The Dirty Truth About Environmental Toxins (And How to Protect Yourself)

The pervasive presence of microplastics and environmental toxins in our daily lives poses a growing threat to human health, with impacts ranging from hormonal disruption and metabolic dysfunction to immune system compromise and chronic inflammation. These contaminants, found in food packaging, water supplies, personal care products, and even the air we breathe, accumulate in the body and contribute to the rise in chronic diseases such as obesity, diabetes, cancer, and autoimmune conditions. Understanding their far-reaching effects is essential, but the good news is that the body has powerful detoxification mechanisms that, when properly supported through dietary choices, lifestyle adjustments, and targeted supplementation, can help mitigate their damage. In this episode, I discuss, along with toxin-expert Dr. Joseph Pizzorno, why we need to take action to reduce toxin exposures, reverse existing damage, and build a foundation for long-term well-being. Dr. Joseph Pizzorno is a transformational leader in medicine. Through half a century of work, he has helped establish and advance the academic, scientific, and clinical protocols for natural, functional, integrative, and environmental medicine. As founding president of Bastyr University in 1978, he coined the term “science-based natural medicine” and led Bastyr to become the first-ever accredited institution in the field. He has set worldwide standards of practice by authoring or co-authoring six textbooks for doctors, including the Textbook of Natural Medicine (over 100,000 copies in 4 languages across 5 editions) and Clinical Environmental Medicine. He is Editor-in-Chief of PubMed-indexed IMCJ—the most widely read, peer-reviewed journal in the field (25,000 copies each issue). He is a founding member of the Board of Directors of the Institute for Functional Medicine, where he served three terms as Chair. A licensed naturopathic physician, educator, researcher, and expert spokesman, he is also the author or co-author of eight consumer books (most recent, Healthy Bones, Healthy You! with his wife Lara). This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here: Microplastics: What They Are, Why They are Dangerous, and How to Protect Yourself Environmental Toxins: How To Eliminate the Silent Killers with Dr. Joseph Pizzorno How To Reduce Your Environmental Toxin Exposure

Speaker names marked ? are inferred from speaking time and the show’s known hosts — they are not voice-verified.

• 0:00Dr. Mark Hyman?

  Coming up on this episode of the Dr. Hyman Show, we are all inundated with these microplastics and these environmental toxins, but there is good news. You can detoxify from these things. You can actually get rid of them from your body. You have to do a little work, but you can. BPA has a rapid clearance rate, so it doesn't really last that long in the body, only about five or six hours. It means about it takes five or six hours for your body to kind of metabolize and get rid of half of the BPA in your body.

• 0:24Dr. Mark Hyman?

  Now, before we jump into today's episode, I'd like to note that while I wish I could help everyone by my personal practice, there's simply not enough time for me to do this at scale. And that's why I've been busy building several passion projects to help you better understand, well, you. If you're looking for data about your biology, check out Function Health for real-time lab insights. And if you're in need of deepening your knowledge around your health journey, well, check out my membership community, Dr. Hyman Plus. And if you're looking for curated trusted supplements and health products for your health journey, visit my website, drhyman.com for my website store and a summary of my favorite and thoroughly tested products. What exactly are microplastics? Well, microplastics are tiny little plastic particles

• 1:07Dr. Mark Hyman?

  less than five millimeters in size. Now, they can be as small as a grain of sand or even smaller, invisible to the naked eye. Microplastics can be broken down even further into minuscule-sized plastic particles called nanoparticles. Now nanoplastics are less than 100 nanometers in size, and for reference, an nanometer is a billionth of a meter, so not very big, and are much, much more difficult to detect versus microplastics. So why are these so bad? They're pervasive in our environment. They're ubiquitous and have become a significant environmental concern due to their widespread pervasiveness in the water, in our soil, and our air. And it can take anywhere between 20 and 500 years for plastic waste to decompose.

• 1:48Dr. Mark Hyman?

  Even then, it never really fully disappears. It just gets smaller and smaller and smaller. Examples of how microplastics show up in our environment are everywhere. Now, because of their small size, microplastics infiltrate ecosystems from the bottom of the ocean to the tops of glaciers. I mean, the Great Pacific Garbage Patch is a microplastic island the size of Texas. It spans from the west coast of North America to Japan, 70% of that debris sinks to the bottom of the ocean. 14 million tons of microplastics exist on the ocean floor. And microplastics have been identified in the core of ice caps in Iceland, where I just came back from. Pretty frightening because it's very remote. Microplastics are easily ingested by wildlife and then they bioaccumulate up the food chain,

• 2:30Dr. Mark Hyman?

  which then of course negatively impacts wildlife and human health because we're at the top of the food chain. So what impacts do microplastics have on human health? Well, in the CDC's National Report on Human Exposure to Environmental Chemicals, scientists analyzed urine samples from 2,517 individuals, a sixth and above for BPA. And they found almost every participant contained BPA, that's bisphenol A. Now, exposure from the time we're in utero is also going on. It's not just what we get when we're alive outside the womb, it's inside the womb. A recent study published in Toxicological Sciences analyzed 62 placenta samples, and microplastics were present in all of them. With polyethylene, what plastic bags and water bottles and food containers are actually made of, these account for most of the nano and microplastics.

• 3:14Dr. Mark Hyman?

  Also, these microplastics affect our immune system, they drive inflammation. Now, when they're inhaled or ingested in our food, they often will cause what we call dysbiosis, or imbalances in the gut flora. They'll cause oxidative stress and inflammation, which just drives further inflammation. And chronic systemic inflammation is associated with every known chronic disease. In fact, a new study in mice found that microplastics have been shown to penetrate the gut barrier, causing a leaky gut, which then creates more issues, right? We get more inflammation and the food particles and bacterial particles then migrate into the bloodstream and the inflammation from there affects every organ, such as our liver, kidneys, brain. And they also affect our metabolic health, causing insulin resistance and worse. So this just screws up your whole liver-gut axis and increases the risk of prediabetes

• 3:59Dr. Mark Hyman?

  and diabetes and insulin resistance. So they affect every aspect of our biology. They also describe hormones. These are also called endocrine disruptors. And many plastics contain chemical additives like phthalates or bisphenol A or BPA and brominated flame retardants, which are just a few of the main ones. So let's look at BPA. BPA is structurally similar to estrogen and actually mimics estrogen in the body. Which is why it's known as a xeno or foreign estrogen. It binds to the estrogen receptors and then it alters hormone signaling, which is not a good thing. BPA causes epigenetic changes, so it literally changes the way your genes are expressed by something called DNA methylation. And then that causes all kinds of other issues, reproductive issues, cancer, metabolic issues, weight gain. It also affects reproductive system function.

• 4:41Dr. Mark Hyman?

  So when you have exposure to these microplastics and chemicals, it impacts your ability to reproduce. And BPA, for example, impacts the female reproductive system and fertility by affects the maturation of eggs in the beginning of your menstrual cycle. And BPA is also associated with PCOS or polycystic ovarian syndrome and endometriosis, which by the way, is an autoimmune disease. BPA doesn't just affect women, it also affects men and it screws up spermatogenesis, meaning the making of new sperm. It's also associated with lower testosterone levels and reduced sperm count, reduced sperm motility and increased sperm DNA damage. Not what you want to have if you're having a baby. And we call these changes epigenetic changes. They're imprinting on your epigenome, which then has transgenerational effects.

• 5:25Dr. Mark Hyman?

