
Invest Like the Best with Patrick O'Shaughnessy
Hosted by Patrick O'Shaughnessy
Written by a model from the transcript; not yet reviewed.
Krishna Rao, the CFO of Anthropic, discusses the business from his unique seat at one of the fastest-growing companies in history. The conversation focuses on compute as the core canvas of their business, the strategic use of the cone of uncertainty, and the allocation of massive hardware resources across Amazon Trainium, Google TPUs, and Nvidia GPUs. Rao explains how Anthropic's multi-cloud and multi-chip strategy, paired with internal automation using tools like Claude Code, allows them to scale rapidly from nine to thirty billion dollars in run rate revenue while maintaining high returns on frontier intelligence.
The episode opens with sponsor messages and a brief introduction by host Patrick O’Neal.
Patrick introduces Krishna Rao and outlines the focus on compute procurement and allocation at Anthropic.
Krishna explains how compute is the lifeblood of Anthropic, framing it as the canvas for all other work.
Krishna details the cone of uncertainty, the need for flexible compute deals, and the three-chip strategy (TPU, GPU, CPU).
Christian’s reflections on scaling mindset, hiring, and balancing personal life.
The conversation shifts to how compute is allocated across model development, internal use, and customer demand, and the collaborative culture behind it.
Krishna outlines Anthropic’s deep partnerships with Amazon, Google, Microsoft, Broadcom, and Nvidia, and how they influence compute procurement.
Krishna explains Anthropic’s pricing philosophy, the stability of prices, and how lower prices can spur higher consumption.
Krishna shares how Anthropic’s finance team uses Claude and Claude Code to automate reporting, budgeting, and strategic analysis.
The episode concludes with a discussion on Anthropic’s capital raising journey, investor expectations, and the company’s growth trajectory.
Discussion of Anthropic’s Series D and E rounds, investor concerns about frontier models and scaling.
Exploration of how research in interpretability, alignment, and safety drives enterprise trust and revenue.
The Lifeblood Canvas of Computeinsight
Rao describes compute as the lifeblood and canvas of the company. Buying too much risks the business, while buying too little leaves them behind the frontier.
Fungible Multi-Chip Strategystrategy
Anthropic utilizes Amazon Trainium, Google TPUs, and Nvidia GPUs fungibly across model development, internal use, and customer serving after years of building orchestration layers.
Scaling Revenue and Intelligencedata
The company grew its run rate revenue from $9 billion to $30 billion in four months, driven by model intelligence leaps and enterprise adoption.
Recursive Self-Improvement in Codeinsight
Over ninety percent of Anthropic's internal code is written by Claude Code, which in turn helps build the next generation of models.
Pricing Stability and Jevons Paradoxinsight
When Anthropic lowered the price of the Opus family, consumption increased far beyond expectations, demonstrating the Jevons paradox in AI token usage.
Automating Finance with Claudestrategy
The finance team uses Claude to produce statutory financial statements and generate monthly financial reviews in thirty minutes instead of hours.
“The compute that we procure, it's the lifeblood of our business.”
“Think of it this way: if you buy too much compute, you go out of business.”
“I would say I spend 30 or 40% of my time on compute even today.”
“We started the year with about $9 billion of run rate revenue, and we ended the quarter with a $30 billion of run rate revenue.”
“We pioneered interpretability, which is, think of it as like an MRI for the model to see inside the neural network how it works.”
“We are really focused on what's really happened is model led growth, enabled byproducts and our go to market team and our distribution.”
“And I think people are beginning to understand that.”
“We prioritize having a strong relationship on this because we do think that regulation has a role to play.”
“We may live in a world where you're diagnosed with a disease that is not curable, but in your lifetime, that cure can be found much more rapidly and you might not die of that disease.”
My guest today is Krishna Rao, the CFO of Anthropic. The center of our conversation is how he navigates the decision around procuring and allocating compute, which he describes as the canvas on which everything else gets built. We talk about what he calls the cone of uncertainty, the three chip platforms Anthropic uses fungibly across Trainium, TPUs, and GPUs, and the daily meetings they run to allocate compute between model development, internal use, and serving customer demand. He explains why the returns to frontier intelligence keep getting higher, especially in enterprise, and how Anthropic thinks about the line between platform and application and why they choose to build their own products like Claude Code. Krishna has such a unique seat watching one of the fastest growing businesses in history, and he is generous in sharing what he has learned since joining the company two years ago. For the full show notes, transcript, and links to mentioned content, check out the episode page here. ----- Become a Colossus member to get our quarterly print magazine and private audio experience, including exclusive profiles and early access to select episodes. Subscribe at colossus.com/subscribe. ----- Ramp’s mission is to help companies manage their spend in a way that reduces expenses and frees up time for teams to work on more valuable projects. Go to ramp.com/invest to sign up for free and get a $250 welcome bonus. ----- Trusted by thousands of businesses, Vanta continuously monitors your security posture and streamlines audits so you can win enterprise deals and build customer trust without the traditional overhead. Invest Like the Best listeners get a special offer of $1,000 off Vanta when you go to vanta.com/invest. ----- WorkOS is the infrastructure B2B and AI-native companies use to sell to enterprise. It covers everything enterprise security requires: SSO, SCIM, RBAC, Audit Logs, AI governance, and more. Trusted by 2,000+ fast-growing companies, including OpenAI, Anthropic, Cursor, and Vercel. ----- Rogo is the AI platform for finance. They're building agents for Wall Street that are trained to understand how bankers and investors actually do work: from diligence and modeling, to turning analysis into deliverables. To learn more, visit rogo.ai/invest. ----- Ridgeline has built a complete, real-time, modern operating system for investment managers. It handles trading, portfolio management, compliance, customer reporting, and much more through an all-in-one real-time cloud platform. Visit ridgelineapps.com. ----- Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com). Timestamps: (00:00:00) Welcome to Invest Like The Best (00:02:29) Episode Intro: Krishna Rao (00:03:14) Compute as Anthropic's Lifeblood (00:05:17) Three Fungible Chip Platforms (00:07:31) The Cone of Uncertainty (00:09:08) Competing Ways to Allocate Compute (00:10:36) What Drives Compute Efficiency (00:12:38) Why Frontier Returns Are So High (00:16:32) How Claude Code Writes Its Own Code (00:18:46) Will Talent Become Obsolete? (00:20:07) How Scaling Laws Are Holding (00:21:54) Exponential Thinking (00:23:17) The Layer Cake of Compute (00:26:36) How Anthropic Deploys New Compute (00:27:53) Platform v. Application Layer (00:32:42) Why Model Pricing Has Stayed Stable (00:35:26) Measuring Return on Compute (00:37:22) Working With Chip Providers (00:38:32) How Anthropic's Finance Team Uses Claude (00:41:32) The Jevons Paradox for Labor (00:43:08) Anthropic's Fundraising & Growth Journey (00:47:31) The Exponential Revenue Curve (00:49:02) The Hardest Thing to Explain to Investors (00:52:15) AI's Public Perception Problem (00:55:38) Mythos (00:57:31) Relationship With Government (00:58:51) Inside Anthropic's Culture (01:03:48) The Next Frontier: Virtual Collaborators (01:06:22) How Leaders Scale With a Business (01:10:55) The Biggest Risks to Continued Progress (01:12:09) What Krishna is Excited About (01:13:45) The Kindest Thing
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