#238 – Francis Collins: National Institutes of Health (NIH)

Francis Collins is the director of the NIH and former head of the Human Genome Project. Please support this podcast by checking out our sponsors: – Ten Thousand: https://www.tenthousand.cc/ and use code LEX to get 15% off – Allform: https://allform.com/lex to get 20% off – SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera – NI: https://www.ni.com/perspectives – Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off EPISODE LINKS: Francis’s Twitter: https://twitter.com/NIHDirector NIH: https://www.nih.gov Human Genome Project: https://www.genome.gov/human-genome-project PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out the sponsors above, it’s the best way to support this podcast – Support on Patreon: https://www.patreon.com/lexfridman – Twitter: https://twitter.com/lexfridman – Instagram: https://www.instagram.com/lexfridman – LinkedIn: https://www.linkedin.com/in/lexfridman – Facebook: https://www.facebook.com/lexfridman – Medium: https://medium.com/@lexfridman OUTLINE: Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) – Introduction (07:44) – Lab-leak theory (10:51) – Gain-of-function research of viruses (23:00) – Bioterrorism (27:30) – Tony Fauci (37:41) – COVID Vaccines (43:46) – Joe Rogan (50:49) – Variants (55:31) – Rapid at home testing (59:44) – Animal testing (1:05:09) – Stepping down as director of the NIH (1:09:03) – Barack Obama (1:11:06) – Accelerating Medicines Partnership (1:21:44) – Faith (1:27:12) – Fear of death (1:30:15) – Meaning of life

Speaker names marked ? are inferred from speaking time and the show’s known hosts — they are not voice-verified.

• 0:00Lex Fridman?

  The following is a conversation with Francis Collins, director of the NIH, the National Institutes of Health, appointed and reappointed to the role by three presidents, Obama, Trump, and Biden. He oversees 27 separate institutes and centers, including NIAID, which makes him Anthony Fauci's boss. At the NIH, Francis helped launch and led a huge number of projects that pushed the frontiers of science, health, and medicine, including one of my favorites, the Brain Initiative, that seeks to map the human brain and understand how the function arises from neural circuitry. Before the NIH, Francis led the Human Genome Project, one of the largest and most ambitious efforts

• 0:45Lex Fridman?

  in the history of science. Given all that, Francis is a humble, thoughtful, kind man. And because of this, to me, he's one of the best representatives of science in the world. He is a man of God, and yet also a friend of the late Christopher Hitchens, who called him, quote, "one of the greatest living Americans." And now, a quick few-second summary of the sponsors. Check them out in the description. It's the best way to support this podcast. First is 10,000, clothes I like to wear for lifting, cardio, and grappling. Second is Allform, my go-to furniture company. Third is Simply Safe, the home security company I use. Fourth is NI, a company that helps engineers

• 1:29Lex Fridman?

  solve the world's toughest problems. And fifth is Magic Spoon, low-carb keto-friendly cereal. So the choice is fashion, furniture, security, engineering, or delicious low-carb cereal. Choose wisely, my friends. And now, onto the full ad reads. As always, no ads in the middle. I do try to make these interesting, but if you skip them, please still check out the sponsors. I enjoy their stuff. Maybe you will, too. This show is brought to you by 10,000 maker of high-quality, well-fitting, comfortable training clothes. I wear their foundation shorts for lifting and cardio, and I wear their fight shorts for training jiu-jitsu and grappling.

• 2:11Lex Fridman?

  It's much easier and I would say more fun to see grappling. It's just a mindless workout. It's nice to get a sweat in, to roll around, all that kind of stuff. But progress is made when you think, especially when you put yourself in bad positions, when you're working your weak points, and you use your mind to solve the puzzles of those weak points. Anyway, when I was grappling recently, I was wearing 10,000 shorts and somebody recognized the logo and asked me how they are. It's kind of cool. It's a very minimalist logo, but it's recognizable, apparently. So I love it. I love the way they feel, the way they look. Anyway, go to 10,000.cc and enter code LEX to receive 15% off your first purchase.

• 2:56Lex Fridman?

  That is 10,000.cc and enter code LEX.

• 3:01Lex Fridman?

  This show is also brought to you by Allform, a furniture company. They ship to your home quickly, take it back for free if you don't like it in the first 100 days. It's easy to assemble. It looks beautiful and feels amazing. I love it. I have a black leather love seat that is actually big enough for two people to sit not awkwardly on. So I shared with a bunch of guests as we kind of talk about life and all those kinds of things. The one that stands out in my memory, I think, is Michael Malice, where we hung out for a bunch of hours after our conversation, talking about life, meaning, history, and politics

• 3:45Lex Fridman?

  on that love seat. So I just love the way it looks, especially given my minimalist aesthetic. It's not flashy, but it's classy. It just looks great. Anyway, go to allform.com/lex. They're offering 20% off all orders if you go to allform.com/lex.

• 4:05Lex Fridman?

  This show is also brought to you by SimpliSafe, a home security company designed to be simple and effective. They just launched their new wireless outdoor security camera. It has an ultra-wide 140-degree field of view, 1080p HD resolution with an 8x zoom. I just like giving the specs, I think. It has a built-in spotlight with color night vision. SimpliSafe was named the best home security system of 2021 by US News and World Report. There's a lot of flexibility, but not too much flexibility. And the deployment of that flexibility is super easy, like specifying what you want and getting it to work, getting it all set up.

• 4:48Lex Fridman?

  Take advantage of SimpliSafe's holiday sale. Get 40% off your new home security system by visiting simplisafe.com/lex. Again, that's simplisafe.com/lex. Hurry up, since this 40% off deal, this holiday deal, ends soon. This show is also brought to you by NI, formerly known as National Instruments. NI is a company that has been helping engineers solve the world's toughest challenges for 40 years. Their motto is "Engineer ambitiously", arguably the best motto of all time. They have a podcast called Testing 123. They have amazing articles at NI.com/perspectives covering engineers and innovators.

• 5:33Lex Fridman?

  I recently saw a story on Instagram where this very ad read was being played while the listener was relaxing and enjoying life. Yeah, but back to engineering. Engineer ambitiously with NI at NI.com/perspectives. There's a lot of amazing articles on there, like I said, that show the importance of failing through the process of testing and learning from those mistakes and improving the system. That's NI.com/perspectives. Go there, you'll enjoy it.

• 6:15Lex Fridman?

  This episode is also brought to you by Magic Spoon, low carb keto friendly cereal. It has zero grams of sugar, 13 to 14 grams of protein, only four net grams of carbs, 140 calories in each serving. Like I said, I love reading off specs, whether that's for hardware or for cereal. You can build your own box or get a variety pack with available flavors like cocoa, fruity, frosted peanut butter, blueberry and cinnamon. They also bring back two flavors, cookies and cream and maple waffle. They brought them back permanently. They did a limited run at first and it sold out immediately. People fell in love. And now they can have a committed relationship with those two flavors.

• 6:59Lex Fridman?

  Anyway, Magic Spoon have a 100% happiness guarantee. So if you don't like it, they refund it. Go to magicspoon.com/lex and use code Lex at checkout to save $5 off your order. That's magicspoon.com/lex and use code Lex. This is the Lex Fridman Podcast and here is my conversation with Francis Collins.

• 7:44Lex Fridman?

  Science at its best is a source of hope. So for me, it's been difficult to watch, as it has during the pandemic, become at times a source of division. What I would love to do in this conversation with you is touch some difficult topics and do so with empathy and humility so that we may begin to regain a sense of trust in science and that it may once again become a source of hope. I hope that's okay with you.

• 8:08Speaker 01

  I love the goal.

• 8:10Lex Fridman?

  Let's start with some hard questions. You called for, quote, "thorough, expert-driven and objective inquiry into the origins of COVID-19." So let me ask, is there a reasonable chance that COVID-19 leaked from a lab?

• 8:25Speaker 01

  I can't exclude that. I think it's fairly unlikely. I wish we had more ability to be able to ask questions of the Chinese government and learn more about what kind of records might have been in the lab that we've never been able to see. But most likely, this was a natural origin of a virus, probably starting in a bat, perhaps traveling through some other intermediate, yet-to-be-identified host, and finding its way into humans.

• 8:52Lex Fridman?

  Is answering this question within the realm of science, do you think, will we ever know?

• 8:57Speaker 01

  I think we might know if we find that intermediate host. And there has not yet been a thorough enough investigation to say that that's not going to happen. And remember, it takes a while to do this. With SARS, it was 14 years before we figured out it was the civet cat that was the intermediate host. With MERS, it was a little quicker to discover it was the camel. With SARS-CoV-2, there's been some looking, but especially now with everything really tense between the US and China. If there's looking going on, we're not getting told about it.

• 9:29Lex Fridman?

  Do you think it's a scientific question or a political question?

• 9:33Speaker 01

  It's a scientific question, but it has political implications.

• 9:37Lex Fridman?

  So the world is full of scientists that are working together, but in the political space, in the political science space, there's tensions. What is it like to do great science in a time of a pandemic when there's political tensions?

