
Summary
Written by a model from the transcript; not yet reviewed.
This episode explores how AI-native startups gain an advantage over established software incumbents that try to layer models on top of existing systems of record. The host and guests examine this dynamic through enterprise procurement, arguing that most actual work happens outside ERP systems across emails, spreadsheets, contracts, and supplier conversations. The guest explains how multi-agent systems can handle these end-to-end workflows and manage negotiations, while the host breaks down the differences between retrieval, process, policy, and principal agents. The discussion highlights why internal AI builds often fail to handle exception handling and why capturing context across multiple systems creates a durable moat for vertical startups.
- Legacy incumbents are limited to their system of record and often fail to complete the end-to-end job because most work happens across external channels. 3:32
- Enterprise procurement spans legal, finance, and cost engineering, meaning simple process automation only solves a fraction of the actual problem. 12:30
- Deploying human-in-the-loop oversight allows negotiation agents to gather feedback and gradually earn enterprise trust for larger financial transactions. 16:19
- Internal AI builds often break down when faced with complex exception handling and the need to map data across multiple changing systems. 42:39
Chapters
- 0:00Podcast Intro and Context
Hosts introduce the episode and explain the focus on AI agents in procurement.
- 0:43AI Native Startups vs Incumbents
Discussion of the advantage of AI-native startups over established vendors in owning end-to-end processes.
- 6:17Four Types of AI Agents
Explanation of retrieval, process, policy, and principal agents and their roles in enterprise workflows.
- 12:20Practical Use Cases and Value
Examples of autonomous negotiations, invoice processing, and real‑time insights that deliver cost savings.
- 14:49Trust and Human‑in‑the‑Loop
Exploration of how trust is built through human oversight and gradual autonomy in negotiations.
- 17:00Future of Dual‑Side AI Agents
Speculation on suppliers and buyers both using AI agents to streamline negotiations and coordination.
- 26:21Multi‑Agent System for Procurement
Vlad describes how Leo’s multi‑agent architecture handles end‑to‑end procurement tasks.
- 34:28Modeling and Fine‑Tuning Strategies
Discussion of using foundation models, harnesses, and outcome‑based training for specialized procurement tasks.
- 38:02Customer Adoption and Moats
How owning the end‑to‑end work creates customer lock‑in and long‑term defensibility.
- 49:41Automating Deployment and Customization
Explains how AI agents enable automated deployment and allow customers to customize solutions via software, reducing manual intervention.
- 50:45Engineering‑Centric Company Culture
Describes the company’s heavy engineering focus and its strategy to avoid being a consulting firm by building self‑service products.
- 52:09Event Highlights and Buyer Feedback
Details the recent procurement event, attendee demographics, and the excitement around AI‑driven procurement solutions.
Highlights
- 3:32
Incumbent Limitations on End-to-End Workinsight
The guest explains that legacy software vendors are constrained by their specific systems of record and cannot complete an entire end-to-end workflow like resolving complex customer cancellations.
- 5:45
Hidden Work Outside System of Recorddata
The guest highlights that an ERP might show an 8,000 dollar final price, but hides dozens of stakeholder meetings, hundreds of emails, and weeks of cost engineering work.
- 7:08
Four Tiers of Autonomous Agentsstrategy
The guest breaks down agents into retrieval, process, policy, and principal categories, demonstrating how judgment increases as agents move from simple verification to strategic compensation decisions.
- 16:19
Building Trust via Human in the Loopstrategy
The guest explains that enterprises never start with fully autonomous negotiation agents, using a human-in-the-loop approach to feed learnings to the agent and scale up trust.
- 20:31
Procurement Touches Multiple Departmentsinsight
The host and guest discuss how enterprise procurement has evolved from an isolated function into a cross-functional process touching legal, finance, and engineering.
- 30:28
Automating Indirect Versus Direct Procurementinsight
The guest contrasts indirect procurement, where high-volume purchases can be fully automated, with direct procurement involving high-stakes suppliers where prep work is massive.
- 42:39
Failure of Internal Enterprise AI Buildsstory
The guest shares an anecdote about a Fortune 500 company that spent months trying to build an internal cash collection product before realizing the context quality was too poor.
Quotes
“No company, no enterprise starts with fully autonomous negotiation agents from day one.”
Unnamed speaker · 16:19 “The opportunity for the AI native startup is to say, we're going to own that entire end to end arc.”
Seema Amble · 4:16 “We are feeding our agent with all the feedback and all the learnings, and then they suddenly trust us for like 10K negotiations, 20K negotiations, 100K negotiations.”
Unnamed speaker · 16:56 “The end result that you see in your system of record is like, oh, instead of like one billion, I paid 900 million dollars.”
Unnamed speaker · 33:01 “So, I mean, this was the third time that we are doing, that we are doing this event.”
Unnamed speaker · 52:43 “And it's like crazy to see that they work in emails and on Microsoft Teams, and in Excel sheets and PowerPoints.”
Unnamed speaker · 54:05 “But it's like highly emotional. So that's a good thing.”
Unnamed speaker · 56:57 “Procurement people gone wild. Yeah, yeah. It's gonna be, that one is in Munich?”
Seema Amble · 55:22
About this episode
a16z’s Seema Amble and Elena Burger sit down with Lio co-founder and CEO Vladimir Keil to ask where AI-native startups have an advantage when incumbent software companies already own the customer, the data, and the system of record. Their answer comes down to the work that happens outside those systems. In procurement, a final price in an ERP can hide hundreds of emails, spreadsheets, supplier conversations, engineering analyses, and decisions across legal, finance, and operations. Vlad explains how Lio uses multi-agent systems to take on more of that end-to-end work, from sourcing and RFQs to negotiation, shipment tracking, and invoices. They also discuss how enterprises learn to trust agents with increasingly consequential decisions, why the last 20% of an internal AI build can require most of the effort, and what happens when both buyers and suppliers have agents working on their behalf.
Transcript
10,804 words · 4 speakers
Speaker names marked are inferred from speaking time and the show’s known hosts — they are not voice-verified.
Topics
- Leo
- A16Z
- Excel
- New York
- Munich
- AI agents
- Accenture
- Coupa
- Microsoft Teams
- PowerPoints
Page updated · transcript and summary are machine-generated