#385 - AMA #82: Applying the tools of longevity in the real world: disease prevention, DEXA scans, artificial sweeteners, injury recovery, stability training, habit formation, protein intake and mTOR activation, and more

View the Show Notes Page for This Episode https://peterattiamd.com/ama82/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=260323-pod-ama82&utm_content=260323-pod-ama82-podfeed Become a Member to Receive Exclusive Content https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=260323-pod-ama82&utm_content=260323-pod-ama82-podfeed Sign Up to Receive Peter's Weekly Newsletter https://peterattiamd.com/newsletter/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=260323-pod-ama82&utm_content=260323-pod-ama82-podfeed In this "Ask Me Anything" (AMA) episode, Peter answers listener questions across a wide range of topics, focusing on practical decision-making and real-world application. He explores how health priorities and strategies should evolve across different decades of life, which chronic diseases are most challenging to manage and how to think about risk hierarchies, and which emerging interventions—beyond exercise—show the most promise for dementia prevention. Peter also breaks down the utility of wearables and explains how to use and interpret DEXA scans effectively. He discusses the challenges of behavior change and how to make healthy habits stick, along with training strategies for balance, stability, and injury resilience, drawing lessons from his own setbacks. Additional topics include high-protein diets and mTOR, how to weigh mechanisms versus outcomes, how to evaluate diet sodas and non-nutritive sweeteners in context, and a range of listener questions covering health fads, emotional health, and sleep routines. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed https://peterattiamd.com/members/private-podcast-feed/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=260323-pod-ama82&utm_content=260323-pod-ama82-podfeedor our website at the AMA #82 show notes page http://peterattiamd.com/ama82/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=260323-pod-ama82&utm_content=260323-pod-ama82-podfeed. If you are not a subscriber, you can learn more about the subscriber benefits here https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=260323-pod-ama82&utm_content=260323-pod-ama82-podfeed. We discuss: Overview of episode topics, emphasizing the goal of providing actionable, real-world health guidance [1:30]; How health priorities and training strategies should evolve from early adulthood through older age [2:45]; Comparing the four major chronic diseases: which are most preventable, most uncertain, and most concerning [8:00]; Emerging strategies for dementia prevention: biomarkers, early detection, and new pharmacologic approaches [15:00]; How to use wearable data effectively: when it's helpful, when it's not, and how to avoid over-reliance [19:00]; DEXA scans: timing, interpretation, and limitations in body composition and bone density tracking [23:00]; Best practices for building sustainable health habits [30:15]; How to train your balance and stability [33:30]; How to recover from injuries and use setbacks to build strength and resilience [36:15]; High protein intake and the impact on mTOR: evaluating mechanisms versus real-world evidence on longevity [38:30]; Diet soda and artificial sweeteners: evaluating risks, benefits, and the importance of context [47:00]; How to balance enjoying life today with making choices that support long-term health and longevity [51:45]; and More. Connect With Peter on Twitter https://twitter.com/PeterAttiaMD, Instagram https://www.instagram.com/peterattiamd/, Facebook https://www.facebook.com/peterattiamd/ and YouTube https://www.youtube.com/channel/UC8kGsMa0LygSX9nkBcBH1Sg

Speaker names marked ? are inferred from speaking time and the show’s known hosts — they are not voice-verified.

• 0:10Dr. Peter Attia?

  Hey everyone, welcome to a sneak peek Ask Me Anything, or AMA, episode of the Drive Podcast. I'm your host, Peter Attia. At the end of this short episode, I'll explain how you can access the AMA episodes in full, along with a ton of other membership benefits we've created. Or you can learn more now by going to peterattiamd.com/subscribe. So without further delay, here's today's sneak peek of the Ask Me Anything episode.

• 0:39Dr. Peter Attia?

  Welcome to Ask Me Anything AMA, episode 82. In today's AMA, I answer listener questions across a wide range of topics. Less about deep dives and more about how I think through real-world trade-offs and apply the science in practice. So what are we talking about here today? We can talk about how health priorities and strategies should shift across different decades of life, which chronic diseases feel toughest to manage, and how I think about that hierarchy of risk, which emerging interventions look most promising beyond exercise, wearables, which consumer metrics are actually useful in practice, DEXA scans, what optimal screening intervals look like and how to interpret the results over time, behavior change, what patients struggle with most

• 1:21Dr. Peter Attia?

  in health routines and how to help changes stick, training for balance, stability, and injury resilience, and lessons from some training setbacks, high protein diets and mTOR, how to think about mechanisms versus outcomes, diet sodas and non-nutritive sweeteners, how to evaluate them, and frankly, what to compare them to, plus a grab bag of some additional listener questions, including health fads, emotional health, and sleep routines. So without further delay, I hope you enjoy AMA number 82.

