The 5 Biggest Longevity Myths—and What to Do Instead

In this episode, I break down five popular longevity myths that may be distracting you from the things that actually have the biggest impact on how long and how well you live. Here’s what I discuss in today’s episode: The common longevity goal that may actually work against you as you get older Why the “perfect” supplement stack can’t replace the habits that matter most The mistake people make when they try to keep their body in constant repair mode What the science really says about red wine, genetics, and the factors that shape how you age Longevity isn’t about building the world’s most complicated routine. It’s about protecting your strength, energy, brain function, and independence for decades to come. Get the fundamentals right first—then layer in the extras. Visit ⁠functionhealth.com for 160+ lab tests at just $365 a year. Have a question you’d love answered on Office Hours? Submit it here. 0:00 Longevity industry hype, fundamentals, and common myths1:11 Myth 1 - The Thinner You Are The Healthier YouWill Age2:40 Myth 2 - Supplements, repair mode, and other longevity myths4:11 Myth 3 - Keeping Your Body In Repair Mode7:54 Myth 4 - Wine is good for you 9:24 Myth 5 - Longevity Is Mostly Genetic10:34 The longevity reality check and what you can change11:13 The real path to healthspan, strength, and independence

Speaker names marked ? are inferred from speaking time and the show’s known hosts — they are not voice-verified.

• 0:00Dr. Mark Hyman?

  Longevity has become an industry. Cold plunges, supplements, wearables, peptides, hyperbaric chambers, elaborate morning routines. And listen, I'm fascinated by this stuff. I use many of these tools myself. I have a morning routine. I do cold plunges. I use certain supplements and peptides. I love experimenting with new ways to optimize my health. I'm always interested in where the science is going. But here's the thing. None of these tools can replace the fundamentals. You can have the perfect supplement stack, track every biomarker, spend thousands of dollars on the latest longevity therapies. But if you're not exercising, you're not building muscle, you're not sleeping well, you're not eating real food, and you're not taking care of your metabolic health,

• 0:43Dr. Mark Hyman?

  you're optimizing the margins while ignoring the foundation. And I think that's where the longevity conversation can sometimes get off track. So today, we're going to cut through some of the noise. What actually matters most if you want to live a longer, healthier life? We're going to talk about that. Because you don't need to give up the cold plunges or throw away yourself from this. You just need to know what deserves your attention first. This episode was brought to you by Function. Get access to over 160 lab tests annually at functionhealth.com/marc. All right, let's dive into the myth. The first myth is the thinner you are, the healthier you'll age. Let's start with the scale. For decades, we've been conditioned to think lower weight equals better health. An excess body fat, particularly visceral fat,

• 1:26Dr. Mark Hyman?

  is absolutely associated with metabolic disease. But here's the problem. Weight doesn't tell you what you're made of. You can lose 20 pounds and celebrate what you see on the scale, but what did you lose? Fat, muscle, both? Because as you get older, preserving muscle becomes incredibly important. Age-related loss of muscle and strength can affect your mobility, your balance, your ability to perform everyday tasks, and ultimately, your independence. The National Institute on Aging notes that exercise can help protect against age-related loss of muscle mass, strength, and function. So I don't want someone who's 65 years old obsessing over getting as thin as possible. I want to know, are you metabolically healthy? Are you strong? How much muscle do you have? Can you move well?

• 2:11Dr. Mark Hyman?

  So do this instead. Get stronger. Stop making weight the only metric. Track your strength and your physical function. Can you carry heavy groceries? Can you get up off the floor without using your hands? Try that. Climb several flights of stairs. Can you maintain your balance on one foot, for example? It's important to make resistance training a regular part of your life. Your goal isn't simply to weigh less at 70, it's to be stronger at 70. Muscle is the key organ of longevity. All right, the second myth is the right supplements can slow aging. Now, this may be the most tempting longevity myth, because wouldn't it be nice? Take the right combination of pills every morning and buy yourself another decade.

• 2:54Dr. Mark Hyman?

  NAD boosters, risperidone, antioxidants, multivitamins. There are absolutely situations where supplements can be useful. If you're deficient in something, treating the deficiency matters. There are nutrients and compounds with interesting evidence for particular health goals. But there's an enormous difference between this supplement affects the biological pathway associated with aging and taking this will make you live longer. We need to stop confusing the two. And here's a great reality check. The NIH researchers analyzed nearly 400,000 healthy US adults, and they followed them for more than 20 years. And they found that regular multivitamin use wasn't associated with a lower risk of death. That doesn't mean that multivitamins are useless.

• 3:35Dr. Mark Hyman?

