Encore: The Shocking Truth About Ozempic & The Effects It Has On The Body | Calley Means & Dr. Tyna Moore

Like most things in life, when it comes to optimizing metabolic health, a nuanced perspective can help. Rather than viewing it as a black-and-white issue, we can take into consideration the big-picture social context we’re facing that encourages ultra-processed foods, obesity, and lifelong medication as well as the micro-level of what people are experiencing as individuals and understanding how to help them when all else fails. Today I’m thrilled to sit down with Dr. Tyna Moore and Calley Means for a grounded discussion that explores both sides of the spectrum, and everything in between. In this episode, we discuss: The controversial discussion of GLP-1 agonists like Ozempic, weighing the pros and cons of these new drugs in treating obesity and metabolic crises (3:34) Challenging the notion of treating obesity with drugs like Ozempic (10:35) An unsettling revelation about the push for using Ozempic in children (12:04) Digging deeper into GLP-1 research and some of the benefits (32:51) Why are children being born metabolically challenged? (41:11) Dr. Moore’s approach to using peptides with her patients and for her own crippling pain, and what they’ve seen (45:19) How our current healthcare system lacks policies and support for behavior change (1:27) While there are always differing views, we know for sure that our food and drug policies aren’t serving the best interests of creating sustainable, empowered health for the masses. I hope you’ll tune in to hear more from this comprehensive and lively discussion. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman’s Weekly Longevity Journal This episode is brought to you by Rupa Health, BIOptimizers, Pique, and Big Bold Health. Streamline your lab orders with Rupa Health. Access more than 3,500 specialty lab tests and register for a FREE live demo at RupaHealth.com. Don’t let stress take over your holidays. Try Magnesium Breakthrough from BiOptimizers. Head to Bioptimizers.com/Hyman and use code HYMAN10 to save 10%. Head over to PiqueLife.com/Hyman20 and get up to 20% off + a complimentary beaker and rechargeable frother. Big Bold Health is offering my listeners 30% off their first order of HTB Rejuvenate Superfood. Head to Bigboldhealth.com and use code DrHyman30.

Speaker names marked ? are inferred from speaking time and the show’s known hosts — they are not voice-verified.

• 0:00Dr. Mark Hyman?

  Hey everyone, it's Dr. Mark Hyman. Thank you so much for being a loyal listener to The Doctor's Pharmacy. For the holidays, I've decided to give my team a little break to rest up and prepare for more content and the new year ahead. So The Doctor's Pharmacy will be replaying some older episodes for the next two weeks. But don't worry, we'll be back with more content and brand new episodes starting Tuesday, December 31st. So for now, here are some of my favorite past episodes of The Doctor's Pharmacy and see you next year.

• 0:29Dr. Mark Hyman?

  Coming up on this episode-

• 0:31Speaker 01

  These peptides have been shown to heal heart tissue and to reverse heart failure. So I've got one patient on it for high blood pressure. Tiny little dose, high blood pressure, blood pressure's down. I personally take it because I have psoriatic arthritis and I have crippling pain from tip to toe. Doesn't matter how clean of a life I live. It doesn't matter how clean my fish tank is. I, menopause hit me. So tiny little doses mitigates my autoimmune conditions like nothing I've ever used.

• 0:59Dr. Mark Hyman?

  So just to give you a little more detail on our guest today, Dr. Tina Moore has nearly three decades of experience in the medical field. She's a leading holistic expert in regenerative medicine and resilient metabolic health. She fixes people who are metabolically busted. She's trained in alternative science and medicine as a naturopathic doctor and chiropractor, and she's a podcast host, a speaker, kettlebell devotee, a mother, and advocate for health autonomy. She's got a great podcast called The Dr. Tina Show. She's passionate about making people actually better. And Callie Means, who's been on the podcast before, is the founder of TruMed, a company that enables tax-free spending on food and exercise. He's also the co-author with his sister, Dr. Casey Means, of Good Energy, The Surprising Connection Between Metabolism and Limitless Health, which is available right

• 1:42Dr. Mark Hyman?

  now. Early in his career, Callie was a consultant for food and pharma companies and is now exposing those practices that they use to weaponize our institutions of trust. In the past year, he's met with 50 members of Congress and presidential candidates advocating policies to combat the corruption of pharma and food industries. He's a graduate of Stanford and Harvard Business School. And this podcast is going to be a doozy. It's a bit long, but I encourage you to stay with us the whole time. We get into all of it, from the macro, what is causing your obesity Our metabolic crisis and what we can do about it from the social and political level, but also on the micro. What about that person sitting in our office or struggling with weight and struggling with being obese and not knowing how to get out of that pickle? And what is the right way to do it? What are the pros and cons of these new drugs,

• 2:27Dr. Mark Hyman?

  GLP-1 agonists? Are there side effects real? Do they have benefits beyond weight loss? Should we be using them? How should we be using them? Are the regular pharmacological approaches wrong? Is there another way using microdosing or compounded pharmaceutical versions of these peptides that might be actually safer and better, used with a 360 approach for lifestyle? So we're going to get all of these and you're going to be in a very robust, sometimes heated discussion about Ozempic and the GLP-1 agonist. So stay with us for the whole thing and I know you'll love it. Let's dive in right now. All right. Welcome Tina and welcome Callie. It's great to have you both on the show. Pumped to beer.

• 3:00Speaker 01

  Thank you.

• 3:01Dr. Mark Hyman?

  Okay, so this is such a rich topic and it's so deep and I spent probably 15 hours preparing for this podcast, my reading, everything that both of you read, reading study after study after study, looking at the data very carefully. And I can honestly say that after not just reading the headlines, but between the lines, reading the research, I've come to understand that this is a very nuanced conversation. It's not just good or bad. It's not just we should do it or we shouldn't do it. It's really about understanding, one, the bigger social context in which this is happening. The bigger social context is we are facing a metabolic health and obesity crisis that's never been seen before in the history of humanity. There's over a billion people who are obese, up to 2 billion people overweight in the world. We

• 3:40Dr. Mark Hyman?

  have in America, it's even worse. We have 42% obese. We have 75% overweight and 93.2% metabolic and healthy, meaning they're on the spectrum of some poor metabolic dysfunction, which is making them on their way towards prediabetes and type 2 diabetes. And the costs are staggering. We know our healthcare costs are now $4.3 trillion in direct costs and probably 80% of that is for chronic disease, mostly caused by our food and primarily driven by this phenomenon of insulin resistance, which is part of what Ozempic and these drugs purport to fix. So as we start to think about how do we solve this problem, you know, I've been thinking about it. From the very macro view, which is how do we deal with the food environment,

• 4:23Dr. Mark Hyman?

  the toxic food environment that's caused us to be in this situation? This is not a genetic problem. There may be genetics that load the gun, but the environment pulls the trigger. And the environment has changed in the last 50 years so dramatically that it's led to an abundance of toxic food, ultra-processed food, high starch and sugar in our diet, ingredients we've never had before that are destroying our microbiome, that are destroying our nutritional resilience, that are causing poor metabolic health and are really at the root of so much of what's going on. So I focused on policy issues. I wrote my food fix, which was, would attempt to kind of lay out why this is happening. Because there was, I couldn't cure diabetes in my office. It's cured on the farm, it's cured in the factory where they make the food, it's cured by, you know, in the grocery store, in the kitchen. That's where diabetes is cured.

• 5:07Dr. Mark Hyman?

  And ultimately, I realized I had to go upstream to deal with the root causes, which is our bigger food system. And we're going to get to talk about that with Callie, because he's been talking about and thinking about it for a long time. And I think his new book, Good Energy, addresses a lot of these issues around metabolic health. It's his sister, Casey Means, who's been on the show. No, I often get them confused. Callie, Casey is... You got it right. I don't know what their parents were thinking, but I think I'll sort it out. And Tina has a very different perspective, which is really around the micro, not the macro, which is how do we deal with individuals struggling with metabolic dysfunction, who've tried everything, done everything, hit the wall, can't make it work, struggle, white-knuckle, and just can't get their bodies back into a state of good metabolic health? And we're going to talk about how she does that, why it's different than the traditional

• 5:49Dr. Mark Hyman?

  approaches to the use of these drugs, and why we need to rethink how we're doing this. So this is going to be a very interesting conversation. I'm really excited to dive in. And so first, we're going to start with the macro and start with Callie, because I want you to set the stage for the situation we're in around our poor metabolic health and obesity, and what this is doing to us as a society, economically, socially, politically, even in terms of our social divisions and conflict, all driven by the effect of these things on our physical and mental health. So can you kind of unpack for us, Callie, how you see the current state of affairs in the realm of weight and obesity? Now, I really just read an article this morning that said... It's not okay to say someone's obese. You have to say they're someone with obesity.

• 6:36Dr. Mark Hyman?

  I get it, but we have got to have to sort of take a hard look at this. And so tell us, from your perspective, how should we be thinking about this problem at a macro level?

• 6:44Speaker 02

  Thank you so much for giving this conversation. Dr. Tina's had a huge impact on me, and I really think this is important. Have a long-form nuanced conversation that goes over the micro and the macro. And as you said, I've been really focused on the macro. I think there's some really important macro considerations that patients need to know before thinking about Ozempic. And that is that this is really about the median American and the median American child. 94% of the country is metabolic dysfunctional. Something has happened all at once, as you point out so well in Food Fix. Just looking at kids, 20 to 25% of young adults having fatty liver disease. 50% of young adults being overweight or obese. By some counts, 33% of young adults having prediabetes.

• 7:25Speaker 02

  It's a moral stain on our country where I think through very observable and very definable situations, we're poisoning our kids. We're poisoning them chiefly by food, the rise of ultra-processed food, which was close to 0% 100 years ago. And now up to 70% of a child's diet by some counts.

• 7:41Dr. Mark Hyman?

  It all started with like, what, Crisco in 1911?

• 7:44Speaker 02

  Yeah, it started with good intentions after World War II to kind of feed the world and make ultra-processed food. But it's been weaponized and, you know, food companies now are one of the largest employers of scientists to weaponize our food against us. And I can't go to a playground with my two-year-old without seeing almost every kid there, you know, drinking Coke, drinking sugary drinks. So fundamentally, this is a question about what is the solve for this metabolic health crisis? And the different branches on that crisis of the diabetes crisis, the heart disease crisis, the obesity crisis. And I think my main point is that the medicalization siloing of chronic disease has been an utter failure.

• 8:21Speaker 02

  Now, I'm not saying a doctor shouldn't prescribe a statin or metformin if that's the case and that's the determination, but the overall default to isolating and medicalizing a chronic condition has been bad. The world would be a better place if we actually didn't go this route of seeing heart disease as statin deficiency, seeing diabetes as a metformin deficiency, seeing high blood pressure as ACE inhibitor deficiency, seeing depression as a SSRI deficiency. My argument, I actually think the data is clear on this, if those drugs were-

• 8:49Dr. Mark Hyman?

  You mean depression is not a prosact deficiency?

• 8:51Speaker 02

  Yeah, exactly. And my argument, I think the data is clear on this, if you actually took those drugs off the table, if they didn't exist, and the medical system actually asked, what's the root cause of these conditions, what should we spend 4.5 trillion dollars on actually solving these conditions, it would actually go to the things you talk about, about core lifestyle habits. And the issue, and what the obesity epidemic represents with 80% of American adults now being overweight or obese, is that we really have a dirty tank. We have fundamentally lost our way in crony capitalism and rigging the system and basically poisoning the American people. And is that an Ozempic deficiency? Should we do more of the same in the, really, the most pronounced chronic condition for the median American, for the median child? Should we be prescribing the Ozempic? And I really

• 9:35Speaker 02

  think when you reel that back, the answer is no, right? I'm not talking about, you know, 400-pound, extremely diabetic person, that's between the patient and the doctor. But when the American Academy of Pediatrics is saying that the average 12-year-old should be on Ozempic, when this is being pushed on 6-year-olds who have an obesity crisis that gets over 20% of kids in the US have childhood obesity, and in Japan, it's 3% to 4%, right? We have unique dynamics happening in America, and it completely takes our eye off the ball to say that's Ozempic deficiency. Novo Nordisk right now is the 12th most valuable company in the world. It's the most valuable company in Europe.

• 10:07Dr. Mark Hyman?

  It's the biggest contributor to GDP in Denmark, the country that-

• 10:12Speaker 02

  Right. But interestingly, their revenue and profits aren't coming from Europe.

• 10:15Dr. Mark Hyman?

  Is it true they don't allow Ozempic to be sold in Denmark? Is that true?

• 10:19Speaker 02

  It's not the standard of care. First off, in Denmark, it's under $100, and they are making all their money off Americans where they charge $1,600 to $1,800.

• 10:27Dr. Mark Hyman?

  A month.

• 10:28Speaker 02

  They're taking advantage of Americans, but it's not the standard of care in Denmark. I was in Denmark last year. They have sound food policies. Their people are biking, walking around. And actually, if you have obesity, you're, the doctor's able to prescribe exercise in a keto diet that's subsidized by the government. Ozempic is not the standard of care for obesity. When you actually look at the stock analysis, 80 to 90% of profit expectations are coming from the United States. They're taking advantage of the United States. So we have a dirty fish tank, right? The problem is not an Ozempic deficiency. The problem is when are we going to say we're going to stop poisoning kids?

• 11:04Dr. Mark Hyman?

  They're talking about using this in kids, but we're filling the schools with ultra-processed junk food that these kids are eating for lunch. And that the school lunch program is so messed up that these kids aren't getting healthy nutritious food that's helping them be metabolically healthy or mentally healthy.

• 11:20Speaker 02

  Right. So then we look at, okay, how would he use this for? The instructions on Ozempic is as a lifetime drug. It actually is those are the warnings, so let's just look at what Novo Nordisk says. They said this is not like a quick use. This is not for a kickstart. This is a lifetime drug and there's actually some serious warnings if you go off the drug and gain the weight back and actually unknown metabolic effects. So that's what Novo Nordisk says. And they're actually saying with the help of the American Academy of Pediatrics, which early in my career I helped pay by pharma companies, is a subsidiary of pharma companies. This Danish company is one of the top contributors to it. They're saying that a 12-year-old, it should be the first line of defense. It shouldn't be after dietary interventions fail. It says if a 12-year-old gains a little bit of weight, put them on this drug for life.

• 11:59Dr. Mark Hyman?

  So the American Academy of Pediatrics doesn't have first-line therapy as life science?

• 12:02Speaker 02

  They're saying that they need urgent, quick interventions on surgery and Ozempic and not after dietary interventions fail. That's what the recent press release and guidance from the American Academy of Pediatrics said.

• 12:13Dr. Mark Hyman?

  Well, that seems pretty messed up.

• 12:14Speaker 02

  The American Academy of Pediatrics has not spoken out about Coca-Cola machines and pediatric boards in classrooms. They've not spoken out about the fact that 10% of food stamp funding goes to Coca-Cola. They've not spoken out about our agriculture subsidies, but they have said that if your 12-year-old gains a little bit of weight, they need to be on this injection for the rest of their life. Now, what's the problem with this, right? As we know from your work, that if you're not taking Taking the opportunity to train that child on metabolically healthy items, to train them on exercise, to train them on healthy food, to train them on having awe and curiosity for what they're putting in their body, they're going to continue to rack up comorbidities. You know, if somebody's anorexic, their LDL levels are probably going to go down right away, but that's not a sustainable long-term strategy. That's essentially what Ozempic does. It's a

• 12:59Speaker 02

  crash course calorie deficit. Not training that child, you know, for any type of awe or curiosity or lifestyle change that's needed, even if they're eating and on this drug for life, right, they're fundamentally still sedentary, like our kids are, and still putting ultra-processed food, which is going to lead to other metabolically healthy items. So what doctors are saying now is that, and I think you've said this, that you have to exercise. You have to, and actually Novo Nordisk is even admitting this. They're saying you have to shift to-

• 13:28Dr. Mark Hyman?

  They've seen from their studies that they lose significantly muscle mass.

• 13:30Speaker 02

  Right. They're saying that it's a huge disaster if you take this drug and don't exercise four to five times a week with weight training-

• 13:37Dr. Mark Hyman?

  Yeah.

• 13:38Speaker 02

  And shift to a non-ultra-processed food, high-protein diet. My message is this-

• 13:42Dr. Mark Hyman?

  Yeah.

• 13:42Speaker 02

  Let's start with that first. Let's start with steering the trillions of dollars of incentives of our medical system to doing that first-

• 13:50Dr. Mark Hyman?

