Christina Applegate and Jamie-Lynn Sigler

Jamie-Lynn Sigler feels giddy about being Conan O’Brien’s friend. Christina Applegate feels awesome about being Conan O’Brien’s friend. Jamie-Lynn and Christina sit down with Conan to discuss their respective MS diagnoses, exploring growth and self-reflection on their podcast MeSsy, and why it’s so important to get specific about your vulnerability. Later, Matt Gourley reveals his family’s eerily accurate Oscars fashion predictions. For Conan videos, tour dates and more visit TeamCoco.com. Got a question for Conan? Call our voicemail: (669) 587-2847.

Speaker names marked ? are inferred from speaking time and the show’s known hosts — they are not voice-verified.

• 0:02Conan O'Brien?

  Who do you shop for first on the holidays, Sona? Was it, do you shop for the kids or do you shop for Tac?

• 0:06Speaker 01

  My kids.

• 0:07Conan O'Brien?

  Okay.

• 0:07Speaker 01

  Or Oki.

• 0:08Conan O'Brien?

  You gotta get them their stuff.

• 0:08Speaker 01

  Or my dog.

• 0:09Conan O'Brien?

  And then your husband is last. Well, guess what? It's that time of year. You feel that, you smell that cinnamon cider in the air? Do you smell that?

• 0:18Speaker 01

  Yeah.

• 0:19Conan O'Brien?

  And you see pumpkins around, people buying turkeys. A little early to buy a turkey. Doesn't matter. Holidays? I would say it's just around the corner, but that's a cliche. It's very nearby in the cupboard. Well, guess what? Amazon delivers joy with low prices on the gifts you want even this early in the season. So get ahead of the season. Shop early gifts, top picks, holiday decor, and advent calendars at low prices. Get ahead, start on holiday gifting with Amazon's low prices. Shop now at amazon.com/holiday.

• 0:52Speaker 02

  This is the story of the one. As a shipping manager, he's running the dock, stocking supplies, and making sure every order goes out on time. And Granger helps him stay prepared. From shipping supplies to PPE to hand tools, he counts on Granger to keep products moving and trucks rolling. So his operation runs smoothly no matter the shift. Call 1-800-GRANGER, click Granger.com, or just stop by. Granger, for the ones who get it done.

• 1:25Speaker 03

  Hi, I'm Jamie Lynn Sigler, and I feel giddy about being Conan O'Brien's friend.

• 1:31Conan O'Brien?

  I like that. That's very nice. Some people can get very mean, and I know that you're not gonna do that, Christina. I know you're not.

• 1:42Speaker 04

  Damn it. I was gonna say, I feel really stupid being Conan O'Brien's friend. I won't. I will change mine to the nicer part of me.

• 1:52Speaker 01

  No.

• 1:53Speaker 04

  Hi, I'm Christina Applegate, and I feel awesome to be Conan O'Brien's friend.

• 2:18Conan O'Brien?

  Hey, everybody.

• 2:21Conan O'Brien?

  It's Conan O'Brien Needs a Friend. I'm Conan O'Brien. Sona laughing really hard. Matt, Matt Gurley joining us as well. And we might as well just talk about this because I just said it. Sona, should you recount what happened?

• 2:34Speaker 01

  Oh my, I don't even know if I can, like, say, give it justice. Because I was talking about something and you-

• 2:40Conan O'Brien?

  You were talking about something and you were talking, we were talking about Ray Fiennes and how much we love Ray Fiennes and how good he is. And then you were going on for a while about how great Ray Fiennes is. And I said, "Well, I'm not, I'm not talking right now, so this is boring."

• 2:53Conan O'Brien?

  Meaning, there's, words are happening, but they're not coming from me, so this is boring. Let's get started. Yeah. And, and you were laughing really hard because it might be the truest thing I've ever said.

• 3:08Speaker 01

  You're just like, "Well, I'm not talking, so I've, you know, like, you've completely checked out because it's not coming out of your mouth."

• 3:14Conan O'Brien?

  It wasn't, you know what happened? It was this moment where I noticed that the words weren't coming out of my skull. So what good could they be? Right? I mean, what could their value possibly be? Right?

• 3:28Speaker 01

  I mean, it's unheard of that anything I would say would have any sort-

• 3:31Conan O'Brien?

  Again, it's happening.

• 3:31Speaker 01

  Yeah.

• 3:32Conan O'Brien?

  I'm like, "What is this?" I'm hearing like, "Wah, wah, wah, wah." It's like Charlie Brown characters hearing their parents.

• 3:38Speaker 01

  You don't even have, hear words coming out of my mouth, like, when I'm talking?

• 3:41Conan O'Brien?

  I'm just counting down. It's like, "When do I get to go?"

• 3:45Speaker 01

  Oh, my God. Oh, my God. You should.

• 3:49Conan O'Brien?

  Did you? I just heard croaking over there. Sounds like there's a toad.

• 3:53Speaker 05

  I will say this, just a teaser for the segment in this episode. We have some Rafe Fiennes related content to cover.

• 3:59Conan O'Brien?

  Oh, good.

• 4:00Speaker 05

  We'll get to this later in the episode.

• 4:02Conan O'Brien?

  And that was, I didn't know that that was happening.

• 4:04Speaker 05

  Coincidence, yeah.

• 4:05Speaker 01

  Yeah, let's get some Rafe Fiennes content.

• 4:08Conan O'Brien?

  You were talking about how he's, he's still got it and he can.

• 4:11Speaker 01

  He's still got, I said, he's still got it and he can, he can get it.

• 4:15Conan O'Brien?

  He can get it.

• 4:16Speaker 01

  I don't know.

• 4:16Conan O'Brien?

  Is that a saying?

• 4:17Speaker 01

  He can get it.

• 4:18Speaker 05

  He can get it?

• 4:19Speaker 01

  Yeah.

• 4:19Speaker 05

  And he can.

• 4:20Speaker 01

  He can get this.

• 4:21Conan O'Brien?

  He can get this.

• 4:21Speaker 05

  They're married.

• 4:22Speaker 01

  Yeah, I know. I'm not gonna fuck Rafe Fiennes. I mean, it's not gonna happen. I shouldn't have said it so, I'm not gonna make love to him.

• 4:30Speaker 05

  Which would it be?

• 4:30Conan O'Brien?

  Make love to him. If you said he's still got it and he can get it, then you're not talking about making love. Oh, Rafe. Pretty come to yon window.

• 4:44Conan O'Brien?

  And let us embrace. Do be gentle. Do be gentle, Rafe. We would be.

• 4:49Speaker 01

  If there was any chance of him coming on, I think I just killed it, right?

• 4:52Speaker 05

  Maybe, maybe if anything, maybe the odds are better.

• 4:55Conan O'Brien?

  Yeah, you just said he's got it and he can get it. You just rang the dinner bell.

• 5:00Speaker 05

  Yeah.

• 5:00Speaker 01

  The ring-a-ding-ding.

• 5:02Speaker 05

  For what it's worth, same here, buddy.

• 5:04Speaker 01

  That killed it. That killed it. No, no, that killed it.

• 5:06Speaker 05

  You don't know.

• 5:07Conan O'Brien?

  Yeah, you'd be gentle.

• 5:08Speaker 05

  I would be gentle.

• 5:09Conan O'Brien?

  Um, I, he's a terrific actor. He's great in everything he's ever done. And I was just remarking that it's hilarious that he always, I mean, it's not hilarious, but when I hosted the Oscars recently, he was in the audience and it was like his, you know, fifth time being nominated and he, he's clearly the, the best actor in the room.

• 5:27Speaker 01

  Yeah.

• 5:27Conan O'Brien?

  He's an amazing actor and they, he'll probably never get an Academy Award. I shouldn't say that. I hope he does, but.

• 5:34Speaker 01

  I hope he does.

• 5:34Conan O'Brien?

  These amazing actors come over from, uh, from the UK and they're insanely incredible and, uh, you know, they don't win and they're, they put a, they're all like, well, you know, still I enjoyed my visit to Qatar and.

• 5:51Conan O'Brien?

  Is Sona around? Yeah. Is Sona around? I'm told she thinks I have it and I could still get it.

• 5:59Speaker 01

  I think it's because they're not, uh, they, you know, they don't do enough like, he needs to like hook up with like, you know, Selena Gomez.

• 6:07Conan O'Brien?

  What?

• 6:08Speaker 01

  Yeah, yeah, it's like something needs to happen.

• 6:10Conan O'Brien?

  Selena Gomez is with Benny Blanco.

• 6:12Speaker 01

  I know, I can't believe you know that.

• 6:13Conan O'Brien?

  I'm sorry, I'm bringing this back again.

• 6:15Speaker 01

  You really are, you just wanna talk about Benny Blanco any chance you can get.

• 6:18Conan O'Brien?

  I, the other day I was driving around and we brought this up on the podcast, but I just wanna repeat it. The most modern sentence that I can think of to say is Benny Blanco's just slid into my DMs.

• 6:30Speaker 01

  Yeah.

• 6:31Conan O'Brien?

  Cause I don't know what that means.

• 6:32Speaker 05

  Any of it.

• 6:33Conan O'Brien?

  Any of it. I don't know what any of it is, but I've memorized it in case I'm ever at a party.

• 6:38Speaker 01

  Oh, okay.

• 6:38Conan O'Brien?

  And someone's questioning, "Hey, man, you seem kinda old, maybe you should move on." I'm gonna say, "Yeah, well Benny Blanco just slid into my DMs."

• 6:46Speaker 05

  And then that person says, "Really? I'm Benny Blanco."

• 6:49Conan O'Brien?

  Yeah, and I'll say, "Well, I'm here in person and if you've got something to say to me, say it face to face." Let's say it face to face, Benny B. If that's even your real name.

• 7:02Conan O'Brien?

  What? What? Say it.

• 7:03Speaker 01

  I love that you're, you're talking about Benny Blanco sliding into your DMs while you're talking to Benny Blanco. That just made me laugh. That really made me laugh.

• 7:11Conan O'Brien?

  I love it's proof at my age that I'm still, that I'm young.

• 7:15Speaker 01

  Yeah.

• 7:15Speaker 05

  Yeah, I believe you've still got, is your Hailey Bieber smoothie over there?

• 7:19Speaker 01

  Yeah.

• 7:19Conan O'Brien?

  Nope, it's not. I threw it out. I was done with it. Um, I love that, uh, I'm trying to, I love anything where someone's like, "Hey, man, you shouldn't be hanging out at this party, you're too old." And, and that I think that me shouting at that moment, "Benny Blanco just slid into my DMs." Everyone would be like, "Whoa, whoa, whoa, whoa, whoa, whoa, he's young."