• 1:56Speaker 01

  Peter, welcome to another AMA. For today's AMA, our goal is to hit a variety of topics and questions that have come through frequently, most commonly, and instead of doing deep dives on some of these topics, what we're going to do is more talk about them, how you would speak with patients about them if they ask these questions, or their questions on how you work with your patients on specific issues. So, goal here is to be much less in-depth and much more practical and actionable. And with this, we'll cover a variety of topics, including how priorities around health shift as people age, the best tools we have to prevent dementia, what wearable data do you

• 2:40Speaker 01

  think is actually useful for your work with patients, how you work with patients to make lasting changes in their health routine, how to think about training for stability, recovering from injuries, question on diet soda, mTORs as it relates to high protein diets, and more. So with that said, I think we'll just jump right into it. First question being, as someone thinks about their trajectory as they age, so if someone goes from their twenties to forties to sixties and beyond, how do you work with patients around how their health priorities, strategies, tactics should shift across those decades as they age?

• 3:20Dr. Peter Attia?

  Well, I mean, I think it's a great question, and I get asked this in various forms all the time, but also I think in the spirit of full disclosure, I don't work with 20-year-olds typically, and therefore, I don't think I have the breadth of experience to really speak intelligently at that age range the way I do, you know, for people in their forties and above, because I- I would bet that the median age of my patient is in the mid 50s with a interquartile range of, call it 40 to 70. So I think broadly, what I would say is that you can get away with so much in your 20s. And again, I don't know that much of our audience even skews that young.

• 4:05Dr. Peter Attia?

  But anybody listening to this who's in their 20s, or certainly anybody who can remember being in their 20s, and even I can, knows that what you can get away with is just incredible. And so one of the things that I talk about with my daughter, for example, who's a teenager, is, look, this is the period of time in which you can overtrain. You can expand the envelope of your capacity. I know that the reason to this day, despite the fact that I don't train that hard, I still have a much higher VO2 max than would be predicted, I think, by my training volume. I owe that all to what I was doing when I was young. That's one example. But I think we can achieve a lot by pushing in our 20s. So I actually would encourage people in their teens and 20s to kind of find their limits a little bit.

• 4:50Dr. Peter Attia?

  Again, you're not going to pay the same price that you will in your 50s or 60s in doing so. Now, obviously, that means you, you know, you still have to be reasonable and don't do things that would would cause injuries. But again, I think that's a period of time for exploration and growth. I think when people get into their 40s, most people start to have that first brush with mortality. And part of that is external. You might be watching your parents' age or things of that nature. But I think also part of it is internal. And even though it's not your own mortality that is readily apparent, it is apparent that you are not the person you were before. Probably, and I would say certainly by the late 40s, that that becomes true. And again, this is, this manifests itself in many ways, right? So for example, patients will say, look, man, there was a day when I could throw down

• 5:35Dr. Peter Attia?

  three drinks a night and feel nothing, and now I just have a headache the next day. Or I don't sleep well, and I don't perform well the next day, and all of those other things. And so I think that that's An insight into what's happening to us physiologically in our 40s and 50s, which says we really need to start being very deliberate about what we do physically and how we think about ourselves in terms of disease management and training. Again, when you look at a disease like atherosclerosis, rarely, rarely is it going to brush up against somebody in their 40s. You can count the number of cases you see where a person has an MI in their 40s. But it is undeniable that most people, at least microscopically,

• 6:18Dr. Peter Attia?

  if they're walking around with high risk factors, don't have a burden of disease. And so really, I would say that by the time you're in your 40s, you really need to be thinking about, what am I doing from a prevention standpoint? You know, I don't want to wait too much longer to start taking those steps. And that means, again, looking after the fundamentals and the basics. So am I metabolically healthy? Because for many people, this is when they start to go off the rails. Am I still faced with dyslipidemia? Or, you know, is hypertension starting to creep up? All of those other things. And of course, I always like to bring it back to physical and exercise. This is really a time where you don't want to start missing workouts. And I know that that's, you know, for some people, it's hard to do. But you're better off doing something very frequently and not getting out of the habit

• 7:03Dr. Peter Attia?

  than you are taking long periods of time off and then coming back and trying to be heroic. Now, I think once you get into your 60s and beyond, the name of the game is maintenance if you've done a good job until that point. But the good news is if you haven't, there's still an enormous opportunity for growth. I think that's an important distinction. So if you've come into the seventh and eighth decade of your life not particularly healthy, that should not be viewed as a scenario by which you decide, well, the die's been cast and away I go. Rather, it would be, no, look, I can still make gains here. We've seen patients that come into our practice in their 60s with a VO2 max in the high teens, low 20s. That doesn't prevent us from training them and getting them to a much higher level of fitness within two or three years.