  Yeah.

• 13:50Speaker 02

  Before we're drugging into it, because it's a contradiction, because what's actually happening is you have doctors at Harvard and the American Academy of Pediatrics saying the reverse. They're saying that obesity is now genetic. They have to define obesity as genetic in order to get taxpayer funding for this drug. You actually have the leading obesity researcher at Harvard, Dr. Fatima Cody-Stanford, saying throw willpower, throw diet, throw exercise out the window. So on the one hand, you actually have doctors arguing that this is a genetic condition and basically a drug deficiency-

• 14:17Dr. Mark Hyman?

  Isn't she conflicted a little bit?

• 14:19Speaker 02

  And she's paid, so we can get into the corruption. So, so, so when we have a dirty tank, when you have this massive societal issue, the biggest branch of the tree of metabolic dysfunction, when are we going to say that our healthcare policy needs to go towards metabolically healthy habits? In this case, Ozempic is a problem for two ways. Number one, it's a distraction. It's, it's once again saying the cure is in the medication. We're telling 50% of 12-year-olds

• 14:48Speaker 02

  obese, you're okay. The doctors aren't saying that the kid has to work out four times a week and shift their diet. That's not what anyone is saying to that kid.

• 14:56Dr. Mark Hyman?

  There's no phys ed in schools anymore, right?

• 14:57Speaker 02

  You're saying you're safe now from this drug. That's why I think this problem is one of the biggest issues in the country. Ozempic is a disaster if the drug was perfect because it's giving the wrong message when it's not the solve to the problem. And there's a massive opportunity cost where for 15 to 18 hundred dollars a month, we could change our agriculture system to regenerative ag. We could give every obese child in the country a card to buy organic whole food. So it's a disaster from that perspective. It's also medically extremely problematic. This actually, to my estimation, you tell me, I think it's actually the highest and most pronounced side effects of any drug widely approved in modern American history. Eighty percent of people on this drug have nausea and 30% have extreme vomiting.

• 15:39Speaker 02

  It has a black box warning, which we should take seriously. If we take the other studies seriously, we should take that very seriously, a black box warning for thyroid cancer. And the issues are so pronounced for mental health because it's disrupting our microbiome, which produces 95% of our serotonin. The EU, which is actually much more quizzical about this drug, is launching a massive investigation for suicidal adiation.

• 16:02Dr. Mark Hyman?

  I looked at that data and I think there's some questions about it.

• 16:05Speaker 02

  Well, this is short term data. Well, this is exactly the point, actually. This is extremely short term indicators. They approved this drug on a 68 week rig study to prove for 12 year olds for life. The research, if it's showing any leading indicators that Novo Nordisk has to admit, that's a serious problem. Because these are, all their studies are funded by Novo Nordisk and very rushed. So if there's any indicator whatsoever which necessitates that black box warning. The other thing I'll say is let's just back up and go to like what I've learned from you, which is that what is our body telling us? If 80% of the people have nausea, 30% are throwing up. What, that's telling us that this drug is producing some unknown metabolic issues throughout our body

• 16:48Speaker 02

  and really has some interconnected problems that we fully don't even understand. That's what it tells me.

• 16:52Dr. Mark Hyman?

  I think it's true. There are a lot of side effects if you take it in a way that actually is prescribed currently. But there are other ways of using the drug, when you're talking about with Tina, that mitigate a lot of the side effects, that avoid a lot of the problems you're talking about. And then aren't using the

• 17:07Dr. Mark Hyman?

  Product that's from the pharmaceutical industry is from compounding pharmacies, which is a kind of a left field thing that people don't know about. But what's really striking is you can get these drugs for $20 a month if you get them from compounding pharmacies and at doses that are far lower that may be effective without a lot of the complications and side effects and combined with a lifestyle. You know, it made me think about the MAPS work, which is psychedelic research and probably this year MDMA therapy with psychotherapy is going to be proved. So it's bundled. You can't get MDMA without also having psychotherapy. You shouldn't be able to get Ozempic or any peptide like that that's driving this problem

• 17:49Dr. Mark Hyman?

  without actually having a bundled service of aggressive lifestyle change, including dietary and exercise training and services.

• 17:58Speaker 02

  Well, I think the MAPS and what's happening with MDMA approval is one of the most important events in the country and probably for another podcast. I just say, and I'm excited about this nuanced conversation, but at working for the pharma companies, I do think this nod to exercise and healthy eating, it is a joke. Like, like the pharma companies are laughing about that, right? They know, right? Fundamentally, we're incentivizing the American people with trillions of dollars to eat poison and then be drugged. The largest industry in the country, every lever of it makes money on interventions on people that are sick and there's a high incentive for people to stay sick. And that's been the history of the post-World War II chronic disease complex. So what we have to do is clean the tank.

• 18:42Dr. Mark Hyman?

  What do you mean by clean the tank?

• 18:43Speaker 02

  We have an ability today to take the $4.5 trillion that we spend on healthcare and when somebody comes in with obesity or when a child comes into obesity for the standard of care to be actually incentivizing and medically recommending diet and exercise as we're already admitting that has to be done on Ozempic already. My point is this. Every patient should know this. Ozempic, everyone agrees that this drug is highly problematic unless you do four to five days a week of intense strength training and shift your diet to non-ultra-processed food, high protein. Do that first and by cleaning the tank, and this is what TruMed's doing, this is what we're lobbying for, we can steer medical dollars. It's the incentives that are damaging us in this country.

• 19:27Speaker 02

  Again, in Japan, look at the obesity rates, look at the childhood obesity rates, look at the diabetes rates. This is a unique problem based on the incentives of America that we can fix, but it's not shoving an injection into 50% of US children.

• 19:43Dr. Mark Hyman?

  Let's look at this from a different perspective because I think all the things you're saying are accurate and I think we need to look at this from the perspective of the paradox between an incredibly toxic food environment. Because you're saying eat better, exercise, but if 67% of kids diets is ultra-processed food, some estimates by some studies show it's 73%. And we live in a toxic nutritional landscape where it's almost impossible to do the right thing. We live in a society that fosters sedentary lifestyle that has no incentives in school for healthy eating or for movement for kids. We have to change the structural phenomena that are driving this. Paul Farmer talked about structural violence. What are the social, political, and economic conditions that drive disease? That has to be dealt with.

• 20:28Dr. Mark Hyman?

  But at the same, and that's what we're doing, that's what you're doing in Washington, that's what I'm doing in Washington with the Food Fix Campaign, is trying to change the policies that are driving this from marketing of junk food to kids, to subsidizing commodity crop that are turned into junk food, to food stamps that are paying for junk food, I mean, the list goes on and on. For paying for nutrition services and in medicine, for changing Medicare reimbursement, changing all the things that we know need to be changed to actually drive a bigger societal systemic change. But there is a paradox here because we are already metabolically, as you say, busted, Tina. And when you have someone who's metabolically screwed up from being in this toxic soup of processed food and junk food and sugar and starch that has caused them to become metabolically obese and metabolically busted.

• 21:13Dr. Mark Hyman?

  It's really hard to kind of get people out of that. It's like they're stuck. One of my professors, Sidney Baker, who's one of the, I think, most brilliant scientific minds in medicine in the 20th century and 21st century, said, you know, sometimes you need 100 horses to get people who are really stuck unstuck. So when you have these really chronically ill patients with multiple dysfunctions metabolically, inflammatory issues, gut issues, immune issues, it takes a lot of effort to pull them out of the mud. And sometimes you need a whole team of 100 horses. And so the question is, how do we, how do we both deal with the things you're talking about, which is the corruption of pharma and the corruption of medicine? And this has happened, by the way, and you talk a lot about this, Kelly, how $27 million

• 21:55Dr. Mark Hyman?

  spent by Ozempic company manufacturer Novo Nordisk to fund doctors and other others who are promoting this drug. So it's, there's a lot of corruption in the system. They're funding the NAACP, so they come out in favor of Ozempics and they say it's systemic racism if you don't prescribe it. But at the same time, we have to deal with all the corruption from the pharma industry and from internally in medicine, how things are done. We have to also accept that we're in this incredible crisis where people are struggling and they can't get better, even if they want to and they try.

• 22:26Speaker 02

  I would just say we have to solve that, we have to assess that crisis. It's the biggest issue we face. The fact that we're getting sicker, more depressed, more infertile at an increasing rate is the biggest issue in the country.

• 22:35Dr. Mark Hyman?

  It is, 100%.

• 22:36Speaker 02

  And nobody would look at that issue and say that the, that we should keep letting that happen and then jab 50% of 12-year-olds with the drug.

• 22:43Dr. Mark Hyman?

  Right.

• 22:43Speaker 02

  There's no evidence that this helps kickstart. This is a lifetime drug, but as many doctors have noted, the second you go off a crash course diet, this is, this is an injectable kind of calorie deficit crash course diet. The data is very clear. The second you go off this drug, you gain the weight back. You have to get to the root cause. You have to get people exercising and food. There's nothing without that.

• 23:06Dr. Mark Hyman?

  True, that can work, but for some people it still doesn't. And as a doctor, seeing patients, you know, with all the best intentions, people struggle, even if they know what to do, even if they're educated, even if they're doing it, I've seen people struggle. And so the question is, is there a way to think about this class of drugs differently? Is there a way to think about it, not from the pharma point of view, which is lifelong drugs, which is high doses, which is pharmaceutical injections that cost $1,700 a month that nobody can afford, that's going to bankrupt society? Is there another way to actually think about using these drugs to help people who really struggle? And what are the pros and cons? And what is the science behind it? And how does this work? And I think this, I would love sort of, Tina, do you start by talking? And we're going to get into all the details.

• 23:51Dr. Mark Hyman?

  Because I see you like in your chair waiting to get going. And I'm going to get you like, oh, come in a minute. Because I think, Callie, you laid it beautifully, how we're in a really screwed up political system, a corporate corruption system with pharma, how they operate, and how they fund things like the promotion of these drugs at wide scale through co-opting professional societies like the American Academy of Pediatrics, by funding, you know, Harvard and other institutions to do the studies, which they get huge amounts of money from. I mean, there's so much corruption in the system. But there is another way to think about helping people who really struggle with their weight and with the metabolic consequences.

• 24:37Dr. Mark Hyman?

  And as, you know, as I was sort of reading your stuff, Tina, and thinking about what your perspective is, and we talked briefly yesterday on the phone, it really, it really brought the question of, why are so many people having trouble? And is there something that is regulating the appetite that's so dysregulated? The GLP-1, and we're going to talk about what is GLP-1? What does it do in the body? How does it work? Because I think this is important for me to understand. We're going to get a little sciency here. But if you understand that maybe, I mean, just maybe, like we have a crisis of hyperinsulinemia, we also may have a crisis of low GLP-1, which is a peptide in the body naturally occurring that helps to regulate appetite. Why are people unable to control their appetite?

• 25:22Dr. Mark Hyman?

  Why are people so, so stuck in knowing what to do and not being able to do it? Is there merit here to this concept that maybe because of factors that we're going to talk about that have come recently in the last 50, 60 years, that have influenced our biology, that have made us low in GLP-1, that's driving us to overeat and overconsume and accelerate this obesity crisis? So, Tina? Why don't you start by helping us and we're gonna let you kind of wind up and hit a home run here. Why don't you start by telling us, like, what is GLP-1? What does it do? Why is it important in the body? And how does it work? Because I don't think most people understand what this is about.

• 26:05Dr. Mark Hyman?

  And then we can get into the idea of, well, maybe there is something going on really with this GLP-1 deficiency concept, and we'll talk about why. I mean, I just read a paper yesterday that GLP-1 deficiency is really common in people with fatty liver disease. Now fatty liver disease is a consequence of our high sugar, starch diet and ultra-processed food. It affects probably 90 million Americans, which is a precursor to heart disease and cancer and diabetes and a whole bunch of other stuff. Even kids as young as 15 are needing liver transplants from fatty liver disease. So we know that at least in fatty liver disease, there is a GLP-1 deficiency. So let's talk about what is it, unpack it, what does it do?

• 26:48Dr. Mark Hyman?

  And then let's talk about this concept of GLP-1 deficiency.

• 26:51Speaker 01

  Sure. So, thank you for having me.

• 26:53Dr. Mark Hyman?

  Of course.

• 26:54Speaker 01

  I'm a huge fan of your work too, Kelly. I think we're all saying-

• 26:57Dr. Mark Hyman?

  I just want to say, we don't have to agree on everything, but we actually like each other.

• 27:00Speaker 01

  We're all friends.

• 27:01Dr. Mark Hyman?

  So this is good. This is good. This is like what America's missing is nuanced conversations that take different perspectives and actually, you know, come up with a place where we can all learn from each other and actually be open to each other's ideas and have a conversation that isn't just black and white.

• 27:15Speaker 01

  Well, the first thing I thought when I got invited onto this podcast was, well, I totally agree with those guys. So what, you know, what am I gonna do here? But I do have some nuanced information I want to share. So my background is I have been in medicine, either working in the field or in practice for nearly 30 years. I've been in naturopathic medicine for 16 years. I was honored to have an incredible mentor for decades, who was an amazing naturopathic physician in a very busy practice. And he taught me early on, way back in the 90s, all about metabolic health, all about insulin resistance, all about type 2 diabetes. That was back when Syndrome X was coming on the scene, which is prediabetes, metabolic syndrome.

• 27:58Speaker 01

  We didn't even have, yeah, we didn't even have metabolic syndrome as a diagnosis at the time. And so that's right when I dropped into his world. He taught me about keeping your waist circumference low. He taught me about fatty liver. He taught me about strength training over cardio. He taught me all the things. My whole platform is about metabolic health and doing all the things and all the things being, you know, mitigate your stress, get your sleep in, protect it, strength train, build muscle, um, high, high protein, low carb, get good, healthy fats, get sunlight, circadian rhythm, all the things.

• 28:29Dr. Mark Hyman?

  Don't forget the vegetables.

• 28:31Speaker 01

  Yes, of course. I know you like your vegetables and I try. But I, this whole thing blew up this last summer with this Ozempic and I thought, well, these have been around for 20 years, these GLP-1 agonists. So why all of a sudden?

• 28:46Dr. Mark Hyman?

  But Ozempic was just approved in 2017.

• 28:48Speaker 01

  Yes, but why all of a sudden with the backlash? And it really raised some flags for me. So I started researching and my background is in regenerative medicine. So regenerative musculoskeletal medicine. I help people rebuild their joints naturally with natural substances, stem cells, PRP. Been doing that for a long, long time. And so the first thing I did was research GLP-1 and its regenerative properties. I always look up things according to what my brain knows. My brain understands pain. I understand regeneration and neuroinflammation. All of those things always interest me greatly. And I found so many studies showing impacts on some of the older versions of GLP-1s and the current versions impacting neuroinflammation very positively. I found data supporting

• 29:33Speaker 01

  its potential use in Alzheimer's and Parkinson's. I found data showing regenerative properties in joints, in cartilage, in ligaments. And I mean, the list goes on and on. I found data showing used early, it could, because it actually heals the pancreas, it can reverse type 1 diabetes if used early and started early, semaglutide specifically. And I thought, this is not at all what I'm hearing. Like this is not lining up at all with what I'm hearing. So of course I got super interested. I did a podcast. The feedback was incredible. I had people from all over the world messaging me, telling me, I do all the things you say. I do all the things you preach. I mean, I was severely, severely censored during COVID for telling people to go outside in the sun, lift weights,

• 30:17Speaker 01

  and eat meat. I mean,

• 30:19Dr. Mark Hyman?

  God, how radical you are.

• 30:20Speaker 01

  I was deplatformed for the work I was pushing back then. So

• 30:25Dr. Mark Hyman?

  Clearly, that's misinformation, right? Eating, eating healthy and exercising and be in the sunlight. God forbid.

• 30:30Speaker 01

  The hashtag sunlight was banned in 2020 off of Instagram. So I have been on this journey of sort of bucking the norm for a long time. And I thought, okay, I'm not, what I'm finding is not lining up with what I'm hearing from everybody. And then, of course, all the health influencers had to come out against it. And everybody was really quite hot on my tails about it. I was getting a lot of hate for even mentioning that there might be other impacts that they have on the body. It's regenerative, it's healing, and it's anti-inflammatory throughout the body. There's GLP-1 receptors throughout the entire body, including the brain. It's not just made in the gut. It's a steroid, or I'm sorry, it's not a steroid. It's a peptide signaling hormone.