• 9:53Speaker 01

  It's very unfortunate. Pasteur said, "Science knows no one country." He was right about that. My whole career, in genetics especially, has depended upon international collaboration between scientists as a way to make discoveries, get things done. Scientists, by their nature, like to be involved in international collaborations. The Human Genome Project, for heaven's sake, 2,400 scientists in six countries, working together, not worrying who is going to get the credit, giving all the data away. I was the person who was supposed to keep all that coordinated, and it was a wonderful experience. And that included

• 10:33Speaker 01

  China. That was sort of their first real entry into a big international, big science kind of project, and they did their part.

• 10:43Speaker 01

  It's very different now.

• 10:44Lex Fridman?

  Continue in the line of difficult questions, especially difficult ethical questions. In 2014, US put a hold on gain-of-function research in response to a number of laboratory biosecurity incidents, including anthrax, smallpox, and influenza. In December 2017, NIH lifted this ban because, quote, "Gain-of-function research is important in helping us identify, understand, and develop strategies and effective countermeasures against rapidly evolving pathogens that pose a threat to public health."

• 11:20Lex Fridman?

  All difficult questions have arguments on both sides. Can you argue the pros and cons of gain-of-function research with viruses?

• 11:29Speaker 01

  I can. And first, let me say, this term "gain-of-function" is causing such confusion that I need to take a minute and just sort of talk about what the common scientific use of that term is and where it is very different when we're talking about the current oversight of potentially dangerous human pathogens.

• 11:52Speaker 01

  As you know, in science, we're doing gain-of-function experiments all the time. We support a lot of cancer immunotherapy at NIH. Right here in our clinical center, there are trials going on where people's immune cells are taken out of their body, treated with a genetic therapy that revs up their ability to discover the cancer that that patient currently has, maybe even at stage four, and then give them back as those little ninja warriors go after the cancer. And it sometimes works dramatically. That's a gain-of-function. You gave that patient a gain in their immune function that may have saved their life. So we've got to be careful not to say, "Oh, gain-of-function is bad."

• 12:33Speaker 01

  Most of what we do in science that's good involves quite a bit of that. And we are all living with gains of function every day. I have a gain-of-function because I'm wearing these eyeglasses. Otherwise, I would not be seeing you as clearly. I'm happy for that gain-of-function. So that's where a lot of confusion has happened. The kind of gain of function which is now subject to very rigorous and very carefully defined oversight is when you are working with an established human pathogen that is known to be potentially causing a pandemic and you are enhancing or potentially enhancing its transmissibility or its virulence.

• 13:15Speaker 01

  We call that EPPP, Enhanced Potential Pandemic Pathogen. That requires this very stringent oversight worked out over three years by the National Science Advisory Board on Biosecurity that needs to be looked at by a panel that goes well beyond NIH to decide, are the benefits worth the risks in that situation? Most of the time, it's not worth the risk. Only three times in the last three or four years have experiments been given permission to go forward. They were all on influenza.

• 13:56Speaker 01

  So I will argue that if you're worried about the next pandemic, the more you know about the coming enemy, the better chance you have to recognize when trouble is starting. And so if you can do it safely, studying influenza or coronaviruses like SARS, MERS, and SARS-CoV-2 would be a good thing to be able to know about. But you have to be able to do it safely because we all know lab accidents can happen. I mean, look at SARS, where there have been lab accidents and people have gotten sick as a result. We don't want to take that chance unless there's a compelling scientific reason. That's why we have this very stringent oversight.

• 14:39Speaker 01

  The experiments being done at the Wuhan Institute of Virology as a subaward to our grant to Eco Health in New York did not meet that standard of requiring that kind of stringent oversight. I want to be really clear about that because there's been so much thrown around about it. Was it gain of function? Well, in the standard use of that term that you would use in science in general, you might say it was. But in the use of that term that applies to this very specific...

• 15:11Speaker 01

  Example of a potential pandemic pathogen, absolutely not. So, nothing went on there that should not have happened based upon the oversight. There was an instance where the grantee institution failed to notify us about the result of an experiment that they were supposed to tell us, where they mixed and matched some viral genomes and got a somewhat larger viral load as a result, but it was not EPPP. It was not getting into that zone that would have required this higher level of scrutiny. It was all bat viruses. These were not human pathogens.

• 15:48Lex Fridman?

  So, they didn't cross the threshold within that gray area that makes for an EPPP?

• 15:54Speaker 01

  They did not. And anybody who's willing to take the time to look at what EPPP means and what those experiments were, would have to agree with what I just said.

• 16:04Lex Fridman?

  What is the biggest reason it didn't cross that threshold? Is it because it wasn't jumping to humans? Is it because it did not have a sufficient increase in virulence of transmissibility? What's your sense?

• 16:16Speaker 01

  EPPP only applies to agents that are known human pathogens of pandemic potential. These were all bat viruses derived in the wild, not shown to be infectious to humans. Just looking at what happened if you took four different bat viruses and you tried moving the spike protein gene from one into one of the others to see whether it would bind better to the ACE2 receptor. That doesn't get across that threshold. And let me also say, for those who are trying to connect the dots here, which is the most troubling part of this, and say, "Well, this is how SARS-CoV-2 got started," that is absolutely demonstrably false.

• 17:00Speaker 01

  These bat viruses that were being studied had only about 80% similarity in their genomes to SARS-CoV-2. They were like decades away in evolutionary terms, and it is really irresponsible for people to claim otherwise.

• 17:16Lex Fridman?

  Speaking of people who claim otherwise, Rand Paul. What do you make of the battle of words between Senator Rand Paul and Dr. Anthony Fauci over this particular point?

• 17:29Speaker 01

  I don't want to talk about specific members of Congress, but I will say it's really unfortunate that Tony Fauci, who is the epitome of a dedicated public servant, has now somehow been targeted for political reasons as somebody that certain figures are trying to discredit, perhaps to try to distract from their own failings. This never should have happened. Here is a person who's dedicated his whole life to trying to prevent illnesses from infectious diseases, including HIV, in the 1980s and 90s, and now probably the most knowledgeable infectious disease physician in the world, and also a really good communicator, is out

• 18:14Speaker 01

  there telling the truth about where we are with SARS-CoV-2 to certain political figures who don't want to hear it and who are therefore determined to discredit him. And that is disgraceful.

• 18:25Lex Fridman?

  So with politicians, they often play games of black and white. They try to sort of use the gray areas of science and then paint their own picture. But I have a question about the gray areas of science. So like you mentioned, gain of function is a term that has very specific scientific meaning, but it also has a more general term. And it's very possible to argue that the, not to argue, not the way politicians argue, but just as human beings and scientists, that there was a gain of function achieved at the Wuhan Institute of Virology, but it didn't cross the threshold. I mean, there's a, it's a, but it could have too.

• 19:09Lex Fridman?

  So here's the thing, when you do these kinds of experiments, unexpected results may be achieved, and that's the gray area of science. You're taking risks with such experiments.

• 19:22Lex Fridman?

  And I am very uncomfortable that we can't discuss the uncertainty and the gray area of this.

• 19:28Speaker 01

  Oh, I'm comfortable discussing the gray area. What I'm uncomfortable with is people deciding to define for themselves what that threshold is, based on sort of some political argument. The threshold was very explicitly laid out. Everybody agreed to that in the basis of this three years of deliberation. So that's what it is. If that threshold needs to be reconsidered, let's reconsider it. But let's not try to take an experiment that's already been done and decide that the threshold isn't what it was, because that really is doing a disservice to the whole process.

• 20:04Lex Fridman?

  I wish there was a discussion, even in response to Rand Paul, and I know we're not talking about specific senators, but just that particular case, I'm saying stuff here. I wish there was an opportunity to talk about, given the current threshold, this is not gain of function, but maybe we need to reconsider the threshold and have an actual, that's an opportunity for discussion about the ethics of gain of function. You said that there was three studies that passed that threshold with influenza. That's a fascinating human question, scientific question about ethics, because you're playing, like you said, there's pros and cons. You're taking risks here to prevent horribly destructive viruses in the future, but you

• 20:47Lex Fridman?

  also are risking creating such viruses in the future. With nuclear weapons and nuclear energy, you are, nuclear energy promises a lot of positive effects, and yet you're taking risks here. With mutually assured destruction, nations possessing nuclear weapons.

• 21:07Speaker 01

  Oh, my.

• 21:08Lex Fridman?

  You're, a lot of people.

• 21:09Speaker 01

  I hope we're not going there.

• 21:10Lex Fridman?

  Well, we're not, but a lot of people argue that that's the reason we've, nuclear weapons is the reason we've prevented world wars. And yet, they also have the risk of starting world wars. And this is what we have to be honest about with the with the benefits of risks of science, that you have to make that calculation. What are the pros and what are the cons?

• 21:31Speaker 01

  I'm totally with you, but I want to reassure you, Lex, that this is not an issue that's been ignored.

• 21:37Lex Fridman?

  Yes.