• 7:48Dr. Peter Attia?

  The same is true with resistance training and things like that. And of course, it's never too late to start taking the preventive steps. Around chronic disease. Alternatively, when a person comes into their 60s and 70s in great shape, our goal is do no harm, right? It's how do we preserve this for as long as possible? And that might mean being a little bit more deliberate in some of the training that we do, maybe trimming a little bit of the work that they do off and adding different types of work to it. But I would say broadly speaking, that would be my approach.

• 8:17Speaker 01

  Jumping off that, the next question we got touches on the kind of major chronic diseases, or as you call them, the four horsemen. Do you want to just run people through real quick what those four are before we get to the question?

• 8:31Dr. Peter Attia?

  Yeah, they're they're sort of the the big four killers in chronic disease land. So atherosclerotic cardiovascular and cerebrovascular disease being one, cancer, all of the neurodegenerative diseases and dementing diseases is the third. And then the foundation upon which these all lie is is metabolic disease, which is a broad term that encompasses everything from insulin resistance through fatty liver disease up until type 2 diabetes.

• 8:57Speaker 01

  And the question, which obviously is going to be a little hard to answer in general, right? Because I know it can vary from person to person. But it was an interesting question around of those major chronic diseases, which do you find the toughest to combat? Or which do you worry about the most when working with your patients?

• 9:17Dr. Peter Attia?

  Well, I'll start with the opposite question, Nick, which is which do I worry about the least? And I worry the least about metabolic disease and cardiovascular and cerebrovascular disease. Because one, we have a pretty good handle on the drivers of those diseases. In fact, we have an exceptional handle on the driver of those diseases. And that's half of the equation. The other half of the equation is in response to that, we also have incredible tools for how to combat them. So when it comes to reducing the risk of diabetes and cardiovascular disease, or even treating them when present, we know what to do. We've got the tools. So now let's really focus on the other two now. The other two are kind of interesting, and so we'll take them one at a time.

• 9:57Dr. Peter Attia?

  In the case of cancer, you're dealing with a disease that has two very clear and well-understood what we would call environmental triggers or behavioral risk factors. The first is smoking, and the second is obesity. Although, as I've said many times before, obesity is simply a proxy, in my view, for the constellation of things that accompanies insulin resistance. So there's a high overlap, of course, between those, but really, I think it's the hyperinsulinemia and the inflammation that often, though not always, accompanies obesity that is driving risk there. So, obviously, when it comes to cancer, step one is mitigate those two things, right? Don't smoke and be as metabolically healthy as possible. But, as anybody listening to this knows, just because you've done those two things

• 10:40Dr. Peter Attia?

  does not for a moment guarantee you're not going to be diagnosed with cancer. And I think that's, in many ways, what makes cancer a very frightening disease, is that, as far as I can tell, at least 50% of cases of cancer arise in individuals for which there is no observable risk factor. And, as Burt Vogelstein, you know, put it many years ago in a then very controversial paper that I believe was in Science, "It's simply about bad luck." And that genes are constantly undergoing mutation, DNA is constantly undergoing mutation. Most of the time, it is being repaired. If it is not being repaired, most of the time, the cells that undergo those non-repaired

• 11:23Dr. Peter Attia?

  DNA mutations are being weeded out. But every once in a while, a population, a clonal population of these will emerge and will evade the immune system and will ultimately become a cancer. And, again, I think that's happening about 50% of the time, which, again, turns our attention, then, to screening. This is why screening is so important, because... It's sort of like playing Russian roulette with three rounds in the chamber. So I would argue that that's pretty scary to me, Nick, when it comes to my health and the health of my family and the health of my patients and friends and anybody that I care about. On the neurodegenerative side, I kind of divide these into two categories, frankly. On the dementia side, we can really stratify a lot based on genes.

• 12:05Dr. Peter Attia?