  It means a supplement isn't a longevity strategy by itself. Instead of more supplements, I want you to master the fundamentals first. Before you spend 300 bucks a month on supplements, ask, am I exercising? Am I sleeping enough? Am I eating mostly whole nutrient-dense foods? Am I maintaining my metabolic health? Am I smoking? How much am I drinking? Am I managing stress? Am I taking care of my gut health? Supplements belong at the top of the pyramid, not the bottom. So use them strategically when there's a reason, but don't supplement your way around the behaviors that have much stronger evidence behind them. A third myth is longevity is about keeping your body in permanent repair mode. Well, here's another longevity idea that's gotten oversimplified.

• 4:20Dr. Mark Hyman?

  Autophagy is good. More autophagy, less mTOR, longer fast, more cellular cleanup. Sounds good. But biology doesn't work in absolutes. And your body actually needs to do two very different jobs if you want to age well. Yes, it needs to clean up and repair, and autophagy is important. But it also needs to rebuild. So think about renovating a house. First, you bring in the demolition crew. They clear out what's old, damaged, no longer working. And that's essentially what autophagy does in your body. It's your cellular cleanup system and recycling system, breaking down damaged proteins and cellular components so they can be cleared or reused.

• 5:01Dr. Mark Hyman?

  Things like fasting and simply giving your body a break from eating can help shift your biology toward those repair pathways. That's important. But eventually, the demolition crew has to leave, and the construction crew has to come in. And that's where mTOR comes in. So what is mTOR? Well, it's one of the body's most important nutrient sensing pathways. I call it the longevity switch. When it's activated, particularly by amino acids from protein and from strength training or resistance training, it helps signaling your body to synthesize protein and build and maintain muscle. Now, as we get older, that becomes incredibly important because one of the things we're fighting against with aging is the loss of muscles.

• 5:45Dr. Mark Hyman?

  So if you're constantly fasting or just eating one meal a day, like people also you'll do, or you're chronically under-eating protein, or you're trying to suppress mTOR all the time because you think that's the secret to longevity, you may be working against another important longevity goal: maintaining muscle. I've talked about this before. The longevity benefits associated with autophagy can have a downside when taken too far because prolonged excessive suppression of these growth pathways can contribute to muscle loss. So do this instead. Cycle between repair and rebuilding. The goal isn't between suppressing mTOR and inducing autophagy or activating mTOR and building muscle. You need both. You want periods when you're not eating overnight, for example, when your body has an opportunity to shift toward cleanup and repair.

• 6:31Dr. Mark Hyman?

  And then you want periods where you're giving your body the raw materials and the stimulus it needs to rebuild. You want to eat adequate, high-quality protein. You want to strength train. You want to build and maintain muscle. And then you give your body time when you're not constantly feeding it to rhythm. Cleanup, rebuild, cleanup, rebuild. That's how your body was designed to work. So don't fall into the trap of thinking, if some fasting is good, more fasting must be better. Not true. Or if sometimes suppressing mTOR is good, activating mTOR must be bad. Nope. The longevity sweet spot isn't keeping your body permanently in one state. It's knowing when to repair and when to rebuild. Let me tell you what a typical physical looks like. Few basic lab tests, no imaging unless something's wrong. With Function, we've created a new standard.

• 7:16Dr. Mark Hyman?

  Labs plus an MRI every single year. You get access to 160-plus lab tests to measure signals in your blood, including inflammation, heart disease risk, metabolic health, and lots more. And you can complete your health baseline with an annual MRI to understand where things are happening. It scans for signs of cancer in the brain, pancreas, kidneys, prostate, and more, plus conditions like strokes, aneurysms of the value liver. Two views, one clear picture. Your first year sets your baseline. Every year, after, shows the trend. Take control and check your health at functionhealth.com/marc. And if you're one of the first 1,000 people this week, use the code MARC2026 for a $50 credit toward your $365 annual membership.

• 7:57Dr. Mark Hyman?

  All right, the fourth myth is a glass of red wine every night is good for you. For years, this was practically treated as medical advice. Have a glass of red wine. It's good for your heart. Maybe you heard of the French paradox. Maybe you heard that risperidone and red wine promotes longevity. But the story has become much less convincing as the research has improved. Here's what we know very clearly today. Alcohol causes cancer. It's an established human carcinogen associated with cancers, including breast, colorectal, liver, esophageal, head and neck cancers. Cancer risk generally increases with greater consumption. Even light drinking, though, can increase the risk of some cancers. So I think we need to separate two completely different statements.

• 8:42Dr. Mark Hyman?

  I enjoy having a glass of wine occasionally, and I'm drinking wine because it's good for me. Those aren't the same thing. Do this instead. Don't confuse pleasure with medicine. If you enjoy an occasional glass of red wine and understand the trade-offs, that's a personal decision. But I wouldn't start drinking alcohol because you're trying to live longer. If what you're after is polyphenols, you don't need red wine to get them. Eat colorful vegetables, berries, herbs, spices, nuts, seeds, teas. The National Cancer Institute specifically notes that despite speculation around red wine, there's no scientific evidence that red wine reduces heart disease risk, but it is a known cause of cancer. Wine can be something you enjoy. Just don't mistake it for a longevity strategy. All right, here we go with myth number five.

