
Invest Like the Best with Patrick O'Shaughnessy
Hosted by Patrick O'Shaughnessy
Written by a model from the transcript; not yet reviewed.
Scott Nolan discusses his transition from early engineer at SpaceX and long-time investor at Founders Fund to founding General Matter, a company tackling the lack of domestic uranium enrichment capacity in the United States. The conversation explores the guest's framework for choosing what to work on, the relationship between government agencies and private enterprise, the critical importance of energy in economic growth, and the taxonomy of advanced nuclear reactors. Nolan explains how the uranium enrichment bottleneck threatens the future of advanced reactors and how his company aims to secure the fuel supply chain for both new reactors and the existing grid.
The episode opens with sponsor messages and a brief host introduction before launching into the main interview.
Patrick O'Neal introduces Scott Nolan, outlining his background at SpaceX, Founders Fund, and his new venture General Matter focused on uranium enrichment.
Scott discusses his decision framework of pursuing useful, impactful problems and how this guided his moves from SpaceX to venture capital to founding General Matter.
Scott recounts his SpaceX experience, the lessons on rapid engineering, and how that mindset translated to tackling the bottleneck of uranium enrichment in the U.S.
He outlines the importance of bringing engineering and manufacturing in-house to overcome the complex subcontractor chains in aerospace and nuclear industries.
Scott presents data linking energy consumption to GDP per capita, arguing that U.S. energy stagnation hampers economic competitiveness against China.
He makes the case for nuclear as the safest, cleanest, and most reliable baseload power source, especially for data centers and industrial processes.
Scott breaks down reactor types by scale—gigawatt grid, megawatt microreactors, and small modular reactors—highlighting their distinct market opportunities.
Explores how data centers can generate power independently and benefit local communities without impacting the grid.
Details the Bring‑Your‑Own‑Energy model where data centers invest in local power and negotiate community acceptance.
Discusses the main obstacles—fuel availability and cost—that could derail advanced nuclear reactors.
Outlines the nuclear fuel supply chain and identifies the lack of high‑assay low‑enriched uranium as a critical cliff.
Why SpaceX Succeeded Early Oninsight
The guest explains that joining SpaceX early was a no-brainer because the incumbent aerospace industry had stagnated for decades under government cost-plus contracts with dozens of layers of subcontractors.
Founder-Friendly Venture Capital Genesisstory
Peter Thiel and Founders Fund started with the premise of giving control back to founders because the most successful companies were founder-run all the way to the end.
The Dangers of Valuation Trendsinsight
The guest argues that hunting for value deals in venture capital is a dangerous mistake because low valuations often signal an inability to raise capital at market prices.
Stranded Demand and Microreactorsstrategy
Founders Fund invested in Radiant to serve stranded demand in remote locations like Alaskan villages where diesel generators command extremely high rates.
Discovering the Nuclear Bottleneckstory
After investing in advanced reactor companies and realizing they all faced a severe fuel shortage, the guest spent a year investigating the nuclear supply chain and identified enrichment as the critical bottleneck.
Collaborative Government Partnershipsstory
The guest shares that working closely with NASA engineers on the Dragon capsule program was remarkably collaborative because the agency staff were true believers who wanted the mission to succeed safely.
Energy Consumption and GDP Correlationdata
There is a very strong statistical correlation with an R-squared over 0.8 between GDP per capita and energy consumption per capita across the countries of Earth.
The US Uranium Enrichment Gapdata
The United States has good capability across the nuclear fuel cycle except for enrichment, having outsourced commercial-scale enrichment to Russia and Europe.
“My framework has always been, just do something that's useful. Do something that you feel like you're making a real contribution and using your talents to make some type of positive impact.”
“I think there's all the classic things. There's the Elon algorithm at this point. I don't think it was explicit back then. It was just, hey, we have to get this rocket launched.”
“Energy use and production is the ultimate proxy for human prosperity, for economic activity, for all these things.”