  So what happens to, let's say, the grandparent can happen to the grandchild because of the insult that happened to the grandparent. This affects the fertility, a progeny of many future generations, which is very scary. And we're seeing all kinds of weird stuff in animals, even in humans, general abnormalities, influence on brain sex development. And BPA also has bad effects for men, right? They're anti-androgen. Androgens are male hormones that are responsible for the maintenance of male sex traits, like, you know, hair on the body and muscle mass and all the things we like with men. But BPA affects the brain sex development in fetuses and alters gene expression. So it literally changes the reproductive system of the developing fetus, which is really terrifying to me. And we're also seeing a lot of linkages to these environmental chemicals and plastics with obesity.

• 6:08Dr. Mark Hyman?

  They're called obesogens, carcinogens, but obesogens. And human studies have shown a positive correlation between urinary levels of BPA and your BMI or your weight. According to the NIH data, this is the National Health and Nutrition Examination Survey data, which is tens of thousands of Americans over decades and decades. Those are the highest levels of BPA exposure, we're more likely to be obese. Now, why? Could it be just because? The people who were studied who had a high BPA also didn't pay much attention to their health for other reasons. That's called the unhealthy user bias. Or maybe, you know, it's because they're eating more processed foods and eating, drinking from more plastic stuff. Maybe that there's a reason there. But the mechanism is that it has estrogenic activity and it promotes fat cell division and accumulation. So basically, BPA causes insulin resistance, it causes more fat cell accumulation,

• 6:51Dr. Mark Hyman?

  it inhibits the release of an important hormone called adiponectin, which is an anti-inflammatory, insulin sensitizing hormone, and it actually also helps regulate blood sugar, burning of fat. And it's secreted by fat cells, but when you have high levels of these toxins, you don't get adiponectin and you don't get all the benefits. BPA is also linked to abnormal cholesterol and dysbiosis, which is a mouse in the gut floor, and dotoxemia, meaning toxins getting in body from the gut that are caused by damaged gut lining. They're also linked to oxidative stress, to insulin resistance, high levels of fasting insulin, and also inhibits fat breakdown and leads to weight gain. So these are really nasty and they're everywhere and it's allowed in our food supply. What else does BPA do? Well, I mean, you probably don't want any of this in your system. And it's, by the way, everywhere. You really have to pay attention to cans and

• 7:35Dr. Mark Hyman?

  packaging and credit card receipts and ATM receipts. All of these have BPA in them. So you just want to, you don't want to touch them. I never get their receipts. Also, BPA causes cancer. It binds to estrogen receptors, the ones we call alpha and beta, and activates the same signaling pathways in these estrogen sensitive tissues that you would, from estrogen, and that leads to breast cancer, ovarian cancer, uterus, can even affect prostate health. This increases all kinds of bad things like cell proliferation, cancer cell formation, cancerous tumors, and depending on the genetics and your environment and level of exposure, your risk is going to be higher. Now, there are other mechanisms that, that, that BPA can cause a damage with, and those include what we call cytotoxicity, which just means it's a poison. So it's just directly poisons

• 8:17Dr. Mark Hyman?

  the cell. It creates oxidative stress and it damages our DNA, which has tumor effects. So there's just many, many pathways that this is bad for you. What else? If there wasn't something else, well, there's another thing, right? Heart disease. The long-term adult exposure to BPA is associated with all sorts of things like heart disease, hypertension, atherosclerosis, plaque development, heart attacks. As we saw, the data is just pretty scary about this. And the research shows, for example, a 10 year study in the UK done by Meltzer and others, found that higher BP exposure correlates with an increased incidence of coronary heart disease, more heart attacks. Another observational study, and this is observational, but it was pretty scary, actually, in the New England Journal of Medicine, and it looked at the presence of micro and nano

• 8:57Dr. Mark Hyman?

  plastics in the plaque of 304 asymptomatic people who underwent carotid endarterectomy, that's cleaning out the blockages in the arteries in the neck, and that can help prevent strokes. And they looked at the microplastics in that plaque, and they tried to track it, how it correlated with heart attack, strokes, and death from all causes about 34 months later. And what was really frightening was that polyethylene, one of these microplastics, was detected in the carotid artery plaque of 58.4% of patients. And PVC, from PVC pipes, polyvinyl chloride from vinyl flooring, credit cards, medical devices, furniture, was detected in 12% of patients. Now, when they looked through a special kind of microscope called an electron microscope, looks at very small, small things,

• 9:38Dr. Mark Hyman?

  it showed visible jagged edged micro and nanoplastic particles in the plaque, significantly increasing the risk for, for primary endpoint events, meaning heart attacks and strokes, by 453%, meaning if, if you had higher amounts of micro and nanoplastics in your carotid artery, you had a much, much higher risk of having a major cardiac event or a stroke than those who didn't have those microplastics in their arteries. Now, other studies have shown that people with high blood pressure and low heart variability tend to have higher total urinary BPA, so that's concerning, so it can cause high blood pressure. And heart variability is a very important measure of your overall cardiovascular fitness. So what are the top sources of microplastic exposure? You want to know, now that it's causing all these bad things, well, ultra-processed food

• 10:20Dr. Mark Hyman?

  and packaging. Just don't eat crap. You're going to feel like crap. It's not good for you. There's no reason to eat it. It's not actually food. You should never, never put that past your lips. And, and I've done many podcasts, you can go back and listen to them on what ultra-processed foods are and what they do, but it's, it's pretty frightening. So where are you going to find also these microplastics? Well, cans, BPA lined cans, coffee cups, lids, who are we drinking all these coffees? I mean, bring your own cup, bring your own can. Salt, even salt has it, table salt, which is, you know, ultra-processed food also has a lot, but sometimes... That has microplastics. Tea bags. You know, tea bags are fine, coffee filters, but they're not. Polypropylene is a type of plastic that's used to seal tea bags and it's kept, keeps them kind of together in hot water, but not good because that plastic can leach into your tea.

• 11:01Dr. Mark Hyman?

  A single plastic tea bag at the brewing temperature can release, get this, 11.6 billion microplastics and 3.1 billion nanoplastics. That's scary. This is from Environmental Science and Technology Journal. Correct. Coffee machines, those plastic tubing and the plastic little things that they do. I mean, I don't, I don't think we should be saying that. Plastic water bottles, soda bottles, any beverage container, which is BPA line, plastic containers, cups, bags, shrink wrap, Tupperware, often cutting boards. You have to be really careful and just try to use natural products. Personal care products, also another big source of these microplastics. Face wash has these microbeads, exfoliants, stalates and lotions, creams, toothpaste. Use Skin Deep, which is a database from the Environmental Working Group. It gives you a guide on what to

• 11:43Dr. Mark Hyman?

  eat, use and eat on your body and what to clean your house with. It doesn't have all these crappy things in them. And watch out for your makeup. As I said, you know, skincare products are full of these microplastics. What about your clothes? Well, clothes also are an issue. Polyester and synthetic fibers also are a big issue because when you wash them, those microplastics drain into our water supply. And a friend of mine has an appliance company, he's a CEO of in Europe called Archilek and has developed a microplastic filter and he's open sourced it to all manufacturers of appliances. I don't know if they're using them, but they should. Now, what about kids? Well, toys, plastic toys, especially those made from polyethylene, which can lead to direct exposure to these chemicals when they're chewed or sucked on by kids. Kids stick everything in their mouth. So all these plastic toys for babies and kids are terrible. Also, there's a bunch of other places

• 12:26Dr. Mark Hyman?

