
Hosted by Jason Calacanis
Written by a model from the transcript; not yet reviewed.
This episode of This Week in Startups covers major industry developments, including a staggering $6.3 billion hack on Binance, a $17 billion acquisition deal where DoorDash agreed to buy Instacart, and a pitch from Hermetic co-founder and CEO Jake Newfield. The host debates the risks of holding large balances on centralized crypto exchanges, discusses the antitrust climate under the current administration, and evaluates the business model and ad revenues behind grocery delivery services. Later, the show features product demos from bounty contestants building an annotated reading and clipping extension.
Jason Calacanis opens the show, announcing the massive Binance hack and setting the stage for the episode’s discussion.
The hosts dive into the specifics of the $6.3 billion theft, Binance’s response, and the broader implications for the crypto industry.
The conversation turns to practical steps for users to protect funds, including moving assets to personal wallets and diversifying bank accounts.
Jason and the host explore CZ’s legal history, including his U.S. conviction, pardon, and how it relates to Binance’s recent crisis.
The hosts analyze DoorDash’s purchase of Instacart, antitrust concerns, and the strategic rationale behind the merger.
The show wraps up with final thoughts, upcoming events, and a teaser for the next episode’s content.
Guest Jake Newfield presents Hermetic’s AI‑driven build automation platform, explaining its market opportunity and funding status.
Jason shares tactics for founders to secure funding, emphasizing lighthouse customers, brand building, and investor communication.
The host outlines a 48‑hour New York event for syndicate members, including dinners and speaker sessions.
The conversation shifts to details about Founder University cohorts in the U.S. and Japan, explaining the pre‑accelerator model and application process.
The hosts introduce the final round of the annotated app contest, explaining the prize and the demo format.
The team walks through the first demo, showcasing how users can annotate tweets, articles, and videos with commentary and share them.
Binance Hit By Massive Hackdata
Binance suffers a complex attack resulting in an estimated $6.3 billion loss, which the host notes as potentially the largest theft in history.
DoorDash announces a cash and stock deal to buy Instacart for $17 billion at $65 a share, offering a 25% premium over its closing price.
M and A Under Trumpinsight
The host argues that major M and A deals will easily pass under the current administration, unlike under Lina Khan's FTC.
Hermetic's AI Build Engineerstrategy
Jake Newfield pitches Hermetic, which provides an AI build engineer called Barn Owl and secured a top AI lab paying $240K for its product.
Why Labs Pay Startupsinsight
Addressing investor concerns about big labs building competing tools, the guest explains that it is a matter of strategic misalignment for labs to build everything themselves.
Brand As A Modern Moatinsight
The host explains that in an era where AI can quickly replicate software features, relentless execution, trust, and brand hospitality serve as the true moats.
Annotated Bounty Submissionsstory
The show reviews live demo submissions for the $5,000 annotated browser extension bounty, featuring tools that allow users to clip and comment on web articles and podcasts.
“If you watch the Americans, this can come at any angle.”
“Binance says it will cover all losses and has set aside more than $6.3 billion of company funds to do just that.”
“I would not trust leaving your money in Binance.”
“We should have a holiday. Or a tradition now that we do, you know how they have, we have Cyber Mondays and stuff like that?”
“The new moat is that you're relentless and that people trust you.”
“I think the new moat is that you're relentless and that people trust you.”
“We want to be the best investor you ever have, not just in this company, but for your entire career as a founder, you have to let my team know if there's anything we can do to support you more.”
“The concept of a pre‑accelerator is, we will work with you for 12 weeks to build your company, get product‑market fit, refine your pitch, hiring, whatever you need to get done.”
“I love how to handle video. Great job.”
“I think it's like, it does what it says. It says what it does.”