• 7:36Speaker 01

  Oh, yeah, yeah. Guys, he's cool. He's cool.

• 7:39Conan O'Brien?

  Let's disregard his rotting face.

• 7:45Speaker 01

  Someone would be rude enough to just be like, "Hey, old guy, why are you at this party?" You know?

• 7:50Speaker 05

  Let's try this out, okay?

• 7:51Conan O'Brien?

  Okay, go ahead.

• 7:51Speaker 05

  All right. "Hey, what's up, granddad? How'd you get in here?"

• 7:54Conan O'Brien?

  What do you mean, "How did I get in here?" Um, I'm a youngster. Benny Blanco just slid into my DMs.

• 7:59Speaker 01

  Youngster.

• 8:00Speaker 05

  What? What are you talking about? Do you even know what a DM is?

• 8:03Conan O'Brien?

  Uh, it's the Demilitarized Zone that separates South Korea from North Korea. It was established-

• 8:08Speaker 05

  This guy's cool. He can say.

• 8:09Conan O'Brien?

  It was established, uh, by the United Nations at the end of the Korean conflict.

• 8:14Speaker 05

  Oh, right, yeah.

• 8:15Conan O'Brien?

  Yeah, yeah, I've actually been there. I've visited the Demilitarized Zone. And Benny Blanco was one of the great architects of the late 19th century.

• 8:22Speaker 05

  Hey, guys, gather round. I'm hearing some crazy whack history stories. This guy's off-

• 8:27Speaker 01

  Yeah, all the women are undressing.

• 8:30Conan O'Brien?

  Yes.

• 8:31Speaker 01

  Yeah.

• 8:31Conan O'Brien?

  That's right. I have the riz.

• 8:34Speaker 05

  Oh, so you really got it. Okay, I'm gonna write the rap.

• 8:36Speaker 01

  You just shouldn't go to those parties. Just if someone invites you, just don't go. You're busy.

• 8:40Conan O'Brien?

  I wouldn't be at those parties. They would find me peering in a window and they would call the police.

• 8:47Speaker 01

  I mean, who knows? You could be. You could go to a party where Benny Blanco and Selena are and then, you know.

• 8:54Conan O'Brien?

  I would know Selena. I would not know Benny Blanco.

• 8:56Speaker 01

  Yeah.

• 8:57Conan O'Brien?

  And I have nothing against Benny Blanco. He's, you know, I think Selena Gomez is cool. I love her. I, I, I'm, I'm all for this Benny Blanco gentleman. I just came up with that sentence when I was driving my car. Benny Blanco just slid into my DMs and I said, "That's gonna get me out of a sticky situation someday or get me into one. I don't know." All right, let's get into it. Enough of my bibble and babble. I think this has been enough. Tomfoolery and skullduggery and Tomthuggery. My guest today, and that's plural guests, today hosts the podcast Messy, which releases new episodes every Tuesday, wherever you get your podcasts. I'm very excited they're here today.

• 9:39Conan O'Brien?

  Christina Applegate and Jamie Lynn Sigler, welcome.

• 9:45Speaker 04

  Conebone. Conebone.

• 9:47Conan O'Brien?

  Conebone.

• 9:48Speaker 04

  Never stuck.

• 9:49Conan O'Brien?

  No, it did. My wife calls me Conebone.

• 9:51Speaker 04

  No, because Tom Hanks came around and did coo-coo.

• 9:54Conan O'Brien?

  Oh, yeah. Yeah.

• 9:55Speaker 04

  And then that became your thing. I was trying to make Conebone happen.

• 9:58Conan O'Brien?

  I'm kinda glad Coco won, frankly. I'm really happy.

• 10:03Speaker 01

  It's never too late. It can still happen.

• 10:05Conan O'Brien?

  Yeah. Um, I, I was gonna start by, first of all, thanking both of you for, for being here and I have very distinct memories of both of you. I'm at that age now where I get very sentimental and I look back over, I don't know, just things that I've done in the past, people I've met. Christina, I remember very clearly you being such a wonderful friend to me on the show. You came on the show so many times and you were always so funny and great and miraculous. And I think I think you you might hold some record for coming on the show.

• 10:42Speaker 04

  I might.

• 10:43Conan O'Brien?

  You might, you might.

• 10:44Speaker 04

  It was like my favorite thing anytime I got a call saying, hey, you know, even like you sometimes would have like a guest like fallout or something. They'd be like, will you come in? I'm like, absolutely. I would love nothing more. I really like you were my favorite interviewer ever. I had so much fun there.

• 11:00Conan O'Brien?

  That's sweet of you. And it helped that you lived in an apartment right above our studio in Rockaway Center. She lived in a.

• 11:06Speaker 04

  Called an apartment. I was outside the bathroom.

• 11:09Conan O'Brien?

  Actually, it was it was a cleaning closet.

• 11:11Speaker 04

  It was a cleaning closet.

• 11:12Conan O'Brien?

  There was a cot and people were like, I can't believe Christina Applegate lives in this shitty.

• 11:20Speaker 04

  And you guys charged me rent.

• 11:21Conan O'Brien?

  Yeah, no. It wasn't a lot of rent. But I just, I wanted to start by thanking you from the bottom of my heart for just always being just this light, always such a great guest, always so fantastic. And I have a very such a very clear memory, Jimmy Lynn. I remembered when The Sopranos first came out and had been on for one season. It was the new thing. Everyone was talking about it. And it's nominated for all these Emmys. We're nominated too. We're in New York. I go, I get on my American Airlines flight and I sit in this American Airlines flight. And then the person sits down next to me and it's James Gandolfini, who I'd never met.

• 12:03Conan O'Brien?

  And we talked the whole way and he was just talking about like, yeah, I don't know what this is. He had such a like, what is this? We're going to an award show. And I went, yeah, you're on the biggest show on television, Jim, and you're the star of it. Anyway, he talked about act. We just had a lovely time.

• 12:19Speaker 04

  Yeah. Oh, that's so cool.

• 12:21Conan O'Brien?

  And my memory is they put me up at this hotel, I think it was the Four Seasons Hotel, and I walk out at one point and you're standing there with your co-star, Robert Isler. And you're just like both standing there and you're you're kids. I mean, how old would you have been?

• 12:37Speaker 04

  Seventeen.

• 12:37Conan O'Brien?

  Yeah, you're just you're kids and you you were standing there right outside where the cars pick people up and and you just both looked like you had been. Beamed to Mars, like you're here at the Emmys. And I chatted with you guys for a second and remembered having this weird look at, oh, you're, this crazy ride is just starting for you. And I'm getting a sneak peek and I remembered you just seeming like, I think she's gonna be good. She seems like such a grounded, nice kid. I think you're gonna be okay.

• 13:09Speaker 03

  That's so nice to say. Well, I can tell you, like, meeting you was, like, that, you, I probably looked like I had just been beamed, beamed to Mars because that's how we felt seeing you. That's how we always felt, like, seeing people that we admired and, like, Christina and actually, and I have talked about that you are our favorite show to do.

• 13:27Conan O'Brien?

  Oh, that's nice.

• 13:27Speaker 03

  Because you just, you set us up to-

• 13:30Speaker 04

  When we're talking to you, when we're talking to Jimmy Kimmel, that's a whole other conversation.

• 13:34Speaker 03

  Yeah, we were lying to Jimmy.

• 13:37Conan O'Brien?

  I had dinner with-

• 13:37Speaker 03

  But I have a distinct memory because my brothers and I bonded over your show.

• 13:42Conan O'Brien?

  Right.

• 13:43Speaker 03

  Like, the bits in your show, we would talk about it all the time. And the first time I did your show, I was able to get my brother, my oldest brother, Adam, in the front row there. And that was like, it's one of those, like, I made it moments that you're able to share with the people that were there with you. So that was one of those for me.

• 13:57Conan O'Brien?

  It's so funny, I have, I don't know if it's the Irish in me or whatever, but I get very nostalgic for all of us floating along on this journey. And then I see these people along the way. And so to get to check in with both of you is very nice. I mean, yes, this is a podcast and we're doing this and there's gonna be an ad or something, but I don't, I don't fucking care about that. I feel like I'm talking to you guys. I'm checking in. Both of you have been through so much and you're doing a beautiful thing, which is you're sharing it, you're talking about it. Very frankly, you have your own podcast, Messy,

• 14:37Conan O'Brien?

  and it's all about MS, which you're both dealing with, and everything that happens. And I know that it's, you're helping a lot of people, but the strange thing I've found about doing a podcast, and I'm not struggling, I'm struggling with just inherent craziness, but, but not MS, but what I have found- Is that it's healing for me to talk to people. And I'm it's I'm imagine there's a component of doing this podcast where both of you are maybe doing some healing for yourselves about having this problem that you're being able to talk about it openly in this forum. Is probably helpful to you.

• 15:19Speaker 04

  Well, absolutely. 100%. I mean, that's how this all came about was when I was came out with my diagnosis in 2021. Our friend Lance said, you got to talk to Jamie because I'm sure you feel like you're on an island and you don't understand what's happening. And that's the person to talk to. And I had met Jamie a few times over the years and it was like we got on the phone and we were on the phone for hours and I felt like so less alone.

• 15:44Conan O'Brien?

  Yeah.

• 15:44Speaker 04

  Sorry, I get I get teary when I talk about my James, but um.

• 15:48Conan O'Brien?

  Yeah.

• 15:49Speaker 04

  It helped it healed me in that moment. And that's how this happened was it was like we're talking about so much information and so much stuff that so many people newly diagnosed or even people who have been diagnosed for years might not know about or or want to say the things that we say, like the brutal honesty about how painful it can be, how lonely it can feel, how awful it is. And then, you know, that's only coming from my mouth because I'm negative Nelly. And then Jamie will be like, but let's breathe, you know, and I love you, Jamie.

• 16:19Speaker 04

  She gets pissed off about it, too.

• 16:20Conan O'Brien?

  Here's the interesting thing is it's it's it's not that one way to go is wrong and one is right. They're both.

• 16:26Speaker 04

  No, no, no, that's I was totally kidding. You know, by the way, it's like we we have helped each other in the sense that I I get to see some a different side to all of this because of her.

• 16:38Conan O'Brien?

  Yep.

• 16:38Speaker 04

  And she gets to be honest about how she feels sometimes about in ways that you didn't, right? I don't want to speak for you.

• 16:43Conan O'Brien?