  I mentioned receipts, you know, credit card receipts, ATM receipts, gas station receipts, medical equipment like II tubing, IV bags, disposable gloves, and all that gets to us over time. They enter the body through food and water, through inhalation, through skin exposure. That's kind of bad news, a little depressing, right? We are all inundated with these microplastics and these environmental toxins, but there is good news. You can detoxify from these things. You can actually get rid of them from your body. You have to do a little work, but you can. BPA has a rapid clearance rate, so it doesn't really last that long in the body, only about five or six hours. Means about it takes five or six hours. For your body to kind of metabolize and get rid of half of the BPA in your body. The bad news, we're exposed all the time, so it's hard for the body to get to net zero. And we're gonna actually measure this in function health panels soon.

• 13:11Dr. Mark Hyman?

  We're gonna measure BPA levels, so you can even test them. You go to functionhealth.com forward slash mark. We're not quite up there yet with that test, but we'll get there soon. We'll also look at PFAS, forever chemicals. So we'll be able to start testing these things and you can see your exposures. So the first step is really to reduce your exposure. How do you do that? Air filters and water filters. So water filters are great. You can use Aqua True, a LinkedIn show notes also, just a reverse osmosis filter. Other types are fine. Swap out plastic food containers for glass ones. Don't eat ultra processed food, right? As you're gonna reduce your exposure to microplastics and phthalates and PFAS from processing and packaging. Swap out your plastic cups for glass cups. Use rock salt like Redmond's Real Salt, that's my favorite. Never heat food or drinks in plastic, ever, in the microwave or anywhere else. Stay away from the instant meals that you cook in plastic, like a cup of noodles, soup, rice. Just don't do that.

• 13:56Dr. Mark Hyman?

  Avoid drinking from plastic water bottles, which is hard to do, but we should definitely be doing that. Both to not pollute the planet with plastic, but also to not pollute ourselves. A new study found that a liter of water from plastic water bottles contained, and this is scary, 240,000 detectable plastic fragments. I'm gonna say that again. A liter of water from a plastic water bottle contains 240,000 detectable plastic fragments. And that's about 10 to 100 times more than previous estimates. And about 90% of these fragments were nanoplastics, not microplastics. Also, you can use a steel water bottle, a stainless steel water bottle. I would encourage you to do that, I have one. Avoid commercial to-go coffee cups, like from a coffee shop. They're usually aligned with BPA.

• 14:37Dr. Mark Hyman?

  Ask to fill a stainless steel travel mug or transfer the hot contents to a safe container, especially right after you get it, because I don't want to leave it in there. Avoid cans, especially acidic food and drinks like soda, tomatoes, leech out unless it's a BPA free can. There's companies that do make those. BPA concentrations up to 40 times higher in canned food from sterilization, pasteurization. Don't try to have canned foods unless you know they're BPA free cans. Don't take the receipt, you know, you can, these, most of these have a BPA coating. You can email it or text it or something, but don't, don't, don't touch it. Don't use plastic teabags. Bags that are organic, unbleached, 100% plastic free, toxic free, cotton coffee filters are fine. Don't use Keurig or plastic tubing for coffee. You can use a stainless steel French press, pour over coffee.

• 15:21Dr. Mark Hyman?

  And again, as I said, say no to receipts. Bad idea. Get an air filter. Air filter is great. I like Air Doctor. I'll put a link in the show notes. Watch out for also something called BPS because as soon as they find a chemical is bad and we're like, oh, BPA is bad. They come up with something else, which may not be better, right? And BPS is used to replace ment for BPA, but it can actually be more toxic. That's how you reduce your exposure. That's the first step is get rid of the source. How do you actually detoxify your body from the microplastics? Well, your body has a built in detoxification system, so you have to support those pathways. And it works better than any crash diet or juice cleanse. So you have to support it by eating the right food. Foods actually have components in them that help your body detoxify. So what are they? Well, antioxidants in general help scavenge free radicals. They protect against DNA damage, oxidative stress.

• 16:06Dr. Mark Hyman?

  Vitamin C is great because it's a great antioxidant and you can get that from citrus fruit, oranges, kiwis, veggies. Vitamin E, another great antioxidant from wheat germ oil, nuts, some veggies. Vitamin A, which is from grass fed beef liver, chicken liver, grass fed meats often have vitamin A. Animal food is the main source. Plant foods don't have actually preformed vitamin A. Melatonin, which you can get in even in your diet, actually from meat, fish, eggs, pistachios. Lots of antioxidants you can take in terms of herbs like quercetin, curcumin, of course, it is in onions, garlic and apples. Carotenoids are like, you know, they sound like where they're from like carrots and yellow vegetables. Flavonoids like berries, elagic acid and pomegranate, EG, CG, which is in green tea, astaxanthin from algae and salmon, krill, curcumin, milk thistle. All these are great to use to help your body detoxify.

• 16:50Dr. Mark Hyman?

  These herbs have been well studied and they have been shown to actually upregulate many of your body's own built in detox pathways. One of the so powerhouses here, and I have these almost every day are what we call cruciferous veggies. Now, these are things like broccoli, collards, kale, Brussels sprouts and so forth, bok choy. But a lot of other things are great too, like dandelion leaves, rosemary and so forth. So all these can really help your body to upregulate these detox pathways. Your body also has a lot of its own antioxidant enzymes, so you can upregulate those. Enzymes by having the right cofactors like copper and zinc for something called SOD. Catalase, another important antioxidant enzyme your body makes. It needs iron and manganese. Glutathione, really, really important. It needs selenium and cysteine and a number of other amino acids.

• 17:33Dr. Mark Hyman?

  A grass fed whey is a great way to boost glutathione, which is high in cysteine. I use originally raised goat whey like Mount Capra. Sulfur rich foods also great for boosting detox pathways. So what are those? All the broccoli family, right? The broccoli, cauliflower, kale, cabbage, Brussels sprouts, watercress. Protein also amino acids are critical for upregulating your detox pathways. So you want to make sure you have at least a gram per pound of ideal body weight. And you have to really need that. Otherwise, if you're detoxing and you don't have the amino acids to support your liver detox pathways, you're going to be in trouble. Also, you need to have the right B vitamins, particularly the B vitamins, B6, B12 and folate to support methylation. Really important. And you can get those from grass fed meat, from pasteurized eggs, poultry. Certain enzymes are really important. Hydration also really important.

• 18:16Dr. Mark Hyman?

  You know, the solution to pollution is dilution. That's what we learned in medical school. Make sure you drink half your weight in ounces of water per day. Use a water filter, as I mentioned, reverse osmosis. Make sure you hydrate to get rid of the toxins. So you want to have plenty of urine, clear urine. If it's yellow, you probably don't have enough water. Fiber, really important. It's like a sponge that binds the toxins and prevents you from reabsorbing them. So try to eat 25 to 30 grams, even up to 50 a day. You can actually take fiber supplements like soluble or insoluble fibers. And insoluble fibers, for example, are non digestible ones that pass through the GI tract. They add bulk to the school, but you want soluble fiber, fruits and veggies, which has kind of like a gel like substance in the intestines and really helps all areas of health. That reduces inflammation, it feeds your gut bugs, it aids your blood sugar control.

• 18:59Dr. Mark Hyman?