• 31:09Dr. Mark Hyman?

  Yeah. Just for people back from peptides are things that our bodies make, and they're the communication networks. There's tens of thousands of these molecules, and insulin is one of them. And people are using peptides like thymosin alpha one or BP157 for sports injuries. These are things that are available. Some of them are prescription, like Ozempic. There are other ones like my Lisi, which is a prescription for sexual arousal in women and men. So there's a lot of things out there that are used as, in traditional medicine, over 70 of these peptides have been approved. And they're, they're things that the body uses naturally. So they're, they're not things that are pharmacological agents. They're actually things that the body has and uses as part of its normal physiology. So GLP-1 is, is that. And so when we say GLP-1 agonist, which is what these class of drugs are, it

• 31:52Dr. Mark Hyman?

  means they work to stimulate the GLP-1 receptors to have the effects of GLP-1.

• 31:57Speaker 01

  Correct. However, semaglutide and terzepatide are actually very closely, well, terzepatide is a little bit different.

• 32:03Dr. Mark Hyman?

  That's my jar for people listening.

• 32:05Speaker 01

  Yeah. Semaglutide is almost bio-identical to GLP-1. It's simply got as little tinkering on one of the amino acids to keep the half-life longer. So GLP-1 that is produced naturally in the body, it's produced by the L cells of our gut. It's also produced in the brain, in the medulla. If it's produced in the brain, I immediately thought, well, it must have use in the brain. And it sure does. It actually has impact on neuroinflammation beyond appetite signaling, beyond any of that. We've got it sort of in this box of being, it slows gastric motility, it decreases appetite by slowing gastric motility, very sort of basic kindergarten version. And then in the brain, it inhibits appetite.

• 32:45Dr. Mark Hyman?

  Right.

• 32:46Speaker 01

  And that's how people have got it. Well, I start looking into it and I'm like, this is a signaling peptide hormone. Why would we macro dose a hormone? You'd feel awful if you were crank and high levels of thyroid or testosterone or estrogen. And those are sex steroid hormones, but still hormones.

• 33:03Dr. Mark Hyman?

  High doses of insulin, which was one of the first peptides ever synthesized and is, you know, has been around for a long time.

• 33:08Speaker 01

  Right. You'd die if you took high doses, too high of a dose. So I got to thinking, well, why don't we just dose physio? I do bio-identical hormone replacement by dosing physiologic doses, which are much, much lower even than some of the standard dosing. So I've always been a fan of starting people very slow and low on any hormone. And I ramp them up and I titrate them up until they get tissue saturation and until their symptoms resolve. And then that's the dose. And then I test to make sure I'm not causing them any harm. And that's how I manage patients on hormones. We've got leptin and ghrelin. Those are peptide signaling hormones. Turns out leptin and ghrelin, so leptin for the audience listening is secreted by your fat. It goes to your brain. It tells your brain you're full. It tells your brain, it's basically the thermostat of the brain. It lets the body

• 33:53Speaker 01

  know energy status, right? Ghrelin is secreted by the stomach and it goes to the brain and tells you you're hungry. I always think grr, ghrelin, right? That's how I remember the two. Ghrelin and leptin don't work if GLP-1 isn't present. The receptors actually don't even come to the cellular surface. So I was like, this is very interesting. Then I started...

• 34:10Dr. Mark Hyman?

  So ghrelin doesn't work because ghrelin seems to be, make you hungry. So if people are hungry, even when they're overweight, then maybe GLP-1 deficient.

• 34:17Speaker 01

  The receptor signaling of, and this was just in rats, but the receptor signaling of the whole orchestra of how these work together, it's much more nuanced, I think, than we understand. The orchestra doesn't work if GLP-1 isn't there. So then I thought, I wonder if we have GLP-1? Deficiency. I wonder if that's a thing, right? It is mechanistically, it's a thing in those with fatty liver, those who are obese and those with type two diabetes. And then I thought, is this a chicken or egg? Is it due to the chronic insulin resistance and the damage to the vagal nerve? And, you know, on and on and the leaky gut and the damage to the gut mucosa and the damage to the microbiome? Is that what is inducing the GLP one deficiency?

• 34:58Dr. Mark Hyman?

  Environmental toxins, who knows, right?

• 35:00Speaker 01

  Then I started talking to my friends who were like the nerdy genetic people. They love their genetic mutations and they started telling me that there's snips, that code for GLP one. And that they're seeing deficiency in those, or they're seeing mutations in those snips. And a lot of people, and in fact, one of my friends runs a diabetes clinic, has done so for decades. Functional medicine, diabetes. And he said that 95% of the patients he's seeing have this genetic snip mutation. So.

• 35:27Dr. Mark Hyman?

  And does that mean like 75% of the people who are overweight in America have this mutation or?

• 35:32Speaker 01

  I don't, I don't know. So what's happening is.

• 35:35Dr. Mark Hyman?

  Unlikely, that's true.

• 35:37Dr. Mark Hyman?

  Yeah, they all get that. Probably like a larger portion of maybe they're severely obese might have that, right? What were you gonna say, Kelly?

• 35:44Speaker 02

  Well, we talk a lot, the genetic arguments brought up a lot. And obviously it's, did genetics change in the last 50 years as obesity has absolutely taken over our country?

• 35:56Dr. Mark Hyman?

  But gene expression changes, right? So I think that's the thing that happens.

• 35:59Speaker 01

  Yeah, gene expression changes.

• 36:00Dr. Mark Hyman?

  Genetic changes. I mean, I think it's, genes are complicated. There was Darwin, which is, you know, genes changed by natural selection over millennia. And then was Lamarck, who said traits can be passed from generation to generation. And Lamarck was kind of nisticist and Darwin won the day. But the truth is they're both right because Darwin is about gene changes. And Mark is really talking about epigenetic changes, which can happen from generation to generation. And I think, I think one of the things we're seeing now is generations of kids who are born to obese parents. And the consequences of that, the epigenetic changes in the womb that happen from the environment that the baby is bathed in. From processed food and sugar and starch and lack of exercise and stress and. All the things, environmental toxins, all of that is programming these children.

• 36:45Dr. Mark Hyman?

  We know this data from many, many epigenetic studies. It's programming these children to be obese, have heart disease, have diabetes, end up with cancer, and many other problems. And they're kind of screwed before they were even born. Yep. So these, these kids come into the world and then they're more likely to be obese. They're more likely to have these programmed epigenetic changes that maybe are, are affecting the expression of the genes. So genes don't change, but the expression changes. And that's, I think, that's an important point. And I agree, Kelly.

• 37:14Speaker 02

  Which, but they could change if that child is provided a whole food diet.

• 37:19Dr. Mark Hyman?

  That's right. Epigenetic changes can be reversed.

• 37:20Speaker 02

  Is exposed to sunlight. So we have an Orwellian situation where we have such a crisis in America that children are in utero developing metabolic dysfunction because we're being, our food is so toxic and our, we've had a sedentary lifestyle and aren't looking at the sunlight and being, you know, sleeping, dysregulated sleeping, chronic stress with our phones. So we have such a bad metabolic health environment that we have an epidemic of kids being born, you know, born with metabolic dysfunction. So it is societally vital. There's nothing more important than this.

• 37:52Dr. Mark Hyman?

  I agree.

• 37:53Speaker 02

  So we have an opportunity. There, it's not a both and. Are we going to, as a matter of public policy and as a matter of focus in that country, change that dynamic of changing our USDA guidelines to say that that two-year-old shouldn't be eating sugar?

• 38:09Dr. Mark Hyman?

  A hundred percent of this.

• 38:10Speaker 02

  When you go the route of Ozempic, when you go the route that this is so bad that we need to jab those children at six, that's a different route. That's a different prioritization.

• 38:20Dr. Mark Hyman?

  I'm not so sure. I'm for giving kids six years old Ozempic. That's another conversation. I, I think that's a little extreme and I.

• 38:27Speaker 02

  But if we agree with the idea, if we actually agree with the science and that this drug is good and should be used as a standard of care, why not?

• 38:34Dr. Mark Hyman?

  I don't think any drug is good or bad. You're thinking from public policy, social. I'm a doctor, Tina's a doctor. We're both thinking about the patient we see in our office who's stuck as you know what. And how do we help them? And I've had patients who have lost 200 pounds, 150 pounds, 110 pounds, 116 pounds, 138 pounds, just using food as medicine.

• 38:55Dr. Mark Hyman?

  But it's tough for them. They can do it. But the question is, is there something else that could be done in a way that actually is, is like Tina was saying, is physiologic, that doesn't use this kind of heavy handed pharmacologic approach to actually help people with fixing some of the metabolic and biochemical things that are going on. And I, I think this is an open question. I think we need more data on this, but I think what you're saying Tina is really interesting, that, that there are effects of this, this natural peptide that are different than just regulating weight. Absolutely. And they may be working through other mechanisms. Uh, you know, I had a patient once say to me recently, can I just take phentermine? And that's a basically an appetite suppressant. Crack.

• 39:37Dr. Mark Hyman?

  It's basically, yeah, it's basically speed or crack. Yeah. Basically, yeah. My crackheads are so skinny because they don't want to eat because they're appetite suppressed. But it's basically speed. And I said, no, no, no, this is really not good because it's going to cause you to be anxious, palpitations, and have all these, you know, issues of sleep. And I think it's not a good idea, but you know, then we talked about Ozempic maybe being a solution because it, it can be done in a way that is, is different, that works physiologically and works on some of these other pathways that I think people aren't aware of, like the neuroinflammation is a big one. And I think what we're seeing is sometimes decreased suicide rates, we're seeing decreased depression, we're seeing a lot of other things with these drugs. And I think, well, how is that happening? And, and what's, what's probably happening in my view is people are eating less of the crap because they don't want it. And, and

• 40:22Dr. Mark Hyman?

  so their brain and their body inflammation is going down. And maybe some of the effects of the GLP-1 drugs are anti-inflammatory by, by mechanism. They are. And they are. And so, so if that's true, then you know, the neuroinflammation crisis, and I, again, I've talked a lot about this on the podcast and written a whole book about it called The Old Dream Mind Solution, is our brains are on fire. And our brains on fire lead to depression, anxiety, suicide, aggression, you know, societal division, Alzheimer's, Parkinson's, I mean, the list goes on and on. Anything that affects the brain is about inflammation. So these drugs may module like that. It's very fascinating. So they're being studied for Alzheimer's and many other things. Now, I, I think the idea that we should just like fall in love with this drug and it's great for everybody and we should.

• 41:04Dr. Mark Hyman?

  Put it in the water. I don't think Tina or anybody I think who is smart about this thinks that. But but for the select patient, in a way, given in a way that can can actually regulate some of these pathways, I'm not so sure it should be thrown out. It's like any any tool. It's like any tool we have in medicine. It's for the right person at the right time.

• 41:24Speaker 02

  Who is the right person? Just generically, I'm just curious.

• 41:26Dr. Mark Hyman?

  Well, that's a great question.

• 41:27Speaker 01

  So let me finish what I was trying to tell you guys. I started using this in patients, and I have only one who is using it for weight loss. Everybody else is on it for a different reason. So and I'm using it at a fifth of the starting dose compounded droplets. And when I started doing this, my colleagues all started who listened to my podcast all started also microdosing GLP-1s in their clinics. And we've all reported back to each other and we're seeing phenomenal results in all different kinds of conditions that leads me to believe that we may actually be able to do away with a lot of the lifestyle pharmaceuticals that people are using. So people are on other drugs for life, such as high blood pressure meds or statin drugs.

• 42:09Speaker 01

  These these peptides have been shown to heal heart tissue and to reverse heart failure. So I've got one patient on it for high blood pressure, tiny little dose, high blood pressure, blood pressure is down. I personally take it because I have psoriatic arthritis and I have crippling pain from tip to toe. It doesn't matter how clean of a life I live. It doesn't matter how clean my fish tank is. I menopause hit me. The brain fog was real and the pain came with it. And I knew it was due to neuroinflammation. So tiny little doses mitigates my autoimmune conditions like nothing I've ever used without any side effects. None of the people I'm using it on, none of the people, none of the patients that my colleagues are using it on are having

• 42:50Speaker 01

  any side effects. You keep the dose low, the nausea, the vomiting, the terrible side effects, the muscle loss, that is all a dosing and management issue. And brand names start in a pre-filled pen. I don't use them. They're too high of a dose. We are mono dosing.

• 43:09Speaker 01

  At high doses, monotherapy, a hormone, and that's why we're seeing these horrific side effects, which I completely agree with. I've listened to your argument on different podcasts, and I'm like, I totally agree with them. I totally agree with what's happening there. But we wouldn't throw out thyroid if all the doctors were overdosing their patients on thyroid. It's a management and dosing issue on the doctor's part. And then how compliant are patients?

• 43:31Dr. Mark Hyman?

  Why is pharma starting the dose so high? I mean, injection first dose is 0.5 mg, then it goes to 1 and 2. You're talking about using 0.1 or 0.08 to start, which is a fifth of that.

• 43:41Speaker 01

  Tiny, because they're dealing with severely metabolically busted people already. And the people I'm dealing with are doing all the things and are generally metabolically healthy.

• 43:50Dr. Mark Hyman?

  But the median American is not. What would you do if you had someone come in, it was like 350 pounds, who would you start? Or the average American.

• 43:57Speaker 01

  So you give them a leg up. I have a license to prescribe, so I prescribe things to give people a leg up. I do use Prozac as needed at very low doses. And the way that I have been taught by my mentor is when a patient comes in, and here's their pharmacological profile, and here's their lifestyle, you lower this as much as humanly possible, or get them off is the goal. The reason I became a naturopathic physician in the state of Oregon, so I could prescribe, is to get people off drugs. And then you bring up their lifestyle.

• 44:25Dr. Mark Hyman?

  You have to have a license to put them on and to take them off.

• 44:26Speaker 01

  You bring up their lifestyle, right? And so you hopefully get this as low as possible. But I'm not opposed to keeping people on tiny little doses. This is not the first drug I microdosed. I microdose Prozac in patients. I've microdosed statins. I microdose all kinds of drugs to give them. You get a different mechanism of action when you use things at tiny little dosages than when you macrodose them. Macrodosing a drug gives you a different pharmacologic impact on the body.

• 44:48Dr. Mark Hyman?

  And do they work at that low dose for people?

• 44:51Speaker 01

  Yeah.

• 44:51Dr. Mark Hyman?

  What if they're, for your patients who are not really doing it for weight issues, I understand.

• 44:55Speaker 01

  Everybody lost weight.

• 44:55Dr. Mark Hyman?

  But what about for people who are like 300 pounds? Would you start with the same dose?

• 44:59Speaker 01

  So I have one patient who is morbidly obese. He's well over 300 something pounds and can't move. In so much pain, he can't move. He sleeps in a lazy boy, spends all day in a lazy boy, doesn't get up, doesn't move, cognition's off, has had too many strokes. I don't even have him at the starting dose yet. And it's been months, and he is very happy. Very slowly shedding the weight.

• 45:21Dr. Mark Hyman?

  Yeah, the starting dose, the pharmacologic starting dose.

• 45:22Speaker 01

  Yes, so I've got him at a fraction of that and he, his cognition has improved. The cognitive impacts have been huge. I've seen it eradicate depression. I've seen it reverse PCOS. I've seen people walk straight into fertility after decades of infertility issues from PCOS, so, and this is all at micro doses. I'm talking droplets.

• 45:42Dr. Mark Hyman?

  So this compound which our body makes maybe is deficient because of why? Why is it because of epigenetic programming? Is it because of our microbiome changing? Because of toxins in the environment?

• 45:54Speaker 01

  I think all of it. You know, the mess of toxic soup we live in. I mean, we live in a toxic soup period. Epigenetically, like you said, mothers, the data around maternal diabetes and metabolic inflammation and the offspring is, you, do you know Pottinger's cats? Did you guys ever hear about Pottinger's cats? So Pottinger in the 30s took cats and he fed, he was a veterinarian. He fed them cooked meat and pasteurized milk.

• 46:21Dr. Mark Hyman?

  Yeah.

• 46:21Speaker 01

  That's all he did was change it. And within one to three generations, they were completely infertile. Their intestines were inflamed and boggy. Their livers were enlarged and fatty infiltrate. And it took him multiple generations with optimal cat diet, which is raw milk and raw meat, multiple generations to reverse them back to a fertile, healthy animal.

• 46:41Dr. Mark Hyman?

  Yeah.