This Week In Startups is made possible by: Stripe: https://stripe.com/startups Rippling: https://rippling.ai/twist Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Plaud: https://plaud.ai/twist Today’s show: Binance lost an estimated $6.3 billion in the biggest crypto hack ever, and Jason proposes a radical solution. The entire tech industry should stop shipping new features for one month a year, and do nothing but patch. (Call it No App November?) On a busy Friday show, Jason and Lon dig into the. Binance breach and look back at Jason’s prescient 2021 warning about leaving your money in crypto exchanges. (He recommends spreading your wealth around various different banks!) Plus, why he’s giving CZ credit for backstopping customer losses out of his own fortune. Plus, DoorDash’s $17B acquisition of Instacart… Did DoorDash overpay? And is this happening now to avoid the harsher regulatory climate should Democrats regain power in the midterms? Then we’ve got Hermetiq co-founder and CEO Jake Newfield, who has twice won the LAUNCH Accelerator’s pitch competition. Hear the celebrated two-minute pitch for an AI build engineer, and find out why Jason thinks having a “lighthouse customer” makes such a huge difference. Finally, we’re awarding the Grand Prize in our $5K bounty competition to create Jason’s Annotated app, and remembering the legendary film and TV actor Sir Patrick Stewart. Guest Jake Newfield on LinkedIn: https://www.linkedin.com/in/jakenewfield/ Hermetiq: https://www.hermetiq.com/ Bazel: https://bazel.build Apply to the LAUNCH Accelerator: https://www.launch.co/apply Relevant Links Binance links the $6.3B theft to a compromised DevOps laptop (BleepingComputer): https://www.bleepingcomputer.com/news/security/binance-links-63-billion-crypto-theft-to-compromised-devops-laptop/ The 1978 Lufthansa heist (History.com): https://www.history.com/articles/1978-lufthansa-heist-jfk-henry-hill-goodfellas Trump pardons Binance founder Changpeng Zhao (KWTX/AP): https://www.kwtx.com/2025/10/23/trump-pardons-binance-founder-changpeng-zhao CrowdStrike: https://www.crowdstrike.com/en-us/ Palo Alto Networks: https://www.paloaltonetworks.com/ Grant Cardone challenges Jason to $1M Bitcoin bet: https://www.thestreet.com/crypto/markets/grant-cardone-challenges-bitcoin-bear-to-1-million-bet DoorDash to acquire Instacart for $17B (TechCrunch): https://techcrunch.com/2026/10/29/doordash-to-acquire-instacart-for-17b/ Economic Liberties calls on the FTC to block the deal: https://www.economicliberties.us/press-release/economic-liberties-calls-on-ftc-to-block-doordash-instacart-merger/ Central Market, H-E-B's upscale banner, expands home delivery (Supermarket News): https://www.supermarketnews.com/foodservice-retail/central-market-expands-curbside-and-home-delivery People are using AI to make their smart TVs dumb again (TechCrunch): https://techcrunch.com/2026/10/19/people-are-using-ai-to-make-their-smart-tvs-dumb-again/ TWiST $5K Bounties: https://bounty.thisweekinstartups.com/ Founder University: https://founder.university/ Founder University x Japan: https://japan.founder.university/ Inside.com domain auction: https://inside.com/ Yank Sing: https://yanksing.com/ Cafe du Monde coffee and chicory: https://shop.cafedumonde.com/product/coffee-beignets/cafe-du-monde-coffee-and-chicory Patrick Stewart, "Star Trek" and "X-Men" actor, dead at 86 (CNN): https://www.cnn.com/2026/10/29/entertainment/patrick-stewart-death “Time Squared” (Star Trek: TNG S2E13): https://memory-alpha.fandom.com/wiki/Time_Squared_(episode) “Green Room” trailer: https://www.youtube.com/watch?v=Q8XSARX3DQg “X-Men: Days of Future Past” trailer: https://www.youtube.com/watch?v=pK2zYHWDZKo Timestamps: 0:00 The largest crypto hack or theft in history 5:45 Jason gives CZ credit for backstopping losses 7:34 Jason’s cybersecurity proposals 11:48 Stripe Startups - Stripe Startups offers early-stage, venture-backed startups access to Stripe fee credits and more. Apply today on https://stripe.com/startups. 14:49 DoorDash buys Instacart for $17B 18:48 Is DoorDash overpaying? 24:28 Thanks to our partners at Rippling! Head to https://rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business. 26:26 Vibecoding your smart TV 27:20 Plaud: If your work depends on conversations - interviews, meetings, calls - you need a Plaud NotePin S. You can check it out at https://plaud.ai/twist and use code TWIST for 10% off! 30:04 Jake Newfield (Hermetiq) gives a perfect pitch 34:13 Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! - Learn more at https://www.northwestregisteredagent.com/twistdomain 37:12 Lead with your lighthouse customer 43:14 The Cafe Du Monde branding lesson 51:10 The Annotated Bounty finals begin 1:04:00 Jason announces the grand prize winner 1:07:34 RIP Sir Patrick Stewart Subscribe to our newsletters on Substack: TWiST: https://twistartups.substack.com/ TWiAI: https://www.thisweekinai.ai/ TWiVC: https://thisweekinvc.substack.com/ Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com
13,738 words · 3 speakers
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