• 21:38Speaker 01

  That this issue about the kind of gain of function that might result in a serious human pathogen has been front and center in many deliberations for a decade or more, involved a lot of my time along the way, by the way, and has been discussed publicly on multiple occasions, including two major meetings of the National Academy of Sciences, getting input from everybody and ultimately arriving at our current framework. Now, we actually, back in January of 2020, just before COVID-19 changed everything, had planned and even charged that same National Science Advisory Board on Biosecurity

• 22:19Speaker 01

  to reconvene and look at the current framework and say, do we have it right? Let's look at the experience over those three years and say, is the threshold too easy, too hard? Do we need to reconsider it? Let's look at the experience. COVID came along, the members of the board said, please, we're all infectious disease experts. We don't have time for this right now. But I think the time is right to do this. I'm totally supportive of that. And that should be just as public a discussion as you can imagine about what are the benefits and the risks. And if somebody decided, ultimately, this came together and said, we just shouldn't be doing these experiments under any circumstances. If that was the conclusion, well, that would be the conclusion. But it hasn't been so far.

• 23:00Lex Fridman?

  If we can briefly look out into the next 100 years on this, I apologize for the existential questions. But it seems obvious to me that as gain-of-function type of research and development becomes easier and cheaper, it will become greater and greater risk. So if it doesn't no longer need to be contained within laboratories of high security.

• 23:31Lex Fridman?

  It feels like this is one of the greatest threats facing human civilization. Do you worry that at some point in the future, a leaked man-made virus may destroy most of human civilization?

• 23:44Speaker 01

  I do worry about the risks. And at the moment where we have the greatest control, the greatest oversight, is when this is federally funded research. But as you're alluding, there's no reason to imagine that's the only place that this kind of activity would go on. If there was an evil source that wished to create a virus that was highly pathogenic in their garage, the technology does get easier. And there is no international oversight about this either, that you could say has the same stringency as what we have in the United States. So yes, that is a concern.

• 24:23Speaker 01

  It would take a seriously deranged group or person to undertake this on purpose, given the likelihood that they too would go down. We don't imagine there are going to be bioweapons that only kill your enemies and don't kill you. Sorry, we're too much alike for that to work. So I don't see it as an imminent risk. There's lots of scary novels and movies written about it. But I do think it's something we have to consider. What are all the things that ought to be watched? You may not know that if somebody is ordering a particular oligonucleotide from one of

• 25:06Speaker 01

  the main suppliers, and it happens to match smallpox, they're going to get caught. So there is effort underway to try to track any nefarious actions that might be going on.

• 25:18Lex Fridman?

  In the United States or internationally? Is there an international collaboration of try to track this stuff?

• 25:23Speaker 01

  There is some. I wish it were stronger. This is a general issue, Lex, in terms of do we have a mechanism, particularly when it comes to ethical issues, to be able to decide what's allowable and what's not and enforce it? I mean, look where we are with germline genome editing for humans, for instance. There is no enforcement mechanism. There's just bully pulpits and governments that get to decide for themselves.

• 25:47Lex Fridman?

  You talked about evil. What about incompetence? Does that worry you? I was born in the Soviet Union. My dad, a physicist, worked at Chernobyl. That comes to mind. That wasn't evil. I was, I don't know what word you want to put it. Maybe incompetence is too harsh. Maybe it's the inherent incompetence of bureaucracy. I don't know. But for whatever reason, there was an accident. Does that worry you?

• 26:10Speaker 01

  Of course it does. We know that SARS, for instance, did manage to leak out of a lab in China two or three times. And at least in some instances, people died, fortunately quickly contained. All one can do, and that's circumstance, because you need to study the virus and understand it in order to keep it from causing a broader pandemic. But you need to insist upon the kind of biosecurity, the BSL 2, 3, and 4 framework, under which those experiments have to be done. And certainly at NIH, we're extremely rigorous about that. But you can't count on every human being to always do exactly what they're supposed to. So there's a risk there, which is another reason why if we're contemplating

• 26:55Speaker 01

  supporting research on pathogens that might be the next pandemic, you have to factor that in, not just whether people are going to do something that we couldn't have predicted, where all of a sudden they created a virus. It's much worse without knowing they were going to do that. But also, just having an accident, that's in the mix when those estimates are done about whether the risk is worth it or not.

• 27:19Lex Fridman?

  Continuing on line of difficult questions.

• 27:23Speaker 01

  We're going to get to fun stuff after a while.

• 27:24Lex Fridman?

  We will soon. I promise.

• 27:30Lex Fridman?

  You are the director of the NIH. You are Dr. Anthony Fauci's, technically, his boss.

• 27:37Speaker 01

  Yep.

• 27:38Lex Fridman?

  You have stood behind him. You have supported him, just like you did already in this conversation. It is painful for me to see division and distrust, but many people in politics and elsewhere have called for Anthony Fauci to be fired. When there are such calls of distrust in public about a leader like Anthony Fauci, who should garner trust, do you think he should be fired?

• 28:03Speaker 01

  Absolutely not. To do so would be basically to give the opportunity for those who want to make up stories about anybody to destroy them. There is nothing in the ways in which Tony Fauci has been targeted that is based upon truth. How could we then accept those cries for his firing as having legitimacy? It's a circular argument. They've decided they don't like Tony, so they make up stuff and they twist comments that he's made about things like gain of function, where he's referring to the very specific gain of function that's covered by this policy.

• 28:47Speaker 01

  And they're trying to say, "He lied to the Congress." That's simply not true. They don't like the fact that Tony changes the medical recommendations about what to do with COVID-19 over the space of more than a year. And they call that flip-flopping, and you can't trust the guy because he says one thing last year and one thing this year. Well, the science has changed. Delta variant has changed everything. You don't want him to be saying the same thing he did a year ago. That would be wrong now. It was the best we could do then. People don't understand that, or else they don't want to understand that. So when you basically whip up a largely political argument against a scientist and hammer at it over and over again, to the point where he now has to have 24/7 security to protect

• 29:32Speaker 01

  him against people who really want to do violence to him, for that to be a reason to say that then he should be fired is to hand the evil forces the victory. I will not do that.

• 29:47Lex Fridman?

  Yet there's something difficult I'm going to try to express to you. So it may be your guitar playing. It may be something else, but there's a humility to you. It may be because you're a man of God. There's a humility to you that garners trust. And when you're in a leadership position representing science, especially in catastrophic events like the pandemic, it feels like as a leader, you have to go far above and beyond your usual duties. And I think there's no question that Anthony Fauci has delivered on his duties.

• 30:32Lex Fridman?

  But it feels like he needs to go above as a science communicator. And if there's a large number of people that are distrusting him, it's also his responsibility to garner their trust, to gain their trust. As a person who's the face of science, are you torn on this? The responsibility of Anthony Fauci, of yourself, to represent science, not just the communication of advising what should be done, but giving people hope, giving people trust in science and alleviating division. Do you think that's also a responsibility of a leader? Or is that unfair to ask?

• 31:16Speaker 01

  I think the best way you give people trust is to tell them the truth. And so they recognize that when you're sharing information, it's the best you've got at that point. And Tony Fauci does that at every moment. I don't think him expressing more humility would change the fact that they're looking for a target of somebody to blame, to basically distract people from the failings of their own political party. Maybe I'm less targeted, not because of the difference in the way in which I convey the information, I'm less visible. If Tony were out of the scene and I was placed in that role, I'd probably be seeing, ratcheting up that same targeting.

• 32:00Lex Fridman?

  I would like to believe that if Tony Fauci said that when I originally made recommendations not to wear masks, that was given on our best available data, and now we know that is a mistake. So, admit with humility that there's an error. That's not, that's not actually correct, but that's a, that's a statement of humility. And I would like to believe, despite the attacks, he would win a lot of people over with that. So, a lot of people, as you're saying, would use that, see, that, here we go, here's that Dr. Anthony Fauci making mistakes, how can we trust him on anything?

• 32:42Lex Fridman?

  I believe if he was, that public display of humility to say that I made an error, that would win a lot of people over. That's my, that's kind of my sense. To face the fire of the attacks from politics, you have, like, politicians will attack no matter what. But the question is the people. To win over the people. The biggest concern I've had is that there is this, this trust of science that's been brewing. And I'm, maybe you can correct me, but I'm a little bit unwilling to fully blame the politicians. Because politicians play their games no matter what.

• 33:25Lex Fridman?

  It just feels like this was an opportunity to inspire people with the power of science. The development of the vaccines, no matter what you think of those vaccines, is one of the greatest accomplishments in the history of science.

• 33:38Speaker 01

  It is indeed.

• 33:39Lex Fridman?

  And the fact that that's not inspiring, listen, I host a podcast. Whenever I say positive stuff about the vaccine, I get to hear a lot of different opinions.

• 33:49Speaker 01

  I bet you do.

• 33:50Lex Fridman?

  The fact that I do is a big problem to me, because it's an incredible, an incredible accomplishment of science. And so, I, I, I'm sorry, but I have to put responsibility on the leaders, even if it's not their mistakes. That's what the leadership is. That's what leadership is. You take responsibility for the situation. I wonder if there's something that could have been done better to give people hope that science will save us as opposed to science will divide us.