  Yeah. But I Yeah. Well, because I was noticing that Jamie Lynn, you got diagnosed much earlier than even I I knew. I was familiar with your diagnosis, but then I was shocked to find out that you got your diagnosis when you were on The Sopranos. You were also working on Broadway at the time. And I just assumed that this came, you know, 10. Years later, because you didn't talk about it, you were afraid to talk about it because you thought. You thought you could get fired. Is that right?

• 17:15Speaker 03

  Yeah, I think there was a lot of reasons. I think the initial, you know, drive to keep her a secret and protect me was the fear of being fired, the fear of not being hireable, not, you know, the fear of what people would think about this and me with this. I also think it allowed me to live in a state of denial for some time. Because if I didn't talk about it with anybody, then maybe it wasn't real. But then, you know, over the years, as the disease started to manifest into what it would be for me physically, and I started to have to make up excuses and lies, it, it was really difficult. And as much as I could,

• 18:00Speaker 03

  like, regret that choice, I think it's really informed a lot about me and my life. And, you know, now, what's so beautiful, like, with messy and having Christina and what I've learned about myself through this process is, you know, when you find community and when you, when you talk to somebody else, you can almost witness yourself a little bit. And you can kind of take a step back and, and really acknowledge what you're going through and acknowledge that it's hard and that it's, that it sucks and that it can be unfair and all of those things, but also really see the catalyst of it being the catalyst for a lot of growth

• 18:42Speaker 03

  and self-reflection. And, you know, I've lived with the disease for almost 24 years now. I was diagnosed when I was 20. And so I'm, I'm, I'm finding my way through and finding sort of the, the, the purpose from this pain. And I feel like, you know, that's all you can do with situations like this. And messy is really what's propelled me into that way of thinking now.

• 19:05Conan O'Brien?

  I think there's an interesting thing that we live in this, as you know, this weird culture with probably misaligned priorities where, you know, people, if you're a quote celebrity, people expect that you shouldn't have anything to complain about and that you're allowed to have problems, but sometimes I think you're expected to have problems that are self-destructive problems, like addiction, or you blew all your money, you know, you did stupid things. But I think there's almost like a sense that, well, wait a minute,

• 19:44Conan O'Brien?

  you can get sick, you can get this disease, but you were on television. It's, I know that sounds like I'm saying something that would be painfully, obviously, true, but I think there is a little bit of a hiccup where you're both beautiful, talented, you know, actresses that people know from iconic work. You have a, you got it, you got sick? What do you mean you got sick? What did you do? No, I didn't do anything. I just, it just happened and it happens to a lot of people. Is that, does that feel that there's a weird way in which it's not fitting the narrative of being a successful, you know, celebrity?

• 20:25Speaker 04

  Well, I think one of the things that I've come across, you know, I mean, and I don't really leave the house anymore. And I mean, if people saw what my life was like on the daily, they wouldn't, they wouldn't be able to do it. Cause I can sometimes not do it. It's really, really hard. But I think that the first thing that I hear from people is how did you get it?

• 20:42Conan O'Brien?

  Yeah.

• 20:42Speaker 04

  Meaning I must have done something wrong.

• 20:44Conan O'Brien?

  Yeah.

• 20:45Speaker 04

  In my life to have this disease. I did it to myself. It's like I had breast cancer as well. So, oh, you must have done something.

• 20:53Conan O'Brien?

  Yeah.

• 20:53Speaker 04

  You know, and it's, and that stigma is, um, you know, I'm used to it now, but it was for a while, like it was so hard to swallow because. Why the F would you think that I would do something to have this?

• 21:07Conan O'Brien?

  Yes.

• 21:07Speaker 04

  Because this is the worst thing I've ever had in my life. It's the worst thing I've ever gone through. So.

• 21:12Conan O'Brien?

  Do you know?

• 21:12Speaker 04

  I'm gonna start crying.

• 21:13Conan O'Brien?

  Do you know?

• 21:13Speaker 04

  I'm the crybaby of the two of us.

• 21:15Conan O'Brien?

  Cry all you want, and then I'm gonna start crying.

• 21:17Speaker 04

  I'm just having a pissy day today. I'm having a bad MSC day, so.

• 21:20Conan O'Brien?

  Oh, I'm sorry. Well, no.

• 21:21Speaker 04

  No.

• 21:21Conan O'Brien?

  But cry, and then I'm gonna cry, and I'm gonna make my assistant David's here, and you'll cry.

• 21:26Speaker 04

  Yeah.

• 21:27Conan O'Brien?

  He, I make him cry all the time.

• 21:28Speaker 05

  Every day.

• 21:29Speaker 04

  Okay.

• 21:30Speaker 05

  Every hour.

• 21:30Conan O'Brien?

  And very verbally abusive.

• 21:32Speaker 01

  This is what this podcast does to people, huh?

• 21:34Conan O'Brien?

  But mine is just like me being really verbally abusive.

• 21:37Speaker 05

  Yeah, if he doesn't make at least five people cry a day.

• 21:39Conan O'Brien?

  Yeah, I feel like I haven't done my job.

• 21:49Conan O'Brien?

  You know, winning an award, that's a big achievement, right?

• 21:51Speaker 01

  Yeah, I love awards.

• 21:52Conan O'Brien?

  Every now and then in life, maybe something nice like that comes your way. Winning them consistently is almost impossible. It just doesn't happen. You know? Well, guess what? Winning five times in six years? You know what that sounds like to me? Sustained excellence.

• 22:06Speaker 01

  Nice.

• 22:07Conan O'Brien?

  Hyundai has done just that, earning the title of America's best SUV brand for 2026 from US News and World Report. You are a very happy Hyundai driver.

• 22:15Speaker 01

  I drive a Hyundai Palisade, and I love my car. I love it. I love driving it around.

• 22:20Conan O'Brien?

  I've been tooling around in an Ioniq 5N, which I love. Beautiful car. Well, listen, whether you need an SUV for everyday life, your next big adventure, or extra room for family and friends, Hyundai has an option for you. The Tucson Hybrid is loaded with technology and built for everyday life. The Santa Fe Hybrid's fully capable and ready for adventure. The Palisade, that's yours, right?

• 22:39Speaker 01

  Hello.

• 22:40Conan O'Brien?

  They're gonna rename that the Sona. The Palisade Hybrid, yeah, delivers premium capability and class-leading interior space with available, I have this memorized, H-Track all-wheel drive up to an EPA-estimated 619 miles of range on vehicles like the Palisade Hybrid and Hyundai's industry-leading warranty. It's easy to see why Hyundai continues to deliver the quality, innovation, technology, and value drivers expect from an award-winning brand. View US News Best Cars at cars.usnews.com and call 562-314-4603 for complete details.

• 23:14Conan O'Brien?

  Your name represents everything you've built, okay? Everything, like, I feel that way about my name. Yeah. It stands for all of the work, good and not so good. But guess what? Your children's names represent their whole futures. Yeah. Your children haven't even started building their futures, but their identities are already valuable. Your child's clean credit history can make them a target for identity thieves. Never thought of it that way, but it's true. Identity thieves can open loans and credit cards using your child's social security number, racking up debt and ruining their credit. And you may not notice until they try and get their first credit card. So it could be a long time. Yeah. Well, guess what? With LifeLock, you can add family members to your plan, giving you the power to block identity threats targeting your children. Now, Sonja, your kids are pretty young still. They are.

• 23:59Conan O'Brien?

  Five, but within a couple of years, you know, they're gonna be buying heavy machinery online. What? They're gonna be, become tractor fanatics. They're gonna be buying tractors online. So if you have expenses or money stolen due to identity theft, you're backed by the million-dollar protection package with up to $3 million coverage in some plans. So join now, save up to 30% off your first year. Go to lifelock.com/conan. That's lifelock.com/conan to save 30%. Terms apply.

• 24:30Conan O'Brien?

  Sonja, you have to admit, the holidays, it's really about hanging with the people you love. Yeah. And getting to be yourself. Not going to some stuffy holiday party where you need to conform to what the man wants you to think about the holidays. Yeah. Yeah, it's about being yourself. Turn your holiday time into Miller time by enjoying a Miller Lite in a place where you're free to enjoy yourself on a walk with a cousin. With a cousin? Why are they getting all specific about? Because it's family. But what about a niece or a nephew? Yeah.

• 25:01Conan O'Brien?

  Like a walk with an ex-wife? I don't know. I mean, they're just throwing, that's a weird, they just made a very specific choice. Yeah. Now's the time for those unexpected holiday side guests and enjoy a great tasting light beer. 'Tis Miller time, as Dickens wrote. Miller Lite is brewed for taste, the taste you can depend on. The original light beer since 1975 and still iconic more than 50 years later. I like to be with my bros, my chums, my posse, crack open a Miller Lite, take a swig, a sip, look around and see my friends. We've known each other forever and we're just hanging out.

• 25:35Speaker 01

  Yeah, you guys are just doing chest bumps and high fiving.

• 25:38Conan O'Brien?

  Miller Lite is great taste done right. Go to millerlite.com/conan to find delivery options near you, or you can pick up some Miller Lite pretty much anywhere they sell beer. Tis Miller time. Celebrate responsibly, Miller Brewing Company, Milwaukee, Wisconsin. 96 calories and 3.2 carbs per 12 ounces.

• 26:00Conan O'Brien?

  I'll tell you, I, where it, I mean, obviously Christina, where it comes from is, um, it's terr- it's terrifying to people that shit happens. And so people need to work backwards and say, okay, wait a minute, wait a minute, wait a minute. Did you eat a lot of food with zinc in it? You know, no, I didn't. Oh, did you, did you take like a lot of escalators? Some people can get MS. No, no, no, that's stupid. That was online, no, whatever, I'm making shit up clearly, but it is, it is a-

• 26:30Speaker 04

  You'd be, you'd be surprised at the, the cures that I get told about. Like, I have this holy water and I know it will cure your MS. I'm like, really? That's amazing because there's millions of us across the globe who still have it.

• 26:44Conan O'Brien?

  Right, right.

• 26:45Speaker 04

  And have probably, you know, done this with the holy, I mean, come on.

• 26:48Conan O'Brien?

  Yeah.

• 26:48Speaker 04

  Come on.

• 26:49Speaker 03

  Well, I think that that's, that's-

• 26:50Speaker 04

  But that's the, yeah, the fear.