• 46:42Speaker 01

  So my, I'm 50. I watched all of this happen. I've seen it. I remember when there was like one kid in school who truly had a glandular problem, who was overweight.

• 46:49Dr. Mark Hyman?

  Yeah.

• 46:50Speaker 01

  I've watched this.

• 46:50Dr. Mark Hyman?

  Erica, my class.

• 46:52Speaker 01

  Yes, I've watched this whole thing unfold. I've watched food change. I've been battling against it too for a long, long time. But we're in a pickle.

• 47:01Dr. Mark Hyman?

  Yeah.

• 47:01Speaker 01

  And I think we're, I think I am actually a few generations into Pottinger, or at least one into the Pottinger's cats. My parents, the boomers, had the convenience foods. Crisco oil came into play and here we are. And my daughter.

• 47:15Dr. Mark Hyman?

  Marjorie, that was what I lived on when I was a kid.

• 47:17Speaker 01

  Yeah, me too, and Wonder Bread and baloney. But my daughter's, my daughter's 24 next week and her generation is a mess. It's a mess.

• 47:25Speaker 02

  Because of the pharmaceutical industrial complex and treating everything in silos.

• 47:29Speaker 01

  I totally agree.

• 47:30Dr. Mark Hyman?

  Yeah.

• 47:30Speaker 02

  But this is treating obesity in silo.

• 47:32Speaker 01

  I'm not talking about treating obesity.

• 47:33Dr. Mark Hyman?

  Kelly, do you see a world in where it's not either or? There may be a role for using these drugs in, in patients to help along with an intensive lifestyle intervention and a functional medicine approach to correct some of the problems that may have been driving the GLP-1 deficiency and not have them on it forever?

• 47:48Speaker 02

  Let me give my high level of respect on that and then go into like certain patient archetypes and cases. I'm really skeptical and I think viewers and listeners just need to make up their own mind. I'm very skeptical at the building of this drug as a miracle drug for all chronic conditions. There has never, by my account, in American history, been a chronic disease pharmaceutical product that's lowered rates of the chronic disease it's ostensibly trying to treat. More statins, more heart disease, more metformin, more diabetes, more SSRIs, more depression. You can go down the list.

• 48:17Speaker 01

  But it's not a drug.

• 48:18Dr. Mark Hyman?

  People don't change their lifestyle.

• 48:20Speaker 02

  Exactly. It's a moral hazard. I talk about my mom a lot, right? My mom was on five different medications, right? When she was diagnosed with cancer, she would have certainly been on Ozempic. She had trouble losing the baby weight and was never obese, but obese after she had me. And, you know, she was on the statin, on the metformin. And there's a choice a doctor has, right? They can follow your work. And when the person has an elevated waistline, or has elevated cholesterol, or has elevated blood sugar, they can open your book and talk about how they have to go on a path of curiosity and a path of metabolic health to get their biomarkers and get their underlying metabolic health more under control. And that cannot be injected. And it cannot be pilled. And frankly, I would

• 49:05Speaker 02

  argue that it's very clear from the data and experience that putting the savior in a lifetime chronic disease treatment has been a total failure because inevitably it's happened.

• 49:14Dr. Mark Hyman?

  I agree. In a perfect world, we'd have a healthy environment in the country where we had all the defaults being healthy, where there wasn't processed food, where people were moving naturally, where we had lower stress, or weren't having, being sleep deprived, where we weren't exposed to a load of environmental toxins. I want that world. 100%. We don't live in that world. And I see patients, for example, who have had complications from conditions. For example, we're doing clearly heart scans, looking at AI interpreted coronary angiograms. And we're seeing people with lots of plaque, and dangerous plaque, and risk plaque. And those people, I will put on medication. It's not the solution to someone who's young, who doesn't have a solution to problem to prevent it. But there may be a time for medications in people's lives that actually can be used.

• 49:59Dr. Mark Hyman?

  In a way that helps reverse the problem.

• 50:01Speaker 02

  And as I said at the beginning, I'm not concerned with that patient. I'm not concerned with that edge case. I'm concerned with the average person listening. I'm concerned with the average American who's overweight or obese. I'm concerned with the average American teen right now who is overweight or obese. I'm concerned with that person. I'm not concerned with the person on the edge cases. Is this the treatment for obesity? And all you need to do is look at JP Morgan, their stock analysis for the Novo Nordisk stock. They project an increase in obesity over the coming 10 years. They project as this drug is prescribed widely and approved and government funded. They assume that obesity is going to go up. You just have to ask why that is.

• 50:36Dr. Mark Hyman?

  Why is that?

• 50:38Speaker 02

  One more quick thing, and I think this really helps.

• 50:39Dr. Mark Hyman?

  Why would they say?

• 50:41Speaker 02

  Because there's never been a chronic disease drug, and this is a drug in history, that has lower rates of the chronic diseases trying to treat. It is a moral hazard. Obesity is not an Ozempic deficiency. Alzheimer's, heart disease, isn't an Ozempic deficiency. The message of this drug, whether you do it at a low dose or high dose, quite frankly, because if you start at a low dose, you have to take it for life in order to maintain it.

• 51:02Speaker 01

  No, you don't.

• 51:03Speaker 02

  You absolutely have to take it for life unless you dramatically change your lifestyle habits. In this case, the drug isn't necessary.

• 51:08Dr. Mark Hyman?

  I think we're on the same page here because I don't think anybody believes that you can use a drug without lifestyle change. And sometimes people need a bridge. For example, some people need like a leg up who are just so stuck. And I am humbled as a doctor because, you know, it's one thing to have, you know, a philosophy based on a really a very pure idea of what we should be doing. But the reality is there are real people with real issues who struggle. And it's, and even with their best efforts, they can't succeed. And so that's, that's a problem I see. And it may be because of the things that are not within their control. In other words, there may be things that are going on biologically with the drastic change in our microbiome and environmental toxins, which I think are the two biggest

• 51:50Dr. Mark Hyman?

  things going on, that make it hard for people to actually correct those things without some help.

• 51:55Speaker 02

  Mark, respect. You, your books and your teachings have changed my life and where I'm on this path. And I just have to say, we need to be clear to the American people, people listening to this, if they're facing metabolic dysfunction, try not eating ultra-processed food. Try cutting that from your diet.

• 52:09Speaker 01

  Have you had a patient in front of you who's dealing with chronic mold or SIRS or severe trauma and adverse childhood events and it doesn't work?

• 52:17Speaker 02

  So I want to go through two patient archetypes, okay? If you are the Median American who is on, you know, a couple of chronic disease medications and overweight or slightly obese, right? Let's go through this. If you go on Ozempic at whatever dose, right? It's only going to work and you can only go off of it. If you radically change your lifestyle habits. So we're all in agreement with that. You can only go off of it.

• 52:41Dr. Mark Hyman?

  So should you do that?

• 52:42Speaker 02

  Unless you radically change.

• 52:44Dr. Mark Hyman?

  Right.

• 52:44Speaker 02

  I just want to make sure we're all aligned on that.

• 52:45Dr. Mark Hyman?

  A hundred percent.

• 52:46Speaker 02

  So, so there's no point in really taking it unless you're going to radically change your habits for life. Not a crash course, not a jump start, but actually really have a, almost a spiritual reset in your life to change your habits.

• 53:01Dr. Mark Hyman?

  I agree.

• 53:01Speaker 02

  Okay. If you go off of it, if you do it and go off of it and don't change your habits, you're going to gain the weight back.

• 53:07Dr. Mark Hyman?

  Correct.

• 53:08Speaker 02

  So if you're going, if we need a massive, and I'm talking for the median person listening. If we need a massive, almost revolutionist country where we have to change our metabolic habits, whether we're taking the drug or not, why not start with that? Why do we need this drug?

• 53:23Dr. Mark Hyman?

  I agree.

• 53:24Speaker 02

  Is there any evidence that it gives a kickstart?

• 53:26Dr. Mark Hyman?

  I agree, I agree. If we, if we have a society where all that's possible, great, we just don't.

• 53:30Speaker 02

  What is the evidence that the drug helps if we're not changing our habits?

• 53:33Speaker 01

  It gives you the ability, well, first of all,

• 53:36Dr. Mark Hyman?

  The ability to change your habits.

• 53:37Speaker 01

  Lose five to 10% of your body weight and see what happens. You start moving more, you feel better, you have less pain, you're more inclined. Most people that I'm seeing on it don't actually want to start changing things significantly until about the two month mark. And all of a sudden they start talking about, hey, doc, what should I do for exercise? What should I be doing beyond walking? There, the hedonic urge to eat the junk is gone.

• 54:01Speaker 02

  It comes back when you go off of it, doesn't it?

• 54:02Speaker 01

  Not always. It actually is having a regenerative impact. There is a long-term regenerative impact and a healing impact from the peptides. And they, we have the data on it. I'm not sure what data you're looking at, but the data I'm looking at is not showing exactly the same thing.

• 54:15Dr. Mark Hyman?

  And I would, I would say Kelly, as pep, just to understand pharmacology versus physiology. So. Someone has a thyroid dysfunction, they have low thyroid hormone, we give them thyroid hormone for life. Now, some people can get off it if you change a lot of things.

• 54:29Speaker 01

  And some people can't.

• 54:30Dr. Mark Hyman?

  Some people can't. You know, if you take a pharmacologic substance, it's working in ways that are inhibiting, blocking, or somehow interfering with normal physiology. Peptides are things that our body uses to regulate its function. I personally use peptides for my own health, I use peptides in my patients for all sorts of different things, from tissue repair, to hormonal support, to immune support, to anxiety and brain health. And they're quite effective, and I don't shy away from using those in the right patient in the right way. So, as a class of compounds, they're different than pharmacologic compounds, even though they've been co-opted by the pharmaceutical industry. Now, the FDA is trying to shut down the use of peptides because they're so effective.

• 55:14Speaker 01

  Right, yes.

• 55:15Dr. Mark Hyman?

  And they're physiologic. So, I always think of something when I treat somebody, is this nature-made or man-made? Right, if it's nature-made, I tend to think that it's working with the body rather than against the body. And the question is, you know, if you give something like vitamin D, which is nature-made, at massive doses, it's gonna cause a lot of harm. But if you give vitamin D to those who are deficient in it in a physiologic dose, it may actually help them function better. So, I'm always kind of thinking about medicine in that perspective. I've worked, for example, with a woman who has struggled for a long time, for decades with weight. And she tried, she tried, she knew what to do. You know, she'd been a victim of terrible trauma when she was younger.

• 55:59Dr. Mark Hyman?

  She saw her mother literally stabbed to death in front of her by her stepfather. She was kidnapped and drowned in a car, she was raised by an abusive aunt. I mean, I saw the amount of trauma she had, and she pulled herself up by her bootstraps, and she was very successful. But she struggled with her weight around this, this is what we call adverse childhood events. And for her, you know, I think she tried this medication, and it really helped her to kind of get back to a level where she could get off the 50, 60, 70, 80 pounds that she needed to get off. And so, you know, it's humbling as a doctor to know, you know, when you can't get people to do the right thing for some reason. There's their trauma, whether it's their emotional state, whether it's their brain functioning, or their brain inflammation. Sometimes these compounds can be helpful.

• 56:43Dr. Mark Hyman?

  So I kind of like to kind of not just do all good, all bad and go. I think we all agree that the way that the pharmaceutical industry is doing this is bad. Like, I don't think any of us have any argument about that. I don't think any of us have an argument that, that, you know, pharma shouldn't be driving all the research. It shouldn't be driving all the, the, the, uh, marketing. They shouldn't be driving all the co-opting of, of the research institutions, the professional associations, physicians promoting it. You know, the government lobbyists, you know, I mean, you know, they're trying to get it approved for Medicare. I'm like, well, gee, you know, for Medicare Part D, which is the drug benefit, the total benefit for all, everybody on all drugs in all America is 145 billion. If just the obese people in Medicare got this, it would be, I think, 267 billion, which is, you know, more than all the rest of the drug benefit put together.

• 57:28Dr. Mark Hyman?

  So that is not a solution. We're working, for example, in Washington, try to get food as medicine covered. We're going to get there, but it's a decade-long fight. In the meantime, we're heading into some crazy, uh, period of, of metabolic disaster in America that we need, we need to do something. So I would like to kind of go back to Tina and talk to Tina about her approach with her patients. Cause I, I, I was, to be just honest, I was pretty skeptical. I was like, I don't know. I think I've prescribed it maybe one or two times in very select patients who really had to get the weight off. They were had Alzheimer's or they had something really serious and I, and I used it very carefully. But, but I really had a, a very similar perspective to you, Callie, that this is something that we should, we should really not be using, that lifestyle works better.

• 58:12Dr. Mark Hyman?

  That, that, you know, that if you, if you look, for example, the studies of gastric bypass, which is the other treatment, uh, which is by the way, far cheaper if you, if you're paying retail for these things. If you give someone a gastric bypass,

• 58:26Dr. Mark Hyman?

  and then you have someone eat the same diet as if they had a gastric bypass, there was no difference in the outcomes. So as to paraphrase Bill Clinton, it's the food stupid, right? And, and, and I was like, wait a minute, is this, if people just did a study, and I've never done this study, cause I looked, I looked to see if there was a study done. Was there a study comparing? Diet, aggressive dietary intervention, the same diet people would eat on a GLP-1 agonist with a GLP-1 agonist, and looked at all these effects. Would neuroinflammation go down? Would fatty liver improve? Would heart failure reverse? I think it would. I don't, I don't know the, how the study worked, but I had a patient like this. She was 66 years old. She had heart failure, liver, fatty liver. She had diabetes. She had all these problems. We didn't use Ozempic. We just used food. And she was off all her medications in three months. She lost 43 pounds in three months, 116 pounds in a year.

• 59:10Dr. Mark Hyman?

  And she got reversal of all these inflammatory things. So was, would she have been helped even more with Ozempic? I don't know. So this is a question I have, and I kind of want Tina to you to talk, talk through how you use this with your patients, because it's, it's a very different approach than, than I think we're talking about with what's happening wide scale in the country. It's like you give us, go to the doctor, you give Ozempic. Now you can buy it online. You can go to Ozempic like websites and they talk to you for five minutes. They give you the drug. And it's like a, it's like a, like a prescription mail that I think should be illegal. But I, I think in the right patient, in the right way, tell us what you're, what you're seeing.

• 59:47Speaker 01

  Well, first of all, I don't use anything in isolation. So the foundations are always the foundations, right? Diet, lifestyle, exercise, sun, all of those are always critical. Sometimes people aren't ready to implement all of those things. And it's quite a bit overwhelming, as you've seen with your patients. You got to start with one thing. I also never use peptides in isolation. I, I like you, use a multitude of them with patients. And I also usually bring in some bio-identical hormone replacement as needed, depending on their age and their condition. And so this is just about one tool in a comprehensive tool belt. And when done that way, I found that you can keep the dose significantly low. And then I cycle it. So just like a hormone.

• 1:00:27Dr. Mark Hyman?

  So not on it for life?

• 1:00:29Speaker 01

  No.

• 1:00:29Dr. Mark Hyman?

  On and off?

• 1:00:30Speaker 01

  On and off, just like I do a hormone. So that off period may be one week out of the month. It may be a month out of every quarter. It may be go off for a period of time and go back on when you need it.

• 1:00:40Dr. Mark Hyman?

  And do they gain the weight back when they do that?

• 1:00:42Speaker 01

  Not if they're metabolically optimized. So I really think that peptides in general work best in folks who are metabolically optimized. So I'm not defending this. For strictly weight loss, I'm using it as an adjunctive tool in a comprehensive toolbox to get people that leg up so that they have the energy, they start to drop the weight, they start to do all the things, or they do better at doing all the things, right? It might be the patient is doing all the things, but they've got a crazy sugar addiction, or who knows? Who knows what it is? Again, mold exposure, Lyme disease, it could be a myriad of things that's keeping their glucose elevated. They are doing everything perfectly and their blood sugar is still elevated. I've seen patients like that. You're like, how is this? How are we still dealing with this elevated hemoglobin A1C? You're lean, you're fit, you're doing everything right, you're eating like a saint. A touch,

• 1:01:27Speaker 01

  just a little touch of something, I don't, it's not always a GLP-1, but there's something that they need, and when we give that, we give what the body needs, it responds in favor, and they improve. And I'd like to say, most women I know on bio-identical hormone replacement will tell you, we don't mind taking it for the rest of our lives. I don't plan on getting off thyroid. I have no desire to get off thyroid. I have no plan of getting off of my estrogen. I have no desire to.