• 34:26Speaker 01

  I think you have more confidence in the ability to get beyond our current divisions than I do after seeing just how deep and dark they have become. Tony Fauci has said multiple times, the recommendation about not wearing masks was for two reasons, a shortage of masks which were needed in hospitals, and a lack of realization early in the course of the epidemic that this was a virus that could heavily infect asymptomatic people. Has that changed? He changed. Now, did he make an error? No, he was making a judgment based on the data available at the time, but he certainly made that clear over and over again.

• 35:10Speaker 01

  It has not stopped those who would like to demonize him from saying, "Well, he just flip-flopped. You can't trust a guy. He says one thing today and one thing tomorrow."

• 35:20Lex Fridman?

  Well, masks is a tricky one, so I'm actually...

• 35:24Speaker 01

  It is a tricky one.

• 35:25Lex Fridman?

  Early on, I'm a co-author on a paper, one of many, but this was a survey paper overlooking the evidence. It's a summary of the evidence we have for the effectiveness of masks. It seems that it's difficult to do rigorous scientific study on masks.

• 35:43Speaker 01

  It is difficult.

• 35:44Lex Fridman?

  There's a lot of philosophical and ethical questions I want to ask you, but within this, it's back to your words and Anthony Fauci's words. When you're dealing with so much uncertainty and so much potential... Uncertainty about how catastrophic this virus is in the early days, and knowing that each word you say may create panic, how do you communicate science with the world?

• 36:16Lex Fridman?

  It's a philosophical, it's an ethical, it's a practical question. There was a discussion about masks a century ago, and that too led to panic. So, I mean, I'm trying to put myself in the mind, in your mind, in the mind of Anthony Fauci in those early days, knowing that there's limited supply of masks. Like, what do you say? Do you fully convey the uncertainty of the situation, of the challenges of the supply chain? Or do you say that masks don't work? That's a complicated calculation. How do you make that calculation?

• 36:58Speaker 01

  It is a complicated calculation. As a scientist, your temptation would be to give a full brain dump of all the details of the information about what's known and what isn't known, and what experiments need to be done. Most of the time, that's not going to play well in a soundbite on the evening news. So you have to kind of distill it down to a recommendation that is the best you can do at that time with the information you've got.

• 37:26Lex Fridman?

  So you're a man of God, and we'll return to that to talk about some also unanswerable philosophical questions. But first, let's linger on the vaccine, because in the religious, in the Christian community, there was some hesitancy with the vaccine.

• 37:44Speaker 01

  Still is.

• 37:45Lex Fridman?

  Still is. There's a lot of data showing high efficacy and safety of vaccines, of COVID vaccines, but still, they are far from perfect, as all vaccines are. Can you empathize with people who are hesitant to take the COVID vaccine or to have their children take the COVID vaccine?

• 38:04Speaker 01

  I can totally empathize, especially when people are barraged by conflicting information coming at them from all kinds of directions.

• 38:14Speaker 01

  I've spent a lot of my time in the last year trying to figure out how to do a better job of listening, because I think we have all got the risk of assuming we know the basis for somebody's hesitancy, and that often doesn't turn out to be what you thought. And the variety of reasons is quite broad. I think a big concern is just this sense of uncertainty about whether this was done too fast, and that corners were cut. And there are good answers to that. Along with that, a sense that maybe this vaccine will have long-term effects that we won't know about for years to come. And one can say,

• 38:59Speaker 01

  that hasn't been seen with other vaccines, and there's no particular reason to think this one's going to be different than the dozens of others that we have experience with. But you can't absolutely say, no, there's no chance of that. So it does come down to listening, and then trying in a fashion that doesn't convey a message that you're smarter than the person you're talking to, because that isn't going to help, to really address what the substance is of the concerns. But my heart goes out to so many people who are fearful about this because of all the information that has been dumped on them, some of it

• 39:41Speaker 01

  by politicians, a lot of it by the internet, some of it by parts of the media that seem to take pleasure in stirring up this kind of fear for their own reasons. And that is shameful. I'm really sympathetic with the people who are confused and fearful. I am not sympathetic with people who are distributing information that's demonstrably false and continue to do so. They're taking lives. I didn't realize how strong that sector of disinformation that would be. And it's been, in many ways, more effective than the means of spreading the truth.

• 40:25Speaker 01

  This is gonna take us into another place, but Lex, if there's something I'm really worried about in this country, and it's not just this country, but it's the one I live in, is that we have another epidemic besides COVID-19, and it's an epidemic of the loss of the anchor of truth. That truth as a means of making decisions, truth as a means of figuring out how to wrestle with a question like, should I get this vaccine for myself or my children, seems to have lost its primacy. And instead, it's an opinion of somebody who expressed it very strongly, or some Facebook

• 41:09Speaker 01

  post that I read two hours ago. And for those to become substitutes for objective truth, not just, of course, for vaccines, but for many other issues, like was the 2020 election actually fair? This worries me deeply. It's bad enough to have polarization and divisions, but to have no way of resolving those by actually saying, okay, what's true here, makes me very worried about the path we're on. And I'm usually an optimist.

• 41:44Lex Fridman?

  Well, to give you an optimistic angle on this, I actually think that the sense that there's no one place for truth is just a thing that will inspire leaders and science communicators to speak not from a place of authority, but from a place of humility. I think it's just challenging people to communicate in a new way, to be listeners first. I think the problem isn't that there's a lot of misinformation. I think that...

• 42:19Lex Fridman?

  People, the internet and the world are distrustful of people who who speak as if they possess the truth with an authoritarian kind of tone.

• 42:33Speaker 01

  Yeah.

• 42:33Lex Fridman?

  Which was, I think, defining for what science was in the 20th century. I just think it has to sound different in the 21st. With, it's a, in the battle of ideas, I think humility and love wins. And that's how science wins, not through having quote unquote, "truth." Because now, everybody can just say, "I have the truth." I think you have to speak, like I said, from humility, not authority. And so it just challenges our leaders to go back and learn to be, pardon my French, less assholes and more kind. And, like you said, to listen, to listen to the experiences of people that are good

• 43:16Lex Fridman?

  people, not the ones who are trying to manipulate the system or play a game and so on. But real, you know, real people who are just afraid of uncertainty, of hurting those they loved, and so on. So I think it's just an opportunity for leaders to go back and take a class in effective communication.

• 43:33Speaker 01

  I'm with you on shifting more from where we are to humility and love. That's got to be the right answer. That's very biblical, by the way.

• 43:42Lex Fridman?

  We'll get there. I have to bring up Joe Rogan. I don't know if you know who he is.

• 43:49Speaker 01

  I do.

• 43:50Lex Fridman?

  He's a podcaster, comedian, fighting commentator, and my now friend.

• 43:55Speaker 01

  And ivermectin believer, too.

• 43:58Lex Fridman?

  Yes, that is the question I have to ask you about. He has gotten some flak in the mainstream media for not getting vaccinated. And when he got COVID recently, taking ivermectin as part of a cocktail of treatments. The NIH actually has a nice page on ivermectin, saying, quote, "There's insufficient evidence to recommend either for or against the use of ivermectin for the treatment of COVID-19. Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide more specific evidence-based guidance on the role of ivermectin in the treatment of COVID-19."

• 44:38Lex Fridman?

  So let me ask, why do you think there has been so much attack on Joe Rogan and anyone else that's talking about ivermectin when there's insufficient evidence for or against?

• 44:49Speaker 01

  Well, let's unpack that. First of all, I think the concerns about Joe are not limited to his taking ivermectin. Much more seriously, his being fairly publicly negative about vaccines at a time where people are dying. 700,000 people have died from COVID-19. Estimates by Kaiser are at least 100,000 of those were unnecessary deaths of unvaccinated people. And for Joe to promote that further, even as this pandemic rages through our population, is simply irresponsible. So yeah, the ivermectin is just one other twist. Obviously, ivermectin has been controversial for months and months.

• 45:34Speaker 01

  The reason that it got particular attention is because of the way in which it seemed to have captured the imagination of a lot of people and to the point where they were taking doses that were intended for livestock. And some of them got pretty sick as a result from overdosing on this stuff. That was not good judgment. The drug itself remains uncertain. There's a recent review that looks at all of the studies of ivermectin and basically concludes that it probably doesn't work. We are running a study right now. I looked at that data this morning in a trial called ACTIVE6, which is one of the ones that my public-private partnership is running.

• 46:16Speaker 01

  We're up to about 400 patients who've been randomized to ivermectin or placebo and should know, perhaps as soon as a month from now, in a very carefully controlled trial, did it help or did it not? So there will be an answer. Coming back to Joe, again, I don't think the fact that he took the ivermectin hoping it might work is that big a knock against him. It's more the conveying of, we don't trust what science says, which is vaccines are going to save your life. We're going to trust what's on the internet that says ivermectin and hydroxychloroquine really do work, even though the scientific community says probably not.

• 46:54Lex Fridman?

  So let me push back on that a little bit. So he doesn't, he doesn't say, let's not listen to science. He doesn't say the vaccine, don't get vaccinated.