  Also binds to the cholesterol and bile acids, helps the excretion. And many of these microplastics are fat soluble, so they're bound to cholesterol. For example, we saw in the study on heart disease that the microplastics were detected in the plaque of arteries, right? Remember that? So you want to eat more fiber, especially the soluble fiber that helps BPA exit the bile through your poop. Now, there are different types and sources of soluble fiber. One of the best types is beta glucans, which are found in oats, but you want glyphosate, gluten free, whole steel coat oats. Pectins, which are in apples, oranges, pears and nuts. Neutalages, which are like, kind of, if you put in water, you'll gum it up pretty quick. But that's great, like flaxseeds, chia seeds, psyllium seeds, inulin, chicory root. These are all prebiotic foods. Drew some artichokes, onions, garlic, asparagus.

• 19:42Dr. Mark Hyman?

  And sweat. Also, you don't want to hear about sweating. Sweating is really important. It's how your body gets rid of a lot of toxins. So in 2012, there was a study of human excretion of BPA in blood, urine, and sweat. And they found that BPA concentrations were higher in sweat than in urine. And out of 20 participants, 16 had detectable BPA concentrations in the sweat, but only two had detectable levels in their blood. So basically, they're fat soluble. So when you sweat, you actually have one of the main mechanisms to get rid of these environmental toxins. That's why I love saunas. The results of the study suggested sweat testing can be a cool tool for checking BPA monitoring. And inducing sweating is a clinically useful tool to facilitate the release of BPA through the skin. It's not routine for doctors to test BPA, but it can be tested in urine or blood, even in sweat, as I mentioned. Function Health is going to be offering that test.

• 20:27Dr. Mark Hyman?

  Go to functionhealth.com/mark to learn more. But yeah, I really want to sweat, right? You really want to sweat to get it out. A certain supplements can be very helpful. CoQ10 has been studied by researchers at Harvard, and it shows that it reduces free radicals caused by BPA in worms, which is, I guess, good. Clarala also can help support detoxification. Probiotics also helpful. They bind to BPA. Thalates, polycyclic aromatic hydrocarbons, so it's like lactobacillus, bifidobacterium, Saccharomyces boulardii, all help your gut health, help improve liver function, prevent all kinds of stuff from going wrong in your body. They have great effects on your endocrine system. Also, you can take other supplements like N-acetylcysteine. I take that every day to boost glutathione. I also take lipoic acid, which is an antioxidant. It helps boost glutathione.

• 21:10Dr. Mark Hyman?

  And you can take some fiber supplements like psyllium, or just take flaxseeds, or even chia seeds every day.

• 21:20Speaker 01

  In the case of toxins, how do toxins actually interact with our biology? Cause such problems?

• 21:27Speaker 02

  Yeah, that's actually, that's a rigorous question. I'm kind of breaking into three categories. Category one is, while we pay attention to individual toxins and know a lot about the disease caused by individual toxins, number one priority is total workload of toxins.

• 21:45Speaker 02

  How much arctic you have, how much lead you have, how much bisphenols you have, how much stylists you have, etc. Because what happens is, all the toxins cause oxidative stress and deplete glutathione from the body. Glutathione is the most important antioxidant in your body, but more importantly, it's the key way we protect our mitochondria. And the longest living people with the least disease have the highest levels of glutathione.

• 22:10Speaker 01

  Yeah, that's right.

• 22:11Speaker 02

  If you quit glutathione, your mitochondria die, and you die sooner and have more disease.

• 22:15Speaker 01

  Yeah.

• 22:16Speaker 02

  Okay, so you got decreased total load. Then we look at, okay, so now, what do the toxins do individually? So they can range from, this is where, classically, the main problem with toxins is, they displace nutrients from the body. So for example, any enzyme that depends upon calcium in the body, if they have high levels of lead, it displaces the calcium from the enzyme so they don't work properly. So they basically poison enzymes. Why is that important? Bodies are enzyme machines. The bodies aren't just machines. Enzymes aren't working, our machines aren't working, and we get sick. That's number one. Direct poisoning of the enzymes by the toxin.

• 22:55Speaker 01

  And just to emphasize that for a minute, enzymes, you know, are such a huge part of our biology that one-third of our DNA codes for enzymes. One-third of our entire genome is coding for enzymes that catalyze metabolic reactions in the body, and all of those have to be functioning for us to be healthy. It's like the metabolic machinery, it has to run everything. And toxins bind to those enzymes in a way that blocks their function, leading to faulty biology, which leads to disease.

• 23:24Speaker 02

  Yes, exactly. Very well said, Mark. Exactly that's what happens. And going on with what you said about DNA, in the second area, or third area now, that's a huge problem now because the toxins is, they damage our DNA. So when you look at the research on the correlation between the biology of a particular toxin and a particular disease we're looking at... If you do it according to age, you don't see very many correlations until about the age of 50. But up until about the age of 50, our body is pretty able to adapt to the damage to the toxin and work around it. But when we hit about age 50, there's two big things that happen. Number one is our body load of persistent toxins has now become much, much higher.

• 24:07Speaker 02

  So these are toxins that take so long to get out of our body, we can't get rid of them.

• 24:11Speaker 01

  Yeah.

• 24:11Speaker 02

  So PCBs, for example, if you go to a restaurant and eat farmed fish, some of the PCBs in the farmed fish have a half-life ranging from 10 to 20 years. It takes four half-lives to get rid of the toxin. If you go eat that farmed fish, and some of those toxins will be in your body for the rest of your life. So what happens is-

• 24:30Speaker 01

  Unless I live to 200, then I'll get rid of them.

• 24:32Speaker 02

  There you go, right. Yeah, you have to live past 100 to get rid of them. Okay. So then, so what's happening is the body load is going up. But now that the body load is going up, we've chemically damaged our DNA, so our ability to respond to them and adapt to them has now become limited, and now all of a sudden, all the disease correlations start showing up.

• 24:55Speaker 01

  So total load, damage to enzymes, and damage to DNA. But there's more effects, right?

• 25:01Speaker 02

  Oh, many more effects.

• 25:02Speaker 01

  The immunotoxicity, which is leading to all the inflammatory and autoimmune diseases, right? Mitochondrial injury, which is poisoning of our energy metabolism. So there's damage to our gut lining that happens because of toxins that damage our enzymes in our gut, make our gut not be able to work. Every level of our biology, there are endocrine disruptors. They disrupt our hormonal function. So at every level of our biology, these compounds are interfering with them. And, you know, I think you know the story, but the reason I got into functional medicine was I was living in China, and long story short, I got poisoned with mercury from the pollution there, cleaning out my air filter, plus I'd eaten tuna fish for decades as a kid, and I had lots of fillings and- I had a level on a challenge test of one hundred and eighty-seven.

• 25:46Speaker 01

  Which is, for those who don't know, like if I see someone over twenty, I get worried. I rarely see anybody over a hundred. I don't remember last time it was a hundred. I've had a couple of people who had higher levels than me. One was a dementia patient and, but, you know, I, I literally had every system in my body break down. My gut broke down, my cognitive brain broke down, my immune system broke down, I felt allergies. Everything broke down and, and I developed a ton of sleep syndrome and, and no one could fix me. Went to the doctor, for years until, actually, I went to the conference where I first met you in Hawaii. And, uh, and I have my conference, like ninety-seven, I think. And I was on a plane with a guy who was a naturopath and I was telling him, I just learned about functional medicine. I was going to my first conference.