• 1:01:52Dr. Mark Hyman?

  Well, let's talk about this, because I think, I think what's, what's in the literature and concerns me is some of the side effects, right? And I think, Kelly, maybe that's what you were about to say.

• 1:02:01Speaker 02

  So, I hear you on the metabolically optimized person, but for somebody, like, more than 50% of American adults, by some measures up to 60% have prediabetes, I think 80% or so don't know it. There's, most people listening are, you know, have indicators of metabolic dysfunction, like, generically, if it's, if it's better for metabolically functional people, which is a very small percentage of the country, what's the, what's the high level?

• 1:02:24Dr. Mark Hyman?

  Well, no, what you were saying was peptides work better.

• 1:02:26Speaker 01

  All peptides.

• 1:02:27Dr. Mark Hyman?

  But, but.

• 1:02:28Speaker 01

  They work in everyone, but they work best when you're, and you can keep the dosage low when folks are generally healthy. Now.

• 1:02:35Dr. Mark Hyman?

  So is very, you know, insulin. If someone's very insulin resistant and type 2 diabetic, they need a lot of insulin to lower their blood sugar, but if someone's insulin sensitive, they need a tiny bit of insulin, right? If they're.

• 1:02:45Speaker 02

  So, so somebody that is metabolic dysfunction will need a good deal more?

• 1:02:48Speaker 01

  Not necessarily. It depends on when they start implementing lifestyle changes. Some people need some help getting there, and the other piece is that. I don't think people need to be on them for life at high. I certainly don't think people need to be high dosed the way that they're being dosed. I think that was just the way the studies were ran. We're also dealing with a population when we're talking about diabetes and obesity, who are already prone to pancreatitis, they're already prone to thyroid cancer, they're already prone to gastroparesis. I mean, the number one risk factor for gastroparesis is type 2 diabetes. And the number one risk factor for thyroid cancer generally is diabetes and obesity. So you have two times the risk. So I'm talking about intervention because these peptides actually, they don't act as just a Band-Aid, Kelly. They heal your metabolism.

• 1:03:31Speaker 01

  They heal your pancreas, they heal your liver, they heal your metabolism.

• 1:03:35Dr. Mark Hyman?

  That's an interesting concept because like, for example, I use BP157. When I have like, and I work out and I get a little strain of muscle, I just pop it in there and it's better. So it regenerates tissue, it repairs tissue. I had a guy who was an elite athlete, he pulled a muscle on his calf and he couldn't do all the things he had to do. I just popped a peptide in there. Someone else, the tennis elbow, I popped a BP157 GHK peptide in there and I did maybe a couple of times and it resolved the problem. Now, that, I think GLP-1 agonist may be a little bit different, I don't know, but they do have a regenerative capacity. That's what these peptides are meant to do in the body. So they're different than drugs. And I think that the pharmaceutical approach is concerning to me because it doesn't include a holistic approach. And you and I do that, obviously. And there are some doctors around the country who are focused on that.

• 1:04:20Dr. Mark Hyman?

  But most of the people getting these drugs are just getting them.

• 1:04:22Speaker 01

  True.

• 1:04:22Dr. Mark Hyman?

  And then, then they have some significant issues. So at the dose that we're seeing that the people are getting, there's very high rates of nausea, very high rates of diarrhea, constipation, like 20, 25%, probably 67% nausea. It tends to go away after a little bit, but it still has a problem. And 80% discontinue them after, I think, a couple of years or a year or two, which is an interesting phenomenon, whether it's cost or side effects or maybe, I don't know what. And then there's the risk of some of these other issues. Now, the absolute number is small because these are rare conditions. But when you look at the data, published data, there's 450% increased risk in bowel obstruction and 900% increased risk in pancreatitis. They seem not trivial. And if you scale it out on the population and the incidence of this,

• 1:05:06Dr. Mark Hyman?

  it might be if, you know... I don't know, 100 million people are taking it, it might be 500,000 people with it, which is not trivial. So how do you, how do you think about these side effects? How do you, how do you see these being different in the patients that you use the microdosing, as you call it, microdose? I wouldn't call it microdose, I'd call it low dose.

• 1:05:21Speaker 01

  Yeah, it's low dose.

• 1:05:22Dr. Mark Hyman?

  Microdose is like micro, but, but low dose, I think you're using low dose, which is, I think, an interesting concept. And by the way, people, you cannot get low dose through the drug companies.

• 1:05:33Speaker 01

  No, the brand name can't.

• 1:05:34Dr. Mark Hyman?

  Compounding pharmacies, and we're going to talk about that and the challenge with that, but it, it, it, there's a way to get it and do it, but it's tricky and you need to be with the right practitioner. But, but given, given these side effects, you talk about what you think about these. Are they, are they as bad as we think? You know, are they just in the people are on high doses? Do you see this in the population who are using smaller doses as you're talking about?

• 1:05:57Speaker 01

  I'm not seeing it in any of my patients. The study that you're referencing, you're right, it was a small, I mean, I think it was like seven out of 600 and something got the bowel obstruction.

• 1:06:08Dr. Mark Hyman?

  Right.

• 1:06:08Speaker 01

  You know, seven people, which looks terrible as a hazard ratio, but.

• 1:06:12Dr. Mark Hyman?

  Right.

• 1:06:12Speaker 01

  And when you scale it out, yes, I agree, but I think we're talking management and dosing being the problem. And when you overdose somebody on a peptide or anything, I mean, when I take too much BPC 157, I, I swell up and I get swollen throughout my body, I get edema. So overdosing somebody on a GLP-1 is, I think, is what's happening. And then we're already, we're taking already brittle, they're metabolically brittle, their vagus nerve is damaged already, their muscle tissue was already pathologic and full of fatty infiltrate.

• 1:06:42Dr. Mark Hyman?

  Like a ribeye.

• 1:06:43Speaker 01

  And then we're slamming them.

• 1:06:44Dr. Mark Hyman?

  Ribeye, wagyu ribeye.

• 1:06:45Speaker 01

  Yeah, and then we're slamming them with monotherapy, high dose GLP-1s. I think it's a disaster.

• 1:06:50Speaker 02

  So for listeners, if they listen to this and go to their doctor and get the prescription of those, they're not saying often that is an overdose.

• 1:06:56Speaker 01

  Yes.

• 1:06:57Speaker 02

  It's actually very dangerous, so.

• 1:06:58Speaker 01

  I don't think it's very dangerous. I think in the wrong person it could be.

• 1:07:01Dr. Mark Hyman?

  Yeah, it tends to have more side effects.

• 1:07:03Speaker 01

  Yes, you're going to get more side effects, isn't that?

• 1:07:04Dr. Mark Hyman?

  Yeah.

• 1:07:05Speaker 01

  And, and the gastroparesis is not permanent, regardless of what the clickbait headlines are telling us.

• 1:07:11Dr. Mark Hyman?

  Meaning, meaning your stomachs kind of stops working if you stop the drug, it'll come back to

• 1:07:15Speaker 01

  Yeah, it comes back online. The thyroid cancer is correlative at best.

• 1:07:20Dr. Mark Hyman?

  Yes, we're in rats.

• 1:07:21Speaker 01

  It's been in rats. That black box warning is in rats that we're given like.

• 1:07:25Dr. Mark Hyman?

  Cancer that doesn't even occur.

• 1:07:26Speaker 02

  So you're saying you're downplaying that, the black box warning?

• 1:07:28Speaker 01

  No, it's in rats.

• 1:07:29Speaker 02

  But you're saying that's not something to worry about?

• 1:07:31Speaker 01

  There's literally no human cases showing positive.

• 1:07:34Speaker 02

  I will just say that the FDA, which is 75% funded by pharma, which is basically a subsidiary of pharma, for them to put, take the step of putting a black box warning means there's pretty scary data, in my opinion, on the thyroid cancer.

• 1:07:44Speaker 01

  I was gonna finish. They took the rat and they gave him 100 times the human dose. And they got a very rare form of medullary thyroid cancer that rats develop spontaneously. And the control group also got a high rate of medullary thyroid cancer. So I'm not downplaying anything. No, I'm talking about what the Cleveland Clinic is showing for the actual data.

• 1:08:03Speaker 02

  Just for listeners, should they be concerned about thyroid issues, hormonal issues, leading up to thyroid cancer?

• 1:08:08Speaker 01

  They should talk to their doctor. And if they have a history of medullary thyroid cancer in their family, they should absolutely, that's a doctor-patient relationship discussion. I'm not defending Ozempic. And I'm not defending it at high doses for weight loss. I'm talking about nuance. We're not throwing out the baby with the bathwater.

• 1:08:24Dr. Mark Hyman?

  I think that's an important point, Tina. I think we have to do it in the right way, in the right context for the right patient. I always say, you know, there's a Buddhist concept called the right medicine. What is the right medicine for this person? Is it a motherectomy if they're left 50 years old living with their mother? That's driving them crazy? Or, you know, or do they need exercise? Or do they need the right nutrient they're deficient in? Or do they need to have some support for their metabolism? And I think, you know, it's, conversation is hard because we're threading a very tight needle here.

• 1:08:51Speaker 01

  Yeah.

• 1:08:52Dr. Mark Hyman?

  Which is, at scale in the population, the way it's being done now, I think is problematic. But is, is there another alternative to think about this? That we can basically encourage people to think about? That includes an aggressive lifestyle intervention with some peptide support? Which I use across many, many other peptides. I use many peptides in my practice for just general therapeutic treatments that, that support the body's own endogenous functioning, which is what I love about peptides. I love things that nature made, that are not. Not that, or God made, not that man made, because they tend to be more problematic. That doesn't mean that these don't have side effects when you use them in huge doses. It looks like vitamin D, right? So, one of the things that also is a problem is muscle loss. And there's a lot of the data is very clear on this. There's been DEXA scans in some of the studies showing significant weight loss.

• 1:09:37Dr. Mark Hyman?

  But, but the truth is, if you just lose weight without exercising and eating protein, you're gonna have the same results.

• 1:09:42Speaker 01

  It's the same percentage on a low calorie diet.

• 1:09:45Dr. Mark Hyman?

  So if you, if you calorie restrict and you don't eat protein and you don't strength train, you are going to lose muscle and you'll lose muscle and fat at about 50% each. And when you gain the weight back, you gain back all fat. And so you strip your metabolism if you do the weight cycling. And which is, which is a real problem. So, how do you, how do you address some of the concerns? Because aside from the, the protein increase needs, when people are on these drugs, they tend to have suppressed appetite. So they don't want to eat as much protein and they don't want to eat as much food. And then they may be even at risk for nutrient deficiencies. So how do you, how do you deal with, with those kinds of, kinds of issues?

• 1:10:23Speaker 01

  Well, first off, I think that's a dosing issue. If you pull back the dosage low enough, people have an appetite and they continue to eat regularly. And interestingly, I've got people eating, claiming to eat the same amount of calories and still having visceral fat loss. And they're tracking themselves. So, there's something changing there. We have data to show that it decreases visceral fat while maintaining and actually inducing muscle protein synthesis. GLP-1s induce muscle protein synthesis through various signaling pathways and through perfusion, blood perfusion and delivery of amino acids. It's folks going on a severely calorically restricted diet that is causing the muscle loss. The doctors are cranking the dose too high, too fast. They're being ramped up way too fast. It's crushing their appetite.

• 1:11:07Speaker 01

  They're going into an anorexic state and they are indeed losing everything. And just like you said, they're gonna end up way worse off at the end of this terrible journey. And so I don't disagree with that. I always say that strength training is non-negotiable and I've said that for decades.

• 1:11:22Dr. Mark Hyman?

  Yeah.

• 1:11:22Speaker 01

  Strength training is non-negotiable, period. If you want to live a long, healthy life and be metabolically optimized and survive the zombie apocalypse,

• 1:11:28Dr. Mark Hyman?

  Getting people to gym is tough, right?

• 1:11:30Speaker 01

  It really is. And so we can blame the doctors, we can blame the pharmaceutical industry, but I'm talking to the patients because you and I both know that compliance is an issue with patients. And they don't always do what we want them to do and they don't always do what we need them to do. So my patients understand the prescription ends if you don't strength train.

• 1:11:45Dr. Mark Hyman?

  Yeah.

• 1:11:46Speaker 01

  I will pull this out. Like, we will no longer be dispensing this. So, strength training, optimizing.

• 1:11:50Dr. Mark Hyman?

  They need to have their Fitbit or their Apple Watch or their OurRing data pumped directly to you so you can see.

• 1:11:57Speaker 01

  Well, I can tell by touching them. I'm a chiropractor. I can tell by their muscle integrity, just by putting my hands on them, whether they're, you know, good musculature or fatty, flaccid muscle.

• 1:12:05Dr. Mark Hyman?

  It's not a bad idea, right? It's not a bad idea to support people and have them track and be accountable as they're doing this because.

• 1:12:11Speaker 01

  That's helpful.

• 1:12:12Dr. Mark Hyman?

  Yeah.

• 1:12:12Speaker 02

  It sounds like we're all in agreement. And I just want to like tailor, like, the person I have in my head is the meeting American who is on the fence about Ozempic, who's hearing the PR that this should be the, you know, standard of care for somebody that's overweight or obese. And I want to be clear, kind of what we're all agreeing on here, which is that Ozempic at the recommended dose, at the dose you would get from your doctor if you go get it, is essentially an injectable crash diet.

• 1:12:38Speaker 01

  That's not all it is. There's a ton of regeneration and healing happening from the peptide.

• 1:12:43Dr. Mark Hyman?

  That's right. I think it's important to talk about what they call pleiotropic effects in medicine, which is the multiple kinds of effects on the body from one compound that's in the body.

• 1:12:52Speaker 02

  Well, if we're going to talk about the interconnectedness of the body, you know, I think we should look at the 80% of people, you know, having serious side effects and the, you mentioned the mental health, but the data's pronounced impact in mental health issues.

• 1:13:07Speaker 01

  That's not correct.

• 1:13:08Speaker 02

  Well, there's an EU investigation into suicidal ideation.

• 1:13:12Speaker 01

  And they came back and said it was not an issue.

• 1:13:14Speaker 02

  They have not. They have not. There's a serious investigation going on in EU that is not resolved. It impacts, the drug, tell me, if this is, the drug is basically gut dysfunction. It.

• 1:13:26Speaker 02

  Messes with our gut where 95% of our serotonin is made. If we're going to talk about

• 1:13:30Speaker 01

  It actually shifts your microbiome into a favorable microbiome and out of a pathologic microbiome.

• 1:13:35Speaker 02

  If we're going to talk about the interconnectivity of the body and the interconnectivity of this drug, I think we would all agree there's much more we don't understand about how this drug impacts the myriad of metabolic dynamics going on with the body than we understand.

• 1:13:50Dr. Mark Hyman?

  There's mixed data, right? I think, you know, there's some data that showed that there was a study looking at antidepressant effects of GLP-1 receptor agonist. It was a meta-analysis with 2,000 people, five randomized trials, one prospective cohort study, and there was about 24 to 60 weeks. And they found that actually it reduced depression in adults and both adults and adults with type 2 diabetes. So there's also studies that show that maybe it's not.

• 1:14:14Speaker 01

  There are not a lot of pharmaceutical companies.

• 1:14:15Speaker 02

  I've got a question. So this drug, we're saying it's a miracle drug that makes you not want to eat, that makes you not want to gamble, that makes you not want to have sex in some cases, there's reports of. It basically decreases, it seems like, desires. So are you worried that there is an impact that this drug has on our dopamine or serotonin levels?

• 1:14:35Speaker 01

  It actually improves dopamine signaling.

• 1:14:37Speaker 02

  By making us not want to engage in the activities that bring us joy?

• 1:14:39Speaker 01

  No, it impacts the HPA axis and imparts a dopamine-urtic effect.

• 1:14:44Speaker 02

  So you're saying flatly that a drug...

• 1:14:46Speaker 01

  It's not a drug. It's a peptide and they're overdosing people on it and that's why they're having terrible side effects. And also when people lose a tremendous amount of weight too fast, they get depressed and suicidal.

• 1:14:55Speaker 02

  So you're not concerned about unknown impacts to our dopamine or serotonin from a drug that by all reports makes us want to do less of the things that bring us joy?

• 1:15:02Dr. Mark Hyman?

  Well, just eating. I don't know if it...

• 1:15:04Speaker 02

  No, no, there's studies coming out.

• 1:15:05Speaker 01

  I'm not seeing any appetite suppression.