• 26:52Speaker 03

  Part of the gift of the, the position, I think, that we have, that it's, you know, taken me a long time to accept. I think, you know, acceptance is hard for anyone, no matter what you're dealing with. I think it's like the, a huge challenge in your life to accept that a situation is what it is. But I, but what I'm looking now as an opportunity is what I thought would sort of bring me out of this business. And I, and even when I was out about having MS and working and it was always people very helpful, like, oh, we'll just walk around it or we'll get you a walking double when the person walks away. You know, so you look able-bodied and normal. You know, now it's at this point where I'm like, no, if you're want to cast me in this, this is the body I'm in.

• 27:35Speaker 03

  Because the, my life doesn't revolve around MS. If anything, it could enrich a story. And I think that we don't see en- enough-

• 27:45Speaker 03

  People like us on camera. We don't see enough people that have disabilities that are not defined by their disability within a story a lot of the time. And so, you know, I think that we do have a position and a power now to really try and change the perception around that celebrities can get sick, but that you can also keep like doing what you love and keep living your life. You know, I think that it's, it's very scary for people. And yeah, you can feel like, you know, people are superhuman when they're a celebrity, but no, we're just human beings that are doing what we love. It just happens to be in front of a lot of people.

• 28:26Conan O'Brien?

  Right, right.

• 28:27Speaker 03

  And now we can use that power for something else.

• 28:29Conan O'Brien?

  It's weird. It's an occupational hazard. I always think it's an occupation like working in a shoe store or anything else. It just has this other side to it, which is people recognize you. They recognize you from working in a shoe store.

• 28:40Speaker 03

  That's how Jim Gandolfini felt. I'm sure he told you that on that plane. Yeah, I mean, he was, he was, he's like, why don't you want my plumber's autograph? Like, it just didn't make sense to him why he had to have that piece of this, you know?

• 28:52Conan O'Brien?

  Right, right. I can completely understand that. One question that came to me is, and this is for both of you, and maybe I'll start with you. Christine is, when did you, what's the first symptom or when did you start to think something isn't, something feels off? Is it subtle or does it hit you like a ton of bricks?

• 29:10Speaker 04

  It was January 2021. My mom had just been diagnosed with cancer for the third time. And there were some other stuff going on in my life. And it was, it was a really stressful, traumatic time. And my toes started to feel numb, just my toes, you know, like a little bit. I was still hiking. I was still playing tennis. I was still doing all the things I could do, but my toes weren't feeling right. And eventually, over those months, it grew from my toes to my ankles to, from my knees down is a whole other ballgame.

• 29:41Conan O'Brien?

  Yeah, yeah.

• 29:44Speaker 04

  I was losing balance and I but at the pain was extraordinary and when I say numb you it's numb but it hurts.

• 29:52Conan O'Brien?

  Yeah.

• 29:52Speaker 04

  So it was like these like very subtle things that happened and I'm finally someone was like, well, it was actually Salma Blair said, can you please go to the neurologist?

• 30:01Conan O'Brien?

  Yeah.

• 30:02Speaker 04

  And I was like, no, there's I was like, there's no way that the both of us from the same movie of MS. I was like, you crazy. And that was like, that was the end of it for, you know, and by then I had gotten so bad and I was in the middle of shooting Dead to Me, so um, we had to really stop for a minute and figure out how to do this. But what's interesting is I look back over time and probably for like six years, I was having weird things happening, like fluorescent lights would bother me and make me dizzy and being up on a platform, I would get afraid of the height. I was never afraid of heights. I'd be playing tennis and like my right leg would buckle and I'd be like, ooh, I must be dehydrated or it's too hot out here.

• 30:45Speaker 04

  I mean, they were like the tiniest little things that you would completely ignore otherwise because there's probably an answer for all of them. But the numbness in my toes and as it started to grow up was was very much announced in my fingers and and it just it starts to, you know, it over time, it gets worse, you know, but it's, that's that's how it happened.

• 31:08Conan O'Brien?

  And when and when you say like, you you've referenced, I think, twice now that you're having a really bad day, what does that mean? You're having a really bad MS day. How does that manifest itself? Is it is it in the physical? Is it dealing with it? Is it it's the physical and that affects you also emotionally too, I imagine?

• 31:26Speaker 04

  Well, yeah, I mean, you know, to go to the bathroom, it's like walking on on needles.

• 31:32Conan O'Brien?

  Yeah.

• 31:33Speaker 04

  And hot lava. So like, I haven't really been able to get out of my bed today. So I'm having just a bad symptomatic day. And that can be, you know, from anything from and I always get scared that this this is now my new normal and I get afraid that this is the new normal and then I'll have a day where I'm never good. I'm just less shitty.

• 31:51Conan O'Brien?

  Yeah.

• 31:52Speaker 04

  So, those less shitty days, I'm like, okay, so that was just a symptomatic day. It was like, either I didn't sleep enough, or I didn't eat enough, or I'm stressed out. A lot of times, stress, or, you know, anything like that really affects it. Can make it much worse. But there isn't a day where I'm like skipping down, you know, skipped Malou down the street. Although I try sometimes, right, Jamie, I'll send you videos. I'm like, I'm trying to skip. I'm skipping today.

• 32:19Conan O'Brien?

  Yeah, exactly.

• 32:20Speaker 04

  And then like the next, then 10 minutes later, I'm like, I can't move a thing.

• 32:23Conan O'Brien?

  I can't move. Or else, she doesn't have MS. There's TMZ footage of her skipping down the lane, singing Skippin' Malou.

• 32:33Speaker 04

  She's making it up. This is damn, I'm good. Damn, I'm a good actress if I'm making this one up.

• 32:38Conan O'Brien?

  Applegate is so full of shit. Always was.

• 32:42Speaker 04

  I would much probably get an Oscar for having Tourette's than I would for, like, and I'm not making fun of Tourette's because I love Balin Out Loud. I don't know if you guys have seen it, but she's real beautiful and I want to be her best friend. But, um, yeah, for the casting.

• 32:57Conan O'Brien?

  But also, I was, uh, I've noticed that, uh, you've always had, uh, and you, and I love that you get to do it on Dead to Me. You get to say some of the meanest things on Dead to Me. And, and it's, and, and you do it where it's like, yes, you're a really good actress, but, um, I can also tell that you're accessing some part of you that wants to tell somebody he's a fuckstick.

• 33:21Speaker 04

  Yes, I don't, I don't know how Liz Feldman knew that, that I existed on the planet. Like, she wrote it, it was already there.

• 33:30Conan O'Brien?

  Yeah.

• 33:30Speaker 04

  And then she was like, oh my God, this is you. And I'm like, sadly, yes, sadly.

• 33:35Conan O'Brien?

  How did you know I had a filthy mouth and a lot of rage?

• 33:38Speaker 04

  The best, the best acting job I've ever done is being Christina Applegate out in the public. That is my greatest adventure.

• 33:45Conan O'Brien?

  That's your Oscar.

• 33:46Speaker 04

  Smart, funny.

• 33:47Conan O'Brien?

  Yeah, yeah. Everything's good.

• 33:49Speaker 04

  Cheery.

• 33:49Conan O'Brien?

  Yeah.

• 33:50Speaker 04

  And then I'm home and I'm like, fuck this shit.

• 33:55Conan O'Brien?

  That's what podcasts are for.

• 33:57Speaker 03

  That's right.

• 33:58Conan O'Brien?

  And Jamie Lynn, when did you know that what happened? How was it for you? Is it the same? Does it start with like tingling in the toes? Or?

• 34:05Speaker 03

  Yeah, that was actually pretty similar for me. When I was 19, I had something similar like weird numbness in my toes. And then it was rising over a couple of days. And it was actually right before we were starting the third season. And I ended up in the emergency room and then the ICU for 14 days. Nobody could figure out what I had. They I had ruled that they had ruled out MS at the time because there was no findings on MRIs or whatever. And I got diagnosed with Lyme's disease, actually initially. And they had had me in a bunch of steroids and antibiotics. And in hindsight, I think the steroids is what like picked me up out of it. But a year and a half after that, started to get that numbness again and went to the I was in the middle of the fourth season and I started to feel the numbness.

• 34:50Speaker 03

  I thought I was just going to kind of ask for more antibiotics. And they redid testing and diagnosed me with MS. So it was shocking and not at all what I was expecting to hear.

• 35:01Conan O'Brien?

  And to hear it, I mean, at that age, you've got to just be, I don't know. Felt like you got hit like by a meteor, like you're standing in a cornfield and a meteor hit you like it's it's it doesn't make any.

• 35:15Speaker 03

  Weird. I can like, I can remember sitting in the hospital room and my parents were there and I had two friends too. And the doctor was talking after he said it became kind of like, like in a movie where all of the talking just starts sounding like muffled and like the room kind of gets dizzy. And I just kind of blocked it out. We went home, I spoke to my family about it. I went to a doctor's appointment for like a checkup for the show. Like you have to get like a sign off that you're healthy. And I told him and he told me I wouldn't, I wouldn't repeat that again. And so that's what I did. I just kept it quiet.

• 35:51Speaker 04

  I didn't know that part.

• 35:53Speaker 03

  Yeah, I mean, he was trying to protect me and I understood, you know, but.

• 35:58Speaker 04

  It's a hard one to hold in though, babe. Especially when you are the best at teaching me to advocate for myself and to have boundaries on set. And to say, hey, this is what I need. You gave me that power. And for you to have to go every day and, and take that.

• 36:13Conan O'Brien?

  Pretend this isn't even happening.

• 36:14Speaker 04

  No, I can't even.

• 36:15Conan O'Brien?

  You can't talk about it.

• 36:17Speaker 04

  It makes me wanna, mm, sad.

• 36:19Conan O'Brien?

  Well, um, it's interesting because we have all these fears. There's a terror. It's not, you know, just in our culture. It's in many cultures. We have a, but particularly we have a terror of people uh, who maybe we've idolized or put up on a pedestal in any way, uh, being sick. The same way we do, there, there's this whole attitude about people getting older. And that's something where people are constantly, uh, feeling that they need to scrub how old they are. Or, or do things or go through ridiculous procedures to make sure that nobody thinks that they're the age they are.

• 37:00Conan O'Brien?

  It's a, it's another kind of, let's just pretend that this doesn't happen to people. And, um, I've taken the very bold move of having no work done. And I think.

• 37:11Speaker 05

  So brave.

• 37:12Conan O'Brien?

  So brave.

• 37:13Speaker 03

  So brave. You're so brave.

• 37:15Conan O'Brien?

  Well, I think of the three of us, I'm the brave one. And in a way.

• 37:20Speaker 03

  You're the hero. You're the hero, Conan.

• 37:21Conan O'Brien?