  And so a person's genes will play a pretty significant role in risk. And obviously, the APO E4 gene is the most obvious of these. But unfortunately, there are other genes that are involved here that are fortunately rare, but unfortunately, highly, highly penetrant and highly un-modifiable in the way that APO E4 is modifiable. So across that spectrum, of course, my concern increases as the genetic risk increases. The good news is I feel we have a lot to offer patients there in terms of prevention today that we didn't have five years ago and 10 years ago in terms of our understanding. So interestingly, I find myself slightly less concerned about this than I was concerned

• 12:50Dr. Peter Attia?

  five and 10 years ago. Now, on some of the neurodegenerative diseases outside of the dementing diseases, I find these to be also terrifying. So here, I'm thinking about diseases like Parkinson's disease or Lou Gehrig's disease, Huntington's disease, of course, which is a genetic condition that arises from a very clear genetic mutation. And, you know, here I find these, you know, I take some comfort in knowing that, at least in the case of, you know, ALS, the prevalence of these are quite low. But again, we still have no earthly clue what's driving them. Yes, there are probably some cases that arise from genetic risk, but the truth of the matter is, we just don't really know. Again, with Parkinson's disease, we certainly are familiar with some of the genetic things

• 13:32Dr. Peter Attia?

  that are driving risk, but that doesn't answer all of it, and therefore, I have concern about those. But I also realize that we have certain things under our control. And just as cognitive reserve allows us to maintain resilience against cognitive decline, so too does movement reserve give us some manner in which we can protect ourselves or at least be resilient towards the neurodegenerative diseases that tackle movement.

• 13:59Speaker 01

  And just to... Double click on a few things on the cardiovascular disease and metabolic diseases. Just because you kind of, how you answered this question was which ones are the toughest to combat, most worried about, just because those diseases are easier to combat, that doesn't necessarily mean that people should ignore those because they're still number one killer in cardiovascular disease and metabolic disease hugely drives everything else, correct?

• 14:29Dr. Peter Attia?

  Absolutely, yeah. I mean, I, if we did nothing else on this podcast but talk about cardiovascular disease and all of the ways that we should be screening for it and preventing it, we would probably save more lives than talking about anything else. And so, yeah, I am still heartbroken when I learn of the death of anybody due to cardiovascular disease, including actually a mentor of mine who died suddenly, somewhat recently, and, you know, insanely healthy individual who just dropped dead of a sudden MI at about the age of 70. This is, this is a guy who, who functioned like he was about 52 and then just dropped dead suddenly. And, yeah, I'll always kick myself for not being more of a hardliner about forcing him to do some of the screening stuff that I, that I think would have made a difference.

• 15:14Speaker 01

  And we'll link in the show notes to various content, podcasts, AMAs, newsletters, et cetera, on cardiovascular disease. The second one to follow up on, which is a question we got, which fits really well with what you just talked about, is for dementia prevention, besides exercise, which you've openly talked about as one of the best ways to reduce the risk of that, what looks most promising to you?

• 15:44Dr. Peter Attia?

  Thank you for listening to today's sneak peek AMA episode of The Drive. If you're interested in hearing the complete version of this AMA, you'll want to become a premium member. It's extremely important to me to provide all of this content without relying on paid ads. To do this, our work is made entirely possible by our members, and in return, we offer exclusive member-only content and benefits above and beyond what is available for free. So if you wanted to- Take your knowledge of this space to the next level. It's our goal to ensure members get back much more than the price of the subscription. Premium membership includes several benefits. First, comprehensive podcast show notes that detail every topic, paper, person, and thing that we discuss in each episode.

• 16:29Dr. Peter Attia?

  And the word on the street is, nobody's show notes rival ours. Second, monthly Ask Me Anything or AMA episodes. These episodes are comprised of detailed responses to subscriber questions typically focused on a single topic and are designed to offer a great deal of clarity and detail on topics of special interest to our members. You'll also get access to the show notes for these episodes, of course. Third, delivery of our premium newsletter, which is put together by our dedicated team of research analysts. This newsletter covers a wide range of topics related to longevity and provides much more detail than our free weekly newsletter. Fourth, access to our private podcast feed that provides you with access to every episode,

• 17:12Dr. Peter Attia?

  including AMAs sans le spiel you're listening to now and in your regular podcast feed. Fifth, the Qualies, an additional member-only podcast we put together that serves as a highlight reel featuring the best excerpts from previous episodes of the drive. This is a great way to catch up on previous episodes without having to go back and listen to each one of them. And finally, other benefits that are added along the way. If you want to learn more and access these member-only benefits, you can head over to peterattiamd.com/subscribe. You can also find me on YouTube, Instagram, and Twitter, all with the handle peteratiaMD. You can also leave us a review on Apple Podcasts or whatever podcast player you use.

• 17:57Dr. Peter Attia?

  This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed.

• 18:10Dr. Peter Attia?

  The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice from any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. Finally, I take all conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit peteratia MD dot com forward slash about, where I keep an up-to-date and active list of all disclosures.