“If you look statistically, it's always been the safest, cleanest baseload.”
“You need it to be highly reliable. And so nuclear is the most reliable.”
“If you have a data center putting billions into both the compute and the power production. Let's say they're even 50 50 on power production and compute.”
“Our North Star metric is dollars per kilo SWU.”
“The team you build is the company you build.”
Scott Nolan spent 12 years at Founders Fund looking for the most important problems that no one else was funding. Then he found a problem so critical, and so ignored, that he couldn't find a company to back. So he started one. General Matter is rebuilding US uranium enrichment. The United States was the world leader in enrichment through the 1980s and then stopped entirely. Today roughly a quarter of US enriched uranium comes from Russia, a ban on those imports takes full effect in 2028, and the advanced reactors everyone is counting on to power the next wave of data centers have no reliable domestic fuel source. Scott believes enrichment is the single bottleneck to a nuclear future, and that the window to solve it is narrow. The conversation covers how Peter Thiel influenced him, why being in love with an idea is dangerous for investors but required for founders, and what it actually takes to rebuild an industrial capability the country let atrophy for 40 years. Please enjoy my conversation with Scott Nolan. For the full show notes, transcript, and links to mentioned content, check out the episode page here. ----- Become a Colossus member to get our quarterly print magazine and private audio experience, including exclusive profiles and early access to select episodes. Subscribe at colossus.com/subscribe. ----- Ramp’s mission is to help companies manage their spend in a way that reduces expenses and frees up time for teams to work on more valuable projects. Go to ramp.com/invest to sign up for free and get a $250 welcome bonus. ----- Trusted by thousands of businesses, Vanta continuously monitors your security posture and streamlines audits so you can win enterprise deals and build customer trust without the traditional overhead. Visit vanta.com/invest. ----- WorkOS is a developer platform that enables SaaS companies to quickly add enterprise features to their applications. Visit WorkOS.com to transform your application into an enterprise-ready solution in minutes, not months. ----- Rogo is the AI platform for finance. They're building agents for Wall Street that are trained to understand how bankers and investors actually do work: from diligence and modeling, to turning analysis into deliverables. To learn more, visit rogo.ai/invest. ----- Ridgeline has built a complete, real-time, modern operating system for investment managers. It handles trading, portfolio management, compliance, customer reporting, and much more through an all-in-one real-time cloud platform. Visit ridgelineapps.com. ----- Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com). Timestamps: (00:00:00) Welcome to Invest Like The Best (00:02:45) Guest Intro: Scott Nolan (00:03:36) SpaceX, Founders Fund & General Matter (00:08:04) What Scott learned from Peter Thiel (00:10:05) The "Avoid Trends" Concept (00:10:55) Finding Important Problems No One Is Working On (00:17:32) Gut v. Intuition (00:18:49) Valuation, Competition & Capital Intensity (00:20:20) Founders Fund Strategy (00:21:06) The Steeper the Up Round, the Greater the Undervaluation (00:21:41) Being in Love with the Problem (00:26:07) Governments, Technology & History (00:28:54) Lessons from SpaceX and Elon (00:29:42) Vertical Integration (00:33:07) The Role of Energy in Civilization (00:37:36) State & Direction of US Energy (00:38:58) Why Nuclear? (00:42:20) Taxonomy of Advanced Reactors (00:45:33) The BYOE Concept (00:46:50) What Could Make Advanced Reactors Fail? (00:48:04) General Matter: Product, Business & Company (00:50:12) Enrichment & Weapons-Grade Uranium (00:56:45) North Star Metric (01:01:05) Building a Great Enduring Company (01:04:01) How Scott Runs the Company (01:06:11) Overcoming Irrational Fears About Nuclear (01:08:25) Why Aren't There More Founders Funds? (01:10:03) Operating vs. Investing (01:11:56) Kindest Thing
15,319 words · 3 speakers
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