213. Nicole Bell: The Hidden Dangers of Lyme Disease—Brain Fog, Alzheimer's & Misdiagnosis
Extend Podcast with Darshan Shah, MD
Hosted by Dr. Darshan Shah
- 49m
- Transcript
Summary
Written by a model from the transcript; not yet reviewed.
This episode explores the hidden dangers of Lyme disease and its co-infections, focusing on why traditional Western medicine frequently misses them. The guest, CEO of Galaxy Diagnostics Nicole Bell, shares her personal journey after her husband was misdiagnosed with early-stage Alzheimer's disease at age 59, only to discover years later that he actually suffered from untreated Lyme disease along with Bartonella and Babesia. Together with the host Dr. Darshan Shah, they discuss how stealth pathogens evade standard antibody blood tests by hiding in low quantities within tissues and crossing the blood-brain barrier. The conversation highlights alternative diagnostic methods such as urine antigen testing and direct blood PCR, while emphasizing that identifying the root infectious cause of neuroinflammation is critical for longevity and effective treatment.
- Standard antibody tests often miss Lyme disease because antibodies take weeks to peak and stealth pathogens hide in tissue rather than blood. 7:52
- Ticks function like dirty needles, transmitting multiple co-infections like Babesia and Bartonella that require treatments completely different from standard doxycycline. 15:27
- Urine antigen testing directly detects free surface proteins shed by Lyme bacteria, providing a more reliable indicator for both acute and chronic cases. 21:00
- Hormonal transitions, high stress, or immune-suppressing events can reactivate dormant, asymptomatic tick-borne infections and trigger severe chronic symptoms years later. 31:46
Chapters
- 0:03Podcast Introduction and Host Background
Dr. Darshan Shah welcomes listeners, introduces the Extend Podcast, and briefly outlines his medical credentials and focus on longevity.
- 0:50Meet Nicole Bell and Her Lyme Journey
Nicole Bell, CEO of Galaxy Diagnostics, shares how her husband's health decline led her to investigate Lyme disease and co‑infections.
- 2:00Why Lyme Disease Is Overlooked in Western Medicine
Nicole explains the prevalence of Lyme disease, the shortcomings of standard blood tests, and how the bacteria hide in tissues rather than blood.
- 2:48The Hidden Link Between Lyme and Alzheimer’s
Nicole discusses how untreated Lyme and co‑infections can trigger neuroinflammation, leading to early onset Alzheimer’s-like symptoms.
- 8:00Challenges of Diagnosing Stealth Pathogens
The conversation covers why antibody tests often miss Lyme, the need for direct detection, and the role of antigen testing.
- 10:00Galaxy Diagnostics’ Urine Antigen Test
Nicole explains the science behind the urine antigen test, its advantages over blood tests, and its potential for early detection.
- 35:06Future Directions and Advocacy
Nicole outlines goals for broader test availability, integration into standard labs, and the need for increased awareness among clinicians and patients.
- 46:37Impact of Chronic Illness on Life
Nicole discusses how chronic illness can devastate even high-functioning individuals, leading to emotional and physical hardship.
- 47:09Book Release: What Lurks in the Woods
Nicole introduces her book, detailing her journey with chronic illness and dementia care.
- 47:51Building Support Networks
She emphasizes the importance of community and empathy for those dealing with chronic illness.
- 48:36Closing Remarks and Thank You
The host thanks Nicole, invites future discussions, and encourages listeners to subscribe and seek professional advice.
Highlights
- 4:40
A Devastating Misdiagnosis Journeystory
The guest recounts how her brilliant husband developed rapid cognitive decline, was diagnosed with late-stage early-onset Alzheimer's, and ultimately passed away before uncovering the true cause: untreated Lyme disease and co-infections.
- 6:32
Infections Driving Alzheimer's Pathologyinsight
Post-mortem analysis of the guest's husband's brain confirmed the presence of Borrelia and Babesia, supporting the view that amyloid plaques and tau tangles are immune responses to underlying chronic stealth infections.
- 8:20
Why Antibody Testing Failsinsight
Standard antibody tests fail because stealth pathogens actively evade the immune system and hide in tissues, meaning low initial antibody titers and testing delays cause over 70 percent of early cases to be missed.
- 15:22
Treating Co-Infections Differentlystrategy
Babesia is a parasitic infection resembling malaria rather than Lyme, meaning frontline doxycycline will fail to treat it and requires an entirely different therapeutic approach.
- 20:33
Urine Antigen Testing Advantagestrategy
Because Lyme bacteria shed surface protein biomarkers that filter through the kidneys into urine, urine antigen tests offer a direct detection method that bypasses flawed antibody measurements.
- 26:50
Exploding Tick Endemic Ratesdata
A study in Ohio tracked black-legged ticks in a county over a ten-year span and found that the percentage carrying Lyme disease jumped from 2 percent to nearly 50 percent.