• 47:05Lex Fridman?

  He says it's okay to ask questions.

• 47:09Speaker 01

  I'm okay with that.

• 47:10Lex Fridman?

  How risky is the vaccine for certain populations? What are the benefits and risks? There's other friends of Joe and friends of mine like Sam Harris, who says, if you look at the data, it's obvious that the benefits outweigh the risks. And what Joe says is, yes, but let's still openly talk about risks. And he often brings up anecdotal evidence of people who've had

• 47:40Lex Fridman?

  highly negative effects from vaccines. Science is not done with anecdotal evidence. And so you could infer a lot of stuff from the way he expresses it. But he also communicates a lot of interesting questions. And that's something maybe you can comment on is, you know, there's certain groups that are healthy. They have, they're younger, they have, they exercise a lot, they get the, you know, nutrition, all those kinds of things. He shows skepticism on whether it's so obvious that they should get vaccinated. And the same is, he makes this, he kind of presents the same kind of skepticism for kids, for young kids.

• 48:24Lex Fridman?

  So with empathy and, you know, listening, my Russian eloquent description of what Joe believes, what, what is your kind of response to that? Why should certain categories of healthy and young people still get vaccinated, do you think?

• 48:43Speaker 01

  Well, first, just to say, it's great for Joe to be a skeptic, to ask questions. We should all be doing that. But then the next step is to go and see what the data says and see if there are actually answers to those questions. So coming to healthy people, I've done a bunch of podcasts besides this one. The one I think I remember most was a podcast with a worldwide wrestling superstar.

• 49:08Lex Fridman?

  Very nice.

• 49:09Speaker 01

  He's about six foot six and just absolutely solid muscle. And he got COVID.

• 49:16Speaker 01

  And he almost died. And recovering from that, he said, I've got to let my supporters know, because you can imagine worldwide wrestling fans are probably not big embracers of the need for vaccines. And he want, he just turned himself into a spokesperson for the fact that this virus doesn't care how healthy you are, how much you exercise, what a great specimen you are. It wiped him out. And we see that. You know, the average person in the ICU right now with COVID-19 is under age 50. I think there's a lot of people still thinking, oh, it's just those old people in the nursing homes, it's not going to be about me. They're wrong.

• 50:01Speaker 01

  And there are plenty of instances of people who were totally healthy with no underlying diseases, taking good care of themselves, not obese, exercising, who have died from this disease. 700 children have died from this disease. Yes, some of them had underlying factors like obesity, but a lot of them did not. So it's fair to say, younger people are less susceptible to serious illness, kids even less so than young adults, but it ain't zero. And if the vaccine is really safe and really effective, then you probably want everybody to take advantage of that, even though some are dropping their risks more than others,

• 50:46Speaker 01

  everybody's dropping their risks some.

• 50:48Lex Fridman?

  Are you worried about variants? So looking out into the future, are you, what's your vision for all the possible trajectories that this virus takes in human society?

• 51:00Speaker 01

  I'm totally worried about the variants. Delta was such an impressive arrival on the scene in all the wrong ways. I mean, it took over. The world.

• 51:12Lex Fridman?

  Yeah.

• 51:12Speaker 01

  In the space of just a couple of months because of its extremely contagious ability.

• 51:18Lex Fridman?

  Viruses would be beautiful if they weren't terrifying.

• 51:20Speaker 01

  Yeah, exactly. I mean, this whole story of viral evolution scientifically is just amazingly elegant. Anybody who really wanted to understand how evolution works in real time, study SARS-CoV-2. Because it's not just Delta, it's Alpha, and it's Beta, and it's Gamma, and it's the fact that these sweep through the world's population by fairly minor differences in fitness. So the real question many people are wrestling is, is Delta it? Is it such a fit virus that nothing else will be able to displace it? I don't know. I mean, there's now Delta AY4,

• 52:00Speaker 01

  which is a variant of Delta that at least in the UK seems to be taking over the Delta population as though it's maybe even a little more contagious? That might be the first hint that we're seeing something new here. It's not a completely different virus. It's still Delta, but it's Delta plus.

• 52:21Speaker 01

  You know, the big worry, Lex, is what's out there that is so different? That the vaccine protection doesn't work?

• 52:33Lex Fridman?

  And we don't know how different it needs to be for the vaccine to start working. That's the terrifying thing about each of these variants. It's like, it's always a pleasant surprise that the vaccine seems to still have efficacy.

• 52:46Speaker 01

  And hooray for our immune system, may I say? Because the vaccine immunized you against that original Wuhan virus.

• 52:56Speaker 01

  Now we can see that especially after two doses and even more so after a booster, your immune system is so clever that it's also making a diversity of antibodies to cover some other things that might happen to that virus to make it a little different. And you're still getting really good coverage. Even for Beta, which was South Africa, B1351, which is the most different, it looks pretty good. But that doesn't mean it will always be as good as that if something gets really far away from the original virus. Now, the good news is we would know what to do in that situation. The mRNA vaccines allow you.

• 53:38Speaker 01

  To redesign the vaccine like that and to quickly get it through a few thousand participants in a clinical trial to be sure it's raising antibodies and then bang, you could go. But I don't want to have to do that. There will be people's lives at risk in the meantime. And what's the best way to keep that from happening? Well, try to cut down the number of infections because you don't get variants unless the virus is replicating in a person.

• 54:03Lex Fridman?

  So how do we solve this thing? How do we get out of this pandemic? What's like if you had a like a wand or something or you could really implement policies? What's the full cocktail of solutions here?

• 54:18Speaker 01

  It's a full cocktail. It's not just one thing. In our own country here in the US, it would be getting those 64 million reluctant people to actually go ahead and get vaccinated.

• 54:28Lex Fridman?

  There's 64 million people who didn't get vaccinated?

• 54:30Speaker 01

  Adults, yes. Not even counting the kids. 64 million. Isn't that astounding? Get the kids vaccinated. Hopefully their parents will see that as a good thing, too. Get those of us who are due for boosters boosted because that's going to reduce our likelihood of having breakthrough infections and keep spreading it. Convince people that until we're really done with this, and we're not now, that social distancing and mask wearing indoors are still critical to cut down the number of new infections. But of course, that's our country. This is a worldwide pandemic. I worry greatly about the fact that low and middle income countries have, for the most part, not even gotten started

• 55:13Speaker 01

  with access to vaccines. And we have to figure out a way to speed that up because otherwise that's where the next variant will probably arrive. And who knows how bad it will be? And it will cross the world quickly, as we've seen happen repeatedly in the last 22 months.

• 55:31Lex Fridman?

  I think I'm really surprised, annoyed, frustrated that testing, rapid at-home testing from the very beginning wasn't a big, big part of the solution. It seems, first of all, nobody's against it. That's one huge plus for testing, that everybody supports. Second of all, like, that's what America is good at, is like mass manufacturer stuff, like stepping up, engineer stepping up and really deploying it. Plus, without the collection of data, is giving people freedom, is giving them information and then freedom to decide what to do with that information. It's such a powerful solution. I don't understand, well, now, I think the Biden administration is, I think, emphasized

• 56:15Lex Fridman?

  like the scaling of testing manufacturers, so, but I just feel like it's an obvious solution. Get a test that's costs less than a dollar to manufacture, costs less than a dollar to buy, and just everybody gets tested every single day. Don't share that data with anyone, you just make the decisions. And I believe in the intelligence of people to make the right decision to stay at home when the test is positive.

• 56:36Speaker 01

  I am so completely with you on that. And NIH has been smack in the middle of trying to make that dream come true. We're running a trial right now in Georgia, Indiana, Hawaii, and where's the other one? Oh, Kentucky. Basically blanketing a community with free testing.

• 56:58Lex Fridman?

  That is beautiful.

• 56:59Speaker 01

  And look to see what happens as far as stemming the spread of the epidemic and measuring it by wastewater, because you can really tell whether you've cut back the amount of infection in the community. Yeah, I'm so with you. We got off to such a bad start with testing. And of course, all the testing was being done for the first several months in big-box laboratories, where you had to send the sample off and put it through the mail somehow and get the result back sometimes five days later after you've already infected a dozen people. It was just a completely wrong model, but it's what we had, and everybody was like, oh, we got to stick with PCR, because if you start using those home tests that are based on antigens lateral flow, probably there's going to be false positives and false negatives.

• 57:43Speaker 01

  Okay, sure, no test is perfect, but... Having a test is not acceptable or accessible is the worst setting. So we NIH with some requests from Congress got a billion dollars to create this program called Rapid Acceleration of Diagnostics, RAD-X. And we turned into a venture capital organization and we invited every small business or academic lab that had a cool idea about how to do home testing to bring it forward. And we threw them into what we called our shark tank of business experts, engineers, technology people. People understood how to deal with supply chains and manufacturing. And right now, today, there are about 2 million tests being done based on what came out of

• 58:28Speaker 01

  that program, including most of the home tests that you can now buy on the pharmacy shelves. We did that and I wish we had done it faster, but it was an amazingly speedy effort. And you're right, companies are really good. Once they've got an FDA emergency use authorization, and we helped a lot of them get that, they can scale up their manufacturing. I think in December, we should have about 410 million tests for that month, ready to go. And if we can get one or two more platforms approved, and by the way, we are now helping FDA by being their validation lab, if we can get a couple more of these approved, we could be in the half a billion tests a month, which is really getting where we need to be.