• 26:27Speaker 01

  And I learned about this, this, uh, this naturopath, I was like, gee, maybe you should check your heavy metals. I'm like, what, really? So I did a hair analysis, I had high levels and then I did a, a challenge test. And that was the beginning of my exploration of functional medicine. So I learned it the hard way. I learned it the hard way and, and I, you know, I find this as well in my patients. So many patients are, you know, come in with these diagnoses and underlying it is, is this toxic load. So, um, let's talk about the kind of big categories of toxins. You mentioned a lot of

• 26:57Speaker 02

  Responsibly, just said.

• 26:58Speaker 01

  Yeah, yeah.

• 26:59Speaker 02

  The immune system. Okay. So the immune system is very, very susceptible to environmental toxins. So I looked, so I just gave, you know, I just gave a lecture on PFAS, it's the perfluorinated compounds.

• 27:09Speaker 01

  And so it's Forever chemicals. Where were they from? Where did they come from?

• 27:14Speaker 02

  Worst place, fast food.

• 27:15Speaker 01

  Fast food?

• 27:16Speaker 02

  Popcorn, fast food are worse by far. Uh, uh, microwave popcorn.

• 27:20Speaker 01

  Microwave popcorn, okay. Cause if you said regular popcorn, I don't know.

• 27:23Speaker 02

  Regular popcorn's fine. Microwave popcorn's problematic. When I was, uh, looking at this, I was looking at, uh, I thought, look at COVID and PFAS. And looked at people who had either no COVID or mild case compared to people had a severe version of COVID. Once got severe version, had fifty to a hundred percent higher levels of PFAS in their body compared to those who did not get bad COVID.

• 27:44Speaker 01

  Wow.

• 27:44Speaker 02

  So I just, just a simple thing like that, enough damage from your system, couldn't get rid of the COVID virus fast enough, now you got problems.

• 27:51Speaker 01

  Yeah, immunotoxicity is a real deal. Uh, you know, I had a, a patient who had, for example, like Crohn's disease and done everything and turned out she had really, really high blood levels. You'd be tested for lead and she got better. I've seen this over and over in my career. You know, um, the, the, the, some of the chemicals other than metals, which we can test for, or blood tests, and we do that at Clenchion Health, where people can get their blood test, but also we do it through, uh, you know, traditional sort of, uh, challenge testing, which is where you take a peeler and it binds the metals and you can see what's going on. And, and it's, the test is really not done in traditional medicine. It's a test that I do for anybody who's got a chronic illness because I have to rule it out. And often I'm surprised, I had a guy, for example, who had long COVID, you just mentioned, uh, and, uh,

• 28:33Speaker 01

  I was kind of shocked, like he had, his mercury was like 93, uh, his challenges were really high, his blood level was 18, and he was struggling with long COVID and gut issues, and I'm like, well, this is what's going on, right?

• 28:45Speaker 02

  Exactly.

• 28:45Speaker 01

  And so I think it's, it's, if any, every start looking, you start seeing it, and I think there's a whole swath of other compounds that are, I would call them in a petrochemical sphere, that are, that are synthesized compounds that are problematic. So what are the top compounds that are, are concerning to you that, that we're exposed to on a regular basis? And, and, and where, where are they found and how do we avoid them?

• 29:07Speaker 02

  Yeah, uh, again, another excellent question. So when I look at the toxins, you know, the easy way to think about them is metals versus chemicals. So we're looking at metals, arsenic, lead, mercury, cadmium, the four big ones. Substantial portion of population have elevated levels that cause a lot of disease. When we're looking at the chemicals, we have perfluorates, the PFAS, the forever chemicals. We've got the, uh, bisphenols. So people think, oh, BPA is bad, I mean, you get plastic that's BPA free. Well, guess what? They put other bisphenols in, they're just as bad. Phthalates, a lot of the health and beauty aids have phthalates in them.

• 29:47Speaker 01

  So skin, like sunblock or makeup?

• 29:50Speaker 02

  Yeah, sunblock, makeup, things like this, a lot of phthalates. Well, why is that problematic? Phthalates bind into receptor sites and get people diabetes. Okay, so, um, There are so many chemicals. I've been systematically working my way through. But so far, in terms of chemicals, these are the three I'm paying the most attention to.

• 30:11Speaker 01

  BPA.

• 30:12Speaker 02

  BPA and phthalates, because there's just so much research. Not saying there aren't other problematic chemicals, but these three by themselves cost so much.

• 30:20Speaker 01

  There are only 144,000 other chemicals.

• 30:24Speaker 02

  Well, there's 12,000 of these forever chemicals. Just one category is 12,000 chemicals.

• 30:28Speaker 01

  I think that's the thing that, you know, somebody is daunting for people because like we're living in a sea of these chemicals.

• 30:33Speaker 02

  Yeah.

• 30:34Speaker 01

  The, you know, the newborn study that the Environmental Working Group did showed there were 287 chemicals in the umbilical cord of a brand new baby before it even took its first breath. And 217 of those chemicals are neurotoxins, everything from flame retardants, pesticides, dioxin, PCBs, you know, DDT, things that were banned, have been banned before, long before, decades before these kids were born. They're in their mothers, and they're in the environment, and they're in these babies. So when you're born, pre-polluted.

• 31:00Speaker 02

  Now we're getting to the next, next set of toxins, and that is the herbicides and the pesticides.

• 31:06Speaker 01

  Agricultural chemicals.

• 31:07Speaker 02

  Yeah, industrial chemicals for agriculture. So let's look at just one category, organophosphate pesticides, okay? If you measure the body load of pregnant women, you measure their level of organophosphate pesticides, and you compare, look at the IQ of children born to women with the top level of organophosphate pesticides compared to women with the lowest level of organophosphate pesticides, and you're not statistically all the differences in weight and ethnicity, things of this nature, just look at organophosphate pesticide levels, highest levels, top 10% of women, seven point drop in the IQ of the children, and you never get it back.

• 31:48Speaker 02

  So in utero, the body is being saturated with neurotoxins, so it isn't any surprise the brain was not developed properly when exposed to neurotoxins.

• 31:57Speaker 01

  Yeah.

• 31:57Speaker 02

  So I said before that I'm focused on PFAS, bisphenols and phthalates. You gotta focus on, on the pesticides, particularly organophosphate pesticides are probably the worst of all them, but you've got chlorinated pesticides are problematic, and many other categories.

• 32:12Speaker 01

  Yeah, it's true. I mean, I think I read a study that was based on farm workers' children, migrant farm workers' children, and they estimated that in the offspring of that cohort, there were 41 million lost IQ points in those children. And, and, you know, I think they're everywhere, right? We're sort of living in a sea of them. We can't really completely avoid them. I'm on the board of the Environmental Working Group, and there's wonderful guides there on how to find products that are low or don't have these compounds. Skin Deep is their skincare database. They have what household products that you can buy for cleaning that are not going to pollute your environment. There's ways you can choose food based on lower pesticide counts

• 32:55Speaker 01

  and thirty dozen Ecliptin. And there's guys that put animal protein in fish you should eat and how to reduce your exposures. So there's a lot of ways to reduce your exposures. But, you know, part of the problem is we really can't avoid them entirely. We're all, like, polluted. And, and I guess they were born people. So from your perspective as a practitioner, you know, you can see this and you can see the data, and it's kind of terrifying. If toxins are causing all the diseases, what the heck can we do about it? Because other than trying to reduce your exposures and stop eating fish and don't eat paint chips and, you know, filter your water and have an air filter in your house and don't use these skincare products and stuff, we're still not going to be completely able to avoid them.

• 33:37Speaker 01

  So, so how do we actually start to think about this from a practical point of view of treating people with environmental toxicity and how do we diagnose them properly?