• 1:15:07Speaker 02

  It's being used as a gambling cessation and an alcohol cessation.

• 1:15:11Dr. Mark Hyman?

  That's good, though.

• 1:15:12Speaker 01

  Yeah, that's awesome. I'm seeing awesome impacts of that.

• 1:15:14Speaker 02

  But it's literally making us not want to do almost everything. That's what the drug's being credited as doing. I'm just saying that doesn't indicate some...

• 1:15:19Speaker 01

  I'm not hearing that from people.

• 1:15:21Dr. Mark Hyman?

  There's an interesting conversation here about dopamine because I think we have dysregulated dopamine and I do genetic testing with my patients and we see polymorphisms or variations in DR dopamine receptors, DRD2 receptors, which affect pleasure.

• 1:15:35Dr. Mark Hyman?

  So some people may need a lot of a substance, whether it's alcohol or sugar or or gambling to actually feel pleasure. And and so there are people who are at risk for increased obesity. It's based on this sort of low hedonic drive to to to pleasure. And I I think the question is, do these drugs modify that in some way? Do they actually not do it in a bad way, but maybe they do it in a good way? Because I think if it's a there's something that can actually help people reduce their addiction and reduce that that drive and actually have pleasure from things that are just things that we all get pleasure from. That would be better.

• 1:16:10Speaker 02

  Let's just I'm just trying to use common sense here, right? I'm not saying it's a bad thing that people are eating a little bit less, that gambling less, engaging alcohol less, engaging in drug use less. But if this drug is basically across the board, making people want to do less of things. That to me demonstrates potential concerns, unknown concerns with impact on our dopamine serotonin levels. I think that's a serious concern.

• 1:16:34Dr. Mark Hyman?

  My joke always is that there's a study in the New England Journal years ago that said we should start to use these new drugs as soon as they come out before the side effects develop. So we don't know what's gonna happen in five, 10, 15 years. We really don't.

• 1:16:44Speaker 01

  Well, we have 20 years of data on GLP-1s, just not semaglutide and terzepatide. And we weren't hearing all of this, these huge mainstream media headlines before that with exenatide that's been around for 20 years and loraclutide and.

• 1:16:58Dr. Mark Hyman?

  Yeah, I mean, there's mixed data on the the suicide thing and some of its population data, the clinical trials don't show that. There's big horror studies of 240,000 people, 1.6 million patients with diabetes prescribed Ozempic, 250,000, 40,000 on Wegovy. And there's a lower incidence of suicidal thoughts in patients. And so I think, you know, I don't think we know. We just have to keep tracking it. I I think you're right. It's it's good to be concerned. And we do need to do post-market surveillance of of what's going on with these drugs and how they impact people's health. But but that's sort of, you know, like I I'm sitting here, honestly, like kind of in the middle and also confused because part of me is like, God, wouldn't it be great to have a leg up?

• 1:17:40Dr. Mark Hyman?

  Because I've been treating people with obesity and overweight issues for 30 years and it's tough. It's really tough for them. They really struggle. They want to do the right thing and they're highly motivated patients. And it's still tough. And so.

• 1:17:54Dr. Mark Hyman?

  I wonder, you know, this is not a miracle drug. And I don't think Tina would say it's a miracle drug. I think, you know, like any compound has a role. And, and so is there a role? How do we use it? Does it make sense to actually think about this differently from, from how the traditional pharmacological medical approaches is, is doing something? And, and, and do we just not dismiss it wholesale as a, as a, as a part of an overall solution? So I think, you know, in the perfect world, we'd totally fix our food system. We would get rid of all the junk. I mean, I had this crazy idea that if we actually gave Ozempic, everybody's overweight. All of a sudden people would stop eating junk food and the industry would collapse and everything. It'd be great. In fact, the CEO, the CEO of Novo Nordisk, who makes Ozempic was getting calls from people in the fast food and junk food industry really concerned about this.

• 1:18:39Dr. Mark Hyman?

  McDonald's is concerned about this because it's cutting into their stomach share. We call it stomach share, which I think is a good thing.

• 1:18:45Speaker 01

  Yeah, the CEO of Cheez-Its, the fact that there is a CEO of Cheez-Its cracks me up. But the CEO of Cheez-Its said, we will keep an eye on this. And they're actually, you know, doing a detour and coming up with potentially supplements to offset their snack sales because they're down. The joint replacement companies are concerned. Dialysis clinic companies are concerned. You know, there's a lot of, there's a lot of big companies that are concerned about this as well. So I feel like, and here's, here's just a total, you know, out in left field. I actually think big pharma is concerned. I think the big pharma companies who don't hold a patent on a GLP-1 agonist are very concerned because they happen to be the ones who hold the patents on the popular statin

• 1:19:26Speaker 01

  drugs and blood pressure drugs that every American ends up on for life. So I really wonder if big pharma isn't actually, you know, depend, you know, war of the big pharma companies. I don't know. I'm speculating, but I've been.

• 1:19:39Speaker 02

  They're, they're thrilled because combi-bodies are going to go up. Combi-bodies are going to go up.

• 1:19:43Dr. Mark Hyman?

  Are they though?

• 1:19:44Speaker 02

  Yeah, because, because.

• 1:19:45Dr. Mark Hyman?

  If we do it right, if we do it how we're doing it now, but if we do it right.

• 1:19:48Speaker 02

  This is why it's zero sum and why it's so important. Combri is going to go up because that happens literally with every chronic disease drug in the history of modern America. They would be literally the first to not be correlated with increased chronic disease. Here's why. Because if you are saying, and I'm, I'm want to understand where. Because you're saying it's a good thing. It seems like that the standard of care, that the high dose is actually going to lead to a lot of reduction in comorbidities. That's the track we're on. We're on the track with a very high dose being open season for the majority of the American people. And if the standard of care when a child is overweight is to prescribe them this drug and not talk to them about your books.

• 1:20:33Dr. Mark Hyman?

  Right.

• 1:20:33Speaker 02

  But that, but that, but we're saying, we're saying that we're saying that comorbidities are going to go down at scale as this drug is widely prescribed. That's what we're on the verge of doing.

• 1:20:41Speaker 01

  I think we're giving doctors a little less credit than they deserve. I'm, I'm.

• 1:20:45Speaker 02

  Well, we might disagree on that.

• 1:20:46Speaker 01

  I'm not a, well, I purposely did not become an MD because I wouldn't do it. I purposely became an naturopathic doctor because I didn't actually have to.

• 1:20:52Dr. Mark Hyman?

  I wanted to go to naturopathic school.

• 1:20:53Speaker 01

  I didn't go, I wasn't going to go work for the evil empire. So from the get go. So I have been watching every single webinar, piece of information that every single medical platform has put out. Medscape, every single one.

• 1:21:08Dr. Mark Hyman?

  On, on this topic.

• 1:21:09Speaker 01

  On this topic. I have been doing nothing but consuming information about this. And in every case, the doctors, the obesity doctors, obesity specialists mean well. They all talk, especially, I watched a whole one on childhood obesity and they were like, we don't want to be injecting children. We can talk about children exercising more and children eating better and children doing all the things. Really, the issue is their parents. Getting the parents.

• 1:21:34Dr. Mark Hyman?

  Schools, it's the, it's the whole environment.

• 1:21:36Speaker 02

  Parents aren't trying to poison their children.

• 1:21:38Speaker 01

  Actually, most children who suffer from obesity have obese parents.

• 1:21:42Speaker 02

  Okay. So we have a situation where.

• 1:21:45Speaker 01

  I wasn't finished.

• 1:21:46Speaker 02

  Eighty percent, sorry, go ahead.

• 1:21:48Speaker 01

  In all of these webinars, they specifically double down on lifestyle.

• 1:21:52Speaker 02

  Yeah.

• 1:21:52Speaker 01

  They specifically double down on lifestyle. And I'm not bought out by Big Pharma. I'm not a fan of the allopathic medical community, but I have been watching all, everything from all sides that I can get my hands on to see where this nuanced conversation is. And in every case, they are talking that we have to be implementing lifestyle strategies for adults and children. And the other part of the conversation that.

• 1:22:12Dr. Mark Hyman?

  But that's true, Tina, but there is no incentives to do that.

• 1:22:14Speaker 01

  I understand that.

• 1:22:15Speaker 02

  Can I, can I?

• 1:22:16Dr. Mark Hyman?

  If there were, I agree with you. It would be amazing if we all start with that.

• 1:22:20Speaker 01

  But the doctors are saying it. At least that they're trying.

• 1:22:23Speaker 02

  Don't look at what they say, look at what they do. They don't know.

• 1:22:26Dr. Mark Hyman?

  They don't, they're not, they're not in the system that allows them to do it. Every doctor I know would want their patient to exercise and eat more and do, and eat less and do better.

• 1:22:34Speaker 02

  Oh, yeah. I've talked to, you know, Harvard obesity doctors off the record where they said they didn't get into this to see kids be obese, but also that they would be laid off and their entire department would be laid off if they don't have more obese children. And they do understand those incentives. Every obesity doctor.

• 1:22:49Dr. Mark Hyman?

  I think they'd be happy to be out of a job for that. They do find something else to do.

• 1:22:52Speaker 02

  But, but, but, but a person at an obesity clinic who has payroll, who has loans underwritten on their new center that requires more children to be obese, let me, let me just, let me back up.

• 1:23:02Dr. Mark Hyman?

  Sure, there are perverse incentives, but I would, I would push back a little bit on doctors kind of being evil in that way. They're, they're.

• 1:23:08Speaker 02

  I think they're stuck. I, I don't think they, I don't think they got into this for kids to be obese, but they, it is just a statement of economic fact that they need more obese children in order to have a job.

• 1:23:17Dr. Mark Hyman?

  Yeah, maybe, but, but I think, I think if you, if you talk to most physicians who are dealing with this, they would love to sort of magically snap their fingers and have some place to send their patients to do an intensive immersive lifestyle change program. I know that's true.

• 1:23:32Speaker 02

  Okay.

• 1:23:32Dr. Mark Hyman?

  And there's, when I was in Washington in 2008 and nine during, during the Obamacare, you know, development of the legislation, I was really working hard to insert into the legislation something called the Take Back Your Health Act, where we basically got the government to pay for intensive lifestyle change with a multidisciplinary team over a long period of time to create sustained behavioral change. Because we know how to change behavior, and when you're talking about that's behavior change, but we don't have any mechanism in our healthcare system to support behavior change. And that, that's really the problem. We don't pay for it. We don't incentivize it. We don't have it. No one has how to do it. I mean, I met with Kathleen Sebelius, who was the head of Health and Human Services at the time, and I proposed this idea to her during this time. She says, this is a great idea, but who's going to know how to do it? Because doctors

• 1:24:17Dr. Mark Hyman?

  aren't trained to do it. They don't know how to do it. They know anything about nutrition. I'm like, you're right, but let me tell you something. When somebody invented angioplasty, you didn't, and you, and you reimbursed it, you didn't have to worry if they were going to figure out how to do it. If you paid them $10,000 to do that, they'd frickin' learn how to do that. And I think, I think we're going in the same situation. It's all about perverse. Financial incentives.

• 1:24:35Speaker 02

  Yeah, let me just double click on that because I think obviously doctors get in this for a reason. I really do think they're stuck, but the raw economic fact is that there's been no more profitable invention in the history of modern American capitalism than a sick child. A sick child is the most profitable entity in the world because that child is not learning metabolic healthy habits and they're continuing to rack up comorbidities. So imagine a high school, right?

• 1:25:00Dr. Mark Hyman?

  Long term, they'll be the most profitable.

• 1:25:01Speaker 02

  Imagine a high school. Well, but they're not going to die right away.

• 1:25:03Speaker 01

  Diabetes is very profitable.

• 1:25:04Speaker 02

  So imagine a high school right now. You've had a doubling of prescriptions for SSRI, statin, metformin among high schoolers. A doubling in less than the past decade. So those drugs are being prescribed like candy. You have diabetes and prediabetes epidemic. You have a high cholesterol epidemic. You have a depression epidemic. You have a high blood pressure epidemic and you have an obesity epidemic in high schools. And those kids are the most profitable patients in America because if you can get to them and say that the high cholesterol is a statin deficiency and the high blood sugars, a metformin deficiency and the obesity is an Ozempic deficiency, they're not learning metabolic healthy habits. It's about the money. Okay, so are doctors evil people? No. Are they complicit in this dynamic knowingly? Absolutely.

• 1:25:48Speaker 02

  That is a profitable. If you take that kid, if you take a 12 year old, and I want to talk to every parent listening right now, it is open season very soon on your 12 year old to give the Ozempic. You're going to be pushed, you're going to be shoved studies down your face. You're going to be saying you're anti-science if you don't give this. You're going to be, you're going to be, you're going to have to sign.

• 1:26:08Dr. Mark Hyman?

  I think you're right.

• 1:26:09Speaker 02

  You're going to have to sign.

• 1:26:10Dr. Mark Hyman?

  I think you're right, Kelly.

• 1:26:10Speaker 02

  They're going to pressure you to say you're going against the American Academy of Pediatrics. They're going to pressure you to jab your 12 year old. That is going to happen. It's going to be open season.

• 1:26:18Dr. Mark Hyman?

  What happens, Kelly, is because doctors are stuck in a system. It's like a black box. And what they don't realize is that most of their education is pharmaceutical driven. I was sitting on a trail of once skiing at a resort and this woman was next to me. So what do you do? I'm in, I'm in, you know, I'm in, you know, pharmaceutical education. I'm like, what do you do? She says, oh, we put on continuing medical education conferences for doctors. So, you know, there really is a corruption of our medical education system. My daughter's in medical school now. I see it. There's a corruption in the research infrastructure and how it's done. And we don't fund the right types of research to support lifestyle intervention. So we have, we have a very screwed up system and doctors don't necessarily know they're in it. It's like the matrix.

• 1:27:03Speaker 02

  What do you, what do you think is gonna happen for a 12 year old if they're prescribed Ozempic and not given lifestyle interventions?

• 1:27:07Dr. Mark Hyman?

  It's a disaster.

• 1:27:08Speaker 01

  What's gonna happen if they don't, though? Like, let's talk about both sides.

• 1:27:11Speaker 02

  So should that marginal 12 year old who's, who's on the borderline of obesity, do you think, are they gonna embark on a path of metabolic health and curiosity? Are they gonna continue to eat ultra-processed food, continue to poison their cells even if it's 80% less?

• 1:27:25Dr. Mark Hyman?

  Well, that's the problem.

• 1:27:26Speaker 02

  That's the problem with Ozempic.

• 1:27:28Speaker 01

  That's when I got into metabolic health, was when I was 12.

• 1:27:29Dr. Mark Hyman?

  I think, though, what Tina was saying before is really key. If you link the prescription of these drugs to certain behaviors and track them.

• 1:27:37Speaker 02

  But that's a cultural, that's, that's a monumental cultural change that would have violent opposition because the second, as a standard of care for medicine, you start talking to a kid, remember, that kid is the most profitable entity in America being sick. So there's gonna be huge violent opposition to, instead of prescribing them a statin and Ozempic to give them the blood sugar solution, or one of your books, and talk to them about exercise and incentivize them to eat a healthy diet. That would immediately take millions of children off the chronic disease treadmill that's fueling the largest and the fastest growing industry in the country.

• 1:28:13Dr. Mark Hyman?

  I don't know. I'm not sure, I'm not sure I agree with you, because I, I said to the CEO of Cleveland Clinic once, I said, well, we're at a, at the World Economic Forum, Toby Cosgrove, and I said, "Listen, Toby," and I was kind of joking, I said, "How would you like me to empty out half your hospitals and cut your bypasses and angioplasties in half?" And he said, "That would be a great idea." I said, "But what, you're making $8 billion a year, what if you're making $4 billion?" He says, "We'll figure it out. We'll figure out what the right thing to do is." So not everybody, obviously, is like that in medicine, but I, I do think that, that, that, that people in medicine generally want to do the right thing, and they don't, if, if they could like, get rid of all of these kids, I, I think they would do it. Now, there are businesses and private equity in medicine now, I mean, it's like, it is a...

• 1:28:51Speaker 02

  Then why isn't the American Academy of Pediatrics talking about diet?

• 1:28:53Dr. Mark Hyman?

  Why? Because they're funded by pharma and the food industry, that's why.

• 1:28:56Speaker 02

  Why isn't, why, why is the, you know, why isn't the American Diabetes Association talking?

• 1:29:00Dr. Mark Hyman?

