity problem is really causing havoc on these joints. I mean, most people in our age group, I don't know how old you are, but I'm guessing we're somewhere in there.

• 12:33Jen Cohen?

  29.

• 12:34Speaker 02

  Always, forever. I'm 28 forever.

• 12:36Jen Cohen?

  Line 39, go on.

• 12:38Speaker 02

  Yeah. Um, I mean, hip replacements are a thing, right? Coming down the chute. Dialysis clinics potentially have something to lose. They're popping up on every corner because long-term metabolic dysfunction is, you know, a 15, 20 year process. You get to type 2 diabetes and they're like, oh, you've hit the magic number, but the damage has been being incurred to the microvasculature, to our joints, to every, to our brains, to everything else, to our kidneys for that entire time. And so now they're at type 2 diabetes. The path beyond that is dialysis, if you make it, if the cardiovascular disease doesn't take you out, it's dementia and Alzheimer's, right? Like, that's the path that most Americans are headed down because of our system. And I'm with

• 13:22Speaker 02

  Everyone who's like, right now, we see Kelly and Casey Means, and they are banging the drum on that fact that we need to change the systems. And I completely agree. And I know Dr. Mark Hyman has been trying to change the systems for a long, long time. I totally agree with that. And that has been my platform as well for decades. But I'm over here like, OK, the house is on fire for a lot of people in this country and the world. And we can talk all we want about how the drywall is flammable and the wood's flammable and the foundation's not built right. We can go on and on, and we need to change all that. I completely, we've got to make it earthquake proof. Totally agree. But there's a frickin' fire right now on this individual, and I need a fire extinguisher.