• 59:13Lex Fridman?

  Wow, yeah, that's a dream. That's a dream for me. It seems like an obvious solution, engineering solution, everybody's behind it, at least the hope versus division. I love it. Okay.

• 59:23Speaker 01

  A happy story.

• 59:26Lex Fridman?

  A happy story.

• 59:27Speaker 01

  I was waiting for one.

• 59:28Lex Fridman?

  Yeah, all right. Well, one last dive into the not happy, but you won't even have to comment on it. Well, comment on the broader philosophical question. So NIH, again, I said, Joe Rogan is the first one who pointed me to this. NIH was recently accused of funding research of a paper that had images of sedated puppies with their heads inserted into small enclosures containing disease-carrying sandflies. So I could just say that this, this story is not true, or at least the...

• 1:00:02Lex Fridman?

  I think it is true that the paper that showed those images cited NIH as a funding source, but that citation is not correct.

• 1:00:10Speaker 01

  That was not correct.

• 1:00:11Lex Fridman?

  Yeah. But that brings up a bigger philosophical question, that it could have been correct. How difficult is it as a director of NIH or just NIH as an organization that's funding so many amazing, deep research studies to ensure the ethical fortitude of those studies when the ethics of science is, there's such a gray area between what is and what isn't ethical?

• 1:00:39Speaker 01

  Well, tough issues. Certainly, animal research is a tough issue.

• 1:00:44Lex Fridman?

  I was going to bring up, it's a good example of that tough issue, is in 2015, you announced that NIH would no longer support any biomedical research involving chimpanzees.

• 1:00:56Speaker 01

  That's right.

• 1:00:57Lex Fridman?

  So that's like one example of looking in the mirror, thinking deeply about what is and isn't ethical, and there was a conclusion that biomedical research on chimps is not ethical.

• 1:01:10Speaker 01

  That was the conclusion. That was based on a lot of deep thinking and a lot of input from people who have considered this issue and a panel of the National Academy of Sciences that was asked to review the issue. I mean, the question that I wanted them to look at was, are we actually learning anything that's really essential from chimpanzee and basic research at this point? Or is it time to say that these closest relatives of ours should not be subjected to that any further and ought to be retired to a sanctuary? And that was the conclusion, that there was really no kind of medical experimentation that needed to be done on chimps in order to proceed. So why are we still doing this?

• 1:01:55Speaker 01

  Many of these were chimpanzees that were purchased because we thought they would be good hosts for HIV/AIDS, and they sort of weren't. And they were kept around in these primate laboratories with people coming up with other things to do, but they weren't compelling scientifically. So I think that was the right decision. I took a lot of flak from some of the scientific community, said, "Well, you're caving in to the animal rights people. And now that you've said no more research on chimps, what's next?"

• 1:02:27Speaker 01

  Certainly, when it comes to companion animals, everybody's heart starts to be hurting when you see anything done that seems harmful to a dog or a cat. I have a cat, I don't have a dog. And I understand that completely. That's why we have these oversight groups that decide before you do any of that kind of research, is it justified? And what kind of provision is going to be made to avoid pain and suffering? And those are, those have input from the public as well as the scientific community. Is that completely saying that every step that's happening there is ethical by some

• 1:03:12Speaker 01

  standard that would be hard for anybody to agree to? No, but at least it's a consensus of what people think is acceptable. Dogs are the only host for some diseases like leishmaniasis, which was that paper that we were not responsible for, but I know why they were doing the experiment, or like lymphatic filariasis, which is an experiment that we are supporting in Georgia that involves dogs getting infected with a parasite, because that's the only model we have to know whether a treatment is going to work or not. So I will defend that. I am not in the place of those who think all animal research is evil, because I think if there's something that's going to be done to save a child from

• 1:03:56Speaker 01

  a terrible disease, or an adult, and it involves animal research that's been carefully reviewed, then I think ethically, while it doesn't make me comfortable, it still seems like it's the right choice. I think to say all animal research should be taken off the table is also very unethical, because that means you have basically doomed a lot of people for whom that research might have saved their lives to having no more hope.

• 1:04:23Lex Fridman?

  And to me personally, there's far greater concerns ethically in terms of factory farming, for example, the treatment of animals in other contexts.

• 1:04:31Speaker 01

  Oh, there's so much that goes on outside of medical research that is much more troubling.

• 1:04:38Lex Fridman?

  That said, I think all cats have to go. That's just my off the record opinion. That's why I'm not involved with any ethical decisions. I'm just joking, Internet ethic. I love cats.

• 1:04:47Speaker 01

  You're a dog person.

• 1:04:48Lex Fridman?

  I'm a dog person, I'm sorry.

• 1:04:50Speaker 01

  Have you seen that New Yorker cartoon where there are two dogs in the bar having a martini? And one is saying that they're dressed up in their business suits and one says to the other, "You know, it's not enough for the dogs to win. The cats have to lose."

• 1:05:05Lex Fridman?

  Uh, that's beautiful. So, a few weeks ago, you've announced that you're resigning from the NIH at the end of the year.

• 1:05:14Speaker 01

  I'm stepping down. I'm still gonna, still gonna be at NIH in a different capacity.

• 1:05:19Lex Fridman?

  Different capacity, right. And it's over a decade of an incredible career overseeing the NIH as its director. What are the things you're most proud of, of the NIH in your time here as its director? Maybe memorable moments?

• 1:05:38Speaker 01

  Uh, there's a lot. In 12 years, science has just progressed in amazing ways over those 12 years.

• 1:05:48Speaker 01

  Uh, think about where we are right now. Something like gene editing, being able to make changes in DNA even for therapeutic purposes, which is now curing sickle cell disease. Unthinkable when I became director in 2009. The ability to study single cells and ask them what they're doing and get an answer. Single cell biology just has emerged in this incredibly powerful way. Uh, having the courage to be able to say, "We could actually understand the human brain", seemed like so far out there and we're in the process of doing that with the Brain Initiative. Uh, taking all that we've learned about the genome and applying it to cancer,

• 1:06:34Speaker 01

  to make individual cancer treatment really precision, and developing cancer immunotherapy, which seemed like sort of a backwater into some of the hottest science around.

• 1:06:46Speaker 01

  All those things sort of erupting and much more to come, I'm sure. We're on an exponential curve of medical research advances and that's glorious to watch. And of course, COVID-19 as a beneficiary of decades of basic science, understanding what mRNA is, understanding basics about coronaviruses and spike proteins and how to combine structural biology and immunology and genomics into this package that allows you to make a vaccine in 11 months. Just, I would never have imagined that possible in 2009. So to have been able to kind of be the midwife, helping all of those things get birthed, that's been just an amazing 12 years.

• 1:07:27Speaker 01

  And as NIH director, you have this convening power and this ability to look across the whole landscape of biomedical research and identify areas that are just like ready for something big to happen, but it isn't going to happen spontaneously without some encouragement, without pulling people together from different disciplines who don't know each other and maybe don't know how to quite understand each other's scientific language and create an environment for that to happen. That has been just an amazing experience. I mean, I mentioned the Brain Initiative as one of those. The Brain Initiative right now, I think there was about 600 investigators working on this. Last week, the whole issue of Nature magazine was about the output of the Brain Initiative

• 1:08:11Speaker 01

  basically now giving us a cell census of what those cells in the brain are doing, which has just never been imaginable. And interestingly, most, more than half of the investigators in the Brain Initiative are engineers. They're not biologists in a traditional sense. I love that, maybe partly because my PhD is in quantum mechanics. So I think it's really a good idea to bring disciplines together and see what happens. That's an exciting thing and I will not ever forget having the chance to announce that program in the East Room of that White House with President Obama, who totally got it

• 1:08:52Speaker 01

  and totally loved science and working with him in some of those rare moments of sort of one-on-one conversation in the old office, just him and me about science, that's a gift.

• 1:09:03Lex Fridman?

  What's it like talking to Barack Obama about science? He seems to be a sponge. I've heard him, I'm an artificial intelligence person and I've heard him talk about AI. And it was like, it made me think of somebody like whispering in his ear or something, because he was saying stuff that totally passed the BS test, like he really understands stuff.

• 1:09:24Speaker 01

  He does.

• 1:09:25Lex Fridman?

  That means he listened to a bunch of experts on AI. He was like explaining the difference between narrow artificial intelligence and strong AI. Like he was, he was saying all this, both technical and philosophical stuff. And it just made me, I don't know, it made me hopeful about the depth of understanding that a human being in political office can attain.

• 1:09:44Speaker 01

  That gave me hope as well, and having those experiences. Oftentimes in a group, I mean, another example was trying to figure out, how do we take what we've learned about the genome and really apply it at scale to figure out how to prevent illness, not just treat it, but prevent it? Out of which came this program called All of Us, this million-strong American cohort of participants who make their electronic health records and their genome sequences and everything else available for researchers to look at. That came out of a couple of conversations with Obama and others in his office. And he asked the best questions. That was what struck me so much.