  Same reason, same reason.

• 1:29:01Speaker 02

  But, but, but, but those are the doctors.

• 1:29:03Dr. Mark Hyman?

  No, they're not. They're the professional associations.

• 1:29:06Speaker 02

  Who, who set the standard of care that most doctors have to follow?

• 1:29:08Dr. Mark Hyman?

  True, but, but doctors aren't necessarily...

• 1:29:11Speaker 02

  Why aren't doctors speaking up?

• 1:29:12Dr. Mark Hyman?

  Some are, some are.

• 1:29:14Speaker 02

  You are, I mean, there's a few.

• 1:29:16Speaker 01

  I've been in this a long time and it's really challenging. It's really, it, it, it's easier said than done because you could put all of these perfect world scenarios in front of a 12 year old and if their parents are not going to comply with it, that kid's stuck, that kid's stuck in that household, having to deal with what's made for dinner for them by their mom and dad. And most cases of childhood obesity are coming, are stemming from obese parents. There's a whole overhaul that we have to do that is so much more nuanced than just changing public policy.

• 1:29:45Dr. Mark Hyman?

  I'm going to work with Tina for a minute on this because I think, I think what you're doing is so unique and I think we can learn from it because you're not practicing metabolic medicine in the same way that most endocrinologists are or doctors are who are prescribing Ozempic or similar drugs. And you're, you're, you're including a very different set of things that you look at, that you treat and that you manage and you don't, you're not finding the same complications, side effects, a weight regain, muscle loss, stomach issues, gastroparesis, nausea, vomiting. You found a way through to do this in a way, in a, in a, in a very different way that I think is worth talking about because, you know, we all agree that the traditional pharmacologic approach is a bad idea. And I agree, getting a 12 year old on Ozempic and just sending them on their way for the

• 1:30:30Dr. Mark Hyman?

  rest of your life is a bad idea. What is the right idea? Like, if, if we can create a, you know, blue ocean and say, okay, what would be the perfect use of these peptides in the world to deal with a really serious crisis that we all agree is happening, which is a metabolic crisis? So in, in a real world scenario, in a perfect world with a blue ocean, how, how would we create a 360 treatment approach, which you've done, to help people regain their metabolic health when they're metabolically busted, which is anywhere arguably between 42 and 93% of Americans?

• 1:31:04Speaker 01

  I always start by giving them something to add and not something to take away. I don't take away the ultra refined carbohydrates right off the bat. People will fight.

• 1:31:13Dr. Mark Hyman?

  Damn, you're nice. I'm like, get off that stiff.

• 1:31:15Speaker 01

  Well, they will fight for their addictions. People will argue for their addictions.

• 1:31:18Dr. Mark Hyman?

  They negotiate, I know.

• 1:31:19Speaker 01

  They tried to tax soda in New York and people flipped out and rioted. People will not let go of their addictions, but if you can get them to acclimate. To a new normal and you can get them to stack some wins and get some little dopamine hits on their own, you start to see change. So I get people walking. I get people increasing their protein. When you increase your protein, you become less hungry, you stop eating as much garbage. It's a slow incremental step up. When they start to feel stronger and their joints feel more stable, we start to get them strength training. I do start to educate them about the evils of ultra refined carbohydrates. I educate. It's tattooed on my wrist, Osiris. I educate my patients so that they understand why they're making these changes. I have them

• 1:32:03Speaker 01

  read good books. I have them own the information because when they own it, they're empowered. Even with best efforts, sometimes we need a little hormone, depending on their age. We might need some probiotic support for a short time. I'm not a big fan of doing that long term. We might need to obviously address nutritional deficiencies. It's a comprehensive holistic way of getting the body back to homeostasis. And when the body comes back to homeostasis, weight starts to fall off.

• 1:32:29Dr. Mark Hyman?

  Yeah.

• 1:32:30Speaker 01

  Right? And so that's part one. Part two, something that no one's talking about, that obesity experts know well, is that getting weight off is actually the easy part. Keeping weight off is incredibly difficult.

• 1:32:41Dr. Mark Hyman?

  Yeah.

• 1:32:41Speaker 01

  So what do we do there? And I think that this-

• 1:32:43Dr. Mark Hyman?

  That's important because, because what we're saying before was that, you know, these are perceived as lifelong drugs, but maybe they're not if we use them properly.

• 1:32:50Speaker 01

  We gotta get leptin signaling corrected. We gotta get ghrelin signaling. We gotta, there's leptin resistance in the brain. There's cortisol. There's all kinds of issues. And so I look at a person comprehensively. I don't look at them as a condition. They come in and they say, I have this, this and this. I'm like, okay, whoop de doo. I'm interested in you.

• 1:33:03Dr. Mark Hyman?

  Yeah.

• 1:33:04Speaker 01

  You know, Mark, let's see what, what's going on with Mark. How do we get Mark back to homeostasis? And things start to fall into place that way. It's a slow, steady process. I realize not everybody has access to doctors like you and I. And I realize that not everybody knows how to practice the way we do, or even wants to practice because it takes time and it's arduous and it's complicated. And it's like trying to hit a moving target, right? But I'm trying to pull people back to center. So when they know better, they do better. They can educate their families. They can, that trickles down. You know, I catch my daughter schooling her friends on things. I catch my husband teaching the work crew about nutrition and his own like, you know, blue- Pollard way. So we teach and we educate and that's all I'm really trying to do about these peptides is like, yes, I understand that monotherapy, high dose, the way it's being handled,

• 1:33:47Speaker 01

  jabbing 12 year olds with it, not the solution, not long term, not sustainable, not a good idea. But there's nuance here and I do think they have a place and so I will use them as needed per the individual. I don't know if that person's going to need it forever. I don't know how metabolically busted they are. I don't know how quickly they're going to respond. And I don't mind if they feel fine taking a tiny little dose of this and cycling it for a long period of time.

• 1:34:11Speaker 01

  I am there to treat them and serve them. I'm not there to impart my policy changes on them for a worldview and say, well, Ozempic's bad, therefore you can't have it. That's not my job.

• 1:34:21Dr. Mark Hyman?

  In a sense, what you're talking about is taking someone who's metabolically busted, as you call it, to what I call metabolically resilient. So when I take a patient who's type 2 diabetic, who's on 100 units of insulin, I'm like, no, you can't have any sugar.

• 1:34:37Speaker 01

  Of course.

• 1:34:38Dr. Mark Hyman?

  You probably can't have any fruit for now. You can't have any flour. Like this is just a hard no, okay? If you want to get reversing your diabetes, you just need a, like Benjamin Franklin said, you need a pound of cure.

• 1:34:50Speaker 01

  Yeah.

• 1:34:50Dr. Mark Hyman?

  Not an ounce of prevention. And then when we get them metabolically resilient, then yeah, you could add that stuff back. And you can try have a little, see how it affects you, have some more fruit. You want to have sugar or dessert once in a while? Okay, if it's the end of a meal. You know, become more metabolically resilient. What you're talking about is shifting people from metabolically busted to metabolically resilient and using a holistic approach that may include peptides, right?

• 1:35:14Speaker 01

  Correct.

• 1:35:14Speaker 02

  But weren't, didn't you say your patients weren't metabolically busted?

• 1:35:18Speaker 01

  Not all of them. They work better in people who are using them to optimize. If we're just using peptides to optimize or we're using a little TRT or a little bio identical hormone replacement in someone who's generally optimized, it's a much lower, easier process.

• 1:35:31Dr. Mark Hyman?

  Like your dad, for example, you mentioned your dad on the podcast. He's got diabetic, he's

• 1:35:35Speaker 01

  He's a mess.

• 1:35:36Dr. Mark Hyman?

  100 pounds overweight. Like what would you do for him?

• 1:35:38Speaker 01

  My dad, doesn't matter what I teach him. He's not going to change his eating habits. He's got a serious addiction.

• 1:35:44Dr. Mark Hyman?

  Yeah.

• 1:35:44Speaker 01

  And so I told him, I was like, hey dad, you've got one foot in the grave, you're in your Early eighties, you're on your way out. His toes are purple. I mean, he's he's looking at toe amputation here in a hot second. He won't walk anywhere. He won't do anything. I said, I am going to crank the dose up on you. I'm going to get this weight off. But you know what? Cranking the dose up in my world does not match what the allopathic system is doing. We're still going very slow and low. And my dad's actually talking now and he's got hope. And it's the first time at Christmas, this Christmas was the first past one that we actually had a conversation. My dad was involved instead of just being checked out and glazed over. So he and he has hope. I bought him a vest, like a puffy vest. I said, so you can wear them on your walks because he can't get a jacket on because he's so heavy. He doesn't want to go outside and be seen. He's embarrassed.

• 1:36:26Speaker 01

  And so I bought him a puffy vest and it didn't quite fit. And he looked at me and he goes, I have, I'm hopeful this is going to fit me soon. And like, I have my dad back. And he's still on a baby dose. You know, it's a little bit higher than the starting dose, but it's still a baby dose and so be it. And if he has to take it forever, so be it. It's working. It's working great. And it's slow and low and the weight, he's so heavy, he can't get on a traditional scale. So we don't even know what his weight is. But his doctor was so impressed. His doctor said, let her manage that. Let her keep going. And you know what I do when I go over? I drop little dietary tidbits. And I'm like, hey, maybe you shouldn't be sucking this down all day, Dad. It's not so good for you.

• 1:37:05Speaker 01

  But he's actually, his lights are on and he's listening. So I had to do something because for three decades I watched him decline and I couldn't do anything. And I'm shocked he's still alive. So I was like, you know what? We're throwing in the Ozempic. We're going to see what happens and

• 1:37:19Dr. Mark Hyman?

  I mean, I'm really curious about what we call these, these sort of non like weight loss effects. And, and I'm reading some papers around Ozempic or not Ozempic, but GLP-1 agonist and longevity. And I know, I'm saying, I'm really interested in longevity. I'm like, wow, this is really interesting. It reduces inflammation. It reduces oxidative stress, improves mitochondrial function. It helps neuroinflammation, all the things that we know cause aging. Now, I do have the thought, well, what if you just lost weight? Would that be enough? I don't know. But, but it's interesting. And I think there's really interesting mechanisms that, that we're kind of just learning about. And I think, like you're right, we can't throw the baby out with the bathwater. There may, this, this, and I think one of the challenges is that people can't get Therapy in the way that we're talking about easily.

• 1:38:04Dr. Mark Hyman?

  And I just want to dive into that for a minute. And this is this whole world of compounded peptides. So for those who are not listening, there's prescription drugs you can get at the drugstore that are FDA approved and that are are brand name usually or generic versions of those. There's a there's a all kinds of compounds, whether it's B vitamins or whether it's glutathione or other things that we use in medicine that have to be made by non-traditional pharmacists called compounding pharmacies. And they produce things like peptides or or intravenous nutrition or different formulations of hormones that you might like that you might not get on a prescription like a cream or a gel. So so compounding is is is tricky because compounded drugs are not well regulated. And so you have to know what you're doing.

• 1:38:49Dr. Mark Hyman?

  You have to find the right pharmacy. You have to make sure they have proper testing for the dosage, the purity, the potency. And the FDA has come out really hard against these. Now, maybe because they're just in good use of pharma, I don't know. But basically, I've been using these compounded peptides for a long time, and I find them extremely effective for myself personally, for my patients, for all sorts of different reasons. And and and semaglutide is just a peptide. And what's really striking is you can get it for like literally pennies a day. And and instead of, you know, costing you $20,000 a year, it might cost you a few hundred dollars a year.

• 1:39:31Dr. Mark Hyman?

  And in fact, a study came out just last week in JAMA talking about the price of of these GLP-1 drugs, maybe going between 75 cents a month, you know, to $72 a month. Even in Canada, it's $300 a month. And here it's like, you know, 17, 1800 dollars a month. So these compounded things are not easy to get. They're not easy to use. You have to mix them up yourself. You have to draw them up like a doctor with putting water in the bottle and sterile and then drawing it up and then injecting it yourself with a needle. It's like a diabetic, you know, diabetics do. They take, you know, an insulin bottle and they pull up the insulin and they but now they have insulin pumps and different things. They don't do that anymore. But it's it's kind of a little bit tricky to use it, right? And then you have to find a doctor who knows what they're doing.

• 1:40:16Dr. Mark Hyman?

  So can you speak to this sort of this version of peptides you're using, the compounded peptides? And and why you use those, why they're different and how you kind of navigate this tricky world?

• 1:40:27Speaker 01

  Well, I've always used compounding pharmacies since I graduated and got a license. And I didn't realize that most doctors didn't, to be honest with you at first. That was my bubble of privilege. But I have found that semaglutide and terzepatide when compounded are always coming premixed. So they're not, you don't have to reconstitute them like some of the other peptides. They're coming mixed up with clear instructions on the label and then patients are to draw them up. I have heard that we're seeing problems, people presenting to the ER because they're taking too much. These peptides-

• 1:40:59Dr. Mark Hyman?

  The prefilled syringes, like the Ozempic is a prefilled syringe. You can't screw it up.

• 1:41:04Speaker 01

  Right, you can't screw it up.

• 1:41:05Dr. Mark Hyman?

  You hit the button, it goes in, dose is-

• 1:41:06Speaker 01

  Can't change the dose. It is what it is.

• 1:41:08Dr. Mark Hyman?

  If you drop too much and you don't know what you're doing-

• 1:41:09Speaker 01

  Right.

• 1:41:10Dr. Mark Hyman?

  You think it's supposed to be 100 units, but it should be 10 units, you're kind of screwed.

• 1:41:15Speaker 01

  Right. So that comes down to doctor education with the patient in the office and being careful of that. And I realize, like you said, there's, you know, internet, telemed doctors, you can just get it sent to you. But even in those cases, the patients I know who are using those, some are going that route and they're finding it to be just fine. No one's run into any problems. When people want the fast route, I think they might start piggybacking. We heard about that woman who died in Australia. She actually was using two separate types of peptides. Neither were prescribed, or maybe one was prescribed and one she got off the internet and she piggybacked them. And she ended up dead. So there are problems and you can get in trouble fast, for sure. Just even the slightest little bit too much and you might have, start seeing some nausea. You might start seeing some stomach aches. So we don't want that.

• 1:42:00Speaker 01

  But I don't think that compounding pharmacies are the danger the FDA is making them out to be. I've been watching the smear campaign lately and it's incredible. They really are on the bender. They don't want these peptides getting released without them being, and I'm sure that is something to do with Big Pharma, we can speculate, but- I don't see any problem with it and you can play with a dose. That's why I like compounding. We can play with the hormone dose. We can play with all the doses and we can in the whole point of compounding to me is that you individualize the medication for the patient in front of you.

• 1:42:30Speaker 02

  We're in total alignment here. We were just talking before we came on that a report said Ozempic costs about $5 to make. They're charging Americans and American taxpayers in many cases and more soon around $1,800 a month and then Germany's paying like $60 a month. So the margins on this product are astounding. That's a scandal and there's definitely a war. Just to be clear, like I'm not anti-drug. I'm kind of a libertarian. Like I think people should have access to biohack and take whatever drugs they want. There's definitely a pronounced thing here. The reason this is getting so much attention is because there's so much profit that can be made from basically taking advantage of the American taxpayer, which is where the opportunity cost really comes in because

• 1:43:14Speaker 02

  those hundreds of billions of dollars could go to actually fixing our food supply.

• 1:43:19Dr. Mark Hyman?

  So it's kind of at a high level, just to kind of summarize, we kind of agree that we have a toxic food environment that's driving this, that we have a world in which our microbiome has been completely destroyed that affects our metabolism weight, that there is a flood of obesages in the environment that are contributing to our metabolic dysfunction, that 92% of Americans are somehow screwed up in their metabolic health and that our current solutions don't work. We're also in agreement that we should be fixing our food system so that we kids are eating healthy stuff in schools and that people aren't exposed to a food carnival everywhere they go of junk food and that people are actually in a medical system that can support nutrition education, that supports intensive lifestyle

• 1:44:04Dr. Mark Hyman?

  therapies, that funds all those things. And you and I are working on that in Washington Cali and we're working hard. But again, it's like, you know, it's like ending slavery or civil rights or women's rights. It's going to take a minute. In the meantime, we're seeing, you know, a crisis of poor metabolic health and, you know, our current solutions aren't working. Now, is the Ozempic revolution the solution? I don't think so.

• 1:44:28Dr. Mark Hyman?