  Maybe the one I, who's been through the most. Cause uh, I mean, maybe I'm going out on a limb here and I'm, I'm told I, I don't have the best sense of the room.

• 37:30Speaker 05

  Yeah.

• 37:31Conan O'Brien?

  But I'm just letting it go as a forty, as a forty-four year old man, I'm just letting it happen.

• 37:39Speaker 05

  No one is fact checking this?

• 37:41Conan O'Brien?

  No, there's no internet. Uh, never was and never will be. Um. So how did you, you guys started talking together? And at one point, because it's such, you know, there's a lot of new technology and new kind of types of broadcasting and reaching out to people that can feel invasive and lame. But I do think that podcasting is particularly well suited to what the two of you were talking about because it's so intimate and people can really hear what both of you are going through. It's a great thing that this medium exists right now for, for what you're doing and for the message that you're trying to get out. And not even that it's a message,

• 38:24Conan O'Brien?

  it's conversations that both of you are having that feel very confessional and that feel like there's no topic, you're not, you're not working through, okay, we're going to get to this, then we're going to get to this, then we're going to get, get to this. It very much feels like you two are hanging out and there are good days and bad days.

• 38:44Speaker 04

  Yeah, I was gonna say, well, um, we never really have a plan. I mean, obviously when we have a guest, we, you know, most of the time there's someone that we know quite well.

• 38:53Conan O'Brien?

  Right.

• 38:53Speaker 04

  So that's easy to just talk with them. We don't have a list of questions, really. I mean, you know, there's, if we start to go off the rails, our, our producer will text like, hey, let's.

• 39:03Speaker 03

  She starts texting us.

• 39:04Speaker 04

  She starts texting and going like, bring it back to something, to like a subject. Um, but I was gonna say that, um, with the podcast, it wasn't like Jamie and I were like, how can we go around talking about this? I mean, it was, I was actually getting my infusion for my MS and Jenna Fisher from The Office, who's a good friend of mine, she came to hang with me for the six hours that it takes. And she's like, and she knows my humor and the way I talk. She's like, you've got to do a podcast, man. And then it was, it was like, after that, Jamie and I started talking. I was like, oh my God, this is like, like our lives. And I feel so much better every time I'm talking. Sorry about that. That's my phone telling me to put my feet in the hot bath with Epsom salts.

• 39:42Conan O'Brien?

  Your phone tells you to do that?

• 39:44Speaker 04

  Yeah, well, I, it does. It knows, it knows that I'm in pain and I need to do it. I have an alarm. I have an alarm for 1:30.

• 39:52Conan O'Brien?

  This is gonna lead into a.

• 39:53Speaker 03

  What is your phone telling you to do?

• 39:54Conan O'Brien?

  Nokia.

• 39:58Conan O'Brien?

  My phone tells me to stop going on that site. It's creepy.

• 40:04Conan O'Brien?

  I'm like, what's creepy about it?

• 40:07Speaker 04

  That's the thing, it really came from our conversations. We always wanted to be honest and raw and real and not have a plan. Because sometimes the best plan is to have no plan. And then other times, I'm just, I'm told to be quiet and to stop talking so much by our producer. No. Yep.

• 40:23Speaker 03

  Not by me. But I also too, you know, MS looks different for everybody. It affects everybody differently, whether it's day to day or just, you know, body to body. And I think it's about, you know, giving yourself the grace and the space to express what you need to feel in the ups and downs of it and also to, you know, not a lot of people know a lot about MS. So also educate, but in general, I think, and we have learned that the more specific you get with your vulnerability, the more universal it becomes for other people. So, you know, we get to hear from a lot of other people that listen to us that don't just have MS,

• 41:03Speaker 03

  that, you know, hear what we're going through and hear what we're, we're trying to push through and accept and all those things through their own filter and how they sort of apply it to their lives. And so, you know, over the past year, it's really been an exercise in Christine and I getting to know each other and sharing a lot about our lives. And I feel like now it's not fully transitioned, but we've opened ourselves up now to having a lot of people really try to help us, help us individually and where we're at. And, you know, it's, we're, we're still here and we, we have children and, and dreams and, and lives and friends and people that we care about. And we're trying to figure out how to, you know, make it the best we can.

• 41:46Conan O'Brien?

  It's also, and, and that's important to point out. It's not, I think, one of the reasons it's such a great idea is that it's not, hey, if you've got MS, you should check out Messy. That's not at all what it's about. Sure, if, if you do, then, then yes, but it really is about. People struggling and actually people that you know, people that I mean, for both of you, there are a lot of people that grew up watching you and have an emotional connection with you. And that's something that's very powerful. That gives you this gift of, oh, they know you. They know you and you're a part of their lives. You're part of a part of their life that they're

• 42:28Conan O'Brien?

  only going to be that old once and you were a big part of their life then. And so now they're getting the gift of perspective of whatever that means. Everyone has stuff in their life, but I'm constantly, um, you know, we just had these fires out here in LA and I'm, you know, so I'm living in a hotel and people will say to me, oh, I'm so sorry. And I cut them off. And I'm like, I'm living in a hotel. I know a lot of people who lost their homes like I so I don't have, I have been inconvenienced. Um, but uh, it's stupid. I, I feel stupid when anyone says anything to me because I know I many people who work here, uh, several, two people that work

• 43:13Conan O'Brien?

  here lost their homes and, and a lot of my writer friends on The Simpsons lost their homes and a lot of people in and around my neighborhood lost their home. And so, uh, I did not, I'm in a hotel. And so my complaint is they don't make the smoothie quite the way I like it. It's not the way I would do it if I was at home. What's wrong with the world? Why does God hate me? God, why have you?

• 43:46Speaker 03

  You need to come on messy and talk about it.

• 43:48Conan O'Brien?

  Yes.

• 43:50Conan O'Brien?

  Well, first of all, before we go any further, before, yeah. Ladies, I'm here to talk about, there's this guy at this high end hotel, Beverly Hills who, um, uh, but no, I think that perspective is not something you get and then you have, like someone gives you a gold pocket watch and you have it in your pocket the rest of your life. I always think it's like stomach crunches or any kind of, you just, you know, unfortunately, you've got to keep doing it or stretching or, you know, any of the rehab or anything of the, of the exercises that you need to do or self-care you need to do, you have to keep at it. I think that's way about perspective. We just have to keep at it because.

• 44:31Conan O'Brien?

  Yes, I am this, but these other people are going through that. And it's always the yin and the yang. It's always going to be that. And so I think the fact that the two of you are sharing this and, you know, Christina, when you were saying earlier, oh, I'm sorry, I'm getting weepy. I'm having a bad day. The whole point is to tell us that and to let it happen.

• 44:54Speaker 04

  Yeah.

• 44:55Speaker 03

  Yeah.

• 44:55Speaker 04

  I mean, we've, we've covered so many topics too. I mean, it's not like if we just sat there and talked about MS all day, we'd be like, wah, wah, wah. Or probably not. I'd just be crying the whole time.

• 45:03Conan O'Brien?

  Right.

• 45:03Speaker 04

  We've had episodes about eating disorders and, and bitches, you know? Like just.

• 45:09Conan O'Brien?

  Well, wait a minute. Let's talk about bitches for a second. I mean, now, now you've got my, I mean.

• 45:14Speaker 03

  Go for it, Christina.

• 45:15Conan O'Brien?

  I was really liking this, but now it's another level.

• 45:18Speaker 04

  She knows that I get pissed off when I lay back when we're recording and I look like this. My fire, my anger inside of myself, talking about bitches. Just people who are just bitches.

• 45:31Conan O'Brien?

  So bitches and bitches.

• 45:33Speaker 03

  Just awful humans.

• 45:34Conan O'Brien?

  Bitches is all genders, right? It's, it's, it's everybody.

• 45:37Speaker 03

  Of course, yeah.

• 45:38Conan O'Brien?

  You know, it includes me is what you're saying, you know?

• 45:42Speaker 04

  You're my biggest bitch ever.

• 45:46Conan O'Brien?

  I knew I'd make it.

• 45:48Speaker 04

  You are my favorite bitch. Well, I can't, I haven't even told Jamie, because Jamie and I are probably going to record next week, because, you know, whatever. And I have so much to tell you about some bitches.

• 46:03Speaker 03

  I can't wait.

• 46:05Speaker 04

  Mama got vicious in the text messages.

• 46:07Conan O'Brien?

  Do you drop names? You don't drop names.

• 46:09Speaker 04

  I don't, no, no, no.

• 46:10Speaker 03

  I think we should. I mean, why not? Well, we, you know, what we have had though is a lot of like past co-stars. Like we had Ed O'Neill. We had Edie Falco. And it was really interesting and wonderful to like have these conversations with people that knew us when we were kids.

• 46:28Conan O'Brien?

  Yeah.

• 46:28Speaker 03

  You know, in our like formative years and really get their perspective of us. And for also to like have a conversation like with Edie where she forever felt like a mother. Other figure to me because of the way we met.

• 46:44Conan O'Brien?

  Yep.

• 46:44Speaker 03

  But now to have a conversation as two women, you know, and, and peers in a way was, it's been really beautiful to be able to like have these deep, personal conversations on the podcast with people that are important to us that also people like relate to us, but to get to see a different side of it.

• 47:03Conan O'Brien?

  Yes. It's interesting to me to, you know, from my lens of, you know, Christina, those times that you would come on or Jamie Lynn, the times you would come on. It's, I would see you in this very, I, I love that format, but it was you know, you know, for the Sopranos, you know, you know, from Mary from children.

• 47:27Conan O'Brien?

  Hey, what's going on? And it's this, it's

• 47:30Speaker 04

  I could listen to you do that all day.

• 47:31Conan O'Brien?

  I know.

• 47:31Speaker 03

  I know, we do.

• 47:32Conan O'Brien?

  I know, I know, but I swear to God, it's, it's, it was 30 years of my life and it's in my head where I'll be brushing my teeth and I'll be like,

• 47:42Conan O'Brien?

  all right, we're back. I'm using Crest toothpaste because it gets it white, you know, but I guess it's still a conversation and I was still getting to know you and you are these, you know, much younger than me and, and, and now I'm checking in on you in this very different way. And it's nice. It feels really nice to speak to both of you and I'm sorry that you got, both of you got hit with this sack of shit because that's what it is for no reason. I'm really sorry about that and it's

• 48:17Speaker 04

  I pooped myself yesterday, so that goes in, goes on brand with

• 48:21Conan O'Brien?

  Me too. I'm just saying.

• 48:24Conan O'Brien?