• 1:10:26Speaker 01

  I mean, a room full of scientists, and we'd be talking about the possible approaches, and he would come up with this incredibly insightful, penetrating question. Not that he knew what the answer was going to be, but he knew what the right question was.

• 1:10:39Lex Fridman?

  I think the core to that is curiosity.

• 1:10:42Speaker 01

  Yeah.

• 1:10:43Lex Fridman?

  It's, I don't think he's even like, he's trying to be a good leader. He's legit curious.

• 1:10:47Speaker 01

  Yes. Legit.

• 1:10:49Lex Fridman?

  That he, almost like a kid in a candy store gets to talk to the world experts. He got, he somehow sneaked into this office and gets to talk to the world experts. And it's, that, that's the kind of energy that I think leads to, uh, to beautiful leadership in the space of science.

• 1:11:05Speaker 01

  Indeed. Another thing I've been able to do as director is to try to break down some of the boundaries that seem to be traditional between the public and the private sectors. When it comes to areas of science that really could and should be open access anyway, why don't we work together? And that was obvious early on. And after identifying a few possible collaborators who are chief scientists of pharmaceutical companies, it looked as like we might be able to do something in that space. Out of that was born something called the Accelerating Medicines Partnership, AMP. And it took a couple of years of convening people who usually didn't talk to each other.

• 1:11:47Speaker 01

  And there was a lot of suspicion, academic scientists saying, oh, those scientists in pharma, they're not that smart. They're just trying to make money. And the academic scientists getting the rap from the pharmaceutical scientists, all they want to do is publish papers. They don't really care about helping anybody. And we found out both of those stereotypes were wrong. And over the course of that couple of years, built a momentum behind three starting projects, one on Alzheimer's, one on diabetes, one on rheumatoid arthritis and lupus. Very different, each one of them, trying to identify what is an area that we both really need to see advance and we could do better together. And it's going to have to be open access, otherwise NIH is not going to play.

• 1:12:29Speaker 01

  And guess what, industry? If you really want to do this, you've got to have skin in the game. We'll cover half the cost. You've got to cover the other half.

• 1:12:36Lex Fridman?

  I love it. Enforcing open access, so resulting in open science.

• 1:12:41Speaker 01

  Millions of dollars gone into this. And it has been a wild success. After many people were skeptical, a couple of years later, we had another project on Parkinson's. More recently, we added one on schizophrenia. Just this week, we added one on gene therapy, on bespoke gene therapy for ultra rare diseases, which otherwise aren't going to have enough commercial appeal. But if we did this together, especially with FDA at the table, and they have been, we could make something happen, turn this into a sort of standardized approach where everything didn't have to be a one-off. I'm really excited about that. So what began as three projects is six, and it's about to be seven next year with a heart failure project.

• 1:13:26Speaker 01

  And all of us have gotten to know each other. And if it weren't for that background, when COVID came along, it would have been a lot harder to build the partnership called Active, which has been my passion for the last 20 months, accelerating COVID-19 therapeutic interventions and vaccines. We just had our leadership team meeting this morning. It was amazing what's been accomplished. That's pretty much 100 people who dropped everything just to work on this, about half from industry and half from government and academia. And that's how we got vaccine master protocols designed. So we all agreed about what the endpoints had to be. And you wondered, why are there 30,000 participants in each of these trials?

• 1:14:09Speaker 01

  It's because of Actives group mapping out what the power needed to be for this to be convincing. Same with therapeutics. We have run at least 20 therapeutic agents through trials that Actives supported in record time. That's how we got monoclonal antibodies that we know work. That's been, that would not have been possible if I didn't already have a sense of how to work with the private sector that came out of AMP. AMP took two years to get started. Actives took two weeks. We just kept the lawyers.

• 1:14:46Lex Fridman?

  Get 100 people over.

• 1:14:47Speaker 01

  Yeah, kept the lawyers out of the room.

• 1:14:49Lex Fridman?

  Now you're going to get yourself in trouble. So I do hope one day the story of this incredible vaccine, development of vaccine protocols and trials and all this kind of details, the messy, beautiful details of science and engineering and that led to the manufacturing, the deployment and the scientific test. It's such a nice dance between engineering and the space of manufacture of the vaccines. You know, you start before the studies are complete, you start making the vaccines just in case if the studies prove to be positive, then you can start deploying them, just like so many parties, like you said, private and public playing together.

• 1:15:31Lex Fridman?

  That's just a beautiful dance that is one of the, is one of, for me, the sources of hope in this very tricky time where there's a lot of things to be cynical about in terms of the games politicians play and the hardship experience of the economy and all those kinds of things. But to me, this dance was of vaccine development was done just beautifully and it gives me hope.

• 1:15:58Speaker 01

  It does me as well. And it was in many ways the finest hour that science has had in a long time, being called upon when every day counted and making sure that time was not wasted and things were done rigorously, but quickly.

• 1:16:17Lex Fridman?

  So you're incredibly good as a leader of the NIH. It seems like you're having a heck of a lot of fun. Why, uh, why step down from this role after so much fun?

• 1:16:28Speaker 01

  Well, no other NIH director has served more than one president after being appointed by one. You're sort of done and the idea of being carried over for a second presidency with Trump, and now a third one with Biden is unheard of. I just think, Lex, that scientific organizations benefit from new vision. And 12 years is a really long time to have the same leader. And if I wasn't going to stick it out for the entire Biden four-year term, it's good not to wait too late during that to signal an intent to step down because the president's got to find the right person, got to nominate them, got to get the Senate to confirm them, which is an unpredictable process right now.

• 1:17:13Speaker 01

  And you don't want to try to do that in the second half of somebody's term as president. This has got to happen now. So I kind of decided back at the end of May that this should be my final year. And I'm okay with that. I do have some mixed emotions because I love the NIH. I love the job. It's exhausting. I'm traditionally, for the last 20 months anyway, working 100 hours a week. It's just, that's what it takes to juggle all of this. And that keeps me from having a lot of time for anything else. And I wouldn't mind, because I don't think I'm done yet. I wouldn't mind having some time to really think about what the next chapter should be. And I have none of that time right now.

• 1:17:59Speaker 01

  Do I have another calling? Is there something else I could contribute that's different than this? I'd like to find that out.

• 1:18:08Lex Fridman?

  I think the right answer is you're just stepping down to focus on your music career. But

• 1:18:15Speaker 01

  That that might not be a good plan for anything very sustainable.

• 1:18:19Lex Fridman?

  But I think that is a sign of a great leader, as George Washington did stepping down at the right time.

• 1:18:25Speaker 01

  Ted Williams.

• 1:18:27Lex Fridman?

  Yes.

• 1:18:28Speaker 01

  Quit when I think he hit a home run on his last at bat and his average was 400 at the time.

• 1:18:35Lex Fridman?

  No one to walk away. I mean, it's hard, but it's beautiful to see in a leader. You also oversaw the Human Genome Project. You may you mentioned the Brain Initiative, which has, you know, it's a it's a dream to map the human brain. And there's the dream to map the the human code, which was the Human Genome Project. And you've said that it is humbling for me and awe inspiring to realize that we have caught the first glimpse of our own instruction book, previously known only to God. How does that, if you can just kind of wax poetic for a second, how does it make you feel that we were able to map

• 1:19:17Lex Fridman?

  this instruction book, look into our own code and be able to reverse engineer it?

• 1:19:24Speaker 01

  It's breathtaking. It's so fundamental. And yet, for all of human history, we're ignorant of the details of what that instruction book looked like. And then we crossed a bridge into the territory of the known. And we had that in front of us, still written in a language that we had to learn how to read. And we're in the process of doing that and will be for decades to come. But we owned it. We had it. And it has such profound consequences. It's it's both a book about our history.

• 1:20:01Speaker 01

  It's a book of sort of the parts list of a human being, the genes that are in there and how they're regulated. And it's also a medical textbook that can teach us things that will provide answers to illnesses we don't understand and alleviate suffering and premature death. So it's a pretty amazing thing to contemplate. And it has utterly transformed the way we do science. And it is in the process of transforming the way we do medicine, although much of that still lies ahead. You know, while we were working on the Genome Project, it was sort of hard to get this sense of awaleness because it was just hard work. And you were getting, you know, another megabase.

• 1:20:46Speaker 01

  Okay, this is good. But when did you actually step back and say, we did it? It's the profoundness of that. I mean, there were two points, I guess. One was the announcement on that June 26, 2000, where the whole world heard, well, we don't quite have it, but we got a pretty good draft. And suddenly people were like realizing, oh, this is, this is a big deal. For me, it was more when we got the full analysis of it, published it in February 2001 in that issue of Nature paper that Eric Lander and Bob Waterston and I were the main authors. And we toiled over and tried to get as much insight as we could in there about what the meaning of all this was.