• 33:51Speaker 02

  So, there's actually some really good news here because there are some very simple things we can do that have huge impact on our toxicity. So the first thing we want to do is toxic garbage. So I recommend that everybody get, have their doctor measure a laboratory test called G G T P. So G G T P is a liver enzyme that in the past was measured to determine if a person had hepatitis. If a person has inflammation in the liver, they start leaking liver enzymes into their blood, and you measure the enzymes in the blood and say, aha, hepatitis. They stopped using GGT for hepatitis because other tests were found to be more reliable that GGT was reacting to other things.

• 34:33Speaker 02

  So it turns out, within the quote "normal range," 10 to 50, depending on the lab, GGT goes up in proportion to toxic load.

• 34:42Speaker 01

  Yeah.

• 34:43Speaker 02

  And as you detoxify, GGT goes down. So I mentioned that COPO1 program I did. So I measured my GGT then, and it was 27. And I thought that was okay, because I saw the research saying, once it's 30, you have an eightfold increased risk of diabetes.

• 34:59Speaker 01

  Yeah.

• 35:00Speaker 02

  Well, it's not concerning to go from 29, no risk, to 30, more risk. So I thought, well, 27 is too high. So I started getting more and more careful. Started getting more careful, went down, a couple of years later, down to 24. Then I measured a few years late, a few years ago, it went down to 17. I just measured it two months ago, I was down to 16.

• 35:16Speaker 01

  Yeah.

• 35:17Speaker 02

  So between a GGT between 15 and 20 means you've done a good job of getting rid of enough toxins that the body doesn't have to increase GGT. Why does the body increase GGT? Because it recycles glutathione, because glutathione protects us from toxins. Okay, you're down to 15 to 20, you probably done a good job getting rid of toxins. Now, if you're below 15, it may not mean you have low toxic load, it may mean you have an inability to increase glutathione to protect you from environmental toxins. So people I've seen with the biggest problems with environmental toxins have low GTTs. I call them "yellow canaries," because they can't protect themselves. So right there, you have to monitor. Now, what's the next thing you just think?

• 36:01Speaker 01

  Well, I just want to say about that test, that test is a really inexpensive, common test. It's not part typically of your annual physical, it's not part of your typical hepatic liver function test. You have to ask for it specifically, it's called GGT. And I think it's something that I've been measuring on every single patient for, it's not going to be high with alcohol, like liver disease, it's going to be high with fatty liver, from diabetes, from a lot of other things. But it's a very important biomarker, and as part of Function Help, which is a company I co-founded, it's part of the standard panel you get for, you know, a hundred or five hundred bucks, a hundred and fifty biomarkers, but it's really important because of that.

• 36:40Speaker 02

  Right, yeah, right on. Very, very useful test. So that way you can monitor what's going on. So as my teacher, Dr. Bastier, would say, "Don't kid yourself." You know, you can think you're living healthily, but you might have this little thing you do here and all this, this food you really love, you can't buy organic, but you eat that anyway. You can find how many of your little exceptions, how bad are they adding up? Okay. The second thing to do is report the body's own natural detox system, systems. And we've spent millions of years evolving these things and we sabotage them. How do we sabotage them?

• 37:18Speaker 02

  A lot of the toxins are excreted from the liver into the gut where we then expect to go out through the stools. But we evolved that system when we're consuming 150, 100 to 150 grams of fiber a day. Now we consume 15 to 20 grams of fiber a day.

• 37:36Speaker 01

  Yeah.

• 37:37Speaker 02

  Eighty-nine percent lower, which means that instead of going out through the stools, it just revolves through enteropathic recirculation. So number one, eat more fiber. Eat more fiber and your body get rid of things more, more effectively. Number two, only organic or grown foods. And number three, from your kitchen, remove all the plastics, remove all the non-stick things. Only use glass and ceramics. It's the only safe things I'm aware of.

• 38:06Speaker 01

  Yeah. Filter your water?

• 38:08Speaker 02

  Yes. Okay. So what we do is we have a, a carbon block filter right in the main coming to our house. So all the water, whether they're drinking it, whether they're taking a shower is clean. And our, on our air conditioning and the heating system in the house, we use what's called a Lennox filter and it's rated at MERV 16, M A R V dash 16. And that will get rid of 99.9% of the toxins in the air in your house.

• 38:35Speaker 01

  Yeah.

• 38:35Speaker 02

  Very effective.

• 38:36Speaker 01

  Yeah. Very important to kind of keep your home environment clean.

• 38:39Speaker 02

  Keep your home environment, that's what we spend lots of time.

• 38:40Speaker 01

  Filled with non-toxic materials. But I, I think, you know, one of the things I was going to bring up is this whole idea of detoxification. And, you know, it was, it was really from a perspective of a traditional doctor and the training I had, it was quackery. Like, you know, our body's detox, whatever, but like, there's no reason to think about improving detoxification.

• 39:02Speaker 01

  And, and yet, when we deeply look at the science of the biology of detoxification, which includes your breath, your skin, your hair, your, your stool, your liver, your kidneys, it's a whole system. And it requires the right building blocks to actually function. It requires the right materials and the pathways have to work. And, and it's, it's a really well worked out model. And yet, we learn nothing about how to fix it, except when you're in the ER, and I was an ER doctor for many years, someone comes in with a Tylenol overdose. We give them this drug, quote drug, called Mucromist, which smells horrible. It smells like rotten eggs.

• 39:46Speaker 01

  You make them drink it, which is like punishment for taking the Tylenol overdose. And, uh, and then you give them a bunch of charcoals. And, and essentially what this compound does is boost glutathione, it's antacetylcytine, which is essentially a supplement, right? And I was like shocked when I learned that later, but it, it literally will rescue the liver from failure after a big insult like a Tylenol overdose, which works by depleting glutathione. So, uh, you know, we, we kind of use it in traditional medicine. We just don't realize what we're doing. But I, I think, I think what I, what I'm looking to talk about is sort of break down, how do we optimize each of the types of detoxification systems we have?

• 40:26Speaker 01

  Because it's really about building in to your life, the automatic ways to upregulate the biology of detoxification in your system. And I, I, I do that every single day now, because I've just built it into my life, because I know I'm not a great detoxifier. I've checked my glutathione snips and I have methylations. So I have genetics that makes me more likely to accumulate toxins. So I have to upregulate those pathways. What, what, what's your approach to sort of giving people guidance all the way from, you know, diet to lifestyle to supplements, to actually help their biology do the things it's supposed to do?

• 41:01Speaker 02

  Yeah, very, very well said. Um, so number one, and number two, and number three are avoidance, avoidance, avoidance. Don't let the stuff into your body. And everyday choices we make. So for example, do you pump your own gasoline? The answer is probably yes. Do you smell the gasoline? Will you smell that gasoline that's benzene going into your body? You're smelling something that doesn't smell right? Get away from it.

• 41:30Speaker 01

  So we need an N95 filter?

• 41:31Speaker 02

  Yeah, right. N95 filter on your nose. Um, so anyway, avoidance, avoidance, avoidance.

• 41:37Speaker 01

  I hold my breath, it's great. I hold my breath for the entire time the gas station is filling your...