  But I'm saying, um, it's very nice. I'm grateful for this medium that allows us to talk this way and check in and people, you know, a lot of people can hear it and hear how you're doing and hear about your podcast, which, uh, and, and it's a, it's just a, I'm very grateful that we get to do this, you know?

• 48:46Speaker 03

  Me too.

• 48:46Speaker 04

  Thank you. I'm, I've been this, my favorite moments, honestly, Conan. When I would come on there for like the 30th time or whatever was when we'd go to commercial and you and I would just talk.

• 48:57Conan O'Brien?

  Yeah.

• 48:57Speaker 04

  It was like, it was like the best thing ever. The show was over, you know, the like pre-interview, we did our bits, I did my snow stories and you and I would just sit and talk.

• 49:06Conan O'Brien?

  Yeah.

• 49:06Speaker 04

  During that two and two, Chuck Bullery.

• 49:09Conan O'Brien?

  Yeah, and I remember.

• 49:10Speaker 03

  Yeah.

• 49:10Conan O'Brien?

  I remember in the commercial break, you know, trying to do that with, with Jamie Lynn and she said, uh, this interview's over. And, um.

• 49:17Speaker 03

  Yeah, usually.

• 49:18Speaker 04

  That's so Jamie.

• 49:18Speaker 03

  But you know.

• 49:19Conan O'Brien?

  She said, she said, this interview's over and then she said, uh, my people and seven people came and took her away. And one of them hit me.

• 49:26Speaker 03

  Yeah, that's exactly what would happen.

• 49:27Conan O'Brien?

  That is not what happened.

• 49:28Speaker 03

  Well, I was actually gonna say, I've just never felt very good at like that side of this business. It's just always felt like, I don't know, it just, it, it would bring out insecurities and things in me that weren't great. However, doing your show, and I mean this with every part of me, there was never an ounce of nerves. You maybe the first time because it was, because I was such a fan, but it was just, you always brought ease and, and enjoyment. I would leave on a high and so happy, like I just had the best, you know, 20 minutes of my life. So, thank you.

• 50:06Speaker 04

  You would get 20 minutes? I'd get like eight to 12.

• 50:09Conan O'Brien?

  No, you were, you would get.

• 50:11Speaker 03

  I was counting commercial breaks.

• 50:13Conan O'Brien?

  Christina would get like five at the most.

• 50:16Speaker 03

  That's why she kept coming back.

• 50:18Speaker 04

  I would also, and.

• 50:19Conan O'Brien?

  I knew if I was cruel to you, Christina, you'd keep coming back and you did.

• 50:22Speaker 04

  Of course, yes. Well, I did. That's why I got that.

• 50:24Speaker 03

  How it works.

• 50:25Speaker 04

  Cleaning closet. But I was gonna say, what was so awesome is that you, you listened.

• 50:30Conan O'Brien?

  Yeah.

• 50:31Speaker 03

  Yeah.

• 50:31Speaker 04

  We sometimes wouldn't even get to the questions, man.

• 50:34Conan O'Brien?

  Yeah.

• 50:35Speaker 04

  Because you, you were like one of the only ones who listened, who didn't have like a vacant look on their face, waiting for the next, like get to the part that you're supposed to say and let's get to the next question. You would listen and so you and I would just, it did feel like real and loose and it wasn't a show. I love you. You know, you know that I've always absolutely adored you.

• 50:53Conan O'Brien?

  Well, I am, I mean, I was coming in today, I knew I'd be talking to both of you and I was, uh, thinking. I really want to check in with them because I care about these people. And I'm invested in them because I have this avuncular like, you know, well, I knew them when they were these young ladies that used to come by and I would make a cookie for them and talk to them. And, you know, and I want to see how they're doing and um, I, I'm so, again, I'd do anything in the world, uh, if I could change this reality for both of you. Uh, and I can't, but anything I can do to raise awareness, to do anything, I mean, uh, my, my father,

• 51:37Conan O'Brien?

  uh, was a scientist who devoted his life to trying to find ways to make people better. And my hope is that, uh, science will find ways, um, and anything we can do. I mean, anything I can do to help both of you, uh, and I'd also like to come on your podcast, you know?

• 51:56Speaker 04

  We would, we would love it. Seriously?

• 51:58Conan O'Brien?

  But here's.

• 51:58Speaker 03

  Well, I didn't think Conan was gonna make me cry today.

• 52:01Conan O'Brien?

  But here's the thing, I want to talk about my fee.

• 52:05Speaker 04

  Oh.

• 52:06Conan O'Brien?

  It's a hundred thousand dollars and it's gotta be in a, it's cash in a suitcase or I fucking walk.

• 52:12Speaker 04

  That's more than I've even made doing the podcast.

• 52:15Conan O'Brien?

  Well, listen, sister. Okay, I'm, it's time for me to get tough with you too. All right?

• 52:21Speaker 03

  Okay.

• 52:21Conan O'Brien?

  You're not, I'm not gonna soften up because of this whole MS thing. I get top dollar.

• 52:27Speaker 05

  You're the next bitch they're gonna talk about?

• 52:29Conan O'Brien?

  Yeah. This bitch wants a hundred thousand dollars to come on the, um, no, I, David, uh, is right here. And David's the one that does the schedule, uh, he's in charge of my life. But I would love to come on and talk to you on your podcast.

• 52:43Speaker 03

  Thank you.

• 52:44Conan O'Brien?

  And, um, and, and do, you know, um, I consider us friends and I would like to help. So let me know what I can do. And I'm just saying that because this is, once this is over, I'm not gonna do anything, you know that? This is just.

• 52:59Speaker 03

  Of course, but this is the image you need to put on.

• 53:02Speaker 04

  Right, so it's been recorded.

• 53:03Conan O'Brien?

  This is what's called performative, um, you know, this is me, is the paparazzi here? And they, they, they get a picture of me going to the hospital to visit, you know, the people. And then I go out the back and I shop for a Rolex, um.

• 53:17Speaker 04

  There you go.

• 53:18Conan O'Brien?

  Yeah, so.

• 53:19Speaker 03

  Real Hollywood secrets here.

• 53:23Speaker 03

  I like it.

• 53:24Conan O'Brien?

  No, I really wanna come do yours and really, I really wanna get into the bitches thing, so.

• 53:30Speaker 04

  Oh, yeah.

• 53:31Speaker 03

  Yeah, maybe we should save the bitch conversation for when Conan comes on.

• 53:34Conan O'Brien?

  Yeah.

• 53:35Speaker 04

  That's so bad. You guys, it's so bad. It's almost like this particular thing that happened this week is like, I don't even know if I can even talk about it.

• 53:41Conan O'Brien?

  Well, I've got my own bitches to talk about, two of whom are in this room.

• 53:45Speaker 04

  You can talk about your bitches.

• 53:47Conan O'Brien?

  I'm looking at one of them right now, Eduardo.

• 53:49Speaker 06

  Eduardo?

• 53:51Speaker 04

  Catching strays over here.

• 53:52Conan O'Brien?

  No, hey, that's not a stray. That is... You know what you did and you're gonna pay for it. Fuck with my microphone.

• 54:02Conan O'Brien?

  I love you both and I haven't even said that. I never said that to my parents, so I shall say it to you. That's not true. I'm kidding. Wait a minute. Hold on, checking. Nope. 1977. The summer Elvis died, I told them. I'm in your corner and let me know what I can do and I will see you on your podcast. We'll talk about bitches.

• 54:23Speaker 04

  Yes, you will.

• 54:25Conan O'Brien?

  I'm thinking about you both and sending you whatever crazy Irish Catholic energy is within me, half of which is malevolent, I'm sure. But...

• 54:36Speaker 03

  I'll take it.

• 54:37Speaker 04

  You know what you can send me? Cause I ask all my very, very, very wealthy friends.

• 54:41Conan O'Brien?

  Yep.

• 54:41Speaker 04

  Six million dollars. Just like, not alone.

• 54:44Conan O'Brien?

  Jesus, I made that today. I mean...

• 54:46Speaker 04

  Okay, just six million. Six million. I know it sounds weird.

• 54:49Conan O'Brien?

  No, I just closed.

• 54:50Speaker 04

  I asked Ed O'Neill for six million. I ask him every time I talk to him.

• 54:52Conan O'Brien?

  I just bought and closed an orphanage and I got six million.

• 54:55Speaker 03

  Okay, there you go.

• 54:56Conan O'Brien?

  And I have a lot of investments with defense contractors who make claymore mines. Those are the mines that really... So, yes, ladies, just have a... Christina, I hope your day gets better. And it is really lovely to talk to both of you and weird thing to say, cause I'm not your uncle, but I'm really proud of both of you. Extremely proud of you. So, I'm your comedy uncle, your weird comedy uncle and...

• 55:24Speaker 04

  Nothing better. Only kind of uncles we want.

• 55:27Conan O'Brien?

  Okay, yeah. The weird comedy uncle with the red wig and be well and thank you so much for being here today and sharing with me. I really appreciate it.

• 55:37Speaker 04

  I love you.

• 55:37Speaker 03

  Thank you for having us.

• 55:38Conan O'Brien?

  All right, bye.

• 55:40Speaker 04

  Bye.

• 55:48Conan O'Brien?

  You know, winning an award, that's a big achievement, right?

• 55:50Speaker 01

  Yeah, I love awards.

• 55:51Conan O'Brien?

  Every now and then in life, maybe something nice like that comes your way. Winning them consistently is almost impossible. It just doesn't happen, you know? Well, guess what? Winning five times in six years? You know what that sounds like to me? Sustained excellence.

• 56:05Speaker 01

  Nice.

• 56:06Conan O'Brien?

  Hyundai has done just that, earning the title of America's best SUV brand for 2026 from US News and World Report. You are a very happy Hyundai driver.

• 56:14Speaker 01

  I drive a Hyundai Palisade and I love my car. I love it. I love driving it around.

• 56:19Conan O'Brien?

  I've been tooling around in an Ioniq 5 N, which I love. Beautiful car. Well, listen, whether you need an SUV for everyday life, your next big adventure, or extra room for family and friends, Hyundai has an option for you. The Tucson Hybrid is loaded with technology and built for everyday life. The Santa Fe Hybrid's fully capable and ready for adventure. The Palisade, that's yours, right?

• 56:38Speaker 01

  Hello.

• 56:39Conan O'Brien?

  They're gonna rename that the Sona. The Palisade Hybrid, yeah, delivers premium capability and class-leading interior space. With available, I had this memorized, H-Track all-wheel drive, up to an EPA-estimated 619 miles of range on vehicles like the Palisade Hybrid and Hyundai's industry-leading warranty. It's easy to see why Hyundai continues to deliver the quality, innovation, technology, and value drivers expect from an award-winning brand. View US News Best Cars at cars.usnews.com and call 562-314-4603 for complete details.