- 35:53
Bartonella and Severe Psychosisstory
A 14-year-old boy suffering from sudden-onset homicidal psychosis and institutionalization tested positive for Bartonella after a nurse noticed skin striae, recovering fully and graduating valedictorian after receiving rifampin.
Quotes
“Lyme disease doesn’t work that way.”
Dr. Darshan Shah · 7:55 “The best time to treat these pathogens is early, right? As soon as you get bit, as soon as you figure it out.”
Unnamed speaker · 9:01 “If you have a new dog or cat or something, you have a flea infestation, that’s an exposure.”
Unnamed speaker · 37:05 “The power in the hands of the caregiver or the patient. Because you know what’s wrong with you. You might not be a medical expert.”
Unnamed speaker · 39:59 “Right? Because in my mess of chaos, one thing people don't realize is how devastating chronic illness can be.”
Unnamed speaker · 46:37 “I found that, like, writing it down helped give it an outlet.”
Unnamed speaker · 47:09 “And it's a good way to know that there's other people that are suffering in the same way.”
Unnamed speaker · 47:51 “Because that community and that support network is a huge piece of getting well.”
Unnamed speaker · 48:11
Sponsored segments
- Next Health 17:32–18:26
- Momentus 33:39–34:35
About this episode
What if a negative Lyme disease test doesn't tell the whole story? And could an overlooked infection be contributing to symptoms like brain fog, chronic fatigue, or even cognitive decline? When Nicole Bell's husband began experiencing personality changes, memory loss, and confusion, doctors diagnosed him with early-onset Alzheimer's disease. But Nicole, an engineer with a background in medical diagnostics, couldn't shake the feeling that something was being missed. Despite initially testing negative for Lyme disease, her husband was later found to have evidence of Lyme and other infections, including Bartonella and Babesia. His decline and eventual passing transformed Nicole's life, inspiring her to become CEO of Galaxy Diagnostics and advocate for better testing for tick-borne diseases. In this episode, Nicole joins me to explore the often-overlooked world of Lyme disease, chronic symptoms, tick-borne infections, and their potential connections to brain health and inflammation. We discuss why Lyme disease can be difficult to diagnose, the limitations of traditional antibody testing, and emerging diagnostic approaches designed to detect infections more directly. In this episode, you'll learn: Why Lyme disease can be difficult to diagnose, especially in its early stages How Lyme disease and other tick-borne infections may affect the brain, joints, heart, and nervous system What researchers are investigating about infections, neuroinflammation, and Alzheimer's disease Why a negative Lyme disease test doesn't always rule out an infection The differences between antibody testing, PCR testing, and emerging urine antigen tests What Bartonella and Babesia are, and why identifying co-infections matters Why Lyme disease doesn't always cause the classic bullseye rash What to know about tick bites, early symptoms, and seeking prompt medical evaluation How to advocate for yourself when you're experiencing unexplained or persistent symptoms We also discuss the challenges of living with chronic illness, the importance of early detection, and Nicole's mission to make more accurate diagnostic tools accessible to patients and healthcare providers. Nicole shares the deeply personal story behind her book, What Lurks in the Woods, and the lessons she learned navigating her husband's illness while raising a family and searching for answers. The biggest takeaway? A negative test isn't always the end of the diagnostic process, especially when symptoms and exposure history suggest there's more to investigate. Understanding your symptoms, asking better questions, and working with knowledgeable healthcare professionals can make an enormous difference in identifying health problems earlier. Because longevity isn't just about treating disease once it appears. It's about recognizing warning signs, understanding potential causes, and giving ourselves the best opportunity to protect our long-term health. Learn more about Dr. Shah: Website: drshah.com https://drshah.com Clinic: next-health.com https://www.next-health.com/ Instagram: @darshanshahmd and @extend_podcast Learn more about Nicole Bell: Website: galaxydx.com https://www.galaxydx.com/ Instagram: @nicoledaniellebell and @galaxydiagnostics Book - What Lurks in the Woods: amazon.com/What-Lurks-Woods https://www.amazon.com/What-Lurks-Woods-Struggle-Chronic/dp/1955711011 Thank You to Our Sponsors! Next Health: Your destination for cutting-edge health optimization - from IV therapy to hormone balancing. Explore at next-health.com https://www.next-health.com/! Momentous: Head to livemomentous.com https://livemomentous.com and use my code DRSHAH at checkout for up to 35% off.
Transcript
9,598 words · 2 speakers
Speaker names marked are inferred from speaking time and the show’s known hosts — they are not voice-verified.
Topics
- Bartonella
- Lyme disease
- Babesia
- Borrelia
- Galaxy Diagnostics
- CDC
- LabCorp
- What Lurks in the Woods
- Nashville
- Ohio
Page updated · transcript and summary are machine-generated