• 1:21:29Speaker 01

  But you also had the sense that we are such beginning readers here. We are still in kindergarten trying to make sense out of this three billion letter book. And we're going to be at this for generations to come.

• 1:21:42Lex Fridman?

  You are a man of faith, Christian, and you are a man of science. What is the role of religion and of science in society and in the individual human mind and heart like yours?

• 1:22:01Speaker 01

  Well, I was not a person of faith when I was growing up. I became a believer in my twenties. Influenced as a medical student by a recognition that I hadn't really thought through the issues of what's the meaning of life? Why are we all here? What happens when you die? Is there a God? Science is not so helpful in answering those questions. So I had to look around in other places and ultimately came to my own conclusion that atheism, which is where I had been, was the least supportable of the choices because it was the assertion of a universal negative, which scientists aren't supposed to do. And agnosticism

• 1:22:45Speaker 01

  came as an attractive option, but felt a little bit like a cop out. So I had to keep going, trying to figure out why do believers actually believe this stuff?

• 1:22:55Speaker 01

  And came to realize it was all pretty compelling that there's no proof. I can't prove to you or anybody else that God exists, but I can say it's pretty darn plausible.

• 1:23:05Speaker 01

  And ultimately, what kind of God is it caused me to search through various religions and see, well, what do, what do people think about that?

• 1:23:15Speaker 01

  And to my surprise, encountered the person of Jesus Christ as unique in every possible way and answering a lot of the questions I couldn't otherwise answer. And somewhat kicking and screaming, I became a Christian. Even though at the time, as a medical student already interested in genetics, people predicted my head would then explode because these were incompatible worldviews. They really have not been for me. I am so fortunate, I think, that in a given day, wrestling with an issue, it can have both the rigorous scientific component and it can have the spiritual component. Covid-19 is a great example.

• 1:24:01Speaker 01

  These vaccines are both an amazing scientific achievement and an answer to prayer.

• 1:24:08Speaker 01

  When I'm wrestling with vaccine hesitancy and trying to figure out what answers to come up with, I get so frustrated sometimes and I'm comforted by reassurances that God is aware of that. This is, I don't have to do this alone. So I know there are people like your friend Sam Harris, who feel differently. Sam wrote a rather famous op ed in the New York Times when I was nominated as the NIH director, saying, "This is a terrible mistake."

• 1:24:39Lex Fridman?

  Oh, no.

• 1:24:40Speaker 01

  You can't have, you can't have, you can't have somebody who believes in God running the NIH. He's just gonna completely ruin the place.

• 1:24:48Lex Fridman?

  Well, I have a testimonial. Christopher Hitchens, a devout atheist, if I could say so.

• 1:24:56Speaker 01

  Oh, yeah.

• 1:24:56Lex Fridman?

  Was a friend of yours and referred to you as, quote, "one of the greatest living Americans," and stated that you were one of the most devout believers he has ever met. He further stated that you were sequencing the genome of the cancer that would ultimately claim his life, and that your friendship, despite their differing opinions on religion, was an example of the greatest armed truce in modern times. What did you learn from Christopher Hitchens about life, or perhaps what is a fond memory you have of this man with whom you've disagreed, but who is also your friend?

• 1:25:30Speaker 01

  Yeah. I loved Hitch. I'm sorry he's gone. Iron sharpens iron. There's nothing better for trying to figure out where you are with your own situation and your own opinions, your own worldviews, than encountering somebody who's completely in another space and who's got the gift, as Hitch did, of challenging everything and doing so over a glass of scotch or two or three. Yeah, we got off to a rough start where in an interaction we had at a rather highbrow dinner, he was really deeply insulting of a question I was asking. But, you know, I was like, okay, that's fine. Let's, let's figure out how

• 1:26:14Speaker 01

  we could have a more civil conversation. And then I really learned to greatly admire his intellect and to find the jousting with him. And it wasn't all about faith, although it often was, was really inspiring and innovating, energizing.

• 1:26:32Speaker 01

  And then when he got cancer, I became sort of his ally, trying to help him find pathways through the various options and maybe helped him to stay around on this planet for an extra six months or so. And I have the warmest feelings of being in his apartment downtown, over a glass of wine, talking about whatever. Sometimes it was science, he was fascinated by science. Sometimes it was Thomas Jefferson. Sometimes it was faith. And I knew it would always be really interesting.

• 1:27:09Lex Fridman?

  So he's now gone.

• 1:27:11Speaker 01

  Yeah.

• 1:27:12Lex Fridman?

  Do you think about your own mortality? Are you afraid of death?

• 1:27:16Speaker 01

  I'm not afraid. I'm not looking forward to it. I don't want to rush it because I feel like I got some things I can still do here. But as a person of faith, I don't think I'm afraid. I'm 71. I know I don't have an infinite amount of time left. And I want to use the time I've got in some sort of way that matters. I'm not ready to become a full-time golfer. But I don't quite know what that is. I do feel that I've had a chance to do amazingly powerful things as far as experiences, and maybe God has something

• 1:27:55Speaker 01

  else in mind. I wrote this book 16 years ago, The Language of God, about science and faith, trying to explain how, from my perspective, these are compatible, these are in harmony, they're complementary, if you are careful about which kind of question you're asking. And to my surprise, a lot of people seemed to be interested in that. They were tired of hearing the extreme voices, like Dawkins at one end, and people like Ken Ham and Answers in Genesis on the other end, saying, if you trust science, you're going to hell. And they thought there must be a way that these things could get along. And that's what I tried

• 1:28:35Speaker 01

  to put forward. And then I started a foundation, BioLogos, which then I had to step away from to become NIH director, which has just flourished, maybe because I stepped away, I don't know. But it now has millions of people who come to that website, and they run amazing meetings. And I think a lot of people have really come to a sense that this is okay. I can love science, and I can love God, and that's not a bad thing. So maybe there's something more I can do in that space. Maybe that book is ready for a second edition.

• 1:29:05Lex Fridman?

  I think so. But when you look back, life is finite. What do you hope your legacy is?

• 1:29:13Speaker 01

  Hmm, I don't know. This whole legacy thing is a little bit hard to embrace. It feels a little self promoting, doesn't it? I sort of feel like in many ways, I went to my own funeral on October 5th, when I announced that I was stepping down and I got the most amazing responses from people, some of whom I knew really well, some of whom I didn't know at all, who were just telling me stories about something that I had contributed to that made a difference to them. And that was incredibly heartwarming and that's enough. You know, I don't want to build an edifice. I don't have a plan for a monument or a statue. God help us. I do feel like I've been incredibly fortunate.

• 1:29:55Speaker 01

  I've had the chance to play a role in things that were pretty profound from the Genome Project to NIH to COVID vaccines. And I ought to be plenty satisfied that I've had enough experiences here to feel pretty good about the way in which my life panned out.

• 1:30:16Lex Fridman?

  We did a bunch of difficult questions in this conversation. Let me ask the most difficult one.

• 1:30:22Lex Fridman?

  That perhaps is the reason you turn to God. What is the meaning of life?

• 1:30:31Lex Fridman?

  Have you figured it out yet?

• 1:30:32Speaker 01

  Expect me to put that into three sentences.

• 1:30:35Lex Fridman?

  We only have a couple of minutes. At least hurry up.

• 1:30:41Speaker 01

  Well, that's not a question I think science helps me with. So you're going to push me into the face zone, which is where I'd want to go with that. I think, well, what is the meaning? Why are we here? What are we put here to do?

• 1:30:54Speaker 01

  I do believe we're here for just a blink of an eye and that our existence somehow goes on beyond that in a way that I don't entirely understand despite efforts to do so. I think we are called upon in this blink of an eye to try to make the world a better place, to try to love people, to try to do a better job of our more altruistic instincts and less of our selfish instincts, to try to be what God calls us to be, people who are holy, not people who are driven by self indulgence. And sometimes I'm better at that

• 1:31:38Speaker 01

  than others. But I think that, for me as a Christian, is a pretty clear, I mean, it's to live out the Sermon on the Mount. Once I read that, I couldn't unread it. All those beatitudes, all the blessings. That's what we're supposed to do. And the meaning of life is to strive for that standard, recognizing you're going to fail over and over again, and that God forgives you.

• 1:32:08Lex Fridman?

  Hopefully to put a little bit of love out there into the world.

• 1:32:11Speaker 01

  That's what it's about.

• 1:32:13Lex Fridman?

  Francis, I'm truly humbled and inspired by both your brilliance and your humility, and that you would spend your extremely valuable time with me today. It was really an honor. Thank you so much for talking today.

• 1:32:27Speaker 01

  I was glad to, and you asked a really good question. So your reputation as the best podcaster has borne itself out here this afternoon.

• 1:32:36Lex Fridman?

  Thank you so much. Thanks for listening to this conversation with Francis Collins. To support this podcast, please check out our sponsors in the description. And now, let me leave you with some words from Isaac Newton, reflecting on his life and work. I seem to have been only like a boy, playing on the seashore and diverting myself in now and then finding a smoother pebble or a prettier shell than ordinary, whilst the great ocean of truth lay all undiscovered before me. Thank you for listening and hope to see you next time.