• 9:27Dr. Mark Hyman?

  Longevity is mostly genetic. Well, this one can make you feel powerless. My dad had diabetes. Heart disease runs in my family. Everyone in my family gets sick in their 60s. Genes absolutely matter. They can influence your susceptibility to certain diseases and aspects of how you age. But your genes don't operate in isolation. They're interacting with your environment and your behaviors every single day. What are you eating? Are you exercising? Are you sleeping? Are you smoking? How much alcohol are you drinking? What's your metabolic health? How connected are you to other people? Are you getting appropriate preventive health care? All these things can impact gene expression. Now, although some factors such as genetics aren't under our control,

• 10:11Dr. Mark Hyman?

  there are modifiable behaviors that can support living longer and healthier and improve our gene expression. So do this instead. Focus on what you can change. You can't choose your parents, but you can choose what you do today. And that means instead of asking, what disease am I destined to get? Ask, knowing my family history, what can I start doing now to reduce my risk? That's a much more useful longevity question. Okay, so here's the longevity reality check. Let's pull all these five myths together for a longevity reality check. Myth, get thinner, instead get stronger. Myth, find the perfect supplement stack, instead master the fundamentals first. Myth, keep your body in repair mode, instead cycle between repair and rebuild.

• 10:55Dr. Mark Hyman?

  Myth, a little red wine is good for you for longevity? Well, instead, enjoy a glass of red wine if you choose to, but don't make it part of your longevity prescription or even any type of framework around health. Myth, your genes determine how you'll age. Instead, focus relentlessly on the variables you can change. Here's what I want you to remember. Longevity doesn't start with a biohack. It starts with the things we already know matter. Move your body, build muscle, eat real food, get good sleep, don't smoke, be thoughtful about alcohol, manage your metabolic health. That's a big one. Stay connected to people you love. Take care of health problems before they become bigger ones. None of that sounds particularly futuristic. And maybe that's the point.

• 11:37Dr. Mark Hyman?

  The longevity industry is constantly giving us something new to optimize. The fundamentals haven't changed nearly as much. So before you worry about the newest supplement or the latest longevity technology, ask yourself, am I doing the things we already know work? When the answer is yes, then start incorporating new practices and supplements into your routine. Because the goal isn't to build the world's most complicated longevity routine, is to reach your 70s, 80s and beyond with strength, with energy, with brain function and independence to actually enjoy those extra years. And that's really what HealthSpan is all about.

• 12:10Dr. Mark Hyman?

  If you love this podcast, please share it with someone else you think would also enjoy it. You can find me on all social media channels at Dr. Mark Hyman. Please reach out. I'd love to hear your comments and questions. Don't forget to rate, review and subscribe to the Dr. Hyman Show wherever you get your podcasts. And don't forget to check out my YouTube channel at Dr. Mark Hyman for video versions of this podcast and more. Thank you so much again for tuning in. We'll see you next time on the Dr. Hyman Show. This podcast is separate from my clinical practice at the Ultra Wellness Center, my work at Cleveland Clinic and Function Health, where I am Chief Medical Officer. This podcast represents my opinions and my guests' opinions. Neither myself nor the podcast endorses the views or statements of my guests. This podcast is for educational purposes only and is not a substitute for professional care by a doctor or other qualified medical professional.

• 12:55Dr. Mark Hyman?

  This podcast is provided with the understanding that it does not constitute medical or other professional advice or services. If you're looking for help in your journey, please seek out a qualified medical practitioner. And if you're looking for a functional medicine practitioner, visit my clinic, the Ultra Wellness Center at ultrawellnesscenter.com and request to become a patient. It's important to have someone in your corner who is a trained, licensed healthcare practitioner and can help you make changes, especially when it comes to your health. This podcast is free as part of my mission to bring practical ways of improving health to the public. So I'd like to express gratitude to sponsors that made today's podcast possible. Thanks so much again for listening.

• 13:33Dr. Mark Hyman?

  When it comes to supplements, you only want the best for your body, the kind with the highest quality, cleanest and most potent ingredients you can get. That's exactly what you'll find at my supplement store, where I've hand-selected each and every product to meet the most rigorous standards for safety, purity and effectiveness. These are the only supplements I recommend to my patients, and they're also what I use myself. Whether you want to optimize longevity or reduce your disease risk or you're looking to improve your sleep, blood sugar, metabolism, gut health, you name it, drhyman.com has the world's best selection of top-quality, premium supplements, all backed by science and expertly vetted by me, Dr. Mark Hyman. So check out drhyman.com because when it comes to your health, nothing less than the very best will do. That's drhyman.com, D-R-H-Y-M-A-N dot com.