  Is the smart use of peptides in the right patients a potential solution done in a different way with a 360 view of lifestyle change and lower doses that mitigate the side effects that can be done in a way that don't lead to rebound weight gain, that don't lead to the muscle loss, that increase protein at a gram per pound, that make you hit the gym, pump iron four times a week, that included with aggressive lifestyle behavioral change support and coaching. I think there's a role for it, but I don't think it's how it's being done now. And I think we all kind of agree with that. Did I miss anything?

• 1:45:03Speaker 02

  A couple of quick reactions is, and this is just my perspective from digging into this issue a lot. I think that if you're extremely obese and diabetic, your case with your father, that seems to make sense. It's like, no complaints there if you're really lost your way, which is the edge case of folks.

• 1:45:21Dr. Mark Hyman?

  If you want 10 pounds off for the summer, no.

• 1:45:23Speaker 02

  Well, the one, I will say, the one case I think is promising is PCOS. I mean, people don't realize PCOS is insulin resistance, essentially in a metabolic dysfunction. If you do a crash diet, you're actually going to increase your fertility, most likely, and reduce the symptoms of PCOS. So for a targeted, basically crash diet to improve your insulin resistance quickly, I don't think it's a long-term solve, but I do actually get that. Again, if you do a big calorie deficit diet and get your insulin resistance under control or fasting, you will improve PCOS. So I do get that. I think the key thing is the average American. The average American, we're facing a toxic environment, and we have to, as a

• 1:46:04Speaker 02

  matter of public policy, get the average American practicing habits that are combating all of these threats to our metabolic health. And I think we are being lied to that this is a long-term solve for that, which is the most pronounced use case. If you are a patient in the kind of middle America-

• 1:46:23Dr. Mark Hyman?

  You mean the mantra of the medical establishment is that this is a lifetime drug?

• 1:46:27Speaker 02

  Yeah, for the majority of the American people, which is why this is the most valuable company in Europe.

• 1:46:31Dr. Mark Hyman?

  Although it's interesting that about 50 to 75% of people quit after a couple of years.

• 1:46:35Speaker 02

  Yeah, so that speaks-

• 1:46:38Speaker 02

  To that that I do believe I do. I actually believe the drug is going to be recalled because the side effects. It's actually extremely pronounced side effects that we talked about. And I actually think the drug's a disaster and going to be recalled that even in the absence of that, it's not the long term solution for the median American. If you are a patient, and particularly if you're a parent, I would be very skeptical when your doctor inevitably tells you that this is a long term solution, the lifetime solution for dealing with metabolic dysfunction. And my big point is if not now, when? This is zero sum. Are we going to spend $1,800 per person per month on an injection? Or are we finally going to ask, in the midst

• 1:47:18Speaker 02

  of a situation where we're mass poisoning children in utero for metabolic dysfunction? Are we going to actually change way and follow what you have been putting the stake?

• 1:47:28Dr. Mark Hyman?

  I mean, I hope so.

• 1:47:31Speaker 02

  We should be very impatient for that. And that's why Ozempic is important, Mark.

• 1:47:35Dr. Mark Hyman?

  I'm in a curious, open minded, but skeptical kind of moment around these GLP-1 agonists. And I'm doing a lot of work and researching what they do, how they work, the complications, the side effects, but also the beneficial effects. And I think the thing about peptides is so fascinating is, and Tina, you hit on this, is they're regenerative. They help to regenerate and repair. So it's a miracle to me. Like, I could take an Advil and sure, my whatever won't hurt for that night, but the next day it's going to fricking hurt. If I take a shot of a peptide, I'm like, damn, that I said, 90s went away, and now I can lift weights again. And I'm like, that was pretty cool. And so I'm like, these are really different

• 1:48:17Dr. Mark Hyman?

  in their biological actions. And so they become drugs because, not because they're patentable, but because the delivery system is patentable. Yes. So what's patentable is a little auto injector, not the actual compound. That's why you can get it in a compounding pharmacy for pennies.

• 1:48:35Speaker 01

  I just want to say that since I released these podcasts on my podcast, I've gotten hundreds.

• 1:48:41Dr. Mark Hyman?

  You're getting lovers and haters?

• 1:48:42Speaker 01

  Well, I've gotten hundreds of messages from people.

• 1:48:44Dr. Mark Hyman?

  Yeah, what have you heard?

• 1:48:45Speaker 01

  And I have a, I don't have the size of audience you do, but I have a sizable audience and I have so many people writing me saying, I'm writing you through tears. Like that exact quote, I'm writing you through tears. Thank you so much for shedding light on this. I have been on these peptides. I do all the things. I follow you. I mean, I know the average American doesn't have access to doctors like us, but they do have, there's so much free education on the internet now.

• 1:49:08Dr. Mark Hyman?

  There is, yeah.

• 1:49:09Speaker 01

  And they are combing through it. They're implementing, they're doing all the things and they just couldn't get over that hump and they started GLP-1 agonist and it got them over that hump and they are crying in gratitude. Hundreds of people messaging me constantly. They're also telling me that they don't tell their husbands they're on it because they're getting shamed. The pharmacist is giving them side eye. Their family comes down on them at every holiday meal because these peptides are being so vilified. So I'm team patient and I'm team whoever's sitting in front of me, like you said, and I'm going to do whatever I need to do to get that person what they need to get that leg up. Because what I'm finding and what my followers are reporting and what my patients are reporting is that once they start on these peptides and they start to take effect and they start to get that decrease in neuroinflammation and they start to lose a few pounds, they want to move.

• 1:49:55Dr. Mark Hyman?

  Yeah.

• 1:49:55Speaker 01

  And they want to eat right and they suddenly have energy because it is impacting the HPA axis and they're suddenly wanting to actually cook the meals instead of going out for fast food or order in. They're starting to implement, implement the strategies that they need to be doing that they just didn't have the energy or the gumption to do before. I don't know what it is that gets people to implement. That has been the one crux of my practice. I cannot figure out why some people implement and some people don't, but some people just need a leg up, so.

• 1:50:21Speaker 02

  I want to be clear too. I, I thought it was, it was very important for me to put some frankly doubt in a listener's head and put some of these macro concerns and frankly systemic concerns as, as folks determine whether to use the standard pharma prescribed Ozempic for themselves or their children. But we're in total agreement with Dr. Tina. I, I think we need to get to a world, I, I really believe the American People will make the right decision if they're not corrupted by bad incentives and bad information. I think it is, you know, it is a scandal that these drugs cost so much.

• 1:50:53Dr. Mark Hyman?

  You just want to blow the medical industrial complex.

• 1:50:55Speaker 02

  Yeah, it's a scandal. It's a scandal that they're being pushed down our throats.

• 1:50:58Dr. Mark Hyman?

  The agricultural food industry complex.

• 1:51:01Speaker 02

  Yeah.

• 1:51:03Dr. Mark Hyman?

  You know, I'm with you on that. I wrote a book about it. I get it.

• 1:51:06Speaker 02

  Yeah, it's very important. And, you know, I think I don't know much about the regenerative aspects of it. I think that's very promising. It's not blanket either or. I think obviously the systemic, I think, ramming these drugs into our arms is a problem. But I really do think we need to get to where, back to, this was a bio, as you mentioned, this is a biohacking kind of, this has been around for decades, these peptides where people have been experimenting. I think that's great. And I think people should be able to experiment. And I just think the societal solution for obesity is a really problematic with this drug.

• 1:51:39Dr. Mark Hyman?

  Well, Kelly, I agree. And I thank you for working on this issue so diligently. You're going all over the country. You're everywhere now. I'm really inspired by your voice and your mission to, you know, get people to wake up to what's going on. I've tried to do it for a long time. You're a bit more passionate and vocal and compelling than I am. So maybe you're going to help push it over.

• 1:52:04Speaker 02

  I'm reading from your hymnal.

• 1:52:05Dr. Mark Hyman?

  I've been like, I've been like, like Sisyphus pushing the rock uphill for like 30 years or 40 years. I think you're like Superman. You're going to push it over the edge and it's going to fly down. So your book is amazing, Good Energy, The Surprising Connection Between Metabolism and Limitless Health. People should definitely get that. You wrote it with your sister, Casey Means. And it lays out a lot of these issues around metabolic health and our social and political issues. It's a must get book. It's out now. So make sure you get it.

• 1:52:30Dr. Mark Hyman?

  And Tina, you know, your work is so important. I think both of you are some of the most thoughtful, committed people I've ever met who are thinking about these deeply and not just sort of at the surface and trying to find real solutions, both on the macro and micro level. And I'm so grateful to both of you and your work. Tina, you have a wonderful free GLP-1 video training series, Ozempic Uncovered. If you want to get deeper with Tina, for sure. There it's Dr. Tina, T, Dr. D R T Y N A dot com forward slash Ozempic uncovered. That's Dr. Tina dot com forward slash Ozempic uncovered. Be sure to look at it. We'll put it all in the show notes. We're going to put all the studies in the show notes we talked about. We're going to put more studies in there. We did probably 20 hours of research that I did. I probably my team did 20 hours on top of that.

• 1:53:15Dr. Mark Hyman?

  You guys have done so much. All that's going in the show notes. You can click through and read the studies yourself. You can make a decision for yourself, but I think what we're talking about is a very different and nuanced view of how to approach this problem of both poor metabolic health. And I love this concept of metabolic debusted and also the macro issue of, you know, how do we deal with this at a social level? So we don't have to give people Ozempic or anything else. We just, you know, somebody sent me a video of like somebody walking around the 70s on the beach in the 70s and there was like not a single person overweight in the 70s. So now it's like, we're all, we're all in this together. So thank you both. Any last thoughts or words from either of you?

• 1:53:51Speaker 01

  Well, there was one study I didn't share and I don't know if we're allowed to talk about it here, but they did it in 2022. They had type 2 diabetics admitted to hospital with COVID. They administered once a week semaglutide for a few weeks. 80% reduction in death and ICU admission. Interesting.

• 1:54:09Dr. Mark Hyman?

  That makes sense. That makes sense because if you're improving metabolic health, you're, you're lowering your risk.

• 1:54:13Speaker 01

  I'm just wondering, aside from the good points that Callie makes, there aren't potentially some smear campaigns on these going forward too.

• 1:54:20Dr. Mark Hyman?

  Yeah. Well, listen, it's, it's, yeah, it's true.

• 1:54:23Speaker 02

  And I would just say, I know we're all in agreement that our body is also a GLP-1 agonist and we can create with food and with supplementation GLP-1. And my company, which we're proud to have you as a supporter of TruMed, we have doctors write interventions to actually combat obesity with food as medicine. Pendulum, I know a company we're fans of has a new product that's specifically formulated. So we actually help if appropriate unlock tax free spending to these items. And that's where I think the rubber really hits the road. We need to be steering money to food and pendulum, not necessarily drugs. And that's what we're doing right now at TruMed.

• 1:55:04Dr. Mark Hyman?

  Talk about enough and we'll put it in the show notes and Tini you talk about a lot, but there are are ways to naturally increase our GLP one. For example, if you are testosterone deficient, if you hit the gym and you pump by and your testosterone go up. If you stop eating sugar and starch, your testosterone will go up. It's the same thing with GLP one. If we're low in GLP one, there are natural ways to do it by eating more protein, by exercising, by taking certain herbs like berberine and cinnamon. There are other things that that actually work to help them. And I want you to just for a second, talk about TruMed because it's a way for people to get access to these kinds of treatments with tax free dollars. So tell us about TruMed for a sec, because I think it's important. If people are wanting to make lifestyle change, but they can't afford it, or they think they have money, there's a way to get access to these things with dollars that are pre-tax dollars.

• 1:55:48Speaker 02

  I go to my mom, the standard American patient. When she had high cholesterol, she got a quick prescription for a statin. That doctor could have written a letter of medical necessity for probiotics, for healthy food, for exercise. And with that letter of medical necessity unlocks tax free spending. There's $150 billion in these HSA FSA accounts. Right now, those are generally just waiting for you to get sick and go to drugs. Yeah, health savings accounts and those often are just you get sick and you buy your drugs, you buy your interventions. Those can go right now to root cause items, to items that you talk about, to Pendulum, to Athletic Greens, to Daily Harvest, to CrossFit, to companies we're proud to partner with right now.

• 1:56:27Dr. Mark Hyman?

  I use my HSA card to buy supplements with TruMed. I use my HSA card to buy, you know, things when I go to get an acupuncture or get a massage or do things that actually help my body.

• 1:56:38Speaker 02

  We've been so proud in the past five months, we've done 130,000 patients, so much that some of the, some of the arms of the healthcare industrial complex are saying, hey, it's moving a little fast. But this is fully within the law right now that medicine can be food, can be supplements, can be exercise. If a doctor outlines those interventions for the prevention or reversal of disease, we can do that. And what our message is, whether you use TruMed or not, if you're about to get your Ozempic or a stat or metformin, if you're going to about to get on that chronic disease treadmill or your child. You can ask your doctor, "Hey, can we do a letter of medical necessity instead? Can we actually outline some dietary, exercise, lifestyle interventions?" And with that

• 1:57:22Speaker 02

  letter, you can actually use tax-free money on those items. We've got to steer money, medical dollars, to these items. So that's what our mission is.

• 1:57:31Dr. Mark Hyman?

  Thank you, Callie, for doing that and making it available. It's such a great thing. And I think you both are providing education, training, doing such good things in the world. I'm really honored to have you on the Doctor's Pharmacy Podcast. Maybe we'll have you back to go deeper. This is a great conversation. I think people hopefully got the sense of what we're talking about and have a little bit more to think about when it comes to this and get out of the binary, black or white conversations and talk about more of the nuance and be able to actually get deep into a topic that matters for all of us, which is getting America healthy, getting us as individuals healthy, and creating a solution that works and includes all the potential levers we have to pull because sometimes we need a pound of cure. So, thank you both, and we'll see you again soon. Thanks for listening today. If you love this podcast, please share it with your friends

• 1:58:16Dr. Mark Hyman?

  and family. Leave a comment on your own best practices on how you upgrade your health and subscribe wherever you get your podcasts. And follow me on all social media channels at DrMarkHyman, and we'll see you next time on the Doctor's Pharmacy. I'm always getting questions about my favorite books, podcasts, gadgets, supplements, recipes, and lots more. And now you can have access to all of this information by signing up for my free Mark's Picks newsletter at drhyman.com/marks picks. I promise I'll only email you once a week on Fridays, and I'll never share your email address or send you anything else besides my recommendations. These are things that have helped me on my health journey, and I hope they'll help you too. Again, that's drhyman.com/marks picks. Thank you again, and we'll see you next time on the Doctor's Pharmacy.

• 1:59:01Dr. Mark Hyman?

  This podcast is separate from my clinical practice at the Ultra Wellness Center and my work at Cleveland Clinic and Function Health, where I'm the Chief Medical Officer. This podcast represents my opinions and my guests' opinions, and neither myself nor the podcast endorse the views or statements of my guests. This podcast is for educational purposes only. This podcast is not a substitute for professional care by a doctor or other qualified medical professional. This podcast is Provided on the understanding that it does not constitute medical or other professional advice or services. If you're looking for your help in your journey, seek out a qualified medical practitioner. You can come see us at the Ultra Wellness Center in Lenox, Massachusetts. Just go to UltraWellnessCenter.com. If you're looking for a functional medicine practitioner near you, you can visit ifm.org and search Find a Practitioner Database.

• 1:59:44Dr. Mark Hyman?

  It's important that you have someone in your corner who is trained, who's a licensed healthcare practitioner, and can help you make changes, especially when it comes to your health. Keeping this podcast free is part of my mission to bring practical ways of improving health to the general public. In keeping with that theme, I'd like to express gratitude to the sponsors that made today's podcast possible.

• 2:00:06Dr. Mark Hyman?

  When it comes to supplements, you only want the best for your body, the kind with the highest quality, cleanest, and most potent ingredients you can get. That's exactly what you'll find at my supplement store, where I've hand-selected each and every product to meet the most rigorous standards for safety, purity, and effectiveness. These are the only supplements I recommend to my patients, and they're also what I use myself. Whether you want to optimize longevity, or reduce your disease risk, or you're looking to improve your sleep, blood sugar, metabolism, gut health, you name it, DrHyman.com has the world's best selection of top-quality, premium supplements, all backed by science and expertly vetted by me, Dr. Mark Hyman. So check out DrHyman.com, because when it comes to your health, nothing less than the very best will do. That's DrHyman.com, D-R-H-Y-M-A-N.com.