• 41:41Speaker 02

  Stand up when... Yes, it's challenging to do. Um, so I think I'll say some specific things to do, but it's every time you have a choice, look at what the less toxic environment, less, the lower environmental toxin load choices that you can make. So, stand up when, when you're pumping your gas like. Uh, when you're having to go out to eat in a restaurant, well, talk to the people at the restaurant, and if it's one of your favorite restaurants. I'm getting a little far-fetched here. Um, cook as much of your own food as you can. Okay? I just read a study on the way over here,

• 42:22Speaker 02

  where it showed that for every meal a person eats out, they didn't differentiate between fast food and, and regular restaurants. Fast food's the worst. Every time a person eats a meal out versus cooking food at home, they increase their blood levels of the phresor chemicals by 1%. 1% per meal? Okay. So, uh, choosing where you eat your food is a way to start. Make it sure that food is organically grown. If you are gonna go out, if you have a failed place to go out, meet with the owner, meet with the cooks, and say, "Can you cook, prepare your food in ways that are less toxic?" And if you are gonna eat, if you are gonna buy food that is from a grocery that's been prepared,

• 43:05Speaker 02

  coming to you in plastic or it's coming to you in lined, um, uh, paper containers, immediately put it into glass. So you might say, "Well, it's been sitting there since it was made and sitting there in the grocery store." So my lecture today I showed, it's time-dependent. Even though it's been going up as long as it's been in the grocery store, if you're leaving that container, it's still gonna keep going up. So at least you can stop it there. So, put everything into glass containers. I said before, it increases your consumption of fiber. But it's also simple things like, you take a multivitamin in your... The majority of the population is deficient in multiple nutrients. I mean, US population, 99% of people are deficient in one or more nutrients.

• 43:46Dr. Mark Hyman?

  Yeah.

• 43:46Speaker 02

  Half are deficient in five or more. So just right there, what are those nutrients needed for? Detox systems. So use a good multivitamin mineral. Does not have to be super high dosage, but it has to be a little bit of everything.

• 43:59Dr. Mark Hyman?

  How do environmental toxins affect our health? Well, they do it through a lot of different mechanisms, but they're basically poisons. And they cause inflammation, they cause oxidative stress, they cause DNA damage. They cause disruption in our mitochondria. They damage our, our stem cells. I mean, the whole flood of environmental toxins, there's over 80,000 of them now. That have been introduced to the industrial sort of world since the early 1900s. That we've never been exposed to before, and we somehow have to figure out how to deal with them. Well, thank God we have a system to do it, but it's still overwhelmed. So environmental toxins, as I said, drive cancer. They are hugely impactful.

• 44:39Dr. Mark Hyman?

  For example, in blood sugar and insulin sensitivity, most people don't realize that diabetes and prediabetes and even obesity can be driven by environmental toxins. Something called bisphenol A, which is a compound that's found in lining a lot of cans, plastic bottles, on paper, receipts from credit cards or gas stations. When you touch that, it goes to your skin and bisphenol A is a huge driver of insulin resistance and prediabetes, independent of what you're eating. It affects cholesterol metabolism. It drives inflammation, oxidative stress, mitochondrial injury, screws up our thyroid function. Affects our appetite, leptin signaling. I mean, pretty much everything gets haywire when we're exposed to too many environmental toxins.

• 45:22Dr. Mark Hyman?

  Now, the downside of living in the modern world is that we're all pre-polluted when we're born. There's 287 known environmental toxins found in the umbilical cord blood of a newborn. I mean, basically they take out the blood of the umbilical cord, send it to a lab. And the average amount of toxins is 287, many of which have been banned for decades, like DDT or PCBs or dioxin. And 217 of those are neurotoxic, meaning they're directly damaging to the brain. There's pesticides, phthalates.

• 45:57Dr. Mark Hyman?

  Bisphenol A, which I just mentioned, flame retardants, heavy metals like mercury, lead, arsenic, and they have huge effects across the spectrum of human health. So what are the ones that we should really be paying attention to, that we really want to avoid and get rid of? The first I just mentioned earlier is bisphenol A, or BPA. It's found in plastic water bottles and canned foods. It's a synthetic compound that mimics estrogen in the body. We call these xenobiotics or xenoestrogens. And they're hugely impactful in regulating hormonal health and risk increasing risk of cancer. And it's been linked BPA to breast cancer, to infertility, reproductive issues, obesity, heart disease. And it's not that hard to get rid of it in your life.

• 46:42Dr. Mark Hyman?

  Basically, don't touch credit card receipts. Don't touch gas station receipts that come out of the machine. Don't eat from plastic bottles unless they're BPA free, or from canned foods unless they're BPA free. So make sure you look at that. You can use stainless steel, glass, bodily packaging, look for BPA canned fruits. The next compound is phthalates. Phthalates are also plasticizers, and they're found in food containers, children's toys. It's banned in Europe. There's a legislation in Europe called REACH. It gets rid of most of these chemicals that are allowed in America. And when there's ever an attempt to limit by law or a bill to reduce our exposures,

• 47:23Dr. Mark Hyman?

  the food industry and chemical industry comes in hard with tons of lobbying dollars, millions and millions and millions, tens of millions of dollars to defeat bills. There was one on bisphenol A that got defeated. And unfortunately, it was trying to be banned, but it didn't pass because there was so much lobbying against it. But it's found in children's toys. It's found in like the plastic little rubber duckies in the bathtub, so they stick it in their mouth. Bad idea. Also, makeup has a lot of phthalates in it. So get rid of all your unhealthy makeups, and we're going to talk about how to do that. But there's a beautiful website called ewg.org, the Environmental Working Group. They have a skin deep database. You can put in your product, what you like to use, or other products you can find that

• 48:06Dr. Mark Hyman?

  have no contaminants, and see the level of toxins and what they are, and find alternatives. So they also are really bad for you because phthalates cause hormonal chaos, they're linked to different cancers, to birth defects, to thyroid problems. So make sure you check it out. And the basic rule is if you wouldn't eat it... You probably shouldn't put it in or on your body, right? So for skincare products, everything goes through the skin. When we go to the emergency room, the heart attack, what's the first thing we do? As a doctor, we slap on a toothpaste tube cream full of nitroglycerin because it goes right through the skin and it's the fastest acting. But I'm taking it by mouth or before we can get an IV in, we just slap that on. And so it goes to the skin, hormone patches, testosterone gels.

• 48:51Dr. Mark Hyman?

  We know the fentanyl patch. I mean, there's all kinds of drugs that are delivered through the skin. So when you're putting on your skin, it's actually getting inside your body. So you want to make sure that if you wouldn't eat it, you shouldn't put it on your body. Like coconut oil, where you can eat that and you can put on your body. So that's a win, but there's a lot of products out there that are safe that you can use. Another one that's concerning is glycol ethers. They're in household cleaning products, cosmetics, paints. They damage fertility, the lead and birth defects, there were some allergies, asthma. And these are really bad because they're pretty much in all of our household cleaning products. And the Environmental Working Group, EWG, also has a whole guide on household cleaning products. So you can use the least contaminated products or ones that have no toxins in them that work well.

• 49:37Dr. Mark Hyman?

  So make sure you check that out. And there are so many other toxins like heavy metals, mercury, lead, arsenic. Mercury is from fish, from our fillings, from coal burning plants, pollution. Lead is often found in crystal wine glasses or glazed plates. I see many, many patients have those and they get sick from that. It can be in the ground, it can be from coal burning. If you live in a cement plant or a coal plant, that basically goes up in the atmosphere, comes down in the soil, your kids are playing with it, be dragged in the house, the baby's on the floor. So lead exposure is real. There's houses that still have leaded paint. All the leaded gasoline that was used for years, all that went in the air and goes down to the soil. It can be in vegetables if you're growing in an urban environment. For example, you're growing greens, you think you're eating kale and being healthy, it could be full lead.

