
Written by a model from the transcript; not yet reviewed.
In this episode of Equity, the host is joined by Matt Murphy, partner at Menlo Ventures, to discuss the explosive growth of Anthropic, the unique dynamics of AI venture investing, and the lessons for modern founders. Murphy reflects on leading Menlo's Series D investment in Anthropic, detailing the non-obvious entry points, the importance of technical leadership under Dario Amodei, and how products like Claude Code and cowork accelerated enterprise adoption. The conversation also explores open-source versus proprietary models, the implications of AI regulation, and the staggering zero-to-one-hundred-million growth curves seen in portfolio companies like Lovable.
Throughout the discussion, the guest and host analyze why AI waves differ from previous technological shifts due to ubiquitous adoption and product-led growth. Murphy explains how platforms are shifting the burden from traditional sales cycles to developer-friendly, highly accessible tools. The episode concludes with a look at upcoming consumer AI opportunities and the accelerating pace of innovation across the startup ecosystem.
Hosts greet listeners and introduce the sponsor, Schneider Electric.
Murphy explains his role as a board observer and ongoing involvement with Anthropic.
Murphy describes how he and his team use Claude for research, internal workflows, and client projects.
Murphy outlines how Anthropic built tools like Claude Code and skills to make the model accessible and grow revenue.
Murphy shares the founding story, founder qualities, and early investment challenges of Anthropic.
Murphy highlights growth and mission of Lovable and Ligora, illustrating the platform model and enterprise adoption.
Discussion on the shift toward open source models for cost control and how enterprises balance multiple models.
Murphy talks about the need for industry-led governance boards and the challenges of regulation.
Murphy explains how AI changes the speed, product focus, and barriers to entry for founders compared to past waves.
Recognizing Special Founders Earlystory
The guest explains why Menlo Ventures went all-in on Anthropic during its Series D in 2024, highlighting Dario Amodei's exceptional technical knowledge and the strategic advantage of backing the creator of ChatGPT.
Building the Right Harnessinsight
The guest details how Anthropic's breakthrough came not just from a great model, but from building harnesses like Claude Code and cowork that make the technology accessible and connect easily to enterprise data.
The Rise of Open Sourcedebate
The host and guest discuss how enterprises and growth startups are increasingly turning to open-source models to optimize cost structures and manage massive token consumption as their applications scale.
Balancing Multiple Modelsstrategy
The guest explains that mature companies will use a hybrid approach, dedicating a percentage of API requests to Claude and the remainder to open-source or custom models for specialized data needs.
Stunning Early Revenue Growthdata
The guest highlights how companies like Lovable and Ligora are scaling from zero to hundreds of millions in record time, representing a completely new velocity in venture-backed software startups.
“I love telling this story because some things were obvious, some things were difficult, some things were very not obvious at the time.”
“But if you don't breadcrumb people and give people a way to use the model, then you're kind of waiting for people to replatform all their applications and, and, you know, you need, you know, just to use the API.”
“The great thing when AI came along is boom, you know, it's available on any device to anyone.”
“If you have a really good idea, there's just so many few barriers in the way for you to go from idea to a product that people actually want than there ever has been before.”
Anthropic leaped to a $47 billion revenue run rate by May, compared to $9 billion in 2025. It’s the kind of growth that Menlo Ventures' Matt Murphy says he's never seen in 25 years of investing, not in the internet wave, not in mobile, not in the first cloud boom. Menlo led Anthropic's $500M Series D, and Murphy has had a front-row seat as the company went from a pre-revenue, pre-launch bet to one of the most valuable startups out there. On this episode of TechCrunch's Equity podcast, Julie Bort talks with Murphy about backing Anthropic before anyone else would, why a great model was never the point, and what's driving the fastest-growing startups he's ever seen. Listen to the full episode to hear more about: Why Menlo bet on Anthropic at a $4 billion pre-revenue valuation when the deal didn't fit cleanly into any of the firm's funds, and why Google and Amazon signing on as investors was an early “green shoot.” Why Murphy says the model was never the real moat, and how Claude Code, MCP, and Claude Skills turned Anthropic from a strong model into a full platform. Murphy's take on the backlash to Anthropic's Mythos rollout, and why he pushes back on the idea that it was more marketing than safety. Why companies like Lovable and Legora are growing faster than any startups Murphy has seen in 25 years, and what that speed means for founders trying to compete. Subscribe to Equity on YouTube, Apple Podcasts, Overcast, Spotify and all the casts. You also can follow Equity on X and Threads, at @EquityPod. Learn more about your ad choices. Visit megaphone.fm/adchoices
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