• 57:13Conan O'Brien?

  Your name represents everything you've built, okay? Everything, like, I feel that way about my name.

• 57:18Speaker 01

  Yeah.

• 57:18Conan O'Brien?

  It stands for all of the work, good and not so good in my life. But guess what? Your children's names represent their whole futures.

• 57:26Speaker 01

  Yeah.

• 57:27Conan O'Brien?

  Your children haven't even started building their futures, but their identities are already valuable. Your child's clean credit history can make them a target for identity thieves. Never thought of it that way, but it's true. Identity thieves can open loans and credit cards using your child's social security number, racking up debt, and ruining their credit. And you may not notice until they try and get their first credit card. So it could be a long time.

• 57:48Speaker 01

  Yeah.

• 57:49Conan O'Brien?

  Well, guess what? With LifeLock, you can add family members to your plan, giving you the power to block identity threats targeting your children. Now, Sony, your kids are pretty young still.

• 57:58Speaker 01

  They are.

• 57:58Conan O'Brien?

  Five, but within a couple of years, you know, they're gonna be buying heavy machinery online.

• 58:04Speaker 01

  What?

• 58:04Conan O'Brien?

  They're gonna be, become tractor fanatics. They're gonna be buying tractors online. So if you have expenses or money stolen due to identity theft, you're backed by the million dollar protection package with up to $3 million coverage in some plans. So join now, save up to 30% off your first year. Go to lifelock.com/conan. That's lifelock.com/conan to save 30%. Terms apply.

• 58:30Conan O'Brien?

  This episode is sponsored by BetterHelp. BetterHelp therapists can help you figure out what rules or traditions aren't serving you and how to rewrite them. And with insurance, many members pay $15 or less. Some pay $0. BetterHelp, they do a great job. You're in good hands. BetterHelp therapists are fully licensed in the United States with at least three years and 1,000 hours of hands-on experience. When it comes to matching with a therapist, BetterHelp does the initial work for you. Just take a short questionnaire to help identify your needs. And if you're not happy with your match, this is the best part. A lot of people think, oh, my God, this is the person I've signed up with. I need to make this work. That's not the case. If it's not a good match, you switch to a different therapist at any time from BetterHelp's tailored recommendations.

• 59:16Conan O'Brien?

  BetterHelp is now in network with more than 125 health plans with many copays as low as $15 for eligible members. And if you don't have eligible insurance or live outside the US, you can still get 20% off your first month. Sign up and get 20% off at betterhelp.com/conan. That's better H E L P dot com slash Conan.

• 59:41Speaker 07

  Okay, I have something very tangentially Oscars related, which I don't think I've said on mic how great a job you did.

• 59:48Conan O'Brien?

  Oh, thank you very much. Thank you. I enjoyed myself thoroughly. I had a really good time.

• 59:51Speaker 07

  The Oscars are big in our family. It's like the Super Bowl. And my wife sat down with my daughter to do a little arts and crafts. And they decided that they would try to predict what all of the famous people would be wearing at the Oscars.

• 1:00:04Conan O'Brien?

  Interesting.

• 1:00:04Speaker 07

  Okay. And so I just want to show you.

• 1:00:06Conan O'Brien?

  Because your daughter is quite young.

• 1:00:08Speaker 07

  She's three and a half.

• 1:00:08Conan O'Brien?

  Three and a half.

• 1:00:09Speaker 07

  And so is my wife.

• 1:00:10Conan O'Brien?

  Yeah.

• 1:00:12Speaker 07

  And this is what my wife did for Cynthia Erivo and Ariana Grande. Okay, I just want to show this.

• 1:00:19Conan O'Brien?

  Wait a minute.

• 1:00:20Speaker 01

  That's pretty close.

• 1:00:22Conan O'Brien?

  They were wearing very architectural dresses.

• 1:00:23Speaker 07

  Look at this. That's insane. And so now I'm living with a woman who is convinced she's psychic. And I don't believe in that kind of stuff, but now I have to say, I don't know what's real anymore.

• 1:00:33Conan O'Brien?

  Wait a minute, wait a minute.

• 1:00:33Speaker 01

  Yeah.

• 1:00:34Conan O'Brien?

  The fact that your wife did that prior to the Oscars and seeing what they were gonna wear. Okay, I'm gonna say this. That is eerie. That is eerily close. Unless, is she someone who pays attention to how they normally?

• 1:00:47Speaker 07

  No, not at all. She had no idea. She just took a guess. I think she was going a kind of off their Wicked characters a little bit, but isn't this incredible?

• 1:00:54Speaker 01

  Does it mean if I say she draws like a 10-year-old too? Okay, okay, yeah, yeah, yeah, yeah.

• 1:00:59Speaker 07

  Certainly is.

• 1:00:59Speaker 01

  Yeah, it's like-

• 1:01:00Conan O'Brien?

  I thought those were pretty good.

• 1:01:01Speaker 01

  Yeah. You do?

• 1:01:03Speaker 07

  Well, wait till you see how my daughter draws.

• 1:01:05Speaker 01

  Oh, I thought those were your daughter. I mean, no offense to Amanda, but...

• 1:01:08Conan O'Brien?

  No, no, but also, we were, you were up close, because I got you some seats.

• 1:01:13Speaker 01

  Yeah, you did. Yeah, you hooked me up.

• 1:01:14Conan O'Brien?

  And you could see Ariana Grande trying to sit in that dress.

• 1:01:19Speaker 01

  Yes.

• 1:01:20Conan O'Brien?

  And she had to, it was not easy.

• 1:01:23Speaker 01

  She had to, I think, sit on the edge of the seat, because it was-

• 1:01:26Conan O'Brien?

  She couldn't recline.

• 1:01:28Speaker 07

  No, those are not sitting dresses.

• 1:01:30Conan O'Brien?

  No, these ain't sitting dresses.

• 1:01:31Speaker 07

  Okay.

• 1:01:32Conan O'Brien?

  Okay, anyway, stay on, we'll stay on topic, okay?

• 1:01:34Speaker 07

  Well, that's it for that, but this is, this came up earlier about Ralph Fiennes. This is my daughter's prediction of, of what Ralph Fiennes would be wearing.

• 1:01:41Conan O'Brien?

  Again, spot on.

• 1:01:43Speaker 07

  She says that's his little hat.

• 1:01:44Speaker 01

  Okay.

• 1:01:45Speaker 07

  But then this is where it gets pretty interesting. This is Zoe Saldana.

• 1:01:49Speaker 01

  Oh.

• 1:01:50Speaker 07

  Okay.

• 1:01:50Conan O'Brien?

  Okay.

• 1:01:51Speaker 07

  And my favorite here, Adrienne Brody. And she pointed out what all of the pieces are here.

• 1:01:58Speaker 01

  Oh.

• 1:01:59Conan O'Brien?

  Little bow, hair, bum bum.

• 1:02:02Speaker 07

  That's his butt, and a toot coming out.

• 1:02:04Speaker 01

  Oh, a fart.

• 1:02:07Speaker 07

  He poopies in potty, and he does go pee pee.

• 1:02:09Speaker 01

  Is it his pee pee, or he's peeping?

• 1:02:12Speaker 07

  I think he's, you know, I'm not sure. I'll have to get back to you on that.

• 1:02:15Speaker 01

  Okay, all right, yeah, I'd like to, I'd like to clarify.

• 1:02:18Conan O'Brien?

  Can I say, I was backstage when all that was going down with Adrian Brody, and all of that happened.

• 1:02:24Speaker 01

  Yeah.

• 1:02:25Speaker 07

  This is accurate.

• 1:02:25Conan O'Brien?

  Yeah, we were hosing that, we were hosing that place down.

• 1:02:28Speaker 01

  He was pooping in the potty, and he had to pee pee.

• 1:02:30Conan O'Brien?

  We all heard it the first time. We're good. We don't need your- Recital of the facts.

• 1:02:37Speaker 07

  Oh, by the way, if you want to see these, just go to at Team Coco Podcasts on Instagram.

• 1:02:41Conan O'Brien?

  So I think that's a pretty, that's pretty impressive.

• 1:02:44Speaker 07

  This is crazy, right?

• 1:02:45Conan O'Brien?

  I think that's crazy that your wife was able to do that.

• 1:02:48Speaker 07

  Look at that.

• 1:02:49Speaker 01

  We should do this. We should predict what people are gonna wear and stuff.

• 1:02:52Speaker 06

  We do it here for certain guests.

• 1:02:55Speaker 01

  Oh, that's right.

• 1:02:55Conan O'Brien?

  Oh, that's right. We should talk about this. Eduardo, please, speak your truth. I'm not involved in this.

• 1:03:00Speaker 06

  There's kind of like an office pool that happens for certain guests.

• 1:03:06Speaker 06

  I'd say the A, A, A-listers. Where the office around here starts to guess and wonder what they're gonna come in dressed like.

• 1:03:13Speaker 07

  To my recollection, it was Goldie Hawn, Jane Fonda, and Al Pacino.

• 1:03:16Speaker 06

  That's right.

• 1:03:17Conan O'Brien?

  Yeah.

• 1:03:17Speaker 06

  Yeah. So there's guesses. So we already kind of.

• 1:03:20Conan O'Brien?

  Now, how close did you come?

• 1:03:22Speaker 06

  I'm not good at this game. But there's other people within the office that are.

• 1:03:26Speaker 01

  So those aren't the only three A, A, A-listers?

• 1:03:29Conan O'Brien?

  No, no.

• 1:03:29Speaker 01

  Those are the only ones we did.

• 1:03:32Conan O'Brien?

  Yeah.

• 1:03:32Speaker 07

  Yeah. But nobody got Goldie Hawn, because she came in in like a body glove wet suit or something like that, remember? She had like a.

• 1:03:38Speaker 01

  Was it a wet suit?

• 1:03:39Speaker 07

  No, it wasn't a wet suit, but it was like a sport tank top or like something.

• 1:03:43Speaker 01

  It was very beachy.

• 1:03:44Speaker 07

  Yeah.

• 1:03:45Conan O'Brien?

  Well, to be fair to her, she came right from deep diving.

• 1:03:50Speaker 07

  That's right.

• 1:03:50Conan O'Brien?

  For pearls without a tank. So, I mean, she came right from that and brought us all fresh pearls.

• 1:03:56Speaker 01

  Yeah.