• 50:20Dr. Mark Hyman?

  Now arsenic also is a big problem and it's found in rice, many places because it's in the ground. It can be in pressure treated lumber that you have on your deck and getting your feet. It can go actually. In uh in chicken feed to prevent the the feed from going moldy, which is great for the feed and the mold, but it's not good for you and it gets in the chicken, you eat it. So it's pretty, it's pretty important for us to make sure that we get rid of those. Um, so I think the the key is um, we need to avoid toxins. And so the question is, what are the top strategies to reduce our toxic burden? Well, we can basically remove the toxins, but we we also have to upregulate our detox system.

• 51:04Dr. Mark Hyman?

  So the first thing is avoid plastics wherever you can. Try stainless steel, like containers, I have those, or glass containers for storing food in your in your fridge. Uh, stealing some water bottles, glass containers are great for leftovers. Um, don't buy water and plastic water bottles, get a water filter. I like Versosmosis and you can actually get a water bottle, bring it with you. Uh, make sure you detox your home. Um, get simple cleaning products, a laundry detergent, cleaning product for windows, for counters, for dishwasher, stuff, everything. And um, there's a great source, Thrive Market. You can get, it's an online grocery store, basically, and you can get all the best cleaners from seventh generation and other eco-friendly, non-toxic food companies.

• 51:45Dr. Mark Hyman?

  Uh, and now, of course, check out AWG's guide on household cleaning products, on skin care products. Uh, they're great. Um, so I think make sure that you just are diligent about getting toxins out of your home. Um, second is mercury is a big one, and often we don't pay attention to what we're eating and people eat tuna fish, swordfish, sushi. Sadly, all the oceans have been polluted and no matter where you get your fish from, it's pretty much pre-polluted. There's microplastics, mercury, uh, and other toxins, PCBs, farm fish can be just as bad. So there are a few kind of ways to get around it. One is to eat very small fish, sardines, mackerel, herring, anchovies.

• 52:26Dr. Mark Hyman?

  Small salmon can be okay, but still that can have mercury. Also, there's a great uh regenerative aquaculture company called SeaTopia dot fish, and they actually provide beautiful, delicious, clean fish that you can get frozen, sent to your home. It's amazing fish, actually. And um, also reduce your exposure to Uh, the, the problems that are from, um, you know, all the, the chemicals in your environment by having the air filter in your house that reduces their airborne pollution. Indoor air pollution is a real thing, whether it's mold or whether it's, um, other things that contaminants off gassing from furniture or rugs.

• 53:05Dr. Mark Hyman?

  I mean, you wanna obviously try to have a clean home and not full of products, but I mean, you buy a Tempur-Pedic bed and it smells awful. It's off gassing. Those are called VOCs, Vals organic compounds. You really wanna avoid those in, in your house. And then, um, you wanna start to learn about how to actually upgrade and increase your body's own detoxification system. And the best way to do that is by using a couple of strategies that are really important. One is maximize your intake of phytochemicals. Uh, plant-based compounds, these nutrients in plants work on upregulating different pathways in the body, including a lot of detox pathways.

• 53:43Dr. Mark Hyman?

  There's amazing cornucopia of phytochemicals that work on boosting glutathione and boosting our detox pathways and increasing our ability to get rid of stuff. So the, the biggest category is the cruciferous vegetables, broccoli, collards, cabbage, kale, Brussels sprouts. They really upregulate glutathione in the body and help to maximize the main detoxifier. Also, there are amazing things like garlic and onions that also contain sulfur that are great for detoxification. Also, things like rosemary, curcumin, ginger, um, and a skin of a lemon. Like if you grate lemon into a salad or something, the skin of a lemon has limonene. These all help upregulate our detox pathways. We also need the right nutrients, right?

• 54:27Dr. Mark Hyman?

  We need methylation support, B12, folate, B6, we need magnesium, selenium, zinc, and, and many other minerals and vitamins to actually help upregulate our detox pathways. We need amino acids and form protein to help with some of the amino acid pathways. So there's lots of ways we now understand the body's own built-in detox system and we have to support it. Uh, the next thing you do is, um, sweat. So your body gets rid of toxins through both exercise, increasing the lymphatic flow and circulation through exercise, increased circulation. And also, um, saunas, uh, so a sauna is an amazing way to boost your detox system and, and help body remove a lot of environmental toxins that you're fat soluble and you can actually measure them on the sweat.

• 55:13Dr. Mark Hyman?

  You also want to take the right supplements, as I mentioned, so you want to take additional support of a good multi, methylating support zinc, vitamin C, glutathione boosting stuff, N-ecylsysteine, lipoic acid, milk thistle, a lot of other herbs can be used to help to boost the body detox pathway. So I highly recommend getting on a regular support system for that. I do because we're all exposed. Sometimes if you have a real big issue, you might need to see a doctor and get treated, like I did for mercury poisoning. I needed chelation. I needed to actually use a medication to help remove the metals from my body. It's lead, you can use EDTA. It's mercury, you can use DMSA. And they're extremely effective. They need to be used properly and safely with a doctor's supervision. There's a lot

• 55:56Dr. Mark Hyman?

  of steps to properly getting rid of mercury, but you need a good functional medicine doctor. If you love this podcast, please share it with someone else you think would also enjoy it. You can find me on all social media channels at Dr. Mark Hyman. Please reach out. I'd love to hear your comments and questions. Don't forget to rate, review, and subscribe to the Dr. Hyman Show wherever you get your podcasts. And don't forget to check out my YouTube channel at Dr. Mark Hyman for video versions of this podcast and more. Thank you so much again for tuning in. We'll see you next time on the Dr. Hyman Show. This podcast is separate from my clinical practice at the Ultra Wellness Center, my work at Cleveland Clinic, and Function Health, where I am Chief Medical Officer. This podcast represents my opinions and my guests' opinions. Neither myself nor the podcast endorses the views or statements of my guests. This podcast is for educational purposes only

• 56:39Dr. Mark Hyman?

  and is not a substitute for professional care by a doctor or other qualified medical professional. This podcast is provided with the understanding that it does not constitute medical or other professional advice or services. If you're looking for help in your journey, please seek out a qualified medical practitioner. And if you're looking for a functional medicine practitioner, visit my clinic, the Ultra Wellness Center at UltraWellnessCenter.com, and request to become a patient. It's important to have someone in your corner who is a trained, licensed healthcare practitioner and can help you make changes, especially when it comes to your health. This podcast is free as part of my mission to bring practical ways of improving health to the public. So I'd like to express gratitude to sponsors that made today's podcast possible. Thanks so much again for listening.

• 57:23Dr. Mark Hyman?

  When it comes to supplements, you only want the best for your body, the kind with the highest quality, cleanest, and most potent ingredients you can get. That's exactly what you'll find at my supplement store, where I've hand-selected each and every product to meet the most rigorous standards for safety, purity, and effectiveness. These are the only supplements I recommend to my patients, and they're also what I use myself. Whether you want to optimize longevity, or reduce your disease risk, or you're looking to improve your sleep, blood sugar, metabolism, gut health, you name it, DrHyman.com has the world's best selection of top-quality, premium supplements, all backed by science and expertly vetted by me, Dr. Mark Hyman. So check out DrHyman.com, because when it comes to your health, nothing less than the very best will do. That's DrHyman.com, D-R-H-Y-M-A-N dot com.