Hosted by Danny Jones
Written by a model from the transcript; not yet reviewed.
This episode covers the history, biology, and geopolitical secrets of the plague, featuring insights from an expert who collaborated directly with former Soviet bioweapons directors. The conversation breaks down how Yersinia pestis operates as a bacterium, why certain regional strains are exceptionally virulent and transmissible, and how Soviet laboratories operated parallel civilian and military programs. The discussion also examines historical outbreak accounts, the mechanics of lab leaks, and the complex realities of vaccine development, exploring why the plague remains uniquely terrifying compared to other pathogens.
The episode opens with a brief advertisement for Humana Medicare plans and a sponsor announcement for QUO, setting the stage for the main interview.
Host welcomes Wendy Orent and outlines her expertise on the plague, framing the discussion around the recent Siberian outbreak.
Wendy explains how her background in biological weapons research led her to author a book on the plague after discovering a key Soviet scientist’s work.
The conversation shifts to the biology of Yersinia pestis, its virulence, antibiotic resistance, and the challenges of making it more transmissible.
The hosts address sensational claims about engineered chimeric plague strains, emphasizing scientific limitations and the lack of evidence.
Wendy describes recent incidents, including the raw marmot kidney case and the mysterious lab‑related death, illustrating ongoing risks.
Discussion covers the limited effectiveness of plague vaccines, quarantine measures, and the difficulty of controlling a disease with animal reservoirs.
Wendy explains Russia’s participation in the BW convention, the existence of clandestine military labs, and the lack of transparency in bioweapons research.
Wendy offers a cautious hypothesis about the accidental aerosolization of plague in a Russian lab, reflecting on the secrecy surrounding the event.
The hosts discuss Russia’s rapid quarantine measures and denial of a plague outbreak after a woman’s death.
A brief ad segment promoting a liver supplement, Dose, appears in the conversation.
The hosts examine past lab leaks worldwide and consider whether the Russian case could be a plague leak.
Discussion of the 1973 Janet Parker smallpox case and other lab leak stories to illustrate recurring safety failures.
A Chicago plague scientist’s accidental death due to a virulent strain exploiting iron overload is recounted.
The hosts argue that the U.S. has no active bioweapons program, citing historical closures and lack of evidence.
The conversation explores the 1346 Siege of Kaffa, debating whether plague bodies were catapulted into the city.
They address and refute the claim that HIV originated from contaminated polio vaccines in Africa.
Soviet Bioweapons Connectionstory
The guest explains how discovering that the director of the smallpox eradication program also directed the Soviet bioweapons program led to a correspondence and eventual friendship with top Soviet plague scientist Igor Damarodsky.
Bacterial Lethalityinsight
The guest explains that Yersinia pestis is a bacterium rather than a virus and represents the deadliest, most virulent pathogen of its kind, capable of completely replacing host organs with masses of bacteria.
Biblical Plague Descriptiondata
The discussion references 1 Samuel regarding the Philistines experiencing swellings in their secret parts alongside an outbreak of mice or rats, marking an ancient description of bubonic plague.
Limits of Genetic Engineeringinsight
The guest argues that engineering plague to make it more virulent is impossible because natural strains are already 100% fatal in their pneumonic and septicemic forms.
Meeting in Russiastory
The guest shares the experience of traveling to Russia with family to meet the retired Soviet scientist, who greeted them with purple hyacinths and displayed intense, penetrating intelligence.
Parsing the Siberian Outbreakstrategy
Analyzing a recent laboratory death in Siberia, the guest deduces that the victim likely inhaled an aerosolized whiff of plague, prompting swift traditional Soviet-style quarantine protocols.
Chicago Lab Incidentstory
The discussion details a tragic lab leak in Chicago where a researcher with undiagnosed hemochromatosis was fatally infected by a crippled strain of plague that fed on iron overload.
“I was studying in those days, writing about biological weapons. That was my first topic when I became a writer.”
“Once I stopped doing book reviews and I started writing articles. Of all things, I hit on biological weapons, and that's how I got my start as a writer.”
“The person who wanted to save humanity from the scourge of smallpox is also directing a bioweapons program.”
“Yersinia pestis, which is the causative agent of plague, is the deadliest, the most virulent, and in the case of the plague strains that the Soviets worked with, the most transmissible.”
“You can't make plague more virulent. You can't make it more transmissible. All you can do is make it a better weapon.”
“The only way to maintain antibiotic resistance is by continually treating somebody with antibiotics. Once you stop, the antibiotic resistant plasmids will fall out, and you'll be left with natural plague.”
“Her, she was a photographer and she spent a lot of her time in upstairs room above a smallpox laboratory.”
“This would be the first one that I know about.”
“They were shut down in 1969 by none other than Richard Milhouse Nixon, who reportedly turned to Kissinger and said, 'We're not really going to use this stuff, are we?'”
“And it's, if, if Bobby Kennedy has his way, and he's able to eliminate a vaccinating against polio, it will come back, and people will die, and people will end up in iron lungs.”
Watch every episode ad-free & uncensored on Patreon: https://patreon.com/dannyjones Wendy Orent is an anthropologist and science writer who specializes in plague, disease evolution & biological weapons. She is best known for her book 'Plague: The Mysterious Past and Terrifying Future of the World’s Most Dangerous Disease'. SPONSORS https://quo.com/danny - Try QUO free PLUS get 20% off your first 6 months. https://irestore.com/djp - Use coed DJP for HUGE savings on iRestore. https://dosedaily.co/danny - Use code DANNY to get 35% off your first subscription. https://butcherbox.com/danny - Get $20 off your first box, plus chicken breast in every box for life or filet or NY strips for a year. https://whiterabbitenergy.com/?ref=DJP - Use code DJP for 20% off. EPISODE LINKS Wendy's book - https://amzn.to/4BatbpV *NEW* DJP MERCH https://dannyjonespodcast.com Get paid to make clips from the show: https://discord.com/invite/dannyjones FOLLOW DANNY JONES https://www.instagram.com/dannyjones https://twitter.com/jonesdanny OUTLINE 00:00:00 - Russian scientist Igor Domaradski 00:10:14 - Types of plague 00:13:32 - First plague was described in the Bible 00:25:18 - Soviet bioweapons research & money 00:39:13 - Russian mad scientist & developing viral plague 00:46:51 - Chimera & antibiotic resistant plague 00:54:34 - Siberia Irkutsk plague outbreak 01:05:16 - US biodefense weapons program 01:11:05 - High security labs & ancient Athens outbreak 01:20:16 - Siege of Caffa & Black Plague 01:33:39 - Treating & abandoning plague victims 01:36:40 - Danger of polio virus 01:45:08 - Berenece Eddy 01:56:12 - Politicizing medicine 02:04:13 - HIV, rabies & ebola Learn more about your ad choices. Visit podcastchoices.com/adchoices
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