• 1:03:58Conan O'Brien?

  Yeah, it was pretty, she was amazing, by the way. Goldie Hawn, if you have not listened to her interview, check it out.

• 1:04:05Conan O'Brien?

  Because I, I love talking to her.

• 1:04:07Speaker 01

  Yeah.

• 1:04:08Conan O'Brien?

  She's incredible. And her memory of things that happened to her when she first moved to New York in the 60s, and she didn't have a place to live yet. It was, and she talked all, about all of it as if it happened yesterday.

• 1:04:23Speaker 01

  I know.

• 1:04:24Conan O'Brien?

  The imagery and everything was incredible.

• 1:04:25Speaker 01

  I love her so much.

• 1:04:26Conan O'Brien?

  Anyway.

• 1:04:27Speaker 01

  But yeah, we do that. We talk about, I mean, Ruthie's the one who's kind of spearheading it, and she goes around.

• 1:04:32Conan O'Brien?

  And makes people guess what they're gonna dress up. Do people ever guess what I'm gonna be wearing when I come in?

• 1:04:37Speaker 01

  No one ever talks about you.

• 1:04:40Conan O'Brien?

  That's weird.

• 1:04:40Speaker 01

  You just never come up.

• 1:04:42Conan O'Brien?

  I guess it's because I'm so ubiquitous.

• 1:04:43Speaker 01

  I think they forget that you do this podcast sometimes.

• 1:04:47Conan O'Brien?

  Also, I tend to wear the same thing a lot.

• 1:04:49Speaker 01

  You do.

• 1:04:51Conan O'Brien?

  I have a kind of a, I have kind of a uniform.

• 1:04:53Speaker 01

  You're like a Steve Jobs.

• 1:04:55Conan O'Brien?

  Yeah.

• 1:04:56Speaker 01

  You know what I mean?

• 1:04:56Conan O'Brien?

  In my ability to lead the world of tech.

• 1:04:59Speaker 01

  No, no, no, no. I meant like, just like, wearing the same stuff a lot.

• 1:05:02Conan O'Brien?

  Oh, I thought you meant the other way in which I-

• 1:05:04Speaker 01

  But this works.

• 1:05:05Conan O'Brien?

  Yeah.

• 1:05:06Speaker 06

  Sometimes we guess what mood you'll come in.

• 1:05:08Speaker 01

  Yes.

• 1:05:09Conan O'Brien?

  Oh! That's true. I mean, cartoonishly, hyperactive?

• 1:05:14Speaker 06

  Yeah.

• 1:05:14Conan O'Brien?

  Versus what?

• 1:05:15Speaker 06

  Scale of one through 10, maybe, like, how-

• 1:05:18Conan O'Brien?

  How high out the novel be turned up?

• 1:05:19Speaker 06

  Yeah, how biddy you might be.

• 1:05:22Conan O'Brien?

  Biddy. What, where are we today?

• 1:05:24Speaker 06

  I think today's like a, you know, I, I find a tendency that when we haven't recorded in a while-

• 1:05:29Conan O'Brien?

  Yes!

• 1:05:29Speaker 06

  There's like this freshness and there's like a layer that's like-

• 1:05:32Conan O'Brien?

  Pent-up bits.

• 1:05:33Speaker 06

  Yeah, but also like, also just friendlier.

• 1:05:36Conan O'Brien?

  That's true.

• 1:05:37Speaker 06

  Like, he's happy to see everyone.

• 1:05:39Conan O'Brien?

  I'm worried about next week, because we have four sessions on the book-

• 1:05:42Speaker 06

  Me too.

• 1:05:42Conan O'Brien?

  And by Friday, he's just gonna be beating us. What, what, uh, well, I don't physically, yes, I do physically beat you. I'm sorry, and that's probably wrong. I shouldn't admit to that on, on mic, but, uh, yes, it is true. I was away from you guys. I've been up in Seattle, uh, visiting my in-laws with my wife, and love Seattle. Shout out to Seattle and shout out to, uh, Pam and Jake Powell.

• 1:06:05Speaker 01

  Seattle!

• 1:06:06Speaker 06

  Seattle!

• 1:06:07Speaker 01

  Powls!

• 1:06:08Conan O'Brien?

  Powls. You're wearing your Seahawks-

• 1:06:10Speaker 06

  Seattle Mariners.

• 1:06:11Conan O'Brien?

  Oh, that's the Mariners, yeah. Um, and, uh, anyway, um-

• 1:06:16Speaker 06

  Yeah, Microsoft.

• 1:06:18Conan O'Brien?

  It doesn't work the same way.

• 1:06:20Speaker 06

  Boeing!

• 1:06:21Speaker 01

  Boeing!

• 1:06:22Conan O'Brien?

  Needles, space or otherwise.

• 1:06:24Speaker 06

  Amazon.

• 1:06:25Conan O'Brien?

  Uh, oops. Anyway-

• 1:06:26Speaker 01

  The wall!

• 1:06:27Conan O'Brien?

  Yeah, had a, uh, had a wonderful time with the Powells, as I always do, and I really love Seattle, uh, but what happened after being away for like eight days is I do miss you guys. And I do miss, um, this total, uh, assery that we engage in. I don't know what else to call it. That's accurate. Foolishness. Uh, so I come in and I'm do- it's bits right away, but-

• 1:06:51Speaker 01

  Bits right away.

• 1:06:53Conan O'Brien?

  Then, when we do a bunch of shows in a row, towards the end, I feel like, uh, one of those, you know, jackpot machines with just the, they've been pulling on the handle again and again and again and again, and there's no coins left!

• 1:07:06Speaker 01

  Oh.

• 1:07:07Conan O'Brien?

  And then I want everyone to fuck off!

• 1:07:11Conan O'Brien?

  There he is.

• 1:07:13Speaker 07

  There he is.

• 1:07:14Conan O'Brien?

  All right. We wrapping it up?

• 1:07:17Speaker 07

  Yeah.

• 1:07:18Conan O'Brien?

  This was just a segment. So there's no, I just look down and I'm introducing. I don't know how this podcast works.

• 1:07:24Speaker 07

  No, you don't.

• 1:07:24Conan O'Brien?

  You won't be doing it for five years.

• 1:07:26Speaker 07

  You know what? Can I talk about something that you don't know how it works? That would help me in editing is every time when you do the intro and you say, these are my guests, blah, blah, blah, blah, blah. And then, then you say their name is the last thing you say. I really need a pause there because there's a musical break between that. And I always have to find a strange.

• 1:07:43Conan O'Brien?

  Okay, that helps me.

• 1:07:44Speaker 07

  Yeah.

• 1:07:45Conan O'Brien?

  That's constructive criticism.

• 1:07:46Speaker 07

  That's right. No, it's nothing you're doing wrong. You didn't know, but I just didn't want to try to explain that to you.

• 1:07:50Conan O'Brien?

  It's been five years. And you've never, ever, ever thought? To maybe just suggest to me? You're that afraid of me?

• 1:08:01Speaker 07

  And that's on me.

• 1:08:02Conan O'Brien?

  Okay.

• 1:08:02Speaker 07

  Yeah.

• 1:08:03Conan O'Brien?

  Well, well, I wish I had a guest that I could introduce right now because I'm going to tell you how I'm going to do it in the future.

• 1:08:08Speaker 07

  Okay. Do you want to just try it again with their names one more time?

• 1:08:11Conan O'Brien?

  Sure.

• 1:08:12Speaker 07

  Uh, with, uh, with Christina.

• 1:08:14Conan O'Brien?

  The end of the episode.

• 1:08:15Speaker 07

  And Jamie Lynn?

• 1:08:16Conan O'Brien?

  Sure. My guest today hosts the podcast Messy, which releases new episodes every Tuesday, wherever you get your podcasts. I'm very excited they're here today.

• 1:08:25Speaker 01

  Oh, man.

• 1:08:36Conan O'Brien?

  Christina Applegate and Jamie Lynn Sigler.

• 1:08:39Speaker 07

  Perfect.

• 1:08:40Conan O'Brien?

  Welcome.

• 1:08:43Speaker 07

  Conan O'Brien Needs a Friend with Conan O'Brien, Sonum of Sessian and Matt Gourley. Produced by me, Matt Gorley. Executive produced by Adam Sachs, Jeff Ross and Nick Liao. Theme song by The White Stripes. Incidental music by Jimmy Vivino. Take it away, Jimmy.

• 1:09:04Speaker 07

  Our supervising producer is Aaron Blair and our associate talent producer is Jennifer Samples. Engineering and mixing by Eduardo Perez and Brendan Burns. Additional production support by Mars Melnick. Talent booking by Paula Davis, Gina Batista, and Britt Kahn. You can rate and review this show on Apple Podcasts and you might find your review read on a future episode. Got a question for Conan? Call the Team Coco hotline at 669-587-2847 and leave a message. It too could be featured on a future episode. You can also get three free months of SiriusXM when you sign up at siriusxm.com/conan. And if you haven't already, please subscribe to Conan O'Brien Needs a Friend wherever fine podcasts are downloaded.

• 1:09:54Conan O'Brien?

  When you hear Alka-Seltzer, you probably think heartburn, right?

• 1:09:56Speaker 05

  Yep.

• 1:09:57Conan O'Brien?

  Well, did you know Alka-Seltzer has a line of cold and flu medications known as Alka-Seltzer Cold? Did you know that, David?

• 1:10:05Speaker 05

  No, but I feel like we need it.

• 1:10:06Conan O'Brien?

  Why didn't you know that, David?

• 1:10:07Speaker 05

  I know you expect me to know everything.

• 1:10:09Conan O'Brien?

  I knew this.

• 1:10:10Speaker 05

  Did you?

• 1:10:10Conan O'Brien?

  Yeah, I've tried it. It's really good. And I like that fizzy, fizzy, fizzy when you drop the Alka-Seltzer Cold into the water.

• 1:10:16Speaker 05

  Yeah.

• 1:10:17Conan O'Brien?

  Alka-Seltzer Cold Fast Dissolves Tablets are designed to deliver cold and flu relief fast. Just drop the two tablets in water and hear those bubbles bursting into action. Ready to work faster than pills. Bubbles faster than pills. Pills take time to dissolve, not bubbles. Next time a cold or flu strikes, quick! Alka-Seltzer Cold. Nothing works faster for cold and flu symptom relief. Among oral products, use as directed.

• 1:10:42Speaker 02

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• 1:11:06Speaker 06

  30 seconds response time requires monitoring plan with outdoor protection starting at $49.99 a month. Visit simplisafe.com/licenses for alarm license information.