
Gradient Dissent: Conversations on AI
Hosted by Lukas Biewald
Written by a model from the transcript; not yet reviewed.
Tuhin Srivastava, CEO of Base10, describes how the company went from a model deployment tool for data scientists (founded 2019) to a fast-growing AI inference company. He says the shift wasn't a pivot but a refocusing: as models grew larger, moved to production, and shifted from data scientists to engineers, infrastructure they'd already built became critical. Early customers included Patreon (Whisper for subtitles) and a friend who fine-tuned Stable Diffusion for music (Refusion), scaling to 100-150 A10G GPUs. The company was 18 people at Series B in late 2023 and is now 110.
Srivastava breaks inference into infrastructure (scaling across thousands of GPUs, fault tolerance) and runtime (how fast models run, measured by time to first token, time per output token, throughput, cost per token). He argues generic shared inference of vanilla models is commoditized, but dedicated deployment of custom and fine-tuned models is not; 99% of Base10's business is dedicated capacity. He compares vLLM, SGLang, and TRT-LLM, and explains why CUDA remains dominant.
On the broader market, he argues inference is the most important market because if models do everything, the only remaining question is what the model needs to do. He predicts we're "out of data" and need an architectural unlock, but sees a thousand-fold of economic value still to unlock. He also describes Base10's "burn the boats" culture, having killed three of four products in 2022.
ChatGPT and Stable Diffusion as Turning Pointsstory
Srivastava says ChatGPT set consumer and developer standards, but Stable Diffusion was the bigger moment because it proved open-source models could be approximately as good as closed ones, injecting excitement into the ecosystem.
Refusion Scaled to 150 A10G GPUsstory
A friend named Seth fine-tuned Stable Diffusion to generate music, called Refusion, and came to Base10 the day before launch needing GPUs. He ended up scaling to 100-150 A10G GPUs, which Srivastava says was mind-blowing at the time.
Generic Inference Is a Commodityinsight
Srivastava argues that serving a vanilla open-source model behind an endpoint is 100% a commodity, but dedicated deployment of custom and fine-tuned models is not, because every workload has different SLAs, hardware constraints, and compliance needs.
Four Key Inference Metrics Explainedstrategy
Srivastava breaks down the four metrics that matter: time to first token (dominated by pre-fill), time per output token (dominated by decode), throughput (a memory bandwidth question), and cost per token (hardware cost plus KV cache usage).
TRT-LLM Fastest, vLLM Most Usabledata
Srivastava says TRT-LLM is by far the fastest on Nvidia chips after about 90 days from a model drop, vLLM is the most usable for anyone, and SGLang sits in between. He compares the convergence to frontend frameworks.
We're Out of Datainsight
Srivastava predicts the next major model unlock requires an architectural breakthrough because we've exhausted available training data. He still sees a thousand-fold of economic value to unlock even without AGI.
Inference as the Final Marketinsight
Srivastava reframes the question from why inference is the fastest-growing market to why it is the most important market, arguing that if models do everything, the only remaining question is what the model needs to do, and it can only run on inference.
Killing Three of Four Productsstrategy
In 2022, Base10 killed three of four products, including an application builder that 20+ people spent 2.5 years building, and a fine-tuning product called Blueprint that a third of the company spent six months on. Srivastava says being okay with throwing things away allows you to take side quests.
In this episode of Gradient Dissent, Lukas Biewald talks with Tuhin Srivastava, CEO and founder of Baseten, one of the fastest-growing companies in the AI inference ecosystem. Tuhin shares the real story behind Baseten’s rise and how the market finally aligned with the infrastructure they’d spent years building. They get into the core challenges of modern inference, including why dedicated deployments matter, how runtime and infrastructure bottlenecks stack up, and what makes serving large models fundamentally different from smaller ones. Tuhin also explains how vLLM, TensorRT-LLM, and SGLang differ in practice, what it takes to tune workloads for new chips like the B200, and why reliability becomes harder as systems scale. The conversation dives into company-building, from killing product lines to avoiding premature scaling while navigating a market that shifts every few weeks. Connect with us here: Tuhin Srivastva: https://www.linkedin.com/in/tuhin-srivastava/ Lukas Biewald: https://www.linkedin.com/in/lbiewald/ Weights & Biases: https://www.linkedin.com/company/wandb/
11,333 words